{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:22:30Z","timestamp":1789438950662,"version":"build-2803163510"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201709370052"],"award-info":[{"award-number":["201709370052"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.actbio.2022.08.025","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T22:22:08Z","timestamp":1660947728000},"page":"346-359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Microfluidic evidence of synergistic effects between mesenchymal stromal cell-derived biochemical factors and biomechanical forces to control endothelial cell function"],"prefix":"10.1016","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-4934","authenticated-orcid":false,"given":"Shuang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan","family":"Tuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van de Peppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4825-7353","authenticated-orcid":false,"given":"Gert-Jan","family":"Kremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke","family":"Koedam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-1908","authenticated-orcid":false,"given":"Georg R.","family":"Pesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-2764","authenticated-orcid":false,"given":"Zaid","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco M.","family":"Hoogenboezem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-669X","authenticated-orcid":false,"given":"Eric M.J.","family":"Bindels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan W.","family":"van Neck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-5795","authenticated-orcid":false,"given":"Pouyan E.","family":"Boukany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes P.T.M.","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-6497","authenticated-orcid":false,"given":"Bram C.J.","family":"van der Eerden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2022.08.025_bib0001","series-title":"Polymer Based Systems on Tissue Engineering, Replacement and Regeneration","first-page":"251","article-title":"Bone tissue engineering by cell transplantation","author":"Bancroft","year":"2002"},{"issue":"4","key":"10.1016\/j.actbio.2022.08.025_bib0002","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/17453674.2017.1321351","article-title":"The risk of non-union per fracture: current myths and revised figures from a population of over 4 million adults","volume":"88","author":"Mills","year":"2017","journal-title":"Acta Orthop."},{"issue":"11","key":"10.1016\/j.actbio.2022.08.025_bib0003","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2016.2775","article-title":"Epidemiology of fracture nonunion in 18 human bones","volume":"151","author":"Zura","year":"2016","journal-title":"JAMA Surg."},{"key":"10.1016\/j.actbio.2022.08.025_bib0004","first-page":"77","article-title":"Treatment strategy for nonunions and malunions","volume":"1","author":"Miranda","year":"2007","journal-title":"Surg. Treat. Orthop. Trauma"},{"issue":"12","key":"10.1016\/j.actbio.2022.08.025_bib0005","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1002\/jor.20263","article-title":"Smoking delays chondrogenesis in a mouse model of closed tibial fracture healing","volume":"24","author":"El-Zawawy","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2022.08.025_bib0006","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00003086-197201000-00017","article-title":"Does diabetes delay fracture healing?","volume":"82","author":"Cozen","year":"1972","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.025_bib0007","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/jor.1100080402","article-title":"Effect of fracture fixation on cortical bone blood flow","volume":"8","author":"Smith","year":"1990","journal-title":"J. Orthop. Res."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.025_bib0008","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/17453679209154720","article-title":"Blood flow and mechanical properties of healing bone. Femoral osteotomies studied in rats","volume":"63","author":"Grundnes","year":"1992","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.actbio.2022.08.025_bib0009","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1097\/00003086-199810001-00010","article-title":"Angiogenesis in fracture repair","volume":"355","author":"Glowacki","year":"1998","journal-title":"Clin. Orthopaed. Relat. Res.\u00ae"},{"issue":"6","key":"10.1016\/j.actbio.2022.08.025_bib0010","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.injury.2011.03.035","article-title":"Angiogenesis in bone regeneration","volume":"42","author":"Hankenson","year":"2011","journal-title":"Injury"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0011","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"issue":"105","key":"10.1016\/j.actbio.2022.08.025_bib0012","first-page":"34","article-title":"Tibial blood supply in relation to fracture healing","author":"Rhinelander","year":"1974","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.025_bib0013","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00441-011-1205-7","article-title":"Inflammatory phase of bone healing initiates the regenerative healing cascade","volume":"347","author":"Schmidt-Bleek","year":"2012","journal-title":"Cell Tissue Res."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.025_bib0014","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ar.1092420304","article-title":"Relationships between endothelial cells, pericytes, and osteoblasts during bone formation in the sheep femur following implantation of tricalciumphosphate-ceramic","volume":"242","author":"Decker","year":"1995","journal-title":"Anat. Rec."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.025_bib0015","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00402-007-0543-0","article-title":"Revascularisation during fracture healing with soft tissue injury","volume":"128","author":"Melnyk","year":"2008","journal-title":"Arch. Orthop. Trauma Surg."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.025_bib0016","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S8756-3282(01)00608-1","article-title":"Prevention of fracture healing in rats by an inhibitor of angiogenesis","volume":"29","author":"Hausman","year":"2001","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0017","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13287-017-0660-9","article-title":"Exosomes of human placenta-derived mesenchymal stem cells stimulate angiogenesis","volume":"8","author":"Komaki","year":"2017","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0018","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13287-018-0815-3","article-title":"Human dental pulp stromal cell conditioned medium alters endothelial cell behavior","volume":"9","author":"Gharaei","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0019","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3727\/096368916X692726","article-title":"Transplantation of human placenta-derived mesenchymal stem cells alleviates critical limb ischemia in diabetic nude rats","volume":"26","author":"Liang","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.actbio.2022.08.025_bib0020","series-title":"Perinatal Stem Cells: Biology, Manufacturing and Translational Medicine","first-page":"167","article-title":"Prenatal mesenchymal stem cell secretome and its clinical implication","author":"Liang","year":"2019"},{"issue":"4","key":"10.1016\/j.actbio.2022.08.025_bib0021","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1006\/exer.2001.1161","article-title":"Effects of angiogenic growth factor combinations on retinal endothelial cells","volume":"74","author":"Castellon","year":"2002","journal-title":"Exp. Eye Res."},{"issue":"8","key":"10.1016\/j.actbio.2022.08.025_bib0022","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/jbm.b.33498","article-title":"Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell\/mesenchymal stem cell-based spheroids in a 3D matrix","volume":"104","author":"Kim","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.025_bib0023","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pharmthera.2014.02.013","article-title":"Mesenchymal stem\/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis","volume":"143","author":"Bronckaers","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"684","key":"10.1016\/j.actbio.2022.08.025_bib0024","article-title":"The importance of mechanical forces for in vitro endothelial cell biology","volume":"11","author":"Gordon","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.actbio.2022.08.025_bib0025","article-title":"Basic techniques in human mesenchymal stem cell cultures: differentiation into osteogenic and adipogenic lineages, genetic perturbations, and phenotypic analyses","volume":"1","author":"Bruedigam","year":"2011","journal-title":"Curr. Protoc. Stem Cell Biol. Chapter"},{"issue":"68","key":"10.1016\/j.actbio.2022.08.025_bib0026","article-title":"Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells","volume":"3","author":"Fierro","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0027","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1038\/s41467-019-10588-0","article-title":"Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies","volume":"10","author":"Park","year":"2019","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.025_bib0028","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"issue":"suppl_2","key":"10.1016\/j.actbio.2022.08.025_bib0029","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"41","key":"10.1016\/j.actbio.2022.08.025_bib0030","doi-asserted-by":"crossref","first-page":"12711","DOI":"10.1073\/pnas.1501597112","article-title":"Connectivity map-based discovery of parbendazole reveals targetable human osteogenic pathway","volume":"112","author":"Brum","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.actbio.2022.08.025_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.025_bib0032","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.025_bib0033","doi-asserted-by":"crossref","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"issue":"43","key":"10.1016\/j.actbio.2022.08.025_bib0034","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.025_bib0035","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/(SICI)1521-3773(19980316)37:5<550::AID-ANIE550>3.0.CO;2-G","article-title":"Soft lithography","volume":"37","author":"Xia","year":"1998","journal-title":"Angew. Chem. Int. Ed Engl."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0036","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/acsami.9b17425","article-title":"3D printing of large areas of highly ordered submicron patterns for modulating cell behavior","volume":"12","author":"Nouri-Goushki","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2022.08.025_bib0037","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2121-12-21","article-title":"\u00b5-Slide chemotaxis: a new chamber for long-term chemotaxis studies","volume":"12","author":"Zengel","year":"2011","journal-title":"BMC Cell Biol."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.025_bib0038","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.celrep.2017.01.042","article-title":"Flow dynamics and HSPC homing in bone marrow microvessels","volume":"18","author":"Bixel","year":"2017","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.025_bib0039","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/apha.12725","article-title":"Effects of shear stress on endothelial cells: go with the flow","volume":"219","author":"Chistiakov","year":"2017","journal-title":"Acta Physiol."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.025_bib0040","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4248\/BR201304002","article-title":"Skeletal blood flow in bone repair and maintenance","volume":"1","author":"Tomlinson","year":"2013","journal-title":"Bone Res."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.025_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2020.02.013","article-title":"Smooth muscle cell reprogramming in aortic aneurysms","volume":"26","author":"Chen","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.actbio.2022.08.025_bib0042","doi-asserted-by":"crossref","first-page":"C444","DOI":"10.1152\/ajpcell.00218.2005","article-title":"Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress","volume":"290","author":"Osborn","year":"2006","journal-title":"Am. J. Physiol.-Cell Physiol."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.025_bib0043","doi-asserted-by":"crossref","first-page":"H719","DOI":"10.1152\/ajpheart.00933.2009","article-title":"A microfluidic wound-healing assay for quantifying endothelial cell migration","volume":"298","author":"van der Meer","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.025_bib0044","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/jcb.20614","article-title":"Mechanotransduction in endothelial cell migration","volume":"96","author":"Li","year":"2005","journal-title":"J. Cell. Biochem."},{"issue":"11","key":"10.1016\/j.actbio.2022.08.025_bib0045","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/bjc.2017.116","article-title":"Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers","volume":"116","author":"Di Mauro","year":"2017","journal-title":"Br. J. Cancer"},{"issue":"18","key":"10.1016\/j.actbio.2022.08.025_bib0046","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1101\/gad.1455706","article-title":"The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta","volume":"20","author":"Shchors","year":"2006","journal-title":"Genes Dev."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.025_bib0047","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/bit.22891","article-title":"Recreating the perivascular niche ex vivo using a microfluidic approach","volume":"107","author":"Carrion","year":"2010","journal-title":"Biotechnol. Bioeng."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.025_bib0048","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1039\/C3IB40267C","article-title":"Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems","volume":"6","author":"Jeon","year":"2014","journal-title":"Integr. Biol."},{"key":"10.1016\/j.actbio.2022.08.025_bib0049","doi-asserted-by":"crossref","DOI":"10.1177\/2041731420954712","article-title":"Characterisation of osteogenic and vascular responses of hMSCs to Ti-Co doped phosphate glass microspheres using a microfluidic perfusion platform","volume":"11","author":"Peticone","year":"2020","journal-title":"J. Tissue Eng."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.025_bib0050","doi-asserted-by":"crossref","DOI":"10.1299\/jbse.18-00521","article-title":"Establishment of an in vitro vascular anastomosis model in a microfluidic device","volume":"14","author":"Watanabe","year":"2019","journal-title":"J. Biomech. Sci. Eng."},{"key":"10.1016\/j.actbio.2022.08.025_bib0051","series-title":"Vascular Morphogenesis: Methods and Protocols","first-page":"57","article-title":"Microfluidic device setting by coculturing endothelial cells and mesenchymal stem cells","author":"Watanabe","year":"2021"},{"issue":"6","key":"10.1016\/j.actbio.2022.08.025_bib0052","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1039\/D0LC01092H","article-title":"Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform","volume":"21","author":"Margolis","year":"2021","journal-title":"Lab Chip"},{"issue":"9","key":"10.1016\/j.actbio.2022.08.025_bib0053","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184595","article-title":"Directional migration of mesenchymal stem cells under an SDF-1\u03b1 gradient on a microfluidic device","volume":"12","author":"Park","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2022.08.025_bib0054","doi-asserted-by":"crossref","first-page":"242","DOI":"10.22203\/eCM.v022a19","article-title":"Effects of endothelial cells on human mesenchymal stem cell activity in a three-dimensional in vitro model","volume":"22","author":"Saleh","year":"2011","journal-title":"Eur. Cell Mater."},{"issue":"7-8","key":"10.1016\/j.actbio.2022.08.025_bib0055","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1089\/ten.tea.2011.0058","article-title":"Toward an in vitro vasculature: differentiation of mesenchymal stromal cells within an endothelial cell-seeded modular construct in a microfluidic flow chamber","volume":"18","author":"Khan","year":"2012","journal-title":"Tissue Eng. Part A"},{"issue":"2","key":"10.1016\/j.actbio.2022.08.025_bib0056","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1299\/jbse.8.114","article-title":"The stabilization effect of mesenchymal stem cells on the formation of microvascular networks in a microfluidic device","volume":"8","author":"Yamamoto","year":"2013","journal-title":"J. Biomech. Sci. Eng."},{"key":"10.1016\/j.actbio.2022.08.025_bib0057","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.764237","article-title":"Vasculogenic potency of bone marrow- and adipose tissue-derived mesenchymal stem\/stromal cells results in differing vascular network phenotypes in a microfluidic chip","volume":"10","author":"Mykuliak","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2022.08.025_bib0058","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.602269","article-title":"Bone angiogenesis and vascular niche remodeling in stress, aging, and diseases","volume":"8","author":"Stucker","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0059","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41536-019-0070-y","article-title":"Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential","volume":"4","author":"Kehl","year":"2019","journal-title":"npj Regener. Med."},{"issue":"8","key":"10.1016\/j.actbio.2022.08.025_bib0060","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1177\/0271678X18776802","article-title":"The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke","volume":"38","author":"Cunningham","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.025_bib0061","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/cbin.10097","article-title":"Hypoxia preconditioned human adipose derived mesenchymal stem cells enhance angiogenic potential via secretion of increased VEGF and bFGF","volume":"37","author":"Liu","year":"2013","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.actbio.2022.08.025_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120633","article-title":"Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs)","volume":"269","author":"Gorgun","year":"2021","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2022.08.025_bib0063","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020312","article-title":"Angiogenic effects of human dental pulp and bone marrow-derived mesenchymal stromal cells and their extracellular vesicles","volume":"9","author":"Merckx","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.actbio.2022.08.025_bib0064","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actbio.2019.12.020","article-title":"Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126","volume":"103","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.025_bib0065","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1089\/ten.tea.2008.0254","article-title":"Influence of adult mesenchymal stem cells on in vitro vascular formation","volume":"15","author":"Sorrell","year":"2009","journal-title":"Tissue Eng. Part A"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0066","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/mmr.2015.3409","article-title":"Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis","volume":"12","author":"Shen","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.025_bib0067","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ijos.2016.39","article-title":"Supportive angiogenic and osteogenic differentiation of mesenchymal stromal cells and endothelial cells in monolayer and co-cultures","volume":"8","author":"B\u00f6hrnsen","year":"2016","journal-title":"Int. J. Oral Sci."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.025_bib0068","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1634\/stemcells.2007-0022","article-title":"Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro","volume":"25","author":"Potapova","year":"2007","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.actbio.2022.08.025_bib0069","doi-asserted-by":"crossref","DOI":"10.1063\/1.3576932","article-title":"Responses of endothelial cells to extremely slow flows","volume":"5","author":"Park","year":"2011","journal-title":"Biomicrofluidics"},{"issue":"7057","key":"10.1016\/j.actbio.2022.08.025_bib0070","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature03952","article-title":"A mechanosensory complex that mediates the endothelial cell response to fluid shear stress","volume":"437","author":"Tzima","year":"2005","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.actbio.2022.08.025_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2017.10.020","article-title":"Migrating myeloid cells sense temporal dynamics of chemoattractant concentrations","volume":"47","author":"Petrie Aronin","year":"2017","journal-title":"Immunity"},{"issue":"20","key":"10.1016\/j.actbio.2022.08.025_bib0072","doi-asserted-by":"crossref","first-page":"13905","DOI":"10.1074\/jbc.M704917200","article-title":"Endothelial cell migration in stable gradients of vascular endothelial growth factor A and fibroblast growth factor 2: effects on chemotaxis and chemokinesis","volume":"283","author":"Barkefors","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.025_bib0073","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/gt.2012.17","article-title":"VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond","volume":"19","author":"Giacca","year":"2012","journal-title":"Gene Ther."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0074","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jcp.1041630121","article-title":"Shear stress modulates endothelial cell morphology and F-actin organization through the regulation of focal adhesion-associated proteins","volume":"163","author":"Girard","year":"1995","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.025_bib0075","doi-asserted-by":"crossref","first-page":"H1937","DOI":"10.1152\/ajpheart.00534.2007","article-title":"Arterial shear stress regulates endothelial cell-directed migration, polarity, and morphology in confluent monolayers","volume":"293","author":"Simmers","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.025_bib0076","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/01.RES.0000259593.07661.1e","article-title":"Endothelial cell migration during angiogenesis","volume":"100","author":"Lamalice","year":"2007","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0077","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s42255-018-0011-x","article-title":"Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis","volume":"1","author":"Diebold","year":"2019","journal-title":"Nat. Metab."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.025_bib0078","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ana.410010502","article-title":"The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat","volume":"1","author":"Oldendorf","year":"1977","journal-title":"Ann. Neurol."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.025_bib0079","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s42255-019-0117-9","article-title":"The metabolic engine of endothelial cells","volume":"1","author":"Falkenberg","year":"2019","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.025_bib0080","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1152\/physrev.00001.2017","article-title":"Endothelial cell metabolism","volume":"98","author":"Eelen","year":"2018","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.025_bib0081","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.21037\/apm-20-121","article-title":"H subtype vascular endothelial cells in human femoral head: an experimental verification","volume":"9","author":"Gao","year":"2020","journal-title":"Ann. Palliat. Med."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122005001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122005001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:59:30Z","timestamp":1761674370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122005001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":81,"alternative-id":["S1742706122005001"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.08.025","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microfluidic evidence of synergistic effects between mesenchymal stromal cell-derived biochemical factors and biomechanical forces to control endothelial cell function","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}