{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:56:27Z","timestamp":1793976987241,"version":"4.8.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101104"],"award-info":[{"award-number":["32101104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770483"],"award-info":[{"award-number":["81770483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070496"],"award-info":[{"award-number":["82070496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100517"],"award-info":[{"award-number":["82100517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M670035ZX"],"award-info":[{"award-number":["2020M670035ZX"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["SBK2020040321"],"award-info":[{"award-number":["SBK2020040321"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["SBK2020042213"],"award-info":[{"award-number":["SBK2020042213"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["0214-14380481"],"award-info":[{"award-number":["0214-14380481"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.actbio.2022.11.057","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T19:58:18Z","timestamp":1670529498000},"page":"175-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":229,"special_numbering":"C","title":["Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing"],"prefix":"10.1016","volume":"157","author":[{"given":"Nan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianze","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2022.11.057_bib0001","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13287-019-1177-1","article-title":"Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte","volume":"10","author":"Jin","year":"2019","journal-title":"Stem. Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2022.11.057_bib0002","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.yexcr.2018.06.035","article-title":"Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K\/Akt signaling pathway","volume":"370","author":"Zhang","year":"2018","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.actbio.2022.11.057_bib0003","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"10.1016\/j.actbio.2022.11.057_bib0004","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1089\/wound.2015.0661","article-title":"Type I and II diabetic adipose-derived stem cells respond in vitro to dehydrated human amnion\/chorion membrane allograft treatment by increasing proliferation, migration, and altering cytokine secretion","volume":"5","author":"Massee","year":"2016","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.actbio.2022.11.057_bib0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbrc.2018.02.076","article-title":"Co-transplantation of exosomes derived from hypoxia-preconditioned adipose mesenchymal stem cells promotes neovascularization and graft survival in fat grafting","volume":"497","author":"Han","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.actbio.2022.11.057_bib0006","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1089\/scd.2017.0296","article-title":"Exosomes derived from hypoxia-treated human adipose mesenchymal stem cells enhance angiogenesis through the PKA signaling pathway","volume":"27","author":"Xue","year":"2018","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.actbio.2022.11.057_bib0007","article-title":"The impact of the hypoxia-VEGF-vascular permeability on COVID-19-infected patients","volume":"1","author":"Cao","year":"2021","journal-title":"Exploration (Beijing)"},{"key":"10.1016\/j.actbio.2022.11.057_bib0008","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biocel.2019.01.017","article-title":"Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells enhance angiogenesis through VEGF\/VEGF-R","volume":"109","author":"Han","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.actbio.2022.11.057_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108615","article-title":"Mechanistic insight into diabetic wounds: pathogenesis, molecular targets and treatment strategies to pace wound healing","volume":"112","author":"Patel","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actbio.2022.11.057_bib0010","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrneph.2017.31","article-title":"The role of the complement system in diabetic nephropathy","volume":"13","author":"Flyvbjerg","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.actbio.2022.11.057_bib0011","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1167\/iovs.19-27644","article-title":"COMP-Ang1 stabilizes hyperglycemic disruption of blood-retinal barrier phenotype in human retinal microvascular endothelial cells","volume":"60","author":"Rochfort","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2022.11.057_bib0012","doi-asserted-by":"crossref","first-page":"28667","DOI":"10.1073\/pnas.2016268117","article-title":"In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment","volume":"117","author":"Ouyang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.actbio.2022.11.057_bib0013","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.matt.2020.04.022","article-title":"Germanene-based theranostic materials for surgical adjuvant treatment: inhibiting tumor recurrence and wound infection","volume":"3","author":"Feng","year":"2020","journal-title":"Matter"},{"issue":"1","key":"10.1016\/j.actbio.2022.11.057_bib0014","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.matt.2021.12.007","article-title":"Precise control of the structure of synthetic hydrogel networks for precision medicine applications","volume":"5","author":"Chen","year":"2022","journal-title":"Matter"},{"issue":"12","key":"10.1016\/j.actbio.2022.11.057_bib0015","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1016\/j.bioactmat.2021.04.039","article-title":"Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue","volume":"6","author":"Cai","year":"2021","journal-title":"Bioactive Mater."},{"key":"10.1016\/j.actbio.2022.11.057_bib0016","doi-asserted-by":"crossref","first-page":"e12830","DOI":"10.1111\/cpr.12830","article-title":"Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis","volume":"53","author":"Qiu","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.actbio.2022.11.057_bib0017","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actbio.2019.12.020","article-title":"Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126","volume":"103","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2022.11.057_bib0018","doi-asserted-by":"crossref","first-page":"447","DOI":"10.15283\/ijsc21050","article-title":"Hypoxic pretreatment of adipose-derived stem cells accelerates diabetic wound healing via circ-Gcap14 and HIF-1alpha\/VEGF mediated angiopoiesis","volume":"14","author":"Wang","year":"2021","journal-title":"Int. J. Stem Cells"},{"key":"10.1016\/j.actbio.2022.11.057_bib0019","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2022.11.057_bib0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13148-019-0610-8","article-title":"Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index","volume":"11","author":"Wu","year":"2019","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.actbio.2022.11.057_bib0021","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bbrc.2019.02.082","article-title":"Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA\/NF-kappaB pathway","volume":"511","author":"Zhang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.actbio.2022.11.057_bib0022","doi-asserted-by":"crossref","first-page":"C848","DOI":"10.1152\/ajpcell.00041.2020","article-title":"Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p\/SIRT1-mediated autophagy","volume":"318","author":"Shi","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.actbio.2022.11.057_bib0023","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181788","article-title":"MiRNA-144-3p inhibits high glucose induced cell proliferation through suppressing FGF16","volume":"39","author":"Chen","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.actbio.2022.11.057_bib0024","doi-asserted-by":"crossref","first-page":"16294","DOI":"10.18632\/aging.103651","article-title":"Circulating exosomal miR-144-3p inhibits the mobilization of endothelial progenitor cells post myocardial infarction via regulating the MMP9 pathway","volume":"12","author":"Liu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.actbio.2022.11.057_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.592833","article-title":"Insulin-containing wound dressing promotes diabetic wound healing through stabilizing HIF-1alpha","volume":"8","author":"Yang","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2022.11.057_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109249","article-title":"TGF-beta1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1\/Nrf2 pathway","volume":"331","author":"Chen","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.actbio.2022.11.057_bib0027","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2020.05.018","article-title":"Role of Nrf2 in MALAT1\/HIF-1alpha loop on the regulation of angiogenesis in diabetic foot ulcer","volume":"156","author":"Jayasuriya","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.actbio.2022.11.057_bib0028","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.biochi.2020.02.011","article-title":"Exosomal Nrf2: From anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases","volume":"171-172","author":"Kahroba","year":"2020","journal-title":"Biochimie"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122007851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706122007851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:59:35Z","timestamp":1761674375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706122007851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":28,"alternative-id":["S1742706122007851"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2022.11.057","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2022.11.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}