{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:40:22Z","timestamp":1792100422643,"version":"4.4.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"am","delay-in-days":376,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15HD096410"],"award-info":[{"award-number":["R15HD096410"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.actbio.2022.08.059","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T06:24:04Z","timestamp":1661927044000},"page":"335-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Distinctive structure, composition and biomechanics of collagen fibrils in vaginal wall connective tissues associated with pelvic organ prolapse"],"prefix":"10.1016","volume":"152","author":[{"given":"Naiwei","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svjetlana","family":"Lozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8115-2812","authenticated-orcid":false,"given":"Rathnayake A.C.","family":"Rathnayake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Botros-Brey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4539-5726","authenticated-orcid":false,"given":"Yin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Damaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong R.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.actbio.2022.08.059_bib0001","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0029-7844(97)00058-6","article-title":"Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence","volume":"89","author":"Olsen","year":"1997","journal-title":"Obstetr. Gynecol."},{"issue":"9566","key":"10.1016\/j.actbio.2022.08.059_bib0002","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(07)60462-0","article-title":"Pelvic organ prolapse","volume":"369","author":"Jelovsek","year":"2007","journal-title":"Lancet North Am. Ed."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0003","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.juro.2011.06.054","article-title":"Alterations in connective tissue metabolism in stress incontinence and prolapse","volume":"186","author":"Chen","year":"2011","journal-title":"J. Urol."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0004","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1067\/mob.2000.105410","article-title":"Urinary incontinence and pelvic organ prolapse in women with Marfan or Ehlers-Danlos syndrome","volume":"182","author":"Carley","year":"2000","journal-title":"Am. J. Obstetr. Gynecol."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.059_bib0005","first-page":"231","article-title":"Pelvic organ prolapse and connective tissue abnormalities in Korean women","volume":"47","author":"Bai","year":"2002","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.actbio.2022.08.059_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9518076","article-title":"Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions","volume":"2018","author":"Bhattarai","year":"2018","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.actbio.2022.08.059_bib0007","doi-asserted-by":"crossref","first-page":"22971","DOI":"10.1038\/srep22971","article-title":"Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content","volume":"6","author":"Ruiz-Zapata","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0008","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1097\/AOG.0b013e3181da7946","article-title":"Alteration of vaginal elastin metabolism in women with pelvic organ prolapse","volume":"115","author":"Zong","year":"2010","journal-title":"Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0009","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00192-005-0045-y","article-title":"Increased expression of matrix metalloproteinase 2 in uterosacral ligaments is associated with pelvic organ prolapse","volume":"17","author":"Gabriel","year":"2006","journal-title":"Int. Urogynecol. J."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0002-9378(96)70243-0","article-title":"The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction","volume":"175","author":"Bump","year":"1996","journal-title":"Am. J. Obstetr. Gynecol."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.059_bib0011","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1074\/jbc.M110709200","article-title":"Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen","volume":"277","author":"Di Lullo","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0012","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/03008207.2012.734879","article-title":"Immunolocalization of collagens (I and III) and cartilage oligomeric matrix protein in the normal and injured equine superficial digital flexor tendon","volume":"54","author":"Sodersten","year":"2013","journal-title":"Connect. Tissue Res."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.059_bib0013","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.micron.2003.11.005","article-title":"Skin aging and natural photoprotection","volume":"35","author":"Wulf","year":"2004","journal-title":"Micron"},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0014","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s00464-010-1373-7","article-title":"Collagen type I: III ratio of the gastroesophageal junction in patients with paraesophageal hernias","volume":"25","author":"Brown","year":"2011","journal-title":"Surg. Endosc."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.059_bib0015","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.bbadis.2012.11.022","article-title":"Molecular assembly and mechanical properties of the extracellular matrix: a fibrous protein perspective","volume":"1832","author":"Muiznieks","year":"2013","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol. Basis Dis."},{"issue":"1\u20132","key":"10.1016\/j.actbio.2022.08.059_bib0016","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cis.2010.10.003","article-title":"Coacervation of tropoelastin","volume":"167","author":"Yeo","year":"2011","journal-title":"Adv. Colloid Interface Sci."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.059_bib0017","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5005\/jp-journals-10026-1032","article-title":"Collagen in health and disease","volume":"2","author":"Sandhu","year":"2012","journal-title":"J. Orofac. Res."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.059_bib0018","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00192-011-1532-y","article-title":"Pelvic organ prolapse and collagen-associated disorders","volume":"23","author":"Lammers","year":"2012","journal-title":"Int. Urogynecol. J."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.059_bib0019","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3892\/etm.2011.204","article-title":"Decreased type III collagen expression in human uterine cervix of prolapse uteri","volume":"2","author":"Iwahashi","year":"2011","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.059_bib0020","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3892\/mmr.2014.2467","article-title":"Differential expression profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases in females with or without pelvic organ prolapse","volume":"10","author":"Wang","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.059_bib0021","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.nano.2015.11.006","article-title":"Identifying distinct nanoscopic features of native collagen fibrils towards early diagnosis of pelvic organ prolapse","volume":"12","author":"Kim","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0022","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.biomaterials.2011.11.005","article-title":"Structural and mechanical profiles of native collagen fibers in vaginal wall connective tissues","volume":"33","author":"Sridharan","year":"2012","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0023","first-page":"75","article-title":"Pelvic Organ Prolapse Quantification System (POP-Q) - a new era in pelvic prolapse staging","volume":"4","author":"Persu","year":"2011","journal-title":"J. Med. Life"},{"issue":"6","key":"10.1016\/j.actbio.2022.08.059_bib0024","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00192-006-0076-z","article-title":"Validation of a simplified technique for using the POPQ pelvic organ prolapse classification system","volume":"17","author":"Swift","year":"2006","journal-title":"Int. Urogynecol J. Pelvic Floor Dysfunct."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.059_bib0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.21926\/rpm.1904007","article-title":"Silk-CNT Mediated Fibroblast Stimulation toward Chronic Wound Repair","volume":"1","author":"Chi","year":"2019","journal-title":"Recent Prog. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0026","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbrc.2018.08.157","article-title":"Electrospun protein-CNT composite fibers and the application in fibroblast stimulation","volume":"504","author":"Chi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.059_bib0027","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3390\/jcs5060148","article-title":"Aligned Collagen-CNT Nanofibrils and the Modulation Effect on Ovarian Cancer Cells","volume":"5","author":"Li","year":"2021","journal-title":"J. Compos. Sci."},{"key":"10.1016\/j.actbio.2022.08.059_bib0028","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2021.04.088","article-title":"Distinctive roles of fibrillar collagen I and collagen III in mediating fibroblast-matrix interaction: a nanoscopic study","volume":"560","author":"Li","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.actbio.2022.08.059_bib0029","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.msec.2015.01.014","article-title":"Effect of CNT on collagen fiber structure, stiffness assembly kinetics and stem cell differentiation","volume":"49","author":"Kim","year":"2015","journal-title":"Mater. Sci. Eng.: C"},{"issue":"2","key":"10.1016\/j.actbio.2022.08.059_bib0030","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00441-012-1410-z","article-title":"Matrix metalloproteinases and epidermal wound repair","volume":"351","author":"Martins","year":"2013","journal-title":"Cell Tissue Res."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.059_bib0031","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.bbrc.2014.06.136","article-title":"Two-way regulation between cells and aligned collagen fibrils: local 3D matrix formation and accelerated neural differentiation of human decidua parietalis placental stem cells","volume":"450","author":"Li","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"32","key":"10.1016\/j.actbio.2022.08.059_bib0032","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1016\/j.biomaterials.2006.06.014","article-title":"Modulation of anisotropy in electrospun tissue-engineering scaffolds: analysis of fiber alignment by the fast Fourier transform","volume":"27","author":"Ayres","year":"2006","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0033","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1021\/bm501403f","article-title":"E-spun composite fibers of collagen and dragline silk protein: fiber mechanics, biocompatibility, and application in stem cell differentiation","volume":"16","author":"Zhu","year":"2015","journal-title":"Biomacromolecules"},{"issue":"12","key":"10.1016\/j.actbio.2022.08.059_bib0034","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0021-9290(00)00150-0","article-title":"Collagen fibril d-period may change as a function of strain and location in ligament","volume":"33","author":"Kukreti","year":"2000","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2022.08.059_bib0035","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M115.682195","article-title":"Excess linoleic acid increases collagen I\/III ratio and'stiffens' the heart muscle following high fat diets","author":"Beam","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.actbio.2022.08.059_bib0036","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/j.0001-6349.2004.00438.x","article-title":"Young women with genital prolapse have a low collagen concentration","volume":"83","author":"S\u00f6derberg","year":"2004","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.059_bib0037","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ajog.2004.09.018","article-title":"The expression and function of the endothelin system in contractile properties of vaginal myofibroblasts of women with uterovaginal prolapse","volume":"192","author":"Poncet","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.059_bib0038","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s00192-008-0643-6","article-title":"The contractile properties of vaginal myofibroblasts: is the myofibroblasts contraction force test a valuable indication of future prolapse development?","volume":"19","author":"Meyer","year":"2008","journal-title":"Int. Urogynecol. J."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0039","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1083\/jcb.105.5.2393","article-title":"Type III collagen can be present on banded collagen fibrils regardless of fibril diameter","volume":"105","author":"Keene","year":"1987","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0040","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1073\/pnas.94.5.1852","article-title":"Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development","volume":"94","author":"Liu","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5616","key":"10.1016\/j.actbio.2022.08.059_bib0041","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/268152a0","article-title":"Rigid control of synthesis of collagen types I and III by cells in culture","volume":"268","author":"Hance","year":"1977","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0042","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/03008207709152608","article-title":"Interaction between collagen type I and type III in conditioning bundles organization","volume":"5","author":"Lapiere","year":"1977","journal-title":"Connect. Tissue Res."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.059_bib0043","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0021-9290(98)00174-2","article-title":"Time-resolved X-ray diffraction from tendon collagen during creep using synchrotron radiation","volume":"32","author":"Sasaki","year":"1999","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.059_bib0044","first-page":"9","article-title":"The importance of collagen fibers in vertebrate biology","volume":"4","author":"Silver","year":"2009","journal-title":"J. Eng. Fibers Fabr."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0045","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0040-6031(00)00619-5","article-title":"Changes in collagen structure: drying, dehydrothermal treatment and relation to long term deterioration","volume":"365","author":"Wess","year":"2000","journal-title":"Thermochim. Acta"},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0046","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.bone.2009.11.020","article-title":"Distribution of type I collagen morphologies in bone: relation to estrogen depletion","volume":"46","author":"Wallace","year":"2010","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0047","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jsb.2010.08.003","article-title":"Nanoscale morphology of Type I collagen is altered in the Brtl mouse model of Osteogenesis Imperfecta","volume":"173","author":"Wallace","year":"2011","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.actbio.2022.08.059_bib0048","first-page":"289","article-title":"Recent studies with the electron microscope on ordered aggregates of the tropocollagen molecule","author":"Hodge","year":"1963","journal-title":"Aspects Protein Struct."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0049","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1016\/S0006-3495(04)74366-0","article-title":"Force spectroscopy of collagen fibers to investigate their mechanical properties and structural organization","volume":"86","author":"Gutsmann","year":"2004","journal-title":"Biophys. J."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.059_bib0050","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0021-9290(03)00135-0","article-title":"Collagen self-assembly and the development of tendon mechanical properties","volume":"36","author":"Silver","year":"2003","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2022.08.059_bib0051","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.actbio.2020.03.046","article-title":"Altered mechanics of vaginal smooth muscle cells due to the lysyl oxidase-like1 knockout","volume":"110","author":"Ferreira","year":"2020","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.059_bib0052","doi-asserted-by":"crossref","first-page":"F545","DOI":"10.1152\/ajprenal.00063.2008","article-title":"Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans","volume":"295","author":"Lee","year":"2008","journal-title":"Am. J. Physiol.-Renal Physiol."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0053","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/SPV.0000000000000104","article-title":"Validation of genetically matched wild-type strain and lysyl oxidase-like 1 knockout mouse model of pelvic organ prolapse","volume":"20","author":"Couri","year":"2014","journal-title":"Female Pelvic Med. Reconstr. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0054","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1038\/s41598-020-60250-9","article-title":"Glycation changes molecular organization and charge distribution in type I collagen fibrils","volume":"10","author":"Bansode","year":"2020","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.actbio.2022.08.059_bib0055","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1021\/bi00234a035","article-title":"A type I collagen with substitution of a cysteine for glycine-748 in the alpha 1(I) chain copolymerizes with normal type I collagen and can generate fractallike structures","volume":"30","author":"Kadler","year":"1991","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0056","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/GCO.0000000000000312","article-title":"What's new in the functional anatomy of pelvic organ prolapse?","volume":"28","author":"DeLancey","year":"2016","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.059_bib0057","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/gme.0b013e3181b0c2ae","article-title":"Age-related pelvic floor modifications and prolapse risk factors in postmenopausal women","volume":"17","author":"Tinelli","year":"2010","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.actbio.2022.08.059_bib0058","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00192-008-0737-1","article-title":"Changes in connective tissue in patients with pelvic organ prolapse\u2013a review of the current literature","volume":"20","author":"Kerkhof","year":"2009","journal-title":"Int. Urogynecol J. Pelvic Floor Dysfunct."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.059_bib0059","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/03008200903204669","article-title":"Effect of selective estrogen receptor modulator\/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast","volume":"51","author":"Irie","year":"2010","journal-title":"Connect. Tissue Res."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.059_bib0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s001920200019","article-title":"Biomechanical properties of prolapsed vaginal tissue in pre- and postmenopausal women","volume":"13","author":"Goh","year":"2002","journal-title":"Int. Urogynecol J. Pelvic Floor Dysfunct."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.059_bib0061","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ajog.2013.10.881","article-title":"Changes in tissue composition of the vaginal wall of premenopausal women with prolapse","volume":"210","author":"Kerkhof","year":"2014","journal-title":"Am. J. Obstetr. Gynecol."},{"issue":"3\u20134","key":"10.1016\/j.actbio.2022.08.059_bib0062","first-page":"785","article-title":"Human endometrial mesenchymal stem cells modulate the tissue response and mechanical behavior of polyamide mesh implants for pelvic organ prolapse repair","volume":"20","author":"Ulrich","year":"2014","journal-title":"Tissue Eng. Part A"},{"issue":"5","key":"10.1016\/j.actbio.2022.08.059_bib0063","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1097\/AOG.0b013e3181a11a85","article-title":"Nonobstetric risk factors for symptomatic pelvic organ prolapse","volume":"113","author":"Miedel","year":"2009","journal-title":"Obstetr. Gynecol."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122005426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122005426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:59:38Z","timestamp":1761674378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122005426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":63,"alternative-id":["S1742706122005426"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.08.059","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinctive structure, composition and biomechanics of collagen fibrils in vaginal wall connective tissues associated with pelvic organ prolapse","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.08.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}