{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:27:15Z","timestamp":1787678835053,"version":"build-2784847793"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"am","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 HD099549"],"award-info":[{"award-number":["R21 HD099549"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.actbio.2022.03.007","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T11:52:00Z","timestamp":1646826720000},"page":"310-319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Characterization of vaginal immune response to a polypropylene mesh: Diabetic vs. normoglycemic conditions"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0282-8664","authenticated-orcid":false,"given":"Rui","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Fisk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Meyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Moalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2022.03.007_bib0001","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1001\/jama.2018.2827","article-title":"Effect of uterosacral ligament suspension vs sacrospinous ligament fixation with or without perioperative behavioral therapy for pelvic organ vaginal prolapse on surgical outcomes and prolapse symptoms at 5 years in the OPTIMAL randomized clinical trial","volume":"319","author":"Jelovsek","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.actbio.2022.03.007_bib0002","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00192-005-1296-3","article-title":"Surgical management of anterior vaginal wall prolapse: an evidencebased literature review","volume":"17","author":"Maher","year":"2006","journal-title":"Int. Urogynecol. J. Pelvic Floor Dysfunct."},{"key":"10.1016\/j.actbio.2022.03.007_bib0003","article-title":"Mid-urethral sling operations for stress urinary incontinence in women","volume":"7","author":"Ford","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.actbio.2022.03.007_bib0004","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1097\/AOG.0b013e31823ed1d9","article-title":"Committee opinion no. 513: vaginal placement of synthetic mesh for pelvic organ prolapse","volume":"118","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/bju.13158","article-title":"Risk factors for mesh erosion after female pelvic floor reconstructive surgery: a systematic review and meta-analysis","volume":"117","author":"Deng","year":"2016","journal-title":"BJU Int."},{"key":"10.1016\/j.actbio.2022.03.007_bib0006","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jogc.2017.05.006","article-title":"No. 351-transvaginal mesh procedures for pelvic organ prolapse","volume":"39","author":"Larouche","year":"2017","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"10.1016\/j.actbio.2022.03.007_bib0007","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1001\/jama.300.11.1311","article-title":"Prevalence of symptomatic pelvic floor disorders in US women","volume":"300","author":"Nygaard","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.actbio.2022.03.007_bib0008","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00192-007-0400-2","article-title":"Analysis of risk factors associated with vaginal erosion after synthetic sling procedures for stress urinary incontinence","volume":"19","author":"Chen","year":"2008","journal-title":"Int. Urogynecol. J. Pelvic Floor Dysfunct."},{"key":"10.1016\/j.actbio.2022.03.007_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/926313","article-title":"Mesh exposure and associated risk factors in women undergoing transvaginal prolapse repair with mesh","volume":"2013","author":"Frankman","year":"2013","journal-title":"Obstet. Gynecol. Int."},{"key":"10.1016\/j.actbio.2022.03.007_bib0010","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00404-007-0375-8","article-title":"Morbidity associated with posterior intravaginal slingplasty for uterovaginal and vault prolapse","volume":"276","author":"Hefni","year":"2007","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.actbio.2022.03.007_bib0011","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ejogrb.2014.03.039","article-title":"Risk factors for mesh erosion after vaginal sling procedures for urinary incontinence","volume":"177","author":"Kokanali","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0012","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/iju.12544","article-title":"Analysis of patient and technical factors associated with midurethral sling mesh exposure and perforation","volume":"21","author":"Osborn","year":"2014","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0013","doi-asserted-by":"crossref","first-page":"g3962","DOI":"10.1136\/bmj.g3962","article-title":"Nearly one in 10 US residents has diabetes, CDC reports","volume":"348","author":"McCarthy","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.actbio.2022.03.007_bib0014","unstructured":"Women's Health USA 2013. https:\/\/mchb.hrsa.gov\/whusa13\/health-status\/health-indicators\/p\/diabetes.html. Accessed on December 28, 2021."},{"key":"10.1016\/j.actbio.2022.03.007_bib0015","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/jog.12363","article-title":"Additional surgical risk factors and patient characteristics for mesh erosion after abdominal sacrocolpopexy","volume":"40","author":"Akyol","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.actbio.2022.03.007_bib0016","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00192-010-1270-6","article-title":"Age and sexual activity are risk factors for mesh exposure following transvaginal mesh repair","volume":"22","author":"Kaufman","year":"2011","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.actbio.2022.03.007_bib0017","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00192-010-1265-3","article-title":"Prevalence and risk factors for mesh erosion after laparoscopic-assisted sacrocolpopexy","volume":"22","author":"Tan-Kim","year":"2011","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.actbio.2022.03.007_bib0018","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/AOG.0000000000000042","article-title":"Symptom resolution after operative management of complications from transvaginal mesh","volume":"123","author":"Crosby","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0019","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0020","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.2337\/db14-0872","article-title":"Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes","volume":"64","author":"Gallagher","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.actbio.2022.03.007_bib0021","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2337\/db13-0927","article-title":"Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice","volume":"63","author":"Mirza","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.actbio.2022.03.007_bib0022","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2337\/db10-0778","article-title":"Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice","volume":"60","author":"Parathath","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.actbio.2022.03.007_bib0023","doi-asserted-by":"crossref","first-page":"F993","DOI":"10.1152\/ajprenal.00637.2014","article-title":"Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy","volume":"308","author":"Kim","year":"2015","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0024","first-page":"E38","article-title":"Effects of diabetes on the osseointegration of dental implants","volume":"12","author":"Mellado-Valero","year":"2007","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"10.1016\/j.actbio.2022.03.007_bib0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1177\/193229681100500315","article-title":"Implant healing in experimental animal models of diabetes","volume":"5","author":"Le","year":"2011","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0026","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3181\/00379727-126-32401","article-title":"Studies of the diabetogenic action of streptozotocin","volume":"126","author":"Junod","year":"1967","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.actbio.2022.03.007_bib0027","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1046\/j.1444-2892.2003.00160.x","article-title":"The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes","volume":"12","author":"Wei","year":"2003","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.actbio.2022.03.007_bib0028","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF02913315","article-title":"Induction of diabetes by Streptozotocin in rats","volume":"22","author":"Akbarzadeh","year":"2007","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.actbio.2022.03.007_bib0029","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","article-title":"The use of animal models in diabetes research","volume":"166","author":"King","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0030","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ajog.2016.03.023","article-title":"Textile properties of synthetic prolapse mesh in response to uniaxial loading","volume":"215","author":"Barone","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0031","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ajog.2015.08.002","article-title":"Characterization of the host inflammatory response following implantation of prolapse mesh in rhesus macaque","volume":"213","author":"Brown","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0032","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10029-014-1220-1","article-title":"Characterisation of the cellular infiltrate in the foreign body granuloma of textile meshes with its impact on collagen deposition","volume":"18","author":"Klinge","year":"2014","journal-title":"Hernia"},{"key":"10.1016\/j.actbio.2022.03.007_bib0033","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10029-009-0580-4","article-title":"Impact of mesh positioning on foreign body reaction and collagenous ingrowth in a rabbit model of open incisional hernia repair","volume":"14","author":"Binnebosel","year":"2010","journal-title":"Hernia"},{"key":"10.1016\/j.actbio.2022.03.007_bib0034","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-3-319-26666-4_12","article-title":"Isolation of mouse and human tumor-associated macrophages","volume":"899","author":"Cassetta","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142520","article-title":"A single 9-colour flow cytometric method to characterise major leukocyte populations in the rat: validation in a model of LPS-induced pulmonary inflammation","volume":"11","author":"Barnett-Vanes","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2022.03.007_bib0036","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cyto.2014.09.005","article-title":"Contributions of cell subsets to cytokine production during normal and impaired wound healing","volume":"71","author":"Mirza","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.actbio.2022.03.007_bib0037","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1017\/ice.2015.249","article-title":"Diabetes and risk of surgical site infection: a systematic review and meta-analysis","volume":"37","author":"Martin","year":"2016","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0038","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2337\/dc17-2131","article-title":"Risk of infection in type 1 and type 2 diabetes compared with the general population: a matched cohort study","volume":"41","author":"Carey","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.actbio.2022.03.007_bib0039","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4093\/dmj.2019.0071","article-title":"Diabetes and the risk of infection: a national cohort study","volume":"43","author":"Kim","year":"2019","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.actbio.2022.03.007_bib0040","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123862","article-title":"Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation","volume":"4","author":"Heymann","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.actbio.2022.03.007_bib0041","first-page":"451","article-title":"Animal models in type 2 diabetes research: an overview","volume":"125","author":"Srinivasan","year":"2007","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.actbio.2022.03.007_bib0042","doi-asserted-by":"crossref","first-page":"e385","DOI":"10.1097\/SPV.0000000000000943","article-title":"Evaluation of host immune cellular and extracellular matrix responses to prolapse mesh with and without tension in a rat model","volume":"27","author":"Bickhaus","year":"2021","journal-title":"Female Pelvic Med. Reconstr. Surg."},{"key":"10.1016\/j.actbio.2022.03.007_bib0043","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/1471-0528.12085","article-title":"Vaginal degeneration following implantation of synthetic mesh with increased stiffness","volume":"120","author":"Liang","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.actbio.2022.03.007_bib0044","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ajog.2014.08.008","article-title":"Impact of prolapse meshes on the metabolism of vaginal extracellular matrix in rhesus macaque","volume":"212","author":"Liang","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0045","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajog.2016.04.008","article-title":"Host response to synthetic mesh in women with mesh complications","volume":"215","author":"Nolfi","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2022.03.007_bib0046","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.actbio.2022.03.007_bib0047","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.actbio.2022.03.007_bib0048","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","article-title":"Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation","volume":"4","author":"Vats","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.actbio.2022.03.007_bib0049","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1038\/ncomms3834","article-title":"The TSC-mTOR pathway regulates macrophage polarization","volume":"4","author":"Byles","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2022.03.007_bib0050","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1182\/blood-2009-01-199497","article-title":"Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6","volume":"114","author":"Dyer","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.actbio.2022.03.007_bib0051","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1084\/jem.166.4.1084","article-title":"Biochemical characterization of a gamma interferon-inducible cytokine (IP-10)","volume":"166","author":"Luster","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.actbio.2022.03.007_bib0052","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1096\/fj.02-0908fje","article-title":"Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop","volume":"18","author":"Campbell","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.actbio.2022.03.007_bib53","unstructured":"National Diabetes Statistics Report, 2017. Estimates of Diabetes and Its Burden in the United States. https:\/\/dev.diabetes.org\/sites\/default\/files\/2019-06\/cdc-statistics-report-2017.pdf. Accessed on March 14, 2022."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122001386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122001386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:53:31Z","timestamp":1761674011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122001386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":53,"alternative-id":["S1742706122001386"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.03.007","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of vaginal immune response to a polypropylene mesh: Diabetic vs. normoglycemic conditions","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}