{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:43:26Z","timestamp":1792154606669,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009187","name":"MRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000686","name":"Royal College of Veterinary Surgeons Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.actbio.2022.06.032","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T22:24:19Z","timestamp":1656541459000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model"],"prefix":"10.1016","volume":"149","author":[{"given":"Nicholas Groth","family":"Merrild","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Holzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoanna","family":"Ariosa-Morejon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-8086","authenticated-orcid":false,"given":"Peter A.","family":"Faull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0666-9747","authenticated-orcid":false,"given":"Jennifer","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Barrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Addison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonia L.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agamemnon E.","family":"Grigoriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0447-5137","authenticated-orcid":false,"given":"Eileen","family":"Gentleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.actbio.2022.06.032_bib0001","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1177\/0363546517745281","article-title":"Randomized study of long-term (15\u201317 Years) outcome after microfracture versus mosaicplasty in knee articular cartilage defects","volume":"46","author":"Solheim","year":"2018","journal-title":"Am. J. Sports Med."},{"issue":"1","key":"10.1016\/j.actbio.2022.06.032_bib0002","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.knee.2014.10.001","article-title":"Arthroscopic mosaicplasty: long-term outcome and joint degeneration progression","volume":"22","author":"Filardo","year":"2015","journal-title":"Knee"},{"issue":"1","key":"10.1016\/j.actbio.2022.06.032_bib0003","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/1947603518783482","article-title":"Long-term survival after microfracture and mosaicplasty for knee articular cartilage repair: a comparative study between two treatments cohorts","volume":"11","author":"Solheim","year":"2020","journal-title":"Cartilage"},{"issue":"12","key":"10.1016\/j.actbio.2022.06.032_bib0004","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1177\/0363546507305455","article-title":"Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up","volume":"35","author":"Marcacci","year":"2007","journal-title":"Am. J. Sports Med."},{"issue":"10","key":"10.1016\/j.actbio.2022.06.032_bib0005","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.joca.2010.06.008","article-title":"New insights into the role of the superficial tangential zone in influencing the microstructural response of articular cartilage to compression","volume":"18","author":"Bevill","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.actbio.2022.06.032_bib0006","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10237-013-0485-0","article-title":"The importance of superficial collagen fibrils for the function of articular cartilage","volume":"13","author":"Hosseini","year":"2014","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.actbio.2022.06.032_bib0007","doi-asserted-by":"crossref","first-page":"210","DOI":"10.22203\/eCM.v020a17","article-title":"Joint surface defects: clinical course and cellular response in spontaneous and experimental lesions","volume":"20","author":"Dell'accio","year":"2010","journal-title":"Eur. Cell Mater."},{"issue":"6","key":"10.1016\/j.actbio.2022.06.032_bib0008","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/archinte.166.6.651","article-title":"Natural history of knee cartilage defects and factors affecting change","volume":"166","author":"Ding","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.actbio.2022.06.032_bib0009","doi-asserted-by":"crossref","first-page":"15040","DOI":"10.1038\/ncomms15040","article-title":"Joint morphogenetic cells in the adult mammalian synovium","volume":"8","author":"Roelofs","year":"2017","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.actbio.2022.06.032_bib0010","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/art.39030","article-title":"Identification of a Prg4-expressing articular cartilage progenitor cell population in mice","volume":"67","author":"Kozhemyakina","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.actbio.2022.06.032_bib0011","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1096\/fj.201600918R","article-title":"Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice","volume":"31","author":"Li","year":"2017","journal-title":"FASEB J."},{"issue":"346","key":"10.1016\/j.actbio.2022.06.032_bib0012","doi-asserted-by":"crossref","first-page":"346ra90","DOI":"10.1126\/scitranslmed.aad8335","article-title":"Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage","volume":"8","author":"Heinemeier","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.actbio.2022.06.032_bib0013","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.joca.2016.11.013","article-title":"Thinning of articular cartilage after joint unloading or immobilization. An experimental investigation of the pathogenesis in mice","volume":"25","author":"Nomura","year":"2017","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.actbio.2022.06.032_bib0014","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1186\/ar2434","article-title":"Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity","volume":"10","author":"Karsdal","year":"2008","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2022.06.032_bib0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/art.11433","article-title":"Expression profiling of metalloproteinases and their inhibitors in cartilage","volume":"50","author":"Kevorkian","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.actbio.2022.06.032_bib0016","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/ar630","article-title":"Aggrecanases and cartilage matrix degradation","volume":"5","author":"Nagase","year":"2003","journal-title":"Arthritis Res. Ther."},{"issue":"12","key":"10.1016\/j.actbio.2022.06.032_bib0017","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"7033","key":"10.1016\/j.actbio.2022.06.032_bib0018","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature03369","article-title":"Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis","volume":"434","author":"Glasson","year":"2005","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.actbio.2022.06.032_bib0019","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/art.11355","volume":"48","author":"Clements","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2022.06.032_bib0020","doi-asserted-by":"crossref","unstructured":"M. de Vries-van Melle, E. Mandl, N. Kps, W. Koevoet, J. Verhear, G. van Osch, An osteochondral culture model to study mechanisms involved in articular cartilage repair, Tissue Eng. Part C Methods 2012.","DOI":"10.1089\/ten.tec.2011.0339"},{"issue":"2","key":"10.1016\/j.actbio.2022.06.032_bib0021","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1365-2818.2012.03606.x","article-title":"Helium ion microscopy for high-resolution visualization of the articular cartilage collagen network","volume":"246","author":"Vanden Berg-Foels","year":"2012","journal-title":"J. Microsc."},{"issue":"6","key":"10.1016\/j.actbio.2022.06.032_bib0022","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/000348940611500611","article-title":"Short-duration enzymatic treatment promotes integration of a cartilage graft in a defect","volume":"115","author":"Janssen","year":"2006","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"5","key":"10.1016\/j.actbio.2022.06.032_bib0023","doi-asserted-by":"crossref","first-page":"R469","DOI":"10.1186\/ar1216","article-title":"Improved cartilage integration and interfacial strength after enzymatic treatment in a cartilage transplantation model","volume":"6","author":"van de Breevaart Bravenboer","year":"2004","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.actbio.2022.06.032_bib0024","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.joca.2002.12.001","article-title":"The cellular responses of articular cartilage to sharp and blunt trauma","volume":"12","author":"Redman","year":"2004","journal-title":"Osteoarthr. Cartil."},{"issue":"4","key":"10.1016\/j.actbio.2022.06.032_bib0025","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/art.10208","article-title":"Specific enzymatic treatment of bovine and human articular cartilage: implications for integrative cartilage repair","volume":"46","author":"Bos","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2022.06.032_bib0026","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3389\/fimmu.2019.01353","article-title":"CTHRC1: a new candidate biomarker for improved rheumatoid arthritis diagnosis","volume":"10","author":"Myngbay","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.actbio.2022.06.032_bib0027","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1074\/jbc.M114.593541","article-title":"The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation","volume":"290","author":"Tillgren","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.actbio.2022.06.032_bib0028","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.joca.2009.11.006","article-title":"Phenotypic characterization of epiphycan-deficient and epiphycan\/biglycan double-deficient mice","volume":"18","author":"Nuka","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"8","key":"10.1016\/j.actbio.2022.06.032_bib0029","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s13238-017-0377-7","article-title":"The minor collagens in articular cartilage","volume":"8","author":"Luo","year":"2017","journal-title":"Protein Cell"},{"issue":"5","key":"10.1016\/j.actbio.2022.06.032_bib0030","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1021\/pr801069c","article-title":"Detection of matrix metalloproteinase active forms in complex proteomes: evaluation of affinity versus photoaffinity capture","volume":"8","author":"Bregant","year":"2009","journal-title":"J. Proteome Res."},{"issue":"2","key":"10.1016\/j.actbio.2022.06.032_bib0031","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/art.22334","article-title":"Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5","volume":"56","author":"Song","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.actbio.2022.06.032_bib0032","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jor.23644","article-title":"Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis","volume":"36","author":"Sieker","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.actbio.2022.06.032_bib0033","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI119526","article-title":"Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints","volume":"100","author":"Lark","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.actbio.2022.06.032_bib0034","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1016\/j.actbio.2013.01.016","article-title":"Biomaterial-mediated delivery of degradative enzymes to improve meniscus integration and repair","volume":"9","author":"Qu","year":"2013","journal-title":"Acta Biomater."},{"issue":"10","key":"10.1016\/j.actbio.2022.06.032_bib0035","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1007\/s11999-011-1856-4","article-title":"Integration of tissue-engineered cartilage with host cartilage: an in vitro model","volume":"469","author":"Theodoropoulos","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"45","key":"10.1016\/j.actbio.2022.06.032_bib0036","doi-asserted-by":"crossref","first-page":"E4832","DOI":"10.1073\/pnas.1414271111","article-title":"Developing functional musculoskeletal tissues through hypoxia and lysyl oxidase-induced collagen cross-linking","volume":"111","author":"Makris","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.actbio.2022.06.032_bib0037","doi-asserted-by":"crossref","first-page":"e60719","DOI":"10.1371\/journal.pone.0060719","article-title":"Induced collagen cross-links enhance cartilage integration","volume":"8","author":"Athens","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.actbio.2022.06.032_bib0038","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/art.23444","article-title":"Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis","volume":"58","author":"Dell'accio","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.actbio.2022.06.032_bib0039","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.matbio.2010.01.001","article-title":"The role of small leucine-rich proteoglycans in collagen fibrillogenesis","volume":"29","author":"Kalamajski","year":"2010","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.actbio.2022.06.032_bib0040","doi-asserted-by":"crossref","first-page":"19065","DOI":"10.1038\/s41598-020-76107-0","article-title":"Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization","volume":"10","author":"Chen","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.actbio.2022.06.032_bib0041","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1002\/art.27436","article-title":"Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4","volume":"62","author":"Coles","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.actbio.2022.06.032_bib0042","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/art.41254","article-title":"Mediation of cartilage matrix degeneration and fibrillation by decorin in post-traumatic osteoarthritis","volume":"72","author":"Li","year":"2020","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"10.1016\/j.actbio.2022.06.032_bib0043","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/art.39547","article-title":"Brief report: JNK-2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis","volume":"68","author":"Ismail","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.actbio.2022.06.032_bib0044","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2018-eular.3101","article-title":"FRI0539\u2005A safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) study with increasing oral doses of glpg1972 administered daily for 29 days shows a strong biomarker effect in patients with KNEE and\/or HIP OA","volume":"77","author":"Deckx","year":"2018","journal-title":"Ann. Rheum. Dis."},{"issue":"17","key":"10.1016\/j.actbio.2022.06.032_bib0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21175992","article-title":"The anti-ADAMTS-5 nanobody((R)) M6495 protects cartilage degradation ex vivo","volume":"21","author":"Siebuhr","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2022.06.032_bib0046","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12862-015-0281-9","article-title":"The evolutionary conservation of the A disintegrin-like and metalloproteinase domain with thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafish","volume":"15","author":"Brunet","year":"2015","journal-title":"BMC Evol. Biol."},{"issue":"2","key":"10.1016\/j.actbio.2022.06.032_bib0047","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.joca.2010.11.008","article-title":"Chondrocyte repopulation of the zone of death induced by osteochondral harvest","volume":"19","author":"McGregor","year":"2011","journal-title":"Osteoarthr. Cartil."},{"issue":"167","key":"10.1016\/j.actbio.2022.06.032_bib0048","doi-asserted-by":"crossref","first-page":"167ra6","DOI":"10.1126\/scitranslmed.3004838","article-title":"Human cartilage repair with a photoreactive adhesive-hydrogel composite","volume":"5","author":"Sharma","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.actbio.2022.06.032_bib0049","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901134","article-title":"Adhesive hydrogels for maxillofacial tissue regeneration using minimally invasive procedures","volume":"9","author":"Salzlechner","year":"2020","journal-title":"Adv. Healthc. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2022.06.032_bib0050","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/03008207.2016.1231180","article-title":"Current strategies for integrative cartilage repair","volume":"58","author":"Boushell","year":"2017","journal-title":"Connect. Tissue Res."},{"issue":"17-18","key":"10.1016\/j.actbio.2022.06.032_bib0051","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1089\/ten.tea.2019.0013","article-title":"Enzyme pretreatment plus locally delivered hb-igf-1 stimulate integrative cartilage repair in vitro","volume":"25","author":"Liebesny","year":"2019","journal-title":"Tissue Eng. Part A"},{"issue":"D1","key":"10.1016\/j.actbio.2022.06.032_bib0052","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122003713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122003713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:56:27Z","timestamp":1761674187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122003713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":52,"alternative-id":["S1742706122003713"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.06.032","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}