{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:36:22Z","timestamp":1792517782887,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"am","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["IR21DK128715\u201301A1"],"award-info":[{"award-number":["IR21DK128715\u201301A1"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.actbio.2022.09.050","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T04:19:46Z","timestamp":1663993186000},"page":"83-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Smart capsule for targeted proximal colon microbiome sampling"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4294-7262","authenticated-orcid":false,"given":"Sina","family":"Nejati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-8411","authenticated-orcid":false,"given":"Jiangshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotoudeh","family":"Sedaghat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole K.","family":"Balog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-6609","authenticated-orcid":false,"given":"Amanda M.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-8014","authenticated-orcid":false,"given":"Ulisses Heredia","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-7970","authenticated-orcid":false,"given":"Venkat","family":"Kasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinam","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-4142","authenticated-orcid":false,"given":"Jay S.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit S.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-782X","authenticated-orcid":false,"given":"Rahim","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"32","key":"10.1016\/j.actbio.2022.09.050_bib0001","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nbt.2942","article-title":"An integrated catalog of reference genes in the human gut microbiome","volume":"328","author":"Li","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2022.09.050_bib0002","doi-asserted-by":"crossref","unstructured":"P.J. Turnbaugh, R.E. Ley, M. Hamady, C.M. Fraser-Liggett, R. Knight, J.I. Gordon, The Human Microbiome Project, Nat. 2007 4497164. 449 (2007) 804\u2013810. doi:10.1038\/nature06244.","DOI":"10.1038\/nature06244"},{"key":"10.1016\/j.actbio.2022.09.050_bib0003","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Huttenhower","year":"2012","journal-title":"Nature."},{"key":"10.1016\/j.actbio.2022.09.050_bib0004","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.phrs.2012.10.007","article-title":"Modulation of intestinal barrier by intestinal microbiota: pathological and therapeutic implications","volume":"69","author":"Natividad","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.actbio.2022.09.050_bib0005","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2006.02.017","article-title":"Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine","volume":"124","author":"Ley","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2022.09.050_bib0006","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"B\u00e4ckhed","year":"2005","journal-title":"Science (80-.)"},{"key":"10.1016\/j.actbio.2022.09.050_bib0007","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"Ba\u00fcmler","year":"2016","journal-title":"Nat."},{"key":"10.1016\/j.actbio.2022.09.050_bib0008","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.aad9378","article-title":"How colonization by microbiota in early life shapes the immune system","volume":"352","author":"Gensollen","year":"2016","journal-title":"Science (80-.)"},{"key":"10.1016\/j.actbio.2022.09.050_bib0009","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ismej.2011.109","article-title":"Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers","volume":"6","author":"Wang","year":"2012","journal-title":"ISME J"},{"key":"10.1016\/j.actbio.2022.09.050_bib0010","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00248-013-0245-9","article-title":"Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients","volume":"66","author":"Wu","year":"2013","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.actbio.2022.09.050_bib0011","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MED.0000000000000523","article-title":"Irritable bowel syndrome and gut microbiota","volume":"27","author":"Canakis","year":"2020","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.actbio.2022.09.050_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-017-0260-z","article-title":"Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome","volume":"5","author":"Labus","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.actbio.2022.09.050_bib0013","doi-asserted-by":"crossref","unstructured":"C.S. Chung, P.F. Chang, C.H. Liao, T.H. Lee, Y. Chen, Y.C. Lee, M.S. Wu, H.P. Wang, Y.H. Ni, Differences of microbiota in small bowel and faeces between irritable bowel syndrome patients and healthy subjects, 51 (2015) 410\u2013419. doi:10.3109\/00365521.2015.1116107.","DOI":"10.3109\/00365521.2015.1116107"},{"key":"10.1016\/j.actbio.2022.09.050_bib0014","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1758-2229.2012.00327.x","article-title":"Structural alterations of faecal and mucosa-associated bacterial communities in irritable bowel syndrome","volume":"4","author":"Durb\u00e1n","year":"2012","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.actbio.2022.09.050_bib0015","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2013.11.033","article-title":"Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice","volume":"146","author":"Gronbach","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.actbio.2022.09.050_bib0016","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/gut.2010.223263","article-title":"Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives","volume":"60","author":"Joossens","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.actbio.2022.09.050_bib0017","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11040298","article-title":"Gut Microbiota and Acute Diverticulitis: role of Probiotics in Management of This Delicate Pathophysiological Balance","volume":"11","author":"Piccioni","year":"2021","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.actbio.2022.09.050_bib0018","first-page":"1","article-title":"Gut Microbiota Association with Diverticular Disease Pathogenesis and Progression: a Systematic Review","volume":"1","author":"Reitano","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.actbio.2022.09.050_bib0019","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1002\/ijc.32055","article-title":"Global trends in colorectal cancer mortality: projections to the year 2035","volume":"144","author":"Araghi","year":"2019","journal-title":"Int. J. Cancer."},{"key":"10.1016\/j.actbio.2022.09.050_bib0020","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41575-019-0189-8","article-title":"Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies","volume":"16","author":"Keum","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.actbio.2022.09.050_bib0021","first-page":"145","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.actbio.2022.09.050_bib0022","first-page":"1","article-title":"Health-related quality of life, work productivity, and indirect costs among patients with irritable bowel syndrome with diarrhea, Health Qual","volume":"15","author":"Buono","year":"2017","journal-title":"Life Outcomes"},{"key":"10.1016\/j.actbio.2022.09.050_bib0023","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1053\/j.gastro.2005.07.059","article-title":"Projected national impact of colorectal cancer screening on clinical and economic outcomes and health services demand","volume":"129","author":"Ladabaum","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.actbio.2022.09.050_bib0024","article-title":"The microbiome of diverticulitis","volume":"22","author":"Jeganathan","year":"2021","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.actbio.2022.09.050_bib0025","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/gutjnl-2020-323020","article-title":"Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19","volume":"70","author":"Yeoh","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.actbio.2022.09.050_bib0026","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.3390\/ijms16047493","article-title":"Impacts of gut bacteria on human health and diseases","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2022.09.050_bib0027","first-page":"26191","article-title":"Dysbiosis of the gut microbiota in disease","volume":"26","author":"Carding","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.actbio.2022.09.050_bib0028","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-020711-074937","article-title":"The microbiome in infectious disease and inflammation","volume":"30","author":"Honda","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.actbio.2022.09.050_bib0029","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2018.08.041","article-title":"Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features","volume":"174","author":"Zmora","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2022.09.050_bib0030","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science (80-.)"},{"key":"10.1016\/j.actbio.2022.09.050_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.00151","article-title":"Current Sampling Methods for Gut Microbiota: a Call for More Precise Devices","volume":"10","author":"Tang","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.actbio.2022.09.050_bib0032","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10350-005-0215-5","article-title":"Morphologic alterations associated with mechanical bowel preparation before elective colorectal surgery: a randomized trial","volume":"49","author":"Bucher","year":"2006","journal-title":"Dis. Colon Rectum."},{"key":"10.1016\/j.actbio.2022.09.050_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-40182-9","article-title":"Effects of bowel preparation on the human gut microbiome and metabolome","volume":"9","author":"Nagata","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2022.09.050_bib0034","series-title":"Proc. - IEEE Int. Conf. Robot. Autom","first-page":"6905","article-title":"Design of a magnetic actuation system for a microbiota-collection ingestible capsule","author":"Finocchiaro","year":"2021"},{"key":"10.1016\/j.actbio.2022.09.050_bib0035","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1109\/TMECH.2020.3043454","article-title":"Blindly Controlled Magnetically Actuated Capsule for Noninvasive Sampling of the Gastrointestinal Microbiome","volume":"26","author":"Shokrollahi","year":"2021","journal-title":"IEEE\/ASME Trans. Mechatronics."},{"key":"10.1016\/j.actbio.2022.09.050_bib0036","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1039\/D1LC00451D","article-title":"Small intestinal sampling capsule for inflammatory bowel disease type detection and management","volume":"22","author":"Nejati","year":"2022","journal-title":"Lab Chip"},{"key":"10.1016\/j.actbio.2022.09.050_bib0037","doi-asserted-by":"crossref","DOI":"10.1039\/C9RA10986B","article-title":"Smart capsule for non-invasive sampling and studying of the gastrointestinal microbiome","author":"Waimin","year":"2020","journal-title":"RSC Adv"},{"key":"10.1016\/j.actbio.2022.09.050_bib0038","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1089\/tmj.2007.0118","article-title":"The Study of a Remote-Controlled Gastrointestinal Drug Delivery and Sampling System","volume":"14","author":"Cui","year":"2008","journal-title":"Telemed. e-Health."},{"key":"10.1016\/j.actbio.2022.09.050_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/aisy.201970052","article-title":"Ingestible Osmotic Pill for In Vivo Sampling of Gut Microbiomes","volume":"1","author":"Rezaei Nejad","year":"2019","journal-title":"Adv. Intell. Syst."},{"key":"10.1016\/j.actbio.2022.09.050_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rcs.2140","article-title":"Capsule robot for gut microbiota sampling using shape memory alloy spring","volume":"16","author":"Rehan","year":"2020","journal-title":"Int. J. Med. Robot. Comput. Assist. Surg."},{"key":"10.1016\/j.actbio.2022.09.050_bib0041","doi-asserted-by":"crossref","first-page":"127175","DOI":"10.1109\/ACCESS.2021.3111086","article-title":"Towards Gut Microbiota Sampling Using an Untethered Sampling Device","volume":"9","author":"Rehan","year":"2021","journal-title":"IEEE Access"},{"key":"10.1016\/j.actbio.2022.09.050_bib0042","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1136\/gutjnl-2020-322465","article-title":"Novel scheme for non-invasive gut bioinformation acquisition with a magnetically controlled sampling capsule endoscope","volume":"70","author":"Ding","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.actbio.2022.09.050_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2020.104109","article-title":"Laser Functionalization of Carbon Membranes for Effective Immobilization of Antimicrobial Silver Nanoparticles","author":"Nejati","year":"2020","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.actbio.2022.09.050_bib0044","doi-asserted-by":"crossref","DOI":"10.1039\/D1TC01289D","article-title":"Laser-induced atmospheric Cu x O formation on copper surface with enhanced electrochemical performance for non-enzymatic glucose sensing","author":"Sedaghat","year":"2021","journal-title":"J. Mater. Chem. C."},{"key":"10.1016\/j.actbio.2022.09.050_bib0045","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.1021\/acsabm.1c00087","article-title":"Flexible microneedle array patch for chronic wound oxygenation and biofilm eradication","volume":"4","author":"Woodhouse","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.actbio.2022.09.050_bib0046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humic.2018.01.001","article-title":"Gut microbiota diversity according to dietary habits and geographical provenance","volume":"7","author":"Senghor","year":"2018","journal-title":"Hum. Microbiome J."},{"key":"10.1016\/j.actbio.2022.09.050_bib0047","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1021\/acsabm.9b01032","article-title":"A wireless implantable strain sensing scheme using ultrasound imaging of highly stretchable zinc oxide\/poly dimethylacrylamide nanocomposite hydrogel","volume":"3","author":"Jiang","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.actbio.2022.09.050_bib0048","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1021\/acsami.1c19805","article-title":"Low-Cost Flexible Glass-Based pH Sensor via Cold Atmospheric Plasma Deposition","volume":"14","author":"Kasi","year":"2022","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.actbio.2022.09.050_bib0049","first-page":"169","article-title":"Guide for the care and use of agricultural animals in research and teaching","year":"2010","journal-title":"Anim. Sci."},{"key":"10.1016\/j.actbio.2022.09.050_bib0050","unstructured":"N.R. Council, Nutrient requirements of swine (2012)."},{"key":"10.1016\/j.actbio.2022.09.050_bib0051","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.aninu.2017.06.008","article-title":"Techniques for evaluating digestibility of energy, amino acids, phosphorus, and calcium in feed ingredients for pigs","volume":"3","author":"Zhang","year":"2017","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.actbio.2022.09.050_bib0052","doi-asserted-by":"crossref","first-page":"e13541","DOI":"10.1111\/nmo.13541","article-title":"More Movement with Evaluating Colonic Transit in Humans","volume":"31","author":"Bharucha","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.actbio.2022.09.050_bib0053","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.5754\/hge10849","article-title":"Study of segmental colonic transit time in healthy men","volume":"58","author":"Tomita","year":"2011","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.actbio.2022.09.050_bib0054","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jpedsurg.2003.10.002","article-title":"Colonic transit time\u2014What is normal?","volume":"39","author":"Wagener","year":"2004","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.actbio.2022.09.050_bib0055","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13734","article-title":"Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: influence of age, gender, and body mass index","volume":"32","author":"Nandhra","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.actbio.2022.09.050_bib0056","doi-asserted-by":"crossref","first-page":"G361","DOI":"10.1152\/ajpgi.00283.2019","article-title":"Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit","volume":"318","author":"M\u00fcller","year":"2020","journal-title":"Am. J. Physiol. - Gastrointest. Liver Physiol."},{"key":"10.1016\/j.actbio.2022.09.050_bib0057","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0887-2333(92)90084-5","article-title":"Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: predictability of human toxicity and comparison with rodent cell culture systems","volume":"6","author":"Jover","year":"1992","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.actbio.2022.09.050_bib0058","doi-asserted-by":"crossref","first-page":"134","DOI":"10.5056\/jnm20148","article-title":"Changes in cecal microbiota and short-chain fatty acid during lifespan of the rat","volume":"27","author":"Choi","year":"2021","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.actbio.2022.09.050_bib0059","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/jps.24365","article-title":"Animal Farm: considerations in Animal Gastrointestinal Physiology and Relevance to Drug Delivery in Humans","volume":"104","author":"Hatton","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.actbio.2022.09.050_bib0060","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3390\/nu12051474","article-title":"The firmicutes\/bacteroidetes ratio: a relevant marker of gut dysbiosis in obese patients?","volume":"12","author":"Magne","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.actbio.2022.09.050_bib0061","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1007\/s10620-020-06173-x","article-title":"Mapping the segmental microbiomes in the human small bowel in comparison with stool: a REIMAGINE study","volume":"65","author":"Leite","year":"2020","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.actbio.2022.09.050_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-30932-6","article-title":"Characterization of bacterial microbiota compositions along the intestinal tract in pigs and their interactions and functions","volume":"8","author":"Crespo-Piazuelo","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122006195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122006195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:59:36Z","timestamp":1761674376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122006195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":62,"alternative-id":["S1742706122006195"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.09.050","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Smart capsule for targeted proximal colon microbiome sampling","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.09.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}