{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:49:04Z","timestamp":1792212544119,"version":"4.4.0"},"reference-count":243,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DK118793"],"award-info":[{"award-number":["1R01DK118793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.actbio.2021.10.045","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T11:16:53Z","timestamp":1635592613000},"page":"73-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"special_numbering":"C","title":["Topical gel-based biomaterials for the treatment of diabetic foot ulcers"],"prefix":"10.1016","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6189-8438","authenticated-orcid":false,"given":"James R.","family":"Bardill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7010-7901","authenticated-orcid":false,"given":"Melissa R.","family":"Laughter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-9648","authenticated-orcid":false,"given":"Michael","family":"Stager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Liechty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa D.","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-8055","authenticated-orcid":false,"given":"Carlos","family":"Zgheib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2021.10.045_bib0001","series-title":"Prevention, National diabetes Statistics report, 2020, Atlanta, GA: Centers for Disease Control and Prevention","author":"Control","year":"2020"},{"key":"10.1016\/j.actbio.2021.10.045_bib0002","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2337\/dci18-0007","article-title":"Economic costs of diabetes in the us in 2017","volume":"41","author":"Care","year":"2018","journal-title":"Diabetes Care."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0003","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S2213-8587(17)30097-9","article-title":"The global economic burden of diabetes in adults aged 20\u201379 years: a cost-of-illness study","volume":"5","author":"Bommer","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0004","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.actbio.2017.04.034","article-title":"Preparation and in vivo evaluation of cationic elastic liposomes comprising highly skin-permeable growth factors combined with hyaluronic acid for enhanced diabetic wound-healing therapy","volume":"57","author":"Choi","year":"2017","journal-title":"Acta. Biomater."},{"issue":"9","key":"10.1016\/j.actbio.2021.10.045_bib0005","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the treatment of chronic wounds","volume":"4","author":"Frykberg","year":"2015","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0006","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/iwj.12443","article-title":"Estimating the costs associated with the management of patients with chronic wounds using linked routine data","volume":"13","author":"Phillips","year":"2016","journal-title":"Int. Wound J."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0331-8540.176206","article-title":"An overview of diabetic foot disease","volume":"13","author":"Dahiru","year":"2016","journal-title":"Nigerian J. Basic Clini. Sci."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.11648\/j.ijde.20180302.11","article-title":"Diabetic foot ulcer: synopsis of the epidemiology and pathophysiology","volume":"3","author":"Ibrahim","year":"2018","journal-title":"Intern. J. Diabetes Endocrinol."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0009","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07853890.2016.1231932","article-title":"Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis","volume":"49","author":"Zhang","year":"2017","journal-title":"Ann. Med."},{"issue":"24","key":"10.1016\/j.actbio.2021.10.045_bib0010","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic foot ulcers and their recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actbio.2021.10.045_bib0011","unstructured":"D. Atlas, International Diabetes federation, IDF Diabetes Atlas, 7th edn. Brussels, Belgium: International Diabetes Federation (2015)."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0012","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/wrr.12384","article-title":"Rapid identification of slow healing wounds","volume":"24","author":"Jung","year":"2016","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0013","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13047-020-00383-2","article-title":"Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer","volume":"13","author":"Armstrong","year":"2020","journal-title":"J. Foot Ankle Res."},{"issue":"10","key":"10.1016\/j.actbio.2021.10.045_bib0014","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actbio.2021.10.045_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2879809","article-title":"Increased mortality in diabetic foot ulcer patients: the significance of ulcer type","volume":"2016","author":"Chammas","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.actbio.2021.10.045_bib0016","doi-asserted-by":"crossref","first-page":"S583","DOI":"10.1016\/j.dsx.2017.04.008","article-title":"Diabetic foot ulcer carries high amputation and mortality rates, particularly in the presence of advanced age, peripheral artery disease and anemia","volume":"11","author":"Costa","year":"2017","journal-title":"Diabetes Metabolic Syndrome:"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0017","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejvs.2013.03.024","article-title":"Short and long term mortality rates after a lower limb amputation","volume":"46","author":"Fortington","year":"2013","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0018","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diacare.26.2.491","article-title":"Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology","volume":"26","author":"Moulik","year":"2003","journal-title":"Diabetes Care."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0019","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2337\/dc17-1836","article-title":"Current challenges and opportunities in the prevention and management of diabetic foot ulcers","volume":"41","author":"Jeffcoate","year":"2018","journal-title":"Diabetes Care."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0020","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1742-481X.2007.00392.x","article-title":"Guest editorial: are diabetes-related wounds and amputations worse than cancer","volume":"4","author":"Armstrong","year":"2007","journal-title":"Int. Wound J."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0021","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1517\/14728214.2013.802305","article-title":"Emerging drugs for the treatment of diabetic ulcers","volume":"18","author":"Tecilazich","year":"2013","journal-title":"Expert Opin. Emerg. Drugs"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0022","first-page":"61","article-title":"Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. diabetic ulcer study group","volume":"183","author":"Steed","year":"1996","journal-title":"J. Am. Coll. Surg."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0023","article-title":"Wound debridement for diabetic foot ulcers: a clinical practice review","volume":"22","author":"Holmes","year":"2019","journal-title":"Diabetic Foot J."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0024","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.diabres.2014.09.024","article-title":"Efficacy of shock wave therapy on chronic diabetic foot ulcer: a single-blinded randomized controlled clinical trial","volume":"106","author":"Omar","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"7","key":"10.1016\/j.actbio.2021.10.045_bib0025","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1067\/j.cpsurg.2014.04.001","article-title":"Effect of negative pressure wound therapy on wound healing","volume":"51","author":"Huang","year":"2014","journal-title":"Curr. Probl. Surg."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0026","doi-asserted-by":"crossref","first-page":"431","DOI":"10.7547\/17-146","article-title":"Effectiveness and duration of plantar pressure off-loading by two designs of felt padding: a preliminary study","volume":"109","author":"Nieto-Gil","year":"2019","journal-title":"J. Am. Podiatr. Med. Assoc."},{"key":"10.1016\/j.actbio.2021.10.045_bib0027","article-title":"Skin tissue engineering: principles and advances","author":"Dhasmana","year":"2018","journal-title":"J. Dermatol Skin 1"},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0028","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/157339912800563963","article-title":"Advances in the topical treatment of diabetic foot ulcers","volume":"8","author":"Papanas","year":"2012","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.actbio.2021.10.045_bib0029","article-title":"Modern exudate management: a review of wound treatments","volume":"1","author":"White","year":"2006","journal-title":"World Wide Wounds"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0030","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.actbio.2021.10.045_bib0031","first-page":"38","article-title":"A closer look at bioengineered alternative tissues","volume":"19","author":"Kim","year":"2006","journal-title":"Podiatry Today"},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0032","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/iwj.12053","article-title":"A prospective, multicentre, randomised controlled study of human fibroblast-derived dermal substitute (Dermagraft) in patients with venous leg ulcers","volume":"10","author":"Harding","year":"2013","journal-title":"Int. Wound J."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0033","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/wrr.12332","article-title":"Comparative effectiveness of a bioengineered living cellular construct vs. a dehydrated human amniotic membrane allograft for the treatment of diabetic foot ulcers in a real world setting","volume":"23","author":"Kirsner","year":"2015","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1586\/17434440.1.1.21","article-title":"Dermagraft\u00ae, a bioengineered human dermal equivalent for the treatment of chronic nonhealing diabetic foot ulcer","volume":"1","author":"Marston","year":"2004","journal-title":"Expert Rev. Med. Devices"},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0036","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/09546634.2018.1530443","article-title":"Skin substitutes for acute and chronic wound healing: an updated review","volume":"31","author":"Dai","year":"2020","journal-title":"J. Dermatol. Treatment"},{"issue":"7","key":"10.1016\/j.actbio.2021.10.045_bib0037","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1089\/wound.2012.0412","article-title":"Clinical impact upon wound healing and inflammation in moist, wet, and dry environments","volume":"2","year":"2013","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0038","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1468-3083.2010.03775.x","article-title":"Management of minor acute cutaneous wounds: importance of wound healing in a moist environment","volume":"25","author":"Korting","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0039","doi-asserted-by":"crossref","DOI":"10.1097\/00129334-200701000-00013","article-title":"The role of moisture balance in wound healing","volume":"20","author":"Okan","year":"2007","journal-title":"Adv. Skin Wound Care"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0040","doi-asserted-by":"crossref","DOI":"10.7603\/s40681-015-0022-9","article-title":"Wound dressings\u2013a review","volume":"5","author":"Dhivya","year":"2015","journal-title":"Biomedicine (Taipei)"},{"issue":"9","key":"10.1016\/j.actbio.2021.10.045_bib0041","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/exd.13290","article-title":"Biomaterials: a potential pathway to healing chronic wounds?","volume":"26","author":"Pop","year":"2017","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0042","series-title":"The Place of Biomaterials in Wound Healing","first-page":"337","author":"Bianchera","year":"2020"},{"key":"10.1016\/j.actbio.2021.10.045_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00481","article-title":"Electrospun biomaterials in the treatment and prevention of scars in skin wound healing","volume":"8","author":"Mulholland","year":"2020","journal-title":"Front Bioeng Biotechnol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0044","article-title":"Functional biomaterials for treatment of chronic wound","volume":"8","author":"Zhang","year":"2020","journal-title":"Front Bioeng Biotechnol."},{"issue":"585","key":"10.1016\/j.actbio.2021.10.045_bib0045","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe4839","article-title":"Advanced bandages for diabetic wound healing","volume":"13","author":"Matoori","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0046","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic wound healing: a review of current management and treatments","volume":"34","author":"Han","year":"2017","journal-title":"Adv. Ther."},{"key":"10.1016\/j.actbio.2021.10.045_bib0047","volume":"6","author":"Eming","year":"2014"},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0048","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12079-016-0330-1","article-title":"Cellular mechanisms of skin repair in humans and other mammals","volume":"10","author":"Ritti\u00e9","year":"2016","journal-title":"J. Cell Commun. Signal"},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0049","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/01926230701584189","article-title":"Novel insights into wound healing sequence of events","volume":"35","author":"Braiman-Wiksman","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0050","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jss.2007.12.754","article-title":"Talactoferrin stimulates wound healing with modulation of inflammation","volume":"149","author":"Engelmayer","year":"2008","journal-title":"J. Surg. Res."},{"issue":"7","key":"10.1016\/j.actbio.2021.10.045_bib0051","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.it.2019.05.001","article-title":"The healing power of neutrophils","volume":"40","author":"Phillipson","year":"2019","journal-title":"Trends Immunol."},{"issue":"11","key":"10.1016\/j.actbio.2021.10.045_bib0052","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1089\/wound.2014.0559","article-title":"Chemokine regulation of neutrophil infiltration of skin wounds","volume":"4","author":"Su","year":"2015","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0053","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1016\/j.jdermsci.2016.08.278","article-title":"Recruitment, activation and function of monocytes\/macrophage in skin wound healing","volume":"84","author":"Willenborg","year":"2016","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0054","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2050-7771-2-1","article-title":"Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases","volume":"2","author":"Yang","year":"2014","journal-title":"Biomark. Res."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/MOT.0000000000000313","article-title":"Role of monocytes and macrophages in regulating immune response following lung transplantation","volume":"21","author":"Chiu","year":"2016","journal-title":"Current Opin. Organ Transplant."},{"key":"10.1016\/j.actbio.2021.10.045_bib0056","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-3-319-54090-0_14","article-title":"Macrophage differentiation in normal and accelerated wound healing","author":"Kotwal","year":"2017","journal-title":"Macrophages"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11926-018-0725-5","article-title":"Macrophages, wound healing, and fibrosis: recent insights","volume":"20","author":"Smigiel","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.actbio.2021.10.045_bib0058","first-page":"2019","article-title":"Skin acute wound healing: a comprehensive review","author":"Ca\u00f1edo-Dorantes","year":"2019","journal-title":"Int. J. Inflam."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0059","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cpen.2011.04.001","article-title":"The physiology of wound healing: injury through maturation","volume":"6","author":"Teller","year":"2011","journal-title":"Perioperat. Nursing Clin."},{"issue":"10","key":"10.1016\/j.actbio.2021.10.045_bib0060","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/wound.2013.0517","article-title":"Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair","volume":"3","author":"Johnson","year":"2014","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0061","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing-A literature review","volume":"91","author":"Gonzalez","year":"2016","journal-title":"An. Bras. Dermatol."},{"issue":"9","key":"10.1016\/j.actbio.2021.10.045_bib0062","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.mpsur.2017.06.004","article-title":"The physiology of wound healing","volume":"35","author":"Singh","year":"2017","journal-title":"Surgery (Oxford)"},{"key":"10.1016\/j.actbio.2021.10.045_bib0063","first-page":"301","article-title":"Fibroblasts and myofibroblasts in wound healing","volume":"7","author":"Darby","year":"2014","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0064","article-title":"Fibroblasts and wound healing: an update","author":"Desjardins-Park","year":"2018","journal-title":"Future Med."},{"issue":"8","key":"10.1016\/j.actbio.2021.10.045_bib0065","article-title":"Wound healing and the role of fibroblasts","volume":"22","author":"Bainbridge","year":"2013","journal-title":"J. Wound Care"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0066","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s13671-018-0234-9","article-title":"Immunology of wound healing","volume":"7","author":"Ellis","year":"2018","journal-title":"Curr. Dermatol. Rep."},{"key":"10.1016\/j.actbio.2021.10.045_bib0067","unstructured":"M. Alhajj, P. Bansal, A. Goyal, Physiology, granulation tissue, statpearls [Internet] (2020)."},{"key":"10.1016\/j.actbio.2021.10.045_bib0068","volume":"2012","author":"Al-Bayaty","year":"2012"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0069","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/wound.2014.0595","article-title":"Topical collagen-based biomaterials for chronic wounds: rationale and clinical application","volume":"5","author":"Gould","year":"2016","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.actbio.2021.10.045_bib0070","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3389\/fphys.2018.00419","article-title":"The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes","volume":"9","author":"Krzyszczyk","year":"2018","journal-title":"Front Physiol."},{"issue":"8","key":"10.1016\/j.actbio.2021.10.045_bib0071","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.it.2011.04.009","article-title":"Neutrophil clearance: when the party is over, clean-up begins","volume":"32","author":"Bratton","year":"2011","journal-title":"Trends Immunol."},{"issue":"7","key":"10.1016\/j.actbio.2021.10.045_bib0072","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/01.ASW.0000416006.55218.d0","article-title":"Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: normal and chronic wounds: biology, causes, and approaches to care","volume":"25","author":"Demidova-Rice","year":"2012","journal-title":"Adv. Skin Wound Care"},{"issue":"12","key":"10.1016\/j.actbio.2021.10.045_bib0073","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in chronic wounds","volume":"17","author":"Zhao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0074","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nri.2017.10","article-title":"Neutrophils as protagonists and targets in chronic inflammation","volume":"17","author":"Soehnlein","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091574","article-title":"Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response","volume":"9","author":"Wood","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.actbio.2021.10.045_bib0076","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/wound.2014.0602","article-title":"Chemokines as therapeutic targets to improve healing efficiency of chronic wounds","volume":"4","author":"Satish","year":"2015","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0077","doi-asserted-by":"crossref","DOI":"10.1111\/1523-1747.ep12276722","article-title":"Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds","volume":"109","author":"Vaalamo","year":"1997","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0078","doi-asserted-by":"crossref","first-page":"277","DOI":"10.12968\/jowc.2016.25.5.277","article-title":"Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence","volume":"25","author":"Lazaro","year":"2016","journal-title":"J. Wound Care"},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0079","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1742-481X.2006.00233.x","article-title":"Topical application of the tumour necrosis factor-\u03b1 antibody infliximab improves healing of chronic wounds","volume":"3","author":"Streit","year":"2006","journal-title":"Int. Wound J."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0014-5793(90)81127-A","article-title":"Tumor necrosis factor bifunctionally regulates matrix metalloproteinases and tissue inhibitor of metalloproteinases (TIMP) production by human fibroblasts","volume":"269","author":"Ito","year":"1990","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0081","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1524-475X.2011.00748.x","article-title":"Tumor necrosis factor-alpha (TNF-\u03b1) is a therapeutic target for impaired cutaneous wound healing","volume":"20","author":"Ashcroft","year":"2012","journal-title":"Wound Repair Regen."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0082","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.ajpath.2015.02.011","article-title":"Substance p promotes wound healing in diabetes by modulating inflammation and macrophage phenotype","volume":"185","author":"Leal","year":"2015","journal-title":"Am. J. Pathol."},{"issue":"03","key":"10.1016\/j.actbio.2021.10.045_bib0083","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1055\/s-2000-7738","article-title":"Serum levels of substance p are decreased in patients with type 1 diabetes","volume":"108","author":"Kunt","year":"2000","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0084","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/jsre.2002.6525","article-title":"Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus","volume":"108","author":"Gibran","year":"2002","journal-title":"J. Surg. Res."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0085","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jss.2009.09.012","article-title":"Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing","volume":"167","author":"Pradhan","year":"2011","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.actbio.2021.10.045_bib0086","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/701738","article-title":"Hyperglycemia-induced changes in hyaluronan contribute to impaired skin wound healing in diabetes: review and perspective","volume":"2015","author":"Shakya","year":"2015","journal-title":"Int. J. Cell Biol."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0087","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/nu9050437","article-title":"The \u201cmetabolic memory\u201d theory and the early treatment of hyperglycemia in prevention of diabetic complications","volume":"9","author":"Testa","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0088","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: the functional role of ros and emerging ROS-modulating technologies for augmentation of the healing process","volume":"14","author":"Dunnill","year":"2017","journal-title":"Int. Wound J."},{"key":"10.1016\/j.actbio.2021.10.045_bib0089","series-title":"Hyperglycemia-induced Oxidative Stress in the Development of Diabetic Foot Ulcers, Diabetes","first-page":"35","author":"Bolajoko","year":"2020"},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0090","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jvs.2012.11.095","article-title":"Expression of neuropeptides and cytokines in a rabbit model of diabetic neuroischemic wound healing","volume":"58","author":"Pradhan Nabzdyk","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.actbio.2021.10.045_bib0091","article-title":"Fabrication, applications and challenges of natural biomaterials in tissue engineering","volume":"20","author":"Ullah","year":"2020","journal-title":"Appl. Mater. Today"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0092","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40204-018-0083-4","article-title":"Synthetic polymeric biomaterials for wound healing: a review","volume":"7","author":"Mir","year":"2018","journal-title":"Prog. Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0093","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0169-409X(01)00189-2","article-title":"Topical formulations and wound healing applications of chitosan","volume":"52","author":"Ueno","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0094","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1021\/bm034130m","article-title":"Chitosan as antimicrobial agent:\u2009 applications and mode of action","volume":"4","author":"Rabea","year":"2003","journal-title":"Biomacromolecules"},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1590\/S0104-14282009000300013","article-title":"A review of the antimicrobial activity of chitosan","volume":"19","author":"Goy","year":"2009","journal-title":"Pol\u00edmeros"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0096","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.sjbs.2017.03.017","article-title":"Chitosan treatment for skin ulcers associated with diabetes","volume":"25","author":"Esc\u00e1rcega-Galaz","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"issue":"13","key":"10.1016\/j.actbio.2021.10.045_bib0097","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1016\/j.biomaterials.2012.01.041","article-title":"The effect of oxidation on the degradation of photocrosslinkable alginate hydrogels","volume":"33","author":"Jeon","year":"2012","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0098","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1081\/DDC-120003853","article-title":"Alginate in drug delivery systems","volume":"28","author":"T\u00f8nnesen","year":"2002","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.actbio.2021.10.045_bib0099","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ijbiomac.2020.12.221","article-title":"In-vivo evaluation of alginate-pectin hydrogel film loaded with simvastatin for diabetic wound healing in streptozotocin-induced diabetic rats","volume":"171","author":"Rezvanian","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112169","article-title":"Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels","volume":"126","author":"Shah","year":"2021","journal-title":"Mater. Sci. Engin."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0101","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/15583724.2017.1315433","article-title":"Hyaluronic acid-based biomaterials: a versatile and smart approach to tissue regeneration and treating traumatic, surgical, and chronic wounds","volume":"57","author":"Hussain","year":"2017","journal-title":"Polym. Rev."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0102","first-page":"78","article-title":"Hyaluronic acid in inflammation and tissue regeneration","volume":"28","author":"Litwiniuk","year":"2016","journal-title":"Wounds"},{"issue":"18","key":"10.1016\/j.actbio.2021.10.045_bib0103","first-page":"2756","article-title":"Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats","volume":"5","author":"Al Bayaty","year":"2010","journal-title":"Scient. Res. Essays"},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0104","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.pharep.2016.07.001","article-title":"Hyaluronan oligosaccharides promote diabetic wound healing by increasing angiogenesis","volume":"68","author":"Wang","year":"2016","journal-title":"Pharmacol. Reports"},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0105","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.nano.2015.03.002","article-title":"Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration","volume":"11","author":"Gainza","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0106","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40824-016-0056-4","article-title":"Development of stabilized growth factor-loaded hyaluronate\u2013 collagen dressing (HCD) matrix for impaired wound healing","volume":"20","author":"Choi","year":"2016","journal-title":"Biomater Res"},{"issue":"8","key":"10.1016\/j.actbio.2021.10.045_bib0107","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/bip.22486","article-title":"Collagen-based biomaterials for wound healing","volume":"101","author":"Chattopadhyay","year":"2014","journal-title":"Biopolymers"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0108","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1097\/PRS.0b013e3181eae781","article-title":"Scarless fetal wound healing: a basic science review","volume":"126","author":"Larson","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"issue":"12","key":"10.1016\/j.actbio.2021.10.045_bib0109","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/term.1691","article-title":"Recombinant human collagen iii gel for transplantation of autologous skin cells in porcine full-thickness wounds","volume":"9","author":"Nuutila","year":"2015","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"7","key":"10.1016\/j.actbio.2021.10.045_bib0110","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/mt.2013.87","article-title":"Topical application of recombinant type vii collagen incorporates into the dermal\u2013epidermal junction and promotes wound closure","volume":"21","author":"Wang","year":"2013","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0111","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.acthis.2013.04.010","article-title":"Topical pluronic F-127 gel application enhances cutaneous wound healing in rats","volume":"116","author":"Kant","year":"2014","journal-title":"Acta. Histochem."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0112","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1021\/bm701301s","article-title":"Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma","volume":"9","author":"Ladd","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2021.10.045_bib0113","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119519","article-title":"Zwitterionic polymer\/polydopamine coating reduce acute inflammatory tissue responses to neural implants","volume":"225","author":"Golabchi","year":"2019","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0114","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nbt.2580","article-title":"Zwitterionic hydrogels implanted in mice resist the foreign-body reaction","volume":"31","author":"Zhang","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0115","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.actbio.2018.02.034","article-title":"Sulfated zwitterionic poly (sulfobetaine methacrylate) hydrogels promote complete skin regeneration","volume":"71","author":"Wu","year":"2018","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0116","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1039\/D0BM01608J","article-title":"Zwitterionic hydrogel for sustained release of growth factors to enhance wound healing","volume":"9","author":"Xiao","year":"2021","journal-title":"Biomater Sci"},{"issue":"10","key":"10.1016\/j.actbio.2021.10.045_bib0117","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1039\/C8TB02590H","article-title":"Zwitterionic poly (sulfobetaine methacrylate) hydrogels with optimal mechanical properties for improving wound healing in vivo","volume":"7","author":"He","year":"2019","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0118","first-page":"1","article-title":"A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers","volume":"2","author":"Fang","year":"2008","journal-title":"Biologics"},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0119","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S1086-5802(16)30386-2","article-title":"Use of regranex gel for diabetic foot ulcers","volume":"38","author":"Piascik","year":"1998","journal-title":"J. Am. Pharm. Assoc. (Wash. DC)"},{"key":"10.1016\/j.actbio.2021.10.045_bib0120","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.1999.79.4.1283","article-title":"Mechanism of action and in vivo role of platelet-derived growth factor","author":"Heldin","year":"1999","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0121","doi-asserted-by":"crossref","first-page":"822","DOI":"10.2337\/diacare.21.5.822","article-title":"Efficacy and safely of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers: a phase iii randomized placebo-controlled double-blind study","volume":"21","author":"Wieman","year":"1998","journal-title":"Diabetes Care."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0122","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00006534-200003000-00065","article-title":"Becaplermin gel (PDGF-BB) as topical wound therapy","volume":"105","author":"Ladin","year":"2000","journal-title":"Plast. Reconstr. Surg."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0123","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2147\/CIA.S1106","article-title":"Becaplermin gel in the treatment of diabetic neuropathic foot ulcers","volume":"3","author":"Papanas","year":"2008","journal-title":"Clin. Interv Aging"},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0124","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2165\/11534570-000000000-00000","article-title":"Benefit-Risk assessment of becaplermin in the treatment of diabetic foot ulcers","volume":"33","author":"Papanas","year":"2010","journal-title":"Drug Saf."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0125","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7547\/15-004","article-title":"Cost-effectiveness of becaplermin gel on diabetic foot ulcer healing: changes in wound surface area","volume":"106","author":"Waycaster","year":"2016","journal-title":"J. Am. Podiatr. Med. Assoc."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0126","first-page":"255","article-title":"Becaplermin (Regranex) for diabetic foot ulcers","volume":"78","author":"Jarvis","year":"2008","journal-title":"Am. Fam. Physician"},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0127","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0128","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/nu8030167","article-title":"Quercetin, inflammation and immunity","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0129","first-page":"41","article-title":"Hyperbaric oxygen therapy treatment for chronic wounds","volume":"2","author":"Kaufman","year":"2020","journal-title":"Lynchburg Journal of Medical Science"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41427-019-0166-2","article-title":"Breathing life into engineered tissues using oxygen-releasing biomaterials","volume":"11","author":"Suvarnapathaki","year":"2019","journal-title":"NPG Asia Materials"},{"key":"10.1016\/j.actbio.2021.10.045_bib0131","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2741\/3272","article-title":"Enhancing oxygen solubility using hemoglobin-and perfluorocarbon-based carriers","volume":"14","author":"Centis","year":"2009","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"3\u20134","key":"10.1016\/j.actbio.2021.10.045_bib0132","doi-asserted-by":"crossref","first-page":"e466","DOI":"10.1093\/milmed\/usz337","article-title":"A supersaturated oxygen emulsion for the topical treatment of ocular trauma","volume":"185","author":"Pate","year":"2020","journal-title":"Mil. Med."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0133","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/17460441.2019.1588879","article-title":"The discovery and development of topical medicines for wound healing","volume":"14","author":"\u00d6hnstedt","year":"2019","journal-title":"Expert. Drug Discov."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0134","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/1523-1747.ep12319188","article-title":"Reduced expression of pdgf and pdgf receptors during impaired wound healing","volume":"109","author":"Beer","year":"1997","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0135","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1464-5491.2006.01773.x","article-title":"The molecular biology of chronic wounds and delayed healing in diabetes","volume":"23","author":"Blakytny","year":"2006","journal-title":"Diabet. Med."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0136","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.2337\/diacare.26.6.1856","article-title":"Human epidermal growth factor enhances healing of diabetic foot ulcers","volume":"26","author":"Tsang","year":"2003","journal-title":"Diabetes Care."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0137","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00006534-199108000-00001","article-title":"Stimulation of healing of chronic wounds by epidermal growth factor","volume":"88","author":"Brown","year":"1991","journal-title":"Plast. Reconstr. Surg."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0138","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/01.sap.0000198731.12407.0c","article-title":"Recombinant human epidermal growth factor (EGF) to enhance healing for diabetic foot ulcers","volume":"56","author":"Hong","year":"2006","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.actbio.2021.10.045_bib0139","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.diabres.2018.06.002","article-title":"Topical epidermal growth factor spray for the treatment of chronic diabetic foot ulcers: a phase iii multicenter, double-blind, randomized, placebo-controlled trial","volume":"142","author":"Park","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0140","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1006\/jsre.1994.1090","article-title":"PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse","volume":"56","author":"Brown","year":"1994","journal-title":"J. Surg. Res."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0141","doi-asserted-by":"crossref","first-page":"e92667","DOI":"10.1371\/journal.pone.0092667","article-title":"Combination therapy accelerates diabetic wound closure","volume":"9","author":"Allen","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.actbio.2021.10.045_bib0142","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1016\/j.bbamcr.2017.08.003","article-title":"Matrix metalloproteinases: the sculptors of chronic cutaneous wounds","volume":"1864","author":"Krishnaswamy","year":"2017","journal-title":"Biochim. Biophys. Acta."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0143","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1021\/acsbiomaterials.8b01348","article-title":"Self-Assembling multidomain peptides: design and characterization of neutral peptide-based materials with pH and ionic strength independent self-assembly","volume":"5","author":"Lopez-Silva","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.actbio.2021.10.045_bib0144","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120401","article-title":"Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury","volume":"265","author":"Lopez-Silva","year":"2021","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0145","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1021\/acsbiomaterials.8b00031","article-title":"Multidomain peptide hydrogel accelerates healing of full-thickness wounds in diabetic mice","volume":"4","author":"Carrejo","year":"2018","journal-title":"ACS Biomater Sci Eng"},{"issue":"40","key":"10.1016\/j.actbio.2021.10.045_bib0146","doi-asserted-by":"crossref","first-page":"E5792","DOI":"10.1073\/pnas.1612277113","article-title":"Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization","volume":"113","author":"Xiao","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0147","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10238-011-0136-7","article-title":"A new protocol for the treatment of the chronic venous ulcers of the lower limb","volume":"12","author":"Maggio","year":"2012","journal-title":"Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0148","doi-asserted-by":"crossref","first-page":"29","DOI":"10.12968\/jowc.2010.19.1.46096","article-title":"Effectiveness of topical application of amino acids to chronic wounds: a prospective observational study","volume":"19","author":"Cassino","year":"2010","journal-title":"J. Wound Care"},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0149","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/1534734609344140","article-title":"Effectiveness and safety of a novel gel dressing in the management of neuropathic leg ulcers in diabetic patients: a prospective double-blind randomized trial","volume":"8","author":"Abbruzzese","year":"2009","journal-title":"Int. J. Low Extrem Wounds"},{"key":"10.1016\/j.actbio.2021.10.045_bib0150","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.actbio.2016.04.030","article-title":"Cell recruiting chemokine-loaded sprayable gelatin hydrogel dressings for diabetic wound healing","volume":"38","author":"Yoon","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2021.10.045_bib0151","doi-asserted-by":"crossref","unstructured":"G.S. Ghatnekar, M.P. O'Quinn, L.J. Jourdan, A.A. Gurjarpadhye, R.L. Draughn, R.G. Gourdie, Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding, (2009).","DOI":"10.2217\/17460751.4.2.205"},{"key":"10.1016\/j.actbio.2021.10.045_bib0152","series-title":"Formulations and Methods of Use For Alpha Connexin C-terminal (ACT) Peptides","author":"Ghatnekar","year":"2015"},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0153","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/wrr.12275","article-title":"Topical administration of a connexin43-based peptide augments healing of chronic neuropathic diabetic foot ulcers: a multicenter, randomized trial","volume":"23","author":"Grek","year":"2015","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0155","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cyto.2014.12.015","article-title":"Topical application of substance p promotes wound healing in streptozotocin-induced diabetic rats","volume":"73","author":"Kant","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.actbio.2021.10.045_bib0156","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jpeds.2016.02.071","article-title":"Overview of lactoferrin as a natural immune modulator","volume":"173","author":"Legrand","year":"2016","journal-title":"J. Pediatr."},{"key":"10.1016\/j.actbio.2021.10.045_bib0157","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.2147\/IJN.S213883","article-title":"Preparation and in vivo evaluation of a topical hydrogel system incorporating highly skin-permeable growth factors, quercetin, and oxygen carriers for enhanced diabetic wound-healing therapy","volume":"14","author":"Jee","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0158","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"issue":"49","key":"10.1016\/j.actbio.2021.10.045_bib0159","doi-asserted-by":"crossref","first-page":"41892","DOI":"10.1021\/acsami.8b08920","article-title":"Tunable hydrogels derived from genetically engineered extracellular matrix accelerate diabetic wound healing","volume":"10","author":"Morris","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0160","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phrs.2008.06.004","article-title":"Oxidative stress in normal and impaired wound repair","volume":"58","author":"Sch\u00e4fer","year":"2008","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0161","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/md17050285","article-title":"Edaravone-loaded alginate-based nanocomposite hydrogel accelerated chronic wound healing in diabetic mice","volume":"17","author":"Fan","year":"2019","journal-title":"Mar Drugs"},{"key":"10.1016\/j.actbio.2021.10.045_bib0162","series-title":"Activation of Skin Renin-Angiotensin System in Streptozotocin-Induced Diabetic Rat, DIABETES","author":"Hao","year":"2010"},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0163","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jid.2017.09.030","article-title":"Topical reformulation of valsartan for treatment of chronic diabetic wounds","volume":"138","author":"Abadir","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.actbio.2021.10.045_bib0164","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/1535370213492688","article-title":"Topical naltrexone accelerates full-thickness wound closure in type 1 diabetic rats by stimulating angiogenesis","volume":"238","author":"McLaughlin","year":"2013","journal-title":"Exp. Biol. Med."},{"issue":"10","key":"10.1016\/j.actbio.2021.10.045_bib0165","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1177\/1535370213502632","article-title":"Topical treatment with the opioid antagonist naltrexone accelerates the remodeling phase of full-thickness wound healing in type 1 diabetic rats","volume":"238","author":"Immonen","year":"2013","journal-title":"Exp. Biol. Med."},{"issue":"1_supplement","key":"10.1016\/j.actbio.2021.10.045_bib0166","article-title":"Comparison of topical pdgf and naltrexone on full-thickness diabetic wound healing","volume":"31","author":"Titunick","year":"2017","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0167","doi-asserted-by":"crossref","first-page":"e8639","DOI":"10.1371\/journal.pone.0008639","article-title":"Expression and function of tnf and IL-1 receptors on human regulatory t cells","volume":"5","author":"Mercer","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0168","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1177\/1099800409346333","article-title":"The role of doxycycline as a matrix metalloproteinase inhibitor for the treatment of chronic wounds","volume":"11","author":"Stechmiller","year":"2010","journal-title":"Biol. Res. Nurs."},{"issue":"10","key":"10.1016\/j.actbio.2021.10.045_bib0169","first-page":"315","article-title":"Treatment of chronic ulcers in diabetic patients with a topical metalloproteinase inhibitor, doxycycline","volume":"15","author":"Chin","year":"2003","journal-title":"Wounds"},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0170","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.atherosclerosis.2011.01.009","article-title":"Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function","volume":"215","author":"Ikeda","year":"2011","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0171","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41427-018-0103-9","article-title":"An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair","volume":"11","author":"Chen","year":"2019","journal-title":"NPG Asia Mater."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0172","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s13346-020-00794-5","article-title":"Levofloxacin nanoemulsion gel has a powerful healing effect on infected wound in streptozotocin-induced diabetic rats","volume":"11","author":"Valizadeh","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"issue":"9","key":"10.1016\/j.actbio.2021.10.045_bib0173","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/wound.2016.0725","article-title":"Topical naltrexone is a safe and effective alternative to standard treatment of diabetic wounds","volume":"6","author":"McLaughlin","year":"2017","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0174","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cmdc.200600171","article-title":"Topical delivery of silver nanoparticles promotes wound healing","volume":"2","author":"Tian","year":"2007","journal-title":"ChemMedChem"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0175","doi-asserted-by":"crossref","DOI":"10.18388\/abp.2013_2016","article-title":"Silver nanoparticles as an alternative strategy against bacterial biofilms","volume":"60","author":"Markowska","year":"2013","journal-title":"Acta Biochim. Pol."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0176","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cmdc.200600171","article-title":"Topical delivery of silver nanoparticles promotes wound healing","volume":"2","author":"Tian","year":"2007","journal-title":"ChemMedChem: Chemistry Enabling Drug Discovery"},{"key":"10.1016\/j.actbio.2021.10.045_bib0177","first-page":"93","volume":"7","author":"Sim","year":"2018"},{"issue":"9","key":"10.1016\/j.actbio.2021.10.045_bib0178","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1007\/s11051-014-2605-x","article-title":"An investigation of in vivo wound healing activity of biologically synthesized silver nanoparticles","volume":"16","author":"Kaler","year":"2014","journal-title":"J. Nanopart. Res."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0179","first-page":"59","article-title":"Study of effect of topical nano silver gel on wound healing","volume":"4","author":"Sharma","year":"2016","journal-title":"J. Adv. Med. Dental Sci. Res."},{"key":"10.1016\/j.actbio.2021.10.045_bib0180","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.carbpol.2018.07.077","article-title":"Topical delivery of chitosan-capped silver nanoparticles speeds up healing in burn wounds: a preclinical study","volume":"200","author":"Oryan","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2021.10.045_bib0181","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijpharm.2019.01.019","article-title":"Silver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits","volume":"559","author":"Masood","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2021.10.045_bib0182","first-page":"47","volume":"15","author":"Kaur","year":"2019"},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0183","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s13346-018-0554-0","article-title":"Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly(vinyl alcohol)-borate hydrogels","volume":"8","author":"Abdelkader","year":"2018","journal-title":"Drug Deliv Transl. Res."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0184","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/bcpt.13248","article-title":"Nebivolol in the treatment of arterial hypertension","volume":"125","author":"Olawi","year":"2019","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0185","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1208\/s12249-016-0574-3","article-title":"Nebivolol-loaded microsponge gel for healing of diabetic wound","volume":"18","author":"Pandit","year":"2017","journal-title":"AAPS PharmSciTech."},{"issue":"13","key":"10.1016\/j.actbio.2021.10.045_bib0186","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.2174\/138161210791050997","article-title":"Gene therapy to improve high-density lipoprotein metabolism and function","volume":"16","author":"Van Craeyveld","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0187","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3390\/ph7040419","article-title":"The impact of lipoproteins on wound healing: topical hdl therapy corrects delayed wound healing in apolipoprotein e deficient mice","volume":"7","author":"Gordts","year":"2014","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.actbio.2021.10.045_bib0188","article-title":"A review of levofloxacin for the treatment of bacterial infections","volume":"1","author":"Noel","year":"2009","journal-title":"Clin. Med. Ther."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0189","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/jac\/dkh412","article-title":"Tissue and serum levofloxacin concentrations in diabetic foot infection patients","volume":"54","author":"Oberdorfer","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.actbio.2021.10.045_bib0190","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.actbio.2019.11.014","article-title":"Injectable, self-healable zwitterionic cryogels with sustained microRNA-cerium oxide nanoparticle release promote accelerated wound healing","volume":"101","author":"Sener","year":"2020","journal-title":"Acta Biomater."},{"issue":"11","key":"10.1016\/j.actbio.2021.10.045_bib0191","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.2337\/db12-0145","article-title":"The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: correction with mesenchymal stem cell treatment","volume":"61","author":"Xu","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0192","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jamcollsurg.2018.09.017","article-title":"Use of cerium oxide nanoparticles conjugated with microRNA-146a to correct the diabetic wound healing impairment","volume":"228","author":"Zgheib","year":"2019","journal-title":"J. Am. Coll. Surg."},{"issue":"9","key":"10.1016\/j.actbio.2021.10.045_bib0193","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2217\/nnm.13.133","article-title":"Cerium oxide nanoparticles: applications and prospects in nanomedicine","volume":"8","author":"Das","year":"2013","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0194","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1021\/acs.nanolett.7b04421","article-title":"Extreme mechanical behavior of nacre-mimetic graphene-oxide and silk nanocomposites","volume":"18","author":"Xie","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2021.10.045_bib0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.590285","article-title":"Nanosilk increases the strength of diabetic skin and delivers CNP-miR146a to improve wound healing","volume":"11","author":"Niemiec","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep45859","article-title":"pH-controlled cerium oxide nanoparticle inhibition of both gram-positive and gram-negative bacteria growth","volume":"7","author":"Alpaslan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2021.10.045_bib0197","volume":"2018","author":"Farias","year":"2018"},{"key":"10.1016\/j.actbio.2021.10.045_bib0198","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jcis.2018.01.110","article-title":"Development of reduced graphene oxide (rGO)-isabgol nanocomposite dressings for enhanced vascularization and accelerated wound healing in normal and diabetic rats","volume":"517","author":"Thangavel","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.actbio.2021.10.045_bib0199","first-page":"234","volume":"10","author":"Blanco-Fernandez","year":"2021"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0200","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s12015-018-9817-x","article-title":"Mesenchymal stem cells on horizon: a new arsenal of therapeutic agents","volume":"14","author":"Abbasi-Malati","year":"2018","journal-title":"Stem Cell Rev. Reports"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0201","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3727\/096368915X687921","article-title":"Adipose-derived stem cells accelerate diabetic wound healing through the induction of autocrine and paracrine effects","volume":"25","author":"Kuo","year":"2016","journal-title":"Cell Transplant."},{"key":"10.1016\/j.actbio.2021.10.045_bib0202","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jss.2017.04.032","article-title":"Adipose-derived stem cells seeded in pluronic F-127 hydrogel promotes diabetic wound healing","volume":"217","author":"Kaisang","year":"2017","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.actbio.2021.10.045_bib0203","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.actbio.2018.05.039","article-title":"A hybrid injectable hydrogel from hyperbranched peg macromer as a stem cell delivery and retention platform for diabetic wound healing","volume":"75","author":"Xu","year":"2018","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.actbio.2021.10.045_bib0204","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1039\/C7SC03913A","article-title":"Injectable hyperbranched poly (\u03b2-amino ester) hydrogels with on-demand degradation profiles to match wound healing processes","volume":"9","author":"Xu","year":"2018","journal-title":"Chem. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0205","doi-asserted-by":"crossref","first-page":"18104","DOI":"10.1038\/srep18104","article-title":"Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0206","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/sj.mt.6300156","article-title":"Thermosensitive hydrogel peg\u2013plga\u2013peg enhances engraftment of muscle-derived stem cells and promotes healing in diabetic wound","volume":"15","author":"Lee","year":"2007","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0207","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1039\/C7BM00479F","article-title":"Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine\u2013a new paradigm for tissue repair","volume":"6","author":"Bj\u00f8rge","year":"2018","journal-title":"Biomater Sci."},{"key":"10.1016\/j.actbio.2021.10.045_bib0208","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.2147\/IJN.S249129","article-title":"Umbilical cord-derived mesenchymal stem cell-derived exosomes combined pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin regeneration","volume":"15","author":"Yang","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2021.10.045_bib0209","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3389\/fphys.2017.00904","article-title":"GMSC-derived exosomes combined with a chitosan\/silk hydrogel sponge accelerates wound healing in a diabetic rat skin defect model","volume":"8","author":"Shi","year":"2017","journal-title":"Front Physiol."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.7150\/thno.29766","article-title":"Engineering bioactive self-healing antibacterial exosomes hydrogel for promoting chronic diabetic wound healing and complete skin regeneration","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0211","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1039\/C9BM01207A","article-title":"The fabrication of a highly efficient self-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healing","volume":"8","author":"Wang","year":"2020","journal-title":"Biomater Sci."},{"key":"10.1016\/j.actbio.2021.10.045_bib0212","first-page":"2012","article-title":"Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats","author":"Lee","year":"2012","journal-title":"Exp Diabetes Res"},{"issue":"10","key":"10.1016\/j.actbio.2021.10.045_bib0213","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.drudis.2017.07.001","article-title":"Curcumin and its topical formulations for wound healing applications","volume":"22","author":"Mohanty","year":"2017","journal-title":"Drug Discov. Today"},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0214","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1080\/21691401.2017.1358731","article-title":"Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation","volume":"46","author":"Sharma","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"10.1016\/j.actbio.2021.10.045_bib0215","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.aanat.2018.11.005","article-title":"Beneficial effect of curcumin nanoparticles-hydrogel on excisional skin wound healing in type-I diabetic rat: histological and immunohistochemical studies","volume":"222","author":"Kamar","year":"2019","journal-title":"Annals of Anatomy - Anatomischer Anzeiger"},{"issue":"19","key":"10.1016\/j.actbio.2021.10.045_bib0216","doi-asserted-by":"crossref","first-page":"16315","DOI":"10.1021\/acsami.8b03868","article-title":"Encapsulation of curcumin nanoparticles with MMP9-Responsive and thermos-sensitive hydrogel improves diabetic wound healing","volume":"10","author":"Liu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0217","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000369220","article-title":"Mangiferin attenuate sepsis-induced acute kidney injury via antioxidant and anti-inflammatory effects","volume":"40","author":"He","year":"2014","journal-title":"Am. J. Nephrol."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0218","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1139\/cjpp-2015-0073","article-title":"Mangiferin suppressed advanced glycation end products (AGEs) through nf-\u03bab deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats","volume":"94","author":"Hou","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0219","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/biof.1292","article-title":"Mangiferin: a xanthonoid with multipotent anti-inflammatory potential","volume":"42","author":"Saha","year":"2016","journal-title":"Biofactors"},{"key":"10.1016\/j.actbio.2021.10.045_bib0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.111997","article-title":"Anticancer and anti-inflammatory properties of mangiferin: a review of its molecular mechanisms","author":"Mei","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0221","first-page":"1","article-title":"Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats","author":"Lwin","year":"2020","journal-title":"Journal of Dermatological Treatment"},{"issue":"11","key":"10.1016\/j.actbio.2021.10.045_bib0222","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1080\/03639045.2018.1496448","article-title":"Preparation, characterization, and in vivo evaluation of nano formulations of ferulic acid in diabetic wound healing","volume":"44","author":"Bairagi","year":"2018","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"6","key":"10.1016\/j.actbio.2021.10.045_bib0223","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3390\/ijms20061305","article-title":"The therapeutic potential of apigenin","volume":"20","author":"Salehi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2021.10.045_bib0224","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.ijbiomac.2016.06.075","article-title":"Fabrication of apigenin loaded gellan gum\u2013chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing","volume":"91","author":"Shukla","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.actbio.2021.10.045_bib0225","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/ecam\/nel028","article-title":"Aqueous extracts of teucrium polium possess remarkable antioxidant activity in vitro","volume":"3","author":"Ljubuncic","year":"2006","journal-title":"Evidence-Based Complem. Alternat. Med."},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0226","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.foodchem.2008.06.064","article-title":"Major flavonoids with antioxidant activity from teucrium polium l","volume":"112","author":"Sharififar","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.actbio.2021.10.045_bib0227","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110189","article-title":"Topical co-administration of teucrium polium hydroethanolic extract and aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model","volume":"127","author":"Gharaboghaz","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actbio.2021.10.045_bib0228","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijbiomac.2018.12.203","article-title":"Health-promoting effects of konjac glucomannan and its practical applications: a critical review","volume":"126","author":"Devaraj","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0229","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110664","article-title":"Antidiabetic effect of konjac glucomannan via insulin signaling pathway regulation in high-fat diet and streptozotocin-induced diabetic rats","volume":"149","author":"Li","year":"2021","journal-title":"Food Res. Int."},{"issue":"18","key":"10.1016\/j.actbio.2021.10.045_bib0230","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1021\/acs.jafc.9b01192","article-title":"Hypoglycemic and hypolipidemic effects of glucomannan extracted from konjac on type 2 diabetic rats","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.actbio.2021.10.045_bib0231","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119340","article-title":"Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors","volume":"219","author":"Gan","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2021.10.045_bib0232","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.colsurfb.2018.02.022","article-title":"An investigation of konjac glucomannan-keratin hydrogel scaffold loaded with avena sativa extracts for diabetic wound healing","volume":"165","author":"Veerasubramanian","year":"2018","journal-title":"Colloids Surf. B"},{"issue":"9","key":"10.1016\/j.actbio.2021.10.045_bib0233","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/sj.ejcn.1601398","article-title":"Therapeutic effects of psyllium in type 2 diabetic patients","volume":"56","author":"Sierra","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0234","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1039\/C7RA10334D","article-title":"Morin incorporated polysaccharide\u2013protein (psyllium\u2013keratin) hydrogel scaffolds accelerate diabetic wound healing in wistar rats","volume":"8","author":"Ponrasu","year":"2018","journal-title":"RSC Adv."},{"issue":"5","key":"10.1016\/j.actbio.2021.10.045_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0095-0","article-title":"Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing","volume":"50","author":"Shen","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.actbio.2021.10.045_bib0236","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/ncomms2271","article-title":"Moving from static to dynamic complexity in hydrogel design","volume":"3","author":"Burdick","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2021.10.045_bib0237","series-title":"Recent Advances in Smart Hydrogels Synthesis","author":"Sikdar","year":"2021"},{"issue":"4","key":"10.1016\/j.actbio.2021.10.045_bib0238","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2021.10.045_bib0239","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.2147\/IJN.S245743","article-title":"Healthcare applications of pH-Sensitive hydrogel-based devices: a review","volume":"15","author":"Hendi","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.actbio.2021.10.045_bib0240","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.copbio.2016.02.009","article-title":"Translational biomaterials\u2014The journey from the bench to the market\u2014Think \u2018product\u2019","volume":"40","author":"Serban","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.actbio.2021.10.045_bib0241","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fbioe.2019.00127","article-title":"Challenges with the development of biomaterials for sustainable tissue engineering","volume":"7","author":"Williams","year":"2019","journal-title":"Front Bioeng. Biotechnol."},{"issue":"2","key":"10.1016\/j.actbio.2021.10.045_bib0242","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijpharm.2013.12.015","article-title":"Natural and synthetic polymers for wounds and burns dressing","volume":"463","author":"Mogo\u015fanu","year":"2014","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.actbio.2021.10.045_bib0243","doi-asserted-by":"crossref","DOI":"10.1038\/am.2017.171","article-title":"Novel biomaterial strategies for controlled growth factor delivery for biomedical applications","volume":"9","author":"Wang","year":"2017","journal-title":"NPG Asia Materials"},{"issue":"29","key":"10.1016\/j.actbio.2021.10.045_bib0244","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201705328","article-title":"Advances in biomaterials for drug delivery","volume":"30","author":"Fenton","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2021.10.045_bib0245","first-page":"49","article-title":"The FDA drug approval process","author":"Eaglstein","year":"2019","journal-title":"Comprehen. Dermatol. Drug Therapy E-Book"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121007145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706121007145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:50:35Z","timestamp":1761673835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706121007145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":243,"alternative-id":["S1742706121007145"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2021.10.045","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical gel-based biomaterials for the treatment of diabetic foot ulcers","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2021.10.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}