{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:30:37Z","timestamp":1791495037054,"version":"4.3.4"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006686","name":"University of Miami","doi-asserted-by":"publisher","award":["1P30CA240139"],"award-info":[{"award-number":["1P30CA240139"]}],"id":[{"id":"10.13039\/100006686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018896","name":"Sylvester Comprehensive Cancer Center, University of Miami Health Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.actbio.2022.08.077","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T23:14:35Z","timestamp":1662592475000},"page":"532-545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Biomaterial-targeted precision nanoparticle delivery to the injured spinal cord"],"prefix":"10.1016","volume":"152","author":[{"given":"Andrew J.","family":"Ciciriello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bapurao","family":"Surnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni D.","family":"Medy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-5272","authenticated-orcid":false,"given":"Shanta","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-7188","authenticated-orcid":false,"given":"Courtney M.","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.actbio.2022.08.077_bib0001","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.077_bib0002","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.addr.2007.08.038","article-title":"Controlled drug delivery in tissue engineering","volume":"60","author":"Biondi","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.077_bib0003","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.addr.2007.03.013","article-title":"Injectable matrices and scaffolds for drug delivery in tissue engineering","volume":"59","author":"Kretlow","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2022.08.077_bib0004","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cobme.2018.02.005","article-title":"Immunomodulatory biomaterials","volume":"6","author":"Dziki","year":"2018","journal-title":"Curr. Opin. Biomed. Eng."},{"issue":"38","key":"10.1016\/j.actbio.2022.08.077_bib0005","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1002\/adma.201402105","article-title":"Hydrogels and scaffolds for immunomodulation","volume":"26","author":"Singh","year":"2014","journal-title":"Adv. Mater."},{"issue":"9","key":"10.1016\/j.actbio.2022.08.077_bib0006","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/acs.accounts.0c00341","article-title":"Biomaterials as local niches for immunomodulation","volume":"53","author":"Adu-Berchie","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.actbio.2022.08.077_bib0007","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jconrel.2015.08.014","article-title":"Controlled release strategies for modulating immune responses to promote tissue regeneration","volume":"219","author":"Dumont","year":"2015","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.actbio.2022.08.077_bib0008","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing hydrogels for controlled drug delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"issue":"12","key":"10.1016\/j.actbio.2022.08.077_bib0009","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1080\/17425247.2016.1200558","article-title":"Carriers for the tunable release of therapeutics: etymological classification and examples","volume":"13","author":"Uskokovi\u0107","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.actbio.2022.08.077_bib0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2013.11.001","article-title":"Polymeric nanoparticle system to target activated microglia\/macrophages in spinal cord injury","volume":"174","author":"Papa","year":"2014","journal-title":"J. Control. Release"},{"issue":"25","key":"10.1016\/j.actbio.2022.08.077_bib0011","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202002560","article-title":"Porous silicon nanoparticles embedded in poly(lactic-co-glycolic acid) nanofiber scaffolds deliver neurotrophic payloads to enhance neuronal growth","volume":"30","author":"Zuidema","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2022.08.077_bib0012","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.colsurfb.2013.02.046","article-title":"Tunable hydrogel\u2014Nanoparticles release system for sustained combination therapies in the spinal cord","volume":"108","author":"Rossi","year":"2013","journal-title":"Colloids Surf., B"},{"key":"10.1016\/j.actbio.2022.08.077_bib0013","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jconrel.2015.09.011","article-title":"On-demand drug delivery from local depots","volume":"219","author":"Brudno","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2022.08.077_bib0014","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fneur.2019.00282","article-title":"Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms","volume":"10","author":"Alizadeh","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.actbio.2022.08.077_bib0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fncel.2020.576037","article-title":"Neuroinflammation treatment via targeted delivery of nanoparticles","volume":"14","author":"Cerqueira","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"21","key":"10.1016\/j.actbio.2022.08.077_bib0016","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.2174\/138161210791920496","article-title":"Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects","volume":"16","author":"Yoo","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"9","key":"10.1016\/j.actbio.2022.08.077_bib0017","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1021\/acs.accounts.9b00228","article-title":"Survey of clinical translation of cancer nanomedicines\u2014Lessons learned from successes and failures","volume":"52","author":"He","year":"2019","journal-title":"Acc. Chem. Res."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.077_bib0018","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat. Rev. Mater."},{"issue":"11","key":"10.1016\/j.actbio.2022.08.077_bib0019","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.addr.2004.02.014","article-title":"Nanoparticle and targeted systems for cancer therapy","volume":"56","author":"Brannon-Peppas","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1 Suppl","key":"10.1016\/j.actbio.2022.08.077_bib0020","first-page":"1","article-title":"Methylprednisolone for acute spinal cord injury: an inappropriate standard of care","volume":"93","author":"Hurlbert","year":"2000","journal-title":"J. Neurosurg."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.077_bib0021","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.sc.3101681","article-title":"High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients","volume":"43","author":"Qian","year":"2005","journal-title":"Spinal Cord"},{"issue":"3","key":"10.1016\/j.actbio.2022.08.077_bib0022","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.addr.2010.04.009","article-title":"The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect","volume":"63","author":"Fang","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"17","key":"10.1016\/j.actbio.2022.08.077_bib0023","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.7150\/thno.49577","article-title":"The EPR effect and beyond: strategies to improve tumor targeting and cancer nanomedicine treatment efficacy","volume":"10","author":"Shi","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2022.08.077_bib0024","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jconrel.2014.03.057","article-title":"EPR: evidence and fallacy","volume":"190","author":"Nichols","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2022.08.077_bib0025","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2016.11.015","article-title":"To exploit the tumor microenvironment: since the EPR effect fails in the clinic, what is the future of nanomedicine?","volume":"244","author":"Danhier","year":"2016","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.actbio.2022.08.077_bib0026","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.biomaterials.2006.09.047","article-title":"Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery","volume":"28","author":"Cheng","year":"2007","journal-title":"Biomaterials"},{"issue":"16","key":"10.1016\/j.actbio.2022.08.077_bib0027","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1073\/pnas.0601755103","article-title":"Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo","volume":"103","author":"Farokhzad","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"45","key":"10.1016\/j.actbio.2022.08.077_bib0028","doi-asserted-by":"crossref","first-page":"17356","DOI":"10.1073\/pnas.0809154105","article-title":"Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA\u2013PEG nanoparticles","volume":"105","author":"Dhar","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"16","key":"10.1016\/j.actbio.2022.08.077_bib0029","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1073\/pnas.1303377110","article-title":"Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles","volume":"110","author":"Kamaly","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"275","key":"10.1016\/j.actbio.2022.08.077_bib0030","doi-asserted-by":"crossref","first-page":"275ra20","DOI":"10.1126\/scitranslmed.aaa1065","article-title":"Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice","volume":"7","author":"Fredman","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"52","key":"10.1016\/j.actbio.2022.08.077_bib0031","doi-asserted-by":"crossref","first-page":"E12333","DOI":"10.1073\/pnas.1816429115","article-title":"Nanotechnology-mediated crossing of two impermeable membranes to modulate the stars of the neurovascular unit for neuroprotection","volume":"115","author":"Surnar","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0032","doi-asserted-by":"crossref","first-page":"15741","DOI":"10.1021\/acsnano.0c09553","article-title":"Brain-accumulating nanoparticles for assisting astrocytes to reduce human immunodeficiency virus and drug abuse-induced neuroinflammation and oxidative stress","volume":"15","author":"Surnar","year":"2021","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.actbio.2022.08.077_bib0033","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1039\/c2cs15344k","article-title":"Targeted polymeric therapeutic nanoparticles: design, development and clinical translation","volume":"41","author":"Kamaly","year":"2012","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.077_bib0034","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1039\/C8BM01340C","article-title":"Peptide ligand-mediated targeted drug delivery of nanomedicines","volume":"7","author":"Jiang","year":"2019","journal-title":"Biomater. Sci."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0035","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1021\/acs.bioconjchem.0c00453","article-title":"In vivo targeting using arylboronate\/nopoldiol click conjugation","volume":"31","author":"Palvai","year":"2020","journal-title":"Bioconjugate Chem."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0036","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1021\/acs.molpharmaceut.1c00535","article-title":"On-demand drug release from click-refillable drug depots","volume":"18","author":"Palvai","year":"2021","journal-title":"Mol. Pharm."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.077_bib0037","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/acscentsci.9b00195","article-title":"Spatially defined drug targeting by in situ host\u2013guest chemistry in a living animal","volume":"5","author":"Zou","year":"2019","journal-title":"ACS Cent. Sci."},{"issue":"35","key":"10.1016\/j.actbio.2022.08.077_bib0038","doi-asserted-by":"crossref","first-page":"12722","DOI":"10.1073\/pnas.1413027111","article-title":"Refilling drug delivery depots through the blood","volume":"111","author":"Brudno","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.077_bib0039","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.expneurol.2007.06.009","article-title":"Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury","volume":"209","author":"Donnelly","year":"2008","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0040","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1021\/acsbiomaterials.0c00844","article-title":"Acute implantation of aligned hydrogel tubes supports delayed spinal progenitor implantation","volume":"6","author":"Ciciriello","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.077_bib0041","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1002\/bit.27781","article-title":"IL-10 lentivirus-laden hydrogel tubes increase spinal progenitor survival and neuronal differentiation after spinal cord injury","volume":"118","author":"Ciciriello","year":"2021","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.actbio.2022.08.077_bib0042","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.actbio.2018.12.052","article-title":"Aligned hydrogel tubes guide regeneration following spinal cord injury","volume":"86","author":"Dumont","year":"2019","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.077_bib0043","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.nano.2009.02.002","article-title":"PEGylated PLGA nanoparticles for the improved delivery of doxorubicin","volume":"5","author":"Park","year":"2009","journal-title":"Nanomed.: Nanotechnol. Biol. Med."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.077_bib0044","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.2042-7158.2011.01376.x","article-title":"Cellular delivery of PEGylated PLGA nanoparticles","volume":"64","author":"Pamujula","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.077_bib0045","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/BJ20101593","article-title":"How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer","volume":"435","author":"Chivers","year":"2011","journal-title":"Biochem. J."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0046","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.biomaterials.2010.12.027","article-title":"Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture","volume":"32","author":"Shikanov","year":"2011","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.actbio.2022.08.077_bib0047","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.1021\/acsbiomaterials.9b01012","article-title":"PLG bridge implantation in chronic SCI promotes axonal elongation and myelination","volume":"5","author":"Smith","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.actbio.2022.08.077_bib0048","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1089\/ten.tea.2019.0321","article-title":"Polycistronic delivery of IL-10 and NT-3 promotes oligodendrocyte myelination and functional recovery in a mouse spinal cord injury model","author":"Smith","year":"2020","journal-title":"Tissue Eng., Part A"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.077_bib0049","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/bit.26838","article-title":"Combinatorial lentiviral gene delivery of pro-oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury","volume":"116","author":"Smith","year":"2019","journal-title":"Biotechnol. Bioeng."},{"issue":"9","key":"10.1016\/j.actbio.2022.08.077_bib0050","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.biomaterials.2012.12.002","article-title":"Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury","volume":"34","author":"Thomas","year":"2013","journal-title":"Biomaterials"},{"issue":"15","key":"10.1016\/j.actbio.2022.08.077_bib0051","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.1021\/ma200675w","article-title":"Stability of Self-Assembled Polymeric Micelles in Serum","volume":"44","author":"Lu","year":"2011","journal-title":"Macromolecules"},{"issue":"27","key":"10.1016\/j.actbio.2022.08.077_bib0052","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1039\/C8TB00474A","article-title":"Combinatorial delivery of bioactive molecules by a nanoparticle-decorated and functionalized biodegradable scaffold","volume":"6","author":"Czekanska","year":"2018","journal-title":"J. Mater. Chem. B"},{"issue":"5","key":"10.1016\/j.actbio.2022.08.077_bib0053","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s12195-019-00593-0","article-title":"Injectable, hyaluronic acid-based scaffolds with macroporous architecture for gene delivery","volume":"12","author":"Ehsanipour","year":"2019","journal-title":"Cell. Mol. Bioeng."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.077_bib0054","doi-asserted-by":"crossref","DOI":"10.1063\/5.0035291","article-title":"Injectable, macroporous scaffolds for delivery of therapeutic genes to the injured spinal cord","volume":"5","author":"Ehsanipour","year":"2021","journal-title":"APL Bioeng."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.077_bib0055","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nmat4294","article-title":"Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks","volume":"14","author":"Griffin","year":"2015","journal-title":"Nat. Mater."},{"issue":"32","key":"10.1016\/j.actbio.2022.08.077_bib0056","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201606471","article-title":"Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion","volume":"29","author":"Nih","year":"2017","journal-title":"Adv. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2022.08.077_bib0057","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.biomaterials.2011.11.002","article-title":"Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury","volume":"33","author":"Tuinstra","year":"2012","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2022.08.077_bib0058","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1089\/ten.teb.2015.0380","article-title":"Mechanotransduction of neural cells through cell-substrate interactions","volume":"22","author":"Stukel","year":"2016","journal-title":"Tissue Eng., Part B"},{"issue":"8","key":"10.1016\/j.actbio.2022.08.077_bib0059","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1529\/biophysj.105.073114","article-title":"Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures","volume":"90","author":"Georges","year":"2006","journal-title":"Biophys. J."},{"issue":"2","key":"10.1016\/j.actbio.2022.08.077_bib0060","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/aa9a4b","article-title":"The interplay of peptide affinity and scaffold stiffness on neuronal differentiation of neural stem cells","volume":"13","author":"Stukel","year":"2018","journal-title":"Biomed. Mater."},{"issue":"9","key":"10.1016\/j.actbio.2022.08.077_bib0061","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1021\/acsbiomaterials.0c00743","article-title":"Effect of nanoparticle composition, size, shape, and stiffness on penetration across the blood\u2013brain barrier","volume":"6","author":"Brown","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.077_bib0062","first-page":"444","article-title":"Size, shape, charge and \u201cstealthy\u201d surface: carrier properties affect the drug circulation time in vivo","volume":"16","author":"Di","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0063","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003937","article-title":"Development of polymeric nanoparticles for blood\u2013brain barrier transfer\u2014Strategies and challenges","volume":"8","author":"Zhang","year":"2021","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2022.08.077_bib0064","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-021-01975-2","article-title":"Nanoparticle-based delivery to treat spinal cord injury\u2014A mini-review","volume":"22","author":"Chakraborty","year":"2021","journal-title":"AAPS PharmSciTech"},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0065","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1007\/s11095-012-0958-3","article-title":"Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery","volume":"30","author":"Kulkarni","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.actbio.2022.08.077_bib0066","first-page":"505","article-title":"In vivo evaluation of a conjugated poly(lactide-ethylene glycol) nanoparticle depot formulation for prolonged insulin delivery in the diabetic rabbit model","volume":"8","author":"Tomar","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.actbio.2022.08.077_bib0067","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2147\/IJN.S121881","article-title":"Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile","volume":"12","author":"Rafiei","year":"2017","journal-title":"Int. J. Nanomedicine"},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0068","doi-asserted-by":"crossref","first-page":"11034","DOI":"10.1021\/acsnano.9b02807","article-title":"Orally administrable therapeutic synthetic nanoparticle for zika virus","volume":"13","author":"Surnar","year":"2019","journal-title":"ACS Nano"},{"issue":"1\u20132","key":"10.1016\/j.actbio.2022.08.077_bib0069","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0168-3659(01)00451-5","article-title":"Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge","volume":"77","author":"Yamamoto","year":"2001","journal-title":"J. Control. Release"},{"issue":"Pt A","key":"10.1016\/j.actbio.2022.08.077_bib0070","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a strategy for improving nanoparticle-based drug and gene delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"30","key":"10.1016\/j.actbio.2022.08.077_bib0071","doi-asserted-by":"crossref","first-page":"14947","DOI":"10.1073\/pnas.1820276116","article-title":"Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury","volume":"116","author":"Park","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.077_bib0072","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1021\/acsnano.1c11578","article-title":"Macrophages Actively Transport Nanoparticles in Tumors After Extravasation","volume":"16","author":"Lin","year":"2022","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.actbio.2022.08.077_bib0073","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1038\/ncomms11980","article-title":"A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries","volume":"7","author":"Mann","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2022.08.077_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2022.102526","article-title":"CAQK modification enhances the targeted accumulation of metformin-loaded nanoparticles in rats with spinal cord injury","volume":"41","author":"Li","year":"2022","journal-title":"Nanomed.: Nanotechnol. Biol. Med."},{"key":"10.1016\/j.actbio.2022.08.077_bib0075","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.2147\/IJN.S202353","article-title":"Targeted delivery of polypeptide nanoparticle for treatment of traumatic brain injury","volume":"14","author":"Wu","year":"2019","journal-title":"Int. J. Nanomedicine"},{"issue":"2","key":"10.1016\/j.actbio.2022.08.077_bib0076","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1152\/physrev.00017.2017","article-title":"The Biology of Regeneration Failure and Success After Spinal Cord Injury","volume":"98","author":"Tran","year":"2018","journal-title":"Physiol. Rev."},{"issue":"78","key":"10.1016\/j.actbio.2022.08.077_bib0077","article-title":"Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury","volume":"14","author":"Yang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.actbio.2022.08.077_bib0078","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202004184","article-title":"Cheerios Effect Inspired Microbubbles as Suspended and Adhered Oral Delivery Systems","volume":"8","author":"Zhao","year":"2021","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.077_bib0079","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1038\/s41467-018-06979-4","article-title":"Cloaking nanoparticles with protein corona shield for targeted drug delivery","volume":"9","author":"Oh","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2022.08.077_bib0080","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0076-6879(90)84259-J","article-title":"Avidin and streptavidin","author":"Green","year":"1990"},{"issue":"35","key":"10.1016\/j.actbio.2022.08.077_bib0081","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.2174\/13816128113199990375","article-title":"The smart targeting of nanoparticles","volume":"19","author":"Friedman","year":"2013","journal-title":"Curr. Pharm. Des."},{"issue":"11","key":"10.1016\/j.actbio.2022.08.077_bib0082","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1021\/jacs.7b00540","article-title":"Controlling Multivalent Binding through Surface Chemistry: model Study on Streptavidin","volume":"139","author":"Dubacheva","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"Pt 3","key":"10.1016\/j.actbio.2022.08.077_bib0083","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/bj2930613","article-title":"Biotin binders selected from a random peptide library expressed on phage","volume":"293","author":"Saggio","year":"1993","journal-title":"Biochem. J."},{"issue":"Pt 2","key":"10.1016\/j.actbio.2022.08.077_bib0084","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1042\/bj2780573","article-title":"Studies on the biotin-binding site of avidin. Minimized fragments that bind biotin","volume":"278","author":"Hiller","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/j.actbio.2022.08.077_bib0085","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jconrel.2016.01.020","article-title":"Nanoparticle-liver interactions: cellular uptake and hepatobiliary elimination","volume":"240","author":"Zhang","year":"2016","journal-title":"J. Control. Release"},{"issue":"18","key":"10.1016\/j.actbio.2022.08.077_bib0086","doi-asserted-by":"crossref","first-page":"8346","DOI":"10.1073\/pnas.0909506107","article-title":"Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields","volume":"107","author":"Chorny","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.actbio.2022.08.077_bib0087","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/ja2084338","article-title":"Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake","volume":"134","author":"Walkey","year":"2012","journal-title":"J. Am. Chem. Soc."},{"issue":"15","key":"10.1016\/j.actbio.2022.08.077_bib0088","doi-asserted-by":"crossref","first-page":"e14545","DOI":"10.14814\/phy2.14545","article-title":"Nanoparticles exhibit greater accumulation in kidney glomeruli during experimental glomerular kidney disease","volume":"8","author":"Liu","year":"2020","journal-title":"Physiol. Rep."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.077_bib0089","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuroscience.2007.06.059","article-title":"Combination of dexamethasone and etanercept reduces secondary damage in experimental spinal cord trauma","volume":"150","author":"Genovese","year":"2007","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.actbio.2022.08.077_bib0090","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1089\/089771501300227332","article-title":"Methylprednisolone reduces spinal cord injury in rats without affecting tumor necrosis factor-alpha production","volume":"18","author":"Taoka","year":"2001","journal-title":"J. Neurotrauma"},{"issue":"8","key":"10.1016\/j.actbio.2022.08.077_bib0091","doi-asserted-by":"crossref","first-page":"656","DOI":"10.5812\/kowsar.1735143X.713","article-title":"Liver injury induced by high-dose methylprednisolone therapy: a case report and brief review of the literature","volume":"11","author":"Gutkowski","year":"2011","journal-title":"Hepat. Mon."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0092","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1345\/aph.1H171","article-title":"Methylprednisolone-induced toxic hepatitis","volume":"40","author":"Topal","year":"2006","journal-title":"Ann. Pharmacother."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.077_bib0093","first-page":"825","article-title":"Liver injury after methylprednisolone pulses: a disputable cause of hepatotoxicity. A case series and literature review. United Eur","volume":"7","author":"Zoubek","year":"2019","journal-title":"Gastroenterol. J."},{"issue":"1","key":"10.1016\/j.actbio.2022.08.077_bib0094","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/s41467-022-28787-7","article-title":"High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2022.08.077_bib0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jconrel.2021.04.016","article-title":"Improving kidney targeting: the influence of nanoparticle physicochemical properties on kidney interactions","volume":"334","author":"Huang","year":"2021","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.actbio.2022.08.077_bib0096","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1073\/pnas.1200718109","article-title":"Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane","volume":"109","author":"Zuckerman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0097","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/nbt1340","article-title":"Renal clearance of quantum dots","volume":"25","author":"Choi","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"10.1016\/j.actbio.2022.08.077_bib0098","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41578-018-0038-3","article-title":"Transport and interactions of nanoparticles in the kidneys","volume":"3","author":"Du","year":"2018","journal-title":"Nat. Rev. Mater."},{"issue":"6","key":"10.1016\/j.actbio.2022.08.077_bib0099","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3390\/ijms18061249","article-title":"Emerging role of the spleen in the pharmacokinetics of monoclonal antibodies, nanoparticles and exosomes","volume":"18","author":"Cataldi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2022.08.077_bib0100","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jconrel.2015.07.024","article-title":"Nanotechnology approaches for inhalation treatment of lung diseases","volume":"219","author":"Kuzmov","year":"2015","journal-title":"J. Control. Release"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122005608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122005608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:54:32Z","timestamp":1761674072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122005608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":100,"alternative-id":["S1742706122005608"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.08.077","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomaterial-targeted precision nanoparticle delivery to the injured spinal cord","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.08.077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}