{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:56:48Z","timestamp":1781524608344,"version":"3.54.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["26201600031C-0-0-1"],"award-info":[{"award-number":["26201600031C-0-0-1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["016100-01"],"award-info":[{"award-number":["016100-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000138","name":"U.S. Department of Education","doi-asserted-by":"publisher","award":["200A180087"],"award-info":[{"award-number":["200A180087"]}],"id":[{"id":"10.13039\/100000138","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007579","name":"Auburn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006778","name":"Georgia Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015196","name":"Wallace H. Coulter Department of Biomedical Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015412","name":"Small Business Technology Transfer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004364","name":"BP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.actbio.2022.05.011","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:45:09Z","timestamp":1652143509000},"page":"73-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Tunable three-dimensional engineered prostate cancer tissues for in vitro recapitulation of heterogeneous in vivo prostate tumor stiffness"],"prefix":"10.1016","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-1325","authenticated-orcid":false,"given":"Nicole L.","family":"Habbit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Anbiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshita","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Hassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Eggert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-2304","authenticated-orcid":false,"given":"Andrew","family":"Brannen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balabhaskar","family":"Prabhakarpandian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-8807","authenticated-orcid":false,"given":"Peter","family":"Panizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-3991","authenticated-orcid":false,"given":"Robert D.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-5609","authenticated-orcid":false,"given":"Elizabeth A.","family":"Lipke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2022.05.011_bib0001","unstructured":"National Cancer Institute, Cancer Stat Facts: Prostate Cancer. (accessed September 20 2020)."},{"issue":"4","key":"10.1016\/j.actbio.2022.05.011_bib0002","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/path.5315","article-title":"Development of a predictive model for stromal content in prostate cancer samples to improve signature performance","volume":"249","author":"Boufaied","year":"2019","journal-title":"J. Pathol."},{"key":"10.1016\/j.actbio.2022.05.011_bib0003","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1038\/onc.2008.271","article-title":"The tumor microenvironment and its role in promoting tumor growth","volume":"27","author":"Whiteside","year":"2008","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.actbio.2022.05.011_bib0004","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.actbio.2022.05.011_bib0005","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1101\/sqb.2016.81.030817","article-title":"Physical and chemical gradients in the tumor microenvironment regulate tumor cell invasion, migration, and metastasis","volume":"81","author":"Oudin","year":"2016","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"10.1016\/j.actbio.2022.05.011_bib0006","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.eml.2018.02.003","article-title":"Complex mechanics of the heterogeneous extracellular matrix in cancer","volume":"21","author":"Malandrino","year":"2018","journal-title":"Extreme Mech. Lett."},{"key":"10.1016\/j.actbio.2022.05.011_bib0007","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.csbj.2018.07.003","article-title":"Biophysics of tumor microenvironment and cancer metastasis - a mini review","volume":"16","author":"Emon","year":"2018","journal-title":"Computat. Struct. Biotechnol. J."},{"issue":"5","key":"10.1016\/j.actbio.2022.05.011_bib0008","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2022.05.011_bib0009","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fonc.2018.00055","article-title":"Defining the role of solid stress and matrix stiffness in cancer cell proliferation and metastasis","volume":"8","author":"Kalli","year":"2018","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15476278.2015.1019687","article-title":"Tissue stiffness dictates development, homeostasis, and disease progression","volume":"11","author":"Handorf","year":"2015","journal-title":"Organogenesis"},{"issue":"2","key":"10.1016\/j.actbio.2022.05.011_bib0011","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tcb.2015.09.009","article-title":"Forcing through tumor metastasis: the interplay between tissue rigidity and epithelial-mesenchymal transition","volume":"26","author":"Wei","year":"2016","journal-title":"Trends Cell Biol."},{"issue":"5","key":"10.1016\/j.actbio.2022.05.011_bib0012","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/ncb3157","article-title":"Matrix stiffness drives epithelial\u2013mesenchymal transition and tumour metastasis through a TWIST1\u2013G3BP2 mechanotransduction pathway","volume":"17","author":"Wei","year":"2015","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0013","article-title":"Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma","volume":"132","author":"Matte","year":"2019","journal-title":"J. Cell Sci."},{"issue":"301","key":"10.1016\/j.actbio.2022.05.011_bib0014","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3010467","article-title":"Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis","volume":"7","author":"Seo","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-cancerbio-050216-034431","article-title":"Extracellular matrix remodeling and stiffening modulate tumor phenotype and treatment response","volume":"1","author":"Leight","year":"2017","journal-title":"Annu. Rev. Cancer Biol."},{"issue":"6","key":"10.1016\/j.actbio.2022.05.011_bib0016","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.bpj.2017.02.012","article-title":"Mechanotransduction-induced reversible phenotypic switching in prostate cancer cells","volume":"112","author":"Aw Yong","year":"2017","journal-title":"Biophys. J."},{"issue":"3","key":"10.1016\/j.actbio.2022.05.011_bib0017","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aaafbc","article-title":"Matrix stiffness and tumor-associated macrophages modulate epithelial to mesenchymal transition of human adenocarcinoma cells","volume":"10","author":"Alonso-Nocelo","year":"2018","journal-title":"Biofabrication"},{"issue":"7","key":"10.1016\/j.actbio.2022.05.011_bib0018","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1021\/mp500059q","article-title":"A 3D biomimetic model of tissue stiffness interface for cancer drug testing","volume":"11","author":"Lam","year":"2014","journal-title":"Mol. Pharmaceutics"},{"issue":"6","key":"10.1016\/j.actbio.2022.05.011_bib0019","article-title":"Three-dimensional in vitro cell culture models in drug discovery and drug repositioning","volume":"9","author":"Langhans","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1376","key":"10.1016\/j.actbio.2022.05.011_bib0020","article-title":"The extracellular, cellular, and nuclear stiffness, a trinity in the cancer resistome\u2014a review","volume":"9","author":"Deville","year":"2019","journal-title":"Front. Oncol."},{"issue":"5","key":"10.1016\/j.actbio.2022.05.011_bib0021","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1039\/c3bm60274e","article-title":"Hyaluronic acid hydrogel stiffness and oxygen tension affect cancer cell fate and endothelial sprouting","volume":"2","author":"Shen","year":"2014","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.actbio.2022.05.011_bib0022","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1038\/srep04414","article-title":"Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models","volume":"4","author":"Chwalek","year":"2014","journal-title":"Sci. Rep."},{"issue":"46","key":"10.1016\/j.actbio.2022.05.011_bib0023","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.1002\/adfm.201502778","article-title":"Tuning the microenvironment: click-crosslinked hyaluronic acid-based hydrogels provide a platform for studying breast cancer cell invasion","volume":"25","author":"Fisher","year":"2015","journal-title":"Adv. Funct. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2022.05.011_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132377","article-title":"Optimum 3D matrix stiffness for maintenance of cancer stem cells is dependent on tissue origin of cancer cells","volume":"10","author":"Jabbari","year":"2015","journal-title":"PLoS One"},{"issue":"5-6","key":"10.1016\/j.actbio.2022.05.011_bib0025","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1089\/ten.tea.2012.0333","article-title":"Three-dimensional-engineered matrix to study cancer stem cells and tumorsphere formation: effect of matrix modulus","volume":"19","author":"Yang","year":"2013","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.actbio.2022.05.011_bib0026","doi-asserted-by":"crossref","first-page":"35367","DOI":"10.1038\/srep35367","article-title":"Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model","volume":"6","author":"Cavo","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0027","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/jbm.a.35899","article-title":"PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture","volume":"105","author":"Pradhan","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"145","key":"10.1016\/j.actbio.2022.05.011_bib0028","article-title":"Cell adhesion and matrix stiffness: coordinating cancer cell invasion and metastasis","volume":"8","author":"Gkretsi","year":"2018","journal-title":"Front.Oncol."},{"key":"10.1016\/j.actbio.2022.05.011_bib0029","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cobme.2018.03.004","article-title":"Biomechanical forces in tissue engineered tumor models","volume":"6","author":"Chim","year":"2018","journal-title":"Curr. Opin. Biomed. Eng."},{"issue":"17","key":"10.1016\/j.actbio.2022.05.011_bib0030","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1016\/j.biomaterials.2008.02.005","article-title":"The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system","volume":"29","author":"Peyton","year":"2008","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2022.05.011_bib0031","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.biomaterials.2005.09.038","article-title":"The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration","volume":"27","author":"Dikovsky","year":"2006","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2022.05.011_bib0032","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a030510","article-title":"Cellular constituents of the prostate stroma: key contributors to prostate cancer progression and therapy resistance","volume":"8","author":"Levesque","year":"2018","journal-title":"Cold Spring Harbor Perspect. Med."},{"issue":"13","key":"10.1016\/j.actbio.2022.05.011_bib0033","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/pros.23867","article-title":"Fibroblast as a critical stromal cell type determining prognosis in prostate cancer","volume":"79","author":"Blom","year":"2019","journal-title":"Prostate"},{"issue":"13","key":"10.1016\/j.actbio.2022.05.011_bib0034","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1021\/la500402m","article-title":"Dual-phase, surface tension-based fabrication method for generation of tumor millibeads","volume":"30","author":"Pradhan","year":"2014","journal-title":"Langmuir"},{"issue":"16","key":"10.1016\/j.actbio.2022.05.011_bib0035","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1016\/j.biomaterials.2004.09.021","article-title":"Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration","volume":"26","author":"DeLong","year":"2005","journal-title":"Biomaterials"},{"issue":"15","key":"10.1016\/j.actbio.2022.05.011_bib0036","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1016\/j.biomaterials.2004.06.047","article-title":"Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures","volume":"26","author":"Almany","year":"2005","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2022.05.011_bib0037","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1007\/s11095-014-1501-5","article-title":"Pharmacokinetics, antitumor and cardioprotective effects of liposome-encapsulated phenylaminoethyl selenide in human prostate cancer rodent models","volume":"32","author":"Kang","year":"2015","journal-title":"Pharmaceut. Res."},{"issue":"5","key":"10.1016\/j.actbio.2022.05.011_bib0038","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0022-5347(17)37546-8","article-title":"The relative proportion of stromal and epithelial hyperplasia is related to the development of symptomatic benign prostate hyperplasia","volume":"147","author":"Shapiro","year":"1992","journal-title":"J. Urol."},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0039","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1038\/s41598-018-21668-4","article-title":"Correlation of 360-degree surface mapping in vivo bioluminescence with multi-spectral optoacoustic tomography in human xenograft tumor models","volume":"8","author":"Brannen","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.actbio.2022.05.011_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-020-00344-9","article-title":"In vitro and ex vivo gene expression profiling reveals differential kinetic response of HSPs and UPR genes is associated with PI resistance in multiple myeloma","volume":"10","author":"Mitra","year":"2020","journal-title":"Blood Cancer J."},{"issue":"5","key":"10.1016\/j.actbio.2022.05.011_bib0041","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"6","key":"10.1016\/j.actbio.2022.05.011_bib0042","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"issue":"7","key":"10.1016\/j.actbio.2022.05.011_bib0043","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1093\/bioinformatics\/btq064","article-title":"GOSemSim: an R package for measuring semantic similarity among GO terms and gene products","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.actbio.2022.05.011_bib0044","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-0716-0301-7_11","article-title":"Gene ontology semantic similarity analysis using GOSemSim","volume":"2117","author":"Yu","year":"2020","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.actbio.2022.05.011_bib0045","unstructured":"S. Sayols, rrvgo: a Bioconductor Package to Reduce and Visualize Gene Ontology Terms, 2020."},{"key":"10.1016\/j.actbio.2022.05.011_bib0046","unstructured":"J. Larsson, eulerr: Area-Proportional Euler and Venn Diagrams with Ellipses., R package version 6.1.0, 2020."},{"issue":"22","key":"10.1016\/j.actbio.2022.05.011_bib0047","article-title":"Microphysiological systems as enabling tools for modeling complexity in the tumor microenvironment and accelerating cancer drug development","volume":"29","author":"Kim","year":"2019","journal-title":"Adv. Funct. Mater."},{"issue":"6","key":"10.1016\/j.actbio.2022.05.011_bib0048","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.3390\/cancers12061452","article-title":"The mechanical microenvironment in breast cancer","volume":"12","author":"Pratt","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.actbio.2022.05.011_bib0049","article-title":"Prediction of biochemical recurrence-free survival of prostate cancer patients leveraging multiple gene expression profiles in tumor microenvironment","volume":"11","author":"Zhou","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0050","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.fob.2014.06.003","article-title":"Diminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffness","volume":"4","author":"Moazzem Hossain","year":"2014","journal-title":"FEBS Open Bio."},{"key":"10.1016\/j.actbio.2022.05.011_bib0051","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jmbbm.2014.09.020","article-title":"PDMS substrate stiffness affects the morphology and growth profiles of cancerous prostate and melanoma cells","volume":"41","author":"Prauzner-Bechcicki","year":"2015","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"9","key":"10.1016\/j.actbio.2022.05.011_bib0052","doi-asserted-by":"crossref","first-page":"e40217","DOI":"10.1371\/journal.pone.0040217","article-title":"Phenotypic characterization of prostate cancer LNCaP cells cultured within a bioengineered microenvironment","volume":"7","author":"Sieh","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0053","doi-asserted-by":"crossref","DOI":"10.1186\/s40064-016-2629-z","article-title":"Impact of adjustable cryogel properties on the performance of prostate cancer cells in 3D","volume":"5","author":"B\u00e4cker","year":"2016","journal-title":"Springerplus"},{"issue":"42","key":"10.1016\/j.actbio.2022.05.011_bib0054","doi-asserted-by":"crossref","first-page":"9718","DOI":"10.1039\/D0TB01570A","article-title":"Material properties of disulfide-crosslinked hyaluronic acid hydrogels influence prostate cancer cell growth and metabolism","volume":"8","author":"Tam","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2022.05.011_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119311","article-title":"3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines","volume":"217","author":"Xu","year":"2019","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.actbio.2022.05.011_bib0056","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.3390\/ijms19051532","article-title":"Fibroblasts in the tumor microenvironment: shield or spear?","volume":"19","author":"Alkasalias","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.actbio.2022.05.011_bib0057","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1016\/j.actbio.2013.04.030","article-title":"Time-dependent cellular morphogenesis and matrix stiffening in proteolytically responsive hydrogels","volume":"9","author":"Kesselman","year":"2013","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.actbio.2022.05.011_bib0058","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4161\/cam.21076","article-title":"Controlling matrix stiffness and topography for the study of tumor cell migration","volume":"6","author":"Kraning-Rush","year":"2012","journal-title":"Cell Adh. Migr."},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0059","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/cancers13010122","article-title":"Characterisation of prostate lesions using transrectal shear wave elastography (SWE) ultrasound imaging: a systematic review","volume":"13","author":"Anbarasan","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.actbio.2022.05.011_bib0060","doi-asserted-by":"crossref","first-page":"955","DOI":"10.7863\/ultra.16.03066","article-title":"Assessment of tumor stiffness with shear wave elastography in a human prostate cancer xenograft implantation model","volume":"36","author":"Wang","year":"2017","journal-title":"J. Ultrasound Med."},{"issue":"5","key":"10.1016\/j.actbio.2022.05.011_bib0061","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.diii.2013.01.017","article-title":"Ultrasound elastography of the prostate: state of the art","volume":"94","author":"Correas","year":"2013","journal-title":"Diagnostic Intervent. Imaging"},{"issue":"1097","key":"10.1016\/j.actbio.2022.05.011_bib0062","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20180970","article-title":"Stiffness of prostate gland measured by transrectal real-time shear wave elastography for detection of prostate cancer: a feasibility study","volume":"92","author":"Ji","year":"2019","journal-title":"Br. J. Radiol."},{"issue":"1","key":"10.1016\/j.actbio.2022.05.011_bib0063","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1148\/radiol.14140567","article-title":"Prostate cancer: diagnostic performance of real-time shear-wave elastography","volume":"275","author":"Correas","year":"2014","journal-title":"Radiology"},{"issue":"4-5","key":"10.1016\/j.actbio.2022.05.011_bib0064","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3233\/CBM-2008-44-505","article-title":"Tissue elasticity properties as biomarkers for prostate cancer","volume":"4","author":"Hoyt","year":"2008","journal-title":"Cancer Biomark"},{"issue":"3","key":"10.1016\/j.actbio.2022.05.011_bib0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1039\/B610522J","article-title":"Soft biological materials and their impact on cell function","volume":"3","author":"Levental","year":"2007","journal-title":"Soft Matter"},{"key":"10.1016\/j.actbio.2022.05.011_bib0066","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-2-2","article-title":"Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer","volume":"2","author":"Stewart","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.actbio.2022.05.011_bib0067","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.biomaterials.2016.10.052","article-title":"A three-dimensional spheroidal cancer model based on PEG-fibrinogen hydrogel microspheres","volume":"115","author":"Pradhan","year":"2017","journal-title":"Biomaterials"},{"issue":"17","key":"10.1016\/j.actbio.2022.05.011_bib0068","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006694","article-title":"Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.actbio.2022.05.011_bib0069","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1749-6632.2001.tb03525.x","article-title":"Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein","volume":"936","author":"Simpson-Haidaris","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122002793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122002793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:23:23Z","timestamp":1778624603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122002793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":69,"alternative-id":["S1742706122002793"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.05.011","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tunable three-dimensional engineered prostate cancer tissues for in vitro recapitulation of heterogeneous in vivo prostate tumor stiffness","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}