{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:21:03Z","timestamp":1781587263437,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"am","delay-in-days":343,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2104723"],"award-info":[{"award-number":["2104723"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010261","name":"Thoracic Surgery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.actbio.2022.07.006","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T01:09:44Z","timestamp":1657415384000},"page":"30-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Influence of Supraphysiologic Biomaterial Stiffness on Ventricular Mechanics and Myocardial Infarct Reinforcement"],"prefix":"10.1016","volume":"149","author":[{"given":"Ravi K.","family":"Ghanta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthi","family":"Pugazenthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5757-357X","authenticated-orcid":false,"given":"Yunge","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Sylvester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Mathew J.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-1033","authenticated-orcid":false,"given":"Rachel A.","family":"Mazur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-4341","authenticated-orcid":false,"given":"Lauren N.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle J.","family":"Lampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.actbio.2022.07.006_bib0001","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1161\/CIRCULATIONAHA.107.727420","article-title":"Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat","volume":"117","author":"Landa","year":"2008","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.actbio.2022.07.006_bib0002","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1073\/pnas.1004097107","article-title":"Injectable hydrogel properties influence infarct expansion and extent of postinfarction left ventricular remodeling in an ovine model","volume":"107","author":"Ifkovits","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.actbio.2022.07.006_bib0003","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jchf.2013.02.006","article-title":"Augmentation of left ventricular wall thickness with alginate hydrogel implants improves left ventricular function and prevents progressive remodeling in dogs with chronic heart failure","volume":"1","author":"Sabbah","year":"2013","journal-title":"JACC Heart Fail"},{"issue":"2","key":"10.1016\/j.actbio.2022.07.006_bib0004","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0735-1097(84)80203-X","article-title":"Early dilation of the infarcted segment in acute transmural myocardial infarction: role of infarct expansion in acute left ventricular enlargement","volume":"4","author":"Erlebacher","year":"1984","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.actbio.2022.07.006_bib0005","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/S0735-1097(02)02121-6","article-title":"Extension of borderzone myocardium in postinfarction dilated cardiomyopathy","volume":"40","author":"Jackson","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.actbio.2022.07.006_bib0006","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1161\/CIRCULATIONAHA.106.671370","article-title":"Adjustable, physiological ventricular restraint improves left ventricular mechanics and reduces dilatation in an ovine model of chronic heart failure","volume":"115","author":"Ghanta","year":"2007","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.actbio.2022.07.006_bib0007","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12265-010-9244-0","article-title":"Infarct restraint to limit adverse ventricular remodeling","volume":"4","author":"Gorman","year":"2011","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"5","key":"10.1016\/j.actbio.2022.07.006_bib0008","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jtcvs.2011.06.014","article-title":"Beneficial effects of the CorCap cardiac support device: five-year results from the Acorn Trial","volume":"143","author":"Mann","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"24","key":"10.1016\/j.actbio.2022.07.006_bib0009","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1161\/CIRCULATIONAHA.106.657270","article-title":"Theoretical impact of the injection of material into the myocardium: a finite element model simulation","volume":"114","author":"Wall","year":"2006","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.actbio.2022.07.006_bib0010","doi-asserted-by":"crossref","first-page":"e21571","DOI":"10.1371\/journal.pone.0021571","article-title":"Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction","volume":"6","author":"Rane","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.actbio.2022.07.006_bib0011","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.healun.2010.03.016","article-title":"Improved myocardial performance in infarcted rat heart by co-injection of basic fibroblast growth factor with temperature-responsive chitosan hydrogel","volume":"29","author":"Wang","year":"2010","journal-title":"J. Heart Lung Transplant."},{"issue":"9","key":"10.1016\/j.actbio.2022.07.006_bib0012","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jacc.2015.12.035","article-title":"Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment","volume":"67","author":"Wassenaar","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.actbio.2022.07.006_bib0013","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/cnm.2610","article-title":"Studying the influence of hydrogel injections into the infarcted left ventricle using the element-free Galerkin method","volume":"30","author":"Legner","year":"2014","journal-title":"Int. J. Numer. Method Biomed. Eng."},{"issue":"7","key":"10.1016\/j.actbio.2022.07.006_bib0014","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1007\/s10439-013-0937-9","article-title":"Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection","volume":"42","author":"Kichula","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2022.07.006_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119289","article-title":"Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarction","volume":"217","author":"Matsumura","year":"2019","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2022.07.006_bib0016","doi-asserted-by":"crossref","first-page":"H2196","DOI":"10.1152\/ajpheart.01017.2005","article-title":"Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance","volume":"290","author":"Berry","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"12","key":"10.1016\/j.actbio.2022.07.006_bib0017","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1021\/acsbiomaterials.7b00374","article-title":"Oligodendrocyte Precursor Cell Viability, Proliferation, and Morphology is Dependent on Mesh Size and Storage Modulus in 3D Poly(ethylene glycol)-Based Hydrogels","volume":"3","author":"Russell","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.actbio.2022.07.006_bib0018","first-page":"e50890","article-title":"Microwave-assisted functionalization of poly(ethylene glycol) and on-resin peptides for use in chain polymerizations and hydrogel formation","volume":"80","author":"Van Hove","year":"2013","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.actbio.2022.07.006_bib0019","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.actbio.2011.01.005","article-title":"Free radical polymerization of poly(ethylene glycol) diacrylate macromers: impact of macromer hydrophobicity and initiator chemistry on polymerization efficiency","volume":"7","author":"Dai","year":"2011","journal-title":"Acta Biomater."},{"issue":"1\u20132","key":"10.1016\/j.actbio.2022.07.006_bib0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijpharm.2008.08.038","article-title":"Network structure and macromolecular drug release from poly(vinyl alcohol) hydrogels fabricated via two crosslinking strategies","volume":"366","author":"Mawad","year":"2009","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.actbio.2022.07.006_bib0021","doi-asserted-by":"crossref","first-page":"H221","DOI":"10.1152\/ajpheart.00495.2009","article-title":"Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat","volume":"298","author":"Fomovsky","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.actbio.2022.07.006_bib0022","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.yjmcc.2012.02.012","article-title":"Regional mechanics determine collagen fiber structure in healing myocardial infarcts","volume":"52","author":"Fomovsky","year":"2012","journal-title":"J. Mol. Cell Cardiol."},{"issue":"12","key":"10.1016\/j.actbio.2022.07.006_bib0023","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1007\/s10439-016-1694-3","article-title":"Sonomicrometry-Based Analysis of Post-Myocardial Infarction Regional Mechanics","volume":"44","author":"Romito","year":"2016","journal-title":"Ann. Biomed. Eng."},{"issue":"6","key":"10.1016\/j.actbio.2022.07.006_bib0024","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1161\/01.CIR.70.6.1057","article-title":"The use of left ventricular end-ejection pressure and peak pressure in the estimation of the end-systolic pressure-volume relationship","volume":"70","author":"Kono","year":"1984","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.actbio.2022.07.006_bib0025","doi-asserted-by":"crossref","first-page":"H501","DOI":"10.1152\/ajpheart.00138.2005","article-title":"Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers","volume":"289","author":"Burkhoff","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"18","key":"10.1016\/j.actbio.2022.07.006_bib0026","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1039\/D0BM00855A","article-title":"Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium","volume":"8","author":"Ghanta","year":"2020","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2022.07.006_bib0027","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0002-8703(93)90071-G","article-title":"Assessment of left ventricular diastolic function in dilated cardiomyopathy with cine magnetic resonance imaging: effect of an angiotensin converting enzyme inhibitor, benazepril","volume":"125","author":"Fujita","year":"1993","journal-title":"Am. Heart J."},{"issue":"3","key":"10.1016\/j.actbio.2022.07.006_bib0028","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1076-6332(05)80722-6","article-title":"Semiautomatic evaluation of left ventricular diastolic function with cine magnetic resonance imaging","volume":"1","author":"Hoff","year":"1994","journal-title":"Acad. Radiol."},{"issue":"3","key":"10.1016\/j.actbio.2022.07.006_bib0029","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/mrm.21677","article-title":"Novel MRI method to detect altered left ventricular ejection and filling patterns in rodent models of disease","volume":"60","author":"Stuckey","year":"2008","journal-title":"Magn. Reson. Med."},{"issue":"2","key":"10.1016\/j.actbio.2022.07.006_bib0030","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.athoracsur.2011.04.051","article-title":"Modification of infarct material properties limits adverse ventricular remodeling","volume":"92","author":"Morita","year":"2011","journal-title":"Ann. Thorac. Surg."},{"issue":"10","key":"10.1016\/j.actbio.2022.07.006_bib0031","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.116.004058","article-title":"Injectable Shear-Thinning Hydrogels for Minimally Invasive Delivery to Infarcted Myocardium to Limit Left Ventricular Remodeling","volume":"9","author":"Rodell","year":"2016","journal-title":"Circ. Cardiovasc. Interv."},{"issue":"3","key":"10.1016\/j.actbio.2022.07.006_bib0032","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/ejhf.449","article-title":"One-year follow-up results from AUGMENT-HF: a multicentre randomized controlled clinical trial of the efficacy of left ventricular augmentation with Algisyl in the treatment of heart failure","volume":"18","author":"Mann","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"4","key":"10.1016\/j.actbio.2022.07.006_bib0033","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/CIRCHEARTFAILURE.111.965731","article-title":"Anisotropic reinforcement of acute anteroapical infarcts improves pump function","volume":"5","author":"Fomovsky","year":"2012","journal-title":"Circ. Heart Fail"},{"issue":"9","key":"10.1016\/j.actbio.2022.07.006_bib0034","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005997","article-title":"Regional Dysfunction After Myocardial Infarction in Rats","volume":"10","author":"Espe","year":"2017","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"11","key":"10.1016\/j.actbio.2022.07.006_bib0035","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1021\/bm201198x","article-title":"Influence of injectable hyaluronic acid hydrogel degradation behavior on infarction-induced ventricular remodeling","volume":"12","author":"Tous","year":"2011","journal-title":"Biomacromolecules"},{"issue":"6","key":"10.1016\/j.actbio.2022.07.006_bib0036","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1089\/ten.tea.2009.0509","article-title":"Impact of degradable macromer content in a poly(ethylene glycol) hydrogel on neural cell metabolic activity, redox state, proliferation, and differentiation","volume":"16","author":"Lampe","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.actbio.2022.07.006_bib0037","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.actbio.2021.10.030","article-title":"Biomaterials via peptide assembly: design, characterization, and application in tissue engineering","volume":"140","author":"Gray","year":"2022","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.actbio.2022.07.006_bib0038","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/acsbiomaterials.9b00389","article-title":"Rapidly Assembling Pentapeptides for Injectable Delivery (RAPID) Hydrogels as Cytoprotective Cell Carriers","volume":"5","author":"Tang","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"6","key":"10.1016\/j.actbio.2022.07.006_bib0039","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2217\/rme.15.47","article-title":"Rebuilding the infarcted heart with noncellular material","volume":"10","author":"Kloner","year":"2015","journal-title":"Regen. Med."},{"issue":"5","key":"10.1016\/j.actbio.2022.07.006_bib0040","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jtcvs.2015.07.035","article-title":"Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium","volume":"150","author":"Gaffey","year":"2015","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"3","key":"10.1016\/j.actbio.2022.07.006_bib0041","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12351","article-title":"A novel cardiac muscle-derived biomaterial reduces dyskinesia and postinfarct left ventricular remodeling in a mouse model of myocardial infarction","volume":"3","author":"O'Connor","year":"2015","journal-title":"Physiol. Rep."},{"issue":"8","key":"10.1016\/j.actbio.2022.07.006_bib0042","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jacc.2011.10.888","article-title":"Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction","volume":"59","author":"Singelyn","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.actbio.2022.07.006_bib0043","doi-asserted-by":"crossref","first-page":"15826","DOI":"10.1038\/s41598-017-15870-z","article-title":"Treatment of Myocardial Infarction with Gene-modified Mesenchymal Stem Cells in a Small Molecular Hydrogel","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"7\u20138","key":"10.1016\/j.actbio.2022.07.006_bib0044","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1089\/ten.tea.2011.0391","article-title":"Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers","volume":"18","author":"Aguado","year":"2012","journal-title":"Tissue Eng. Part A"},{"issue":"5","key":"10.1016\/j.actbio.2022.07.006_bib0045","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/acsbiomaterials.9b00389","article-title":"Rapidly Assembling Pentapeptides for Injectable Delivery (RAPID) Hydroglels as Cytoprotective Cell Carriers","volume":"5","author":"Tang","year":"2019","journal-title":"ACS Biomater. Sci. Eng."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122004007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122004007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:54:45Z","timestamp":1761674085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122004007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":45,"alternative-id":["S1742706122004007"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.07.006","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.20.107276","asserted-by":"object"}]},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of Supraphysiologic Biomaterial Stiffness on Ventricular Mechanics and Myocardial Infarct Reinforcement","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}