{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:05:57Z","timestamp":1793322357417,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["VS200"],"award-info":[{"award-number":["VS200"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022NSFSC1939"],"award-info":[{"award-number":["2022NSFSC1939"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51903172"],"award-info":[{"award-number":["51903172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073216"],"award-info":[{"award-number":["52073216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20B040004"],"award-info":[{"award-number":["LY20B040004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.actbio.2022.07.055","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T04:48:24Z","timestamp":1659415704000},"page":"480-490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"special_numbering":"C","title":["A reactive oxygen species-replenishing coordination polymer nanomedicine disrupts redox homeostasis and induces concurrent apoptosis-ferroptosis for combinational cancer therapy"],"prefix":"10.1016","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-4294","authenticated-orcid":false,"given":"Zhuangzhuang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-E","family":"Cun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4465-0262","authenticated-orcid":false,"given":"Yuji","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-9869","authenticated-orcid":false,"given":"Bin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2022.07.055_bib0001","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2017.01.004","article-title":"Reactive oxygen species and cancer paradox: to promote or to suppress?","volume":"104","author":"Galadari","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.actbio.2022.07.055_bib0002","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ctrv.2008.07.004","article-title":"Elevated copper and oxidative stress in cancer cells as a target for cancer treatment","volume":"35","author":"Gupte","year":"2009","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.actbio.2022.07.055_bib0003","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1021\/acs.biomac.9b00628","article-title":"Recent advances on reactive oxygen species-responsive delivery and diagnosis system","volume":"20","author":"Ye","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2022.07.055_bib0004","doi-asserted-by":"crossref","first-page":"9157","DOI":"10.1039\/C7TB02359F","article-title":"A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(II) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy","volume":"5","author":"Xu","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2022.07.055_bib0005","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.actbio.2022.07.055_bib0006","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acs.chemrev.8b00626","article-title":"Reactive oxygen species (ROS)-based nanomedicine","volume":"119","author":"Yang","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.actbio.2022.07.055_bib0007","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1021\/acs.chemrev.0c00977","article-title":"Biomedicine meets Fenton chemistry","volume":"121","author":"Tang","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.actbio.2022.07.055_bib0008","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/anie.201805664","article-title":"Chemodynamic therapy: tumour microenvironment-mediated Fenton and Fenton-like reactions","volume":"58","author":"Tang","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2022.07.055_bib0009","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.actbio.2022.07.055_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101162","article-title":"Recent advances in enhanced chemodynamic therapy strategies","volume":"39","author":"Tian","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.actbio.2022.07.055_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214267","article-title":"Recent advances on endogenous\/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy","volume":"451","author":"Sun","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.actbio.2022.07.055_bib0012","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1002\/adma.201300929","article-title":"Tumor redoxheterogeneity-responsive prodrug nanocapsules for cancer chemotherapy","volume":"25","author":"Wang","year":"2013","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2022.07.055_bib0013","article-title":"Metal\u2013organic frameworks for biomedical applications","volume":"16","author":"Yang","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.actbio.2022.07.055_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119619","article-title":"Metal-organic frameworks for stimuli-responsive drug delivery","volume":"230","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2022.07.055_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201801526","article-title":"Metal-organic framework-based stimuli-responsive systems for drug delivery","volume":"6","author":"Cai","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2022.07.055_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2022.102686","article-title":"Copper-based metal\u2013organic frameworks for biomedical applications","volume":"305","author":"Cun","year":"2022","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.actbio.2022.07.055_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121335","article-title":"Leveraging disulfiram to treat cancer: mechanisms of action, delivery strategies, and treatment regimens","volume":"281","author":"Lu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2022.07.055_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.125667","article-title":"Bone-targeted oxidative stress nanoamplifier for synergetic chemo\/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS","volume":"399","author":"Huang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2022.07.055_bib0019","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.actbio.2022.02.030","article-title":"ROS-activated nanoscale coordination polymers for enhanced ultrasound-mediated therapy for the treatment of cancer","volume":"143","author":"Zhao","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2022.07.055_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201606314","article-title":"Metal-organic framework nanoparticles in photodynamic therapy: current status and perspectives","volume":"27","author":"Lismont","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2022.07.055_bib0021","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1021\/jacs.5b11720","article-title":"One-pot synthesis of metal-organic frameworks with encapsulated target molecules and their applications for controlled drug delivery","volume":"138","author":"Zheng","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2022.07.055_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202001251","article-title":"Redox responsive metal organic framework nanoparticles induces ferroptosis for cancer therapy","volume":"16","author":"He","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.actbio.2022.07.055_bib0023","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1016\/j.apsb.2021.01.016","article-title":"Tumor microenvironments self-activated nanoscale metal-organic frameworks for ferroptosis based cancer chemodynamic\/photothermal\/chemo therapy","volume":"11","author":"Liang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.actbio.2022.07.055_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120278","article-title":"Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem","volume":"258","author":"Zhang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2022.07.055_bib0025","doi-asserted-by":"crossref","first-page":"38114","DOI":"10.1021\/acsami.1c11017","article-title":"Hypoxia-adapted sono-chemodynamic treatment of orthotopic pancreatic carcinoma using copper metal\u2013organic frameworks loaded with an ultrasound-induced free radical initiator","volume":"13","author":"Sun","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2022.07.055_bib0026","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Bio."},{"key":"10.1016\/j.actbio.2022.07.055_bib0027","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201902885","article-title":"A tumor-microenvironment-activated nanozyme-mediated theranostic nanoreactor for imaging-guided combined tumor therapy","volume":"31","author":"Liu","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2022.07.055_bib0028","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jconrel.2021.04.013","article-title":"Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy","volume":"334","author":"Yang","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2022.07.055_bib0029","doi-asserted-by":"crossref","first-page":"9937","DOI":"10.1021\/jacs.9b03457","article-title":"Synthesis of copper peroxide nanodots for H2O2 self-supplying chemodynamic therapy","volume":"141","author":"Lin","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2022.07.055_bib0030","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1021\/acs.biomac.8b01423","article-title":"Cinnamaldehyde-based poly(ester-thioacetal) to generate reactive oxygen species for fabricating reactive oxygen species-responsive nanoparticles","volume":"19","author":"Xu","year":"2018","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2022.07.055_bib0031","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.7150\/thno.49731","article-title":"Broaden sources and reduce expenditure: tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy","volume":"10","author":"Xu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2022.07.055_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120429","article-title":"Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy","volume":"266","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2022.07.055_bib0033","doi-asserted-by":"crossref","first-page":"10001","DOI":"10.1021\/acsami.1c20416","article-title":"A nanoarchitectonic approach enables triple modal synergistic therapies to enhance antitumor effects","volume":"14","author":"Mo","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2022.07.055_bib0034","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jconrel.2019.07.029","article-title":"Intracellular cascade activated nanosystem for improving ER+ breast cancer therapy through attacking GSH-mediated metabolic vulnerability","volume":"309","author":"Xiong","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2022.07.055_bib0035","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.bbamcr.2008.05.027","article-title":"Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity","volume":"1783","author":"Gao","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.actbio.2022.07.055_bib0036","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202000013","article-title":"A multistage cooperative nanoplatform enables intracellular co-delivery of proteins and chemotherapeutics for cancer therapy","volume":"32","author":"Zhang","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2022.07.055_bib0037","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.actbio.2022.02.033","article-title":"Dual stimuli-responsive dendronized prodrug derived from poly(oligo-(ethylene glycol) methacrylate)-based copolymers for enhanced anti-cancer therapeutic effect","volume":"143","author":"Luo","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2022.07.055_bib0038","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1021\/jacs.7b11114","article-title":"A facile ion-doping strategy to regulate tumor microenvironments for enhanced multimodal tumor theranostics","volume":"140","author":"Bai","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2022.07.055_bib0039","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1039\/C7TB02479G","article-title":"A reactive oxygen species-responsive prodrug micelle with efficient cellular uptake and excellent bioavailability","volume":"6","author":"Xu","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2022.07.055_bib0040","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.actbio.2018.12.020","article-title":"DOX loaded aggregation-induced emission active polymeric nanoparticles as a fluorescence resonance energy transfer traceable drug delivery system for self-indicating cancer therapy","volume":"85","author":"Wang","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2022.07.055_bib0041","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.actbio.2022.05.030","article-title":"Copper-based theranostic nanocatalysts for synergetic photothermal-chemodynamic therapy","volume":"147","author":"Zuo","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2022.07.055_bib0042","doi-asserted-by":"crossref","first-page":"14715","DOI":"10.1021\/acsnano.0c00764","article-title":"Electron-accepting micelles deplete reduced nicotinamide adenine dinucleotide phosphate and impair two antioxidant cascades for ferroptosis-induced tumor eradication","volume":"14","author":"Guo","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2022.07.055_bib0043","doi-asserted-by":"crossref","first-page":"10564","DOI":"10.1021\/acsami.0c20254","article-title":"Novel engineered bacterium\/black phosphorus quantum dot hybrid system for hypoxic tumor targeting and efficient photodynamic therapy","volume":"13","author":"Ding","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2022.07.055_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.128222","article-title":"In-situ drug generation and controllable loading: rational design of copper-based nanosystems for chemo-photothermal cancer therapy","volume":"409","author":"Pan","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2022.07.055_bib0045","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1039\/C7TB02479G","article-title":"A reactive oxygen species-responsive prodrug micelle with efficient cellular uptake and excellent bioavailability","volume":"6","author":"Xu","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2022.07.055_bib0046","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2019.05.035","article-title":"The role of thiols in antioxidant systems","volume":"140","author":"Ulrich","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.actbio.2022.07.055_bib0047","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1021\/acs.nanolett.9b02904","article-title":"Triggered all-active metal organic framework: ferroptosis machinery contributes to the apoptotic photodynamic antitumor therapy","volume":"19","author":"Meng","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2022.07.055_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121351","article-title":"Two birds with one stone: copper metal-organic framework as a carrier of disulfiram prodrug for cancer therapy","volume":"612","author":"Pan","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2022.07.055_bib0049","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41467-019-14199-7","article-title":"Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2022.07.055_bib0050","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1038\/ncomms9003","article-title":"Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications","volume":"6","author":"Liu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2022.07.055_bib0051","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1073\/pnas.98.2.479","article-title":"Simultaneous observation of the O\u2014O and Fe\u2014O2 stretching modes in oxyhemoglobins","volume":"98","author":"Das","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2022.07.055_bib0052","first-page":"784","article-title":"Iron-doxorubicin prodrug loaded liposome nanogenerator programs multimodal ferroptosis for efficient cancer therapy","volume":"16","author":"Yang","year":"2021","journal-title":"Asian J. Pharm."},{"key":"10.1016\/j.actbio.2022.07.055_bib0053","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1016\/S0021-9258(18)34832-4","article-title":"The horseradish peroxidase-catalyzed oxidation of 3,5,3\u2019,5\u2019-tetramethylbenzidine. Free radical and charge-transfer complex intermediates","volume":"257","author":"Josephy","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2022.07.055_bib0054","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.apcatb.2012.05.044","article-title":"Electro-Fenton oxidation of pesticides with a novel Fe3O4@Fe2O3\/activated carbon aerogel cathode: high activity, wide pH range and catalytic mechanism","volume":"125","author":"Zhao","year":"2012","journal-title":"Appl. Catal., B"},{"key":"10.1016\/j.actbio.2022.07.055_bib0055","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.1021\/acs.nanolett.0c02622","article-title":"Tailored chemodynamic nanomedicine improves pancreatic cancer treatment via controllable damaging neoplastic cells and reprogramming tumor microenvironment","volume":"20","author":"Chen","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2022.07.055_bib0056","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.msec.2011.04.010","article-title":"Controlled release of drug from folate-decorated and graphene mediated drug delivery system: synthesis, loading efficiency, and drug release response","volume":"31","author":"Depan","year":"2011","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2022.07.055_bib0057","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1002\/ange.200351289","article-title":"Single-wall carbon nanotube\u2013ferrocene nanohybrids: observing intramolecular electron transfer in functionalized SWNTs","volume":"115","author":"Guldi","year":"2003","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2022.07.055_bib0058","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0014-5793(84)81130-8","article-title":"Hydroxyl radical production and DNA damage induced by anthracycline-iron complex","volume":"172","author":"Muindi","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1016\/j.actbio.2022.07.055_bib0059","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1039\/C7TB02479G","article-title":"A reactive oxygen species-responsive prodrug micelle with efficient cellular uptake and excellent bioavailability","volume":"6","author":"Xu","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2022.07.055_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121410","article-title":"Oral nanotherapeutics based on Antheraea pernyi silk fibroin for synergistic treatment of ulcerative colitis","volume":"282","author":"Ma","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2022.07.055_bib0061","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201900171","article-title":"Polymer structure-guided self-assisted preparation of poly(ester-thioether)-based hollow porous microspheres and hierarchically interconnected microcages for drug release","volume":"19","author":"Cheng","year":"2019","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.actbio.2022.07.055_bib0062","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2019.02.013","article-title":"Oxidative stress injury in doxorubicin-induced cardiotoxicity","volume":"307","author":"Songbo","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.actbio.2022.07.055_bib0063","doi-asserted-by":"crossref","first-page":"eaax1346","DOI":"10.1126\/sciadv.aax1346","article-title":"Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells","volume":"6","author":"Xue","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2022.07.055_bib0064","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1038\/s41467-019-09566-3","article-title":"Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2022.07.055_bib0065","doi-asserted-by":"crossref","first-page":"F1318","DOI":"10.1152\/ajprenal.00036.2014","article-title":"OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury","volume":"306","author":"Xiao","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.actbio.2022.07.055_bib0066","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nrd3137","article-title":"Targeting mitochondria for cancer therapy","volume":"9","author":"Fulda","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.actbio.2022.07.055_bib0067","first-page":"2643","article-title":"Nanocatalytic tumor therapy by single-atom catalysts","volume":"13","author":"Huo","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2022.07.055_bib0068","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."},{"key":"10.1016\/j.actbio.2022.07.055_bib0069","doi-asserted-by":"crossref","first-page":"11536","DOI":"10.1021\/jacs.2c03973","article-title":"Iron-sensitive prodrugs that trigger active ferroptosis in drug-tolerant pancreatic cancer cells","volume":"144","author":"Antoszczak","year":"2022","journal-title":"J. Am. Chem. Soc."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122004597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122004597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:00:59Z","timestamp":1761674459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122004597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":69,"alternative-id":["S1742706122004597"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.07.055","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A reactive oxygen species-replenishing coordination polymer nanomedicine disrupts redox homeostasis and induces concurrent apoptosis-ferroptosis for combinational cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.07.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}