{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:42:37Z","timestamp":1790116957052,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016190","name":"Trond Mohn stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.actbio.2023.03.029","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T03:07:03Z","timestamp":1680232023000},"page":"269-281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Mechanical behavior and collagen structure of degenerative mitral valve leaflets and a finite element model of primary mitral regurgitation"],"prefix":"10.1016","volume":"164","author":[{"given":"Mohammad Javad","family":"Sadeghinia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Martin","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Urheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Matongo","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vegard Skalstad","family":"Ellensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Haaverstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard A.","family":"Holzapfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Skallerud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victorien","family":"Prot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.actbio.2023.03.029_bib0001","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary presentation and management of valvular heart disease","volume":"140","author":"Iung","year":"2019","journal-title":"Circulation"},{"issue":"9540","key":"10.1016\/j.actbio.2023.03.029_bib0002","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"The Lancet"},{"issue":"16","key":"10.1016\/j.actbio.2023.03.029_bib0003","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/eurheartj\/ehq222","article-title":"Degenerative mitral valve regurgitation: best practice revolution","volume":"31","author":"Adams","year":"2010","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.actbio.2023.03.029_bib0004","first-page":"e005971","article-title":"Pathophysiology of degenerative mitral regurgitation","volume":"11","author":"Antoine","year":"2018","journal-title":"Circulation: Cardiovascular Imaging"},{"key":"10.1016\/j.actbio.2023.03.029_bib0005","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrcardio.2015.161","article-title":"Mitral valve diseasemorphology and mechanisms","volume":"12","author":"Levine","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"issue":"4","key":"10.1016\/j.actbio.2023.03.029_bib0006","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1053\/j.semtcvs.2016.08.015","article-title":"Comparative histopathological analysis of mitral valves in Barlow disease and fibroelastic deficiency","volume":"28","author":"Hjortnaes","year":"2016","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"issue":"2","key":"10.1016\/j.actbio.2023.03.029_bib0007","first-page":"23","article-title":"Characterization of degenerative mitral valve disease: differences between fibroelastic deficiency and barlows disease","volume":"8","author":"van Wijngaarden","year":"2021","journal-title":"J. Cardiovasc. Dev. Dis."},{"issue":"5","key":"10.1016\/j.actbio.2023.03.029_bib0008","first-page":"e002989","article-title":"Dynamic phenotypes of degenerative myxomatous mitral valve disease","volume":"8","author":"Clavel","year":"2015","journal-title":"Circulation: Cardiovascular Imaging"},{"issue":"4","key":"10.1016\/j.actbio.2023.03.029_bib0009","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"5","key":"10.1016\/j.actbio.2023.03.029_bib0010","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1067\/mtc.2001.117621","article-title":"Mechanical properties of myxomatous mitral valves","volume":"122","author":"Barber","year":"2001","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"12","key":"10.1016\/j.actbio.2023.03.029_bib0011","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1016\/j.jbiomech.2004.10.005","article-title":"Structural effects of an innovative surgical technique to repair heart valve defects","volume":"38","author":"Dal Pan","year":"2005","journal-title":"J. Biomech."},{"issue":"03","key":"10.1016\/j.actbio.2023.03.029_bib0012","doi-asserted-by":"crossref","first-page":"1450031","DOI":"10.1142\/S0219519414500316","article-title":"Constitutive modeling and finite element analysis of myxomatous mitral leaflet tissue","volume":"14","author":"Zhong","year":"2014","journal-title":"J. Mech. Med. Biol."},{"issue":"1\u20132","key":"10.1016\/j.actbio.2023.03.029_bib0013","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10659-021-09829-5","article-title":"Influence of annular dynamics and material behavior in finite element analysis of Barlows mitral valve disease","volume":"145","author":"Aguilera","year":"2021","journal-title":"J. Elast."},{"key":"10.1016\/j.actbio.2023.03.029_bib0014","doi-asserted-by":"crossref","first-page":"111226","DOI":"10.1016\/j.jbiomech.2022.111226","article-title":"Finite element analysis of mitral valve annuloplasty in Barlows disease","volume":"142","author":"Aguilera","year":"2022","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.actbio.2023.03.029_bib0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.athoracsur.2007.03.040","article-title":"The geoform disease-specific annuloplasty system: afinite element study","volume":"84","author":"Votta","year":"2007","journal-title":"Ann. Thorac. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2023.03.029_bib0016","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s10439-012-0620-6","article-title":"Finite element modeling of mitral valve dynamic deformation using patient-specific multi-slices computed tomography scans","volume":"41","author":"Wang","year":"2013","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2023.03.029_bib0017","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13239-016-0291-9","article-title":"Finite element analysis of patient-specific mitral valve with mitral regurgitation","volume":"8","author":"Pham","year":"2017","journal-title":"Cardiovasc. Eng. Technol."},{"issue":"6","key":"10.1016\/j.actbio.2023.03.029_bib0018","doi-asserted-by":"crossref","first-page":"e2831","DOI":"10.1002\/cnm.2831","article-title":"Computational virtual evaluation of the effect of annuloplasty ring shape","volume":"33","author":"Choi","year":"2017","journal-title":"Int. J. Numer. Method. Biomed. Eng."},{"key":"10.1016\/j.actbio.2023.03.029_bib0019","doi-asserted-by":"crossref","first-page":"109730","DOI":"10.1016\/j.jbiomech.2020.109730","article-title":"Finite element analysis of MitraClip procedure on a patient-specific model with functional mitral regurgitation","volume":"104","author":"Kong","year":"2020","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.actbio.2023.03.029_bib0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jmbbm.2009.05.004","article-title":"On modelling and analysis of healthy and pathological human mitral valves: two case studies","volume":"3","author":"Prot","year":"2010","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"June","key":"10.1016\/j.actbio.2023.03.029_bib0021","first-page":"1","article-title":"Alterations in human mitral valve mechanical properties secondary to left ventricular remodeling: a biaxial mechanical study","volume":"9","author":"Vandemaele","year":"2022","journal-title":"Front. cardiovasc. med."},{"key":"10.1016\/j.actbio.2023.03.029_bib0022","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.actbio.2022.01.003","article-title":"Biomechanics of mitral valve leaflets: second harmonic generation microscopy, biaxial mechanical tests and tissue modeling","volume":"141","author":"Sadeghinia","year":"2022","journal-title":"Acta. Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2023.03.029_bib0023","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1115\/1.2834305","article-title":"A constitutive law for mitral valve tissue","volume":"120","author":"May-Newman","year":"1998","journal-title":"J. Biomech. Eng."},{"issue":"8","key":"10.1016\/j.actbio.2023.03.029_bib0024","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/nme.1983","article-title":"Transversely isotropic membrane shells with application to mitral valve mechanics. constitutive modelling and finite element implementation","volume":"71","author":"Prot","year":"2007","journal-title":"Int. J. Numer. Methods. Eng."},{"key":"10.1016\/j.actbio.2023.03.029_bib0025","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.actbio.2015.12.001","article-title":"A meso-scale layer-specific structural constitutive model of the mitral heart valve leaflets","volume":"32","author":"Zhang","year":"2016","journal-title":"Acta. Biomater."},{"key":"10.1016\/j.actbio.2023.03.029_bib0026","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.actbio.2019.11.028","article-title":"Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture in soft collagenous tissues","volume":"102","author":"Jett","year":"2020","journal-title":"Acta. Biomater."},{"key":"10.1016\/j.actbio.2023.03.029_bib0027","doi-asserted-by":"crossref","first-page":"105401","DOI":"10.1016\/j.jmbbm.2022.105401","article-title":"Ex vivo experimental characterizations for understanding the interrelationship between tissue mechanics and collagen microstructure of porcine mitral valve leaflets","volume":"134","author":"Fitzpatrick","year":"2022","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"4","key":"10.1016\/j.actbio.2023.03.029_bib0028","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12195-018-0529-8","article-title":"The three-dimensional microenvironment of the mitral valve: insights into the effects of physiological loads","volume":"11","author":"Ayoub","year":"2018","journal-title":"Cell. Mol. Bioeng."},{"issue":"1","key":"10.1016\/j.actbio.2023.03.029_bib0029","doi-asserted-by":"crossref","first-page":"131141","DOI":"10.1002\/(SICI)1097-4636(199807)41:1<131::AID-JBM16>3.0.CO;2-Q","article-title":"The aortic valve microstructure: effects of transvalvular pressure","volume":"41","author":"Sacks","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"issue":"1","key":"10.1016\/j.actbio.2023.03.029_bib0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1115\/1.2401186","article-title":"The relation between collagen fibril kinematics and mechanical properties in the mitral valve anterior leaflet","volume":"129","author":"Liao","year":"2007","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2023.03.029_bib0031","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.actbio.2017.11.040","article-title":"Pressure-induced microstructural changes in porcine tricuspid valve leaflets","volume":"67","author":"Pant","year":"2018","journal-title":"Acta. Biomater."},{"key":"10.1016\/j.actbio.2023.03.029_bib0032","unstructured":"Abaqus: Dassault Syst\u00e8mes Simulia Corp., Providence, RI, USA, 2019. www.simulia.com."},{"key":"10.1016\/j.actbio.2023.03.029_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2019.109462","article-title":"The effects of -80\u2218c short-term storage on the mechanical response of tricuspid valve leaflets","volume":"98","author":"Salinas","year":"2020","journal-title":"J Biomech"},{"key":"10.1016\/j.actbio.2023.03.029_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105371","article-title":"Microstructure and mechanics of the bovine trachea: layer specific investigations through SHG imaging and biaxial testing","volume":"134","author":"Ayyalasomayajula","year":"2022","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2023.03.029_bib0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1242\/dev.105.1.61","article-title":"A whole-mount immunocytochemical analysis of the expression of the intermediate filament protein vimentin in xenopus","volume":"105","author":"Dent","year":"1989","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.actbio.2023.03.029_bib0036","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nn.3447","article-title":"SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction","volume":"16","author":"Ke","year":"2013","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.actbio.2023.03.029_bib0037","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cell.2015.06.067","article-title":"Clarifying tissue clearing","volume":"162","author":"Richardson","year":"2015","journal-title":"Cell"},{"issue":"80","key":"10.1016\/j.actbio.2023.03.029_bib0038","doi-asserted-by":"crossref","first-page":"20120760","DOI":"10.1098\/rsif.2012.0760","article-title":"An automated approach for three-dimensional quantification of fibrillar structures in optically cleared soft biological tissues","volume":"10","author":"Schriefl","year":"2012","journal-title":"J. R. Soc. Interface."},{"issue":"4","key":"10.1016\/j.actbio.2023.03.029_bib0039","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1529\/biophysj.106.100586","article-title":"The role of backscattering in SHG tissue imaging","volume":"93","author":"L\u00e9gar\u00e9","year":"2007","journal-title":"Biophys. J."},{"issue":"16","key":"10.1016\/j.actbio.2023.03.029_bib0040","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1016\/j.jbiomech.2008.05.039","article-title":"Towards an analytical model of soft biological tissues","volume":"41","author":"Federico","year":"2008","journal-title":"J. Biomech."},{"issue":"138","key":"10.1016\/j.actbio.2023.03.029_bib0041","doi-asserted-by":"crossref","first-page":"20170766","DOI":"10.1098\/rsif.2017.0766","article-title":"A discrete fibre dispersion method for excluding fibres under compression in the modelling of fibrous tissues","volume":"15","author":"Li","year":"2018","journal-title":"J. R. Soc. Interface"},{"issue":"1\u20133","key":"10.1016\/j.actbio.2023.03.029_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1010835316564","article-title":"A new constitutive framework for arterial wall mechanics and a comparative study of material models","volume":"61","author":"Holzapfel","year":"2000","journal-title":"J. Elast."},{"key":"10.1016\/j.actbio.2023.03.029_bib0043","series-title":"Nonlinear solid Mechanics. A Continuum Approach for Engineering","author":"Holzapfel","year":"2000"},{"key":"10.1016\/j.actbio.2023.03.029_bib0044","series-title":"Intraoperative Imaging and Image-Guided Therapy","first-page":"277","article-title":"3D slicer: a platform for subject-specific image analysis, visualization, and clinical support","author":"Kikinis","year":"2014"},{"issue":"3","key":"10.1016\/j.actbio.2023.03.029_sbref0044","first-page":"447","article-title":"Nondestructive analysis of mitral valve collagen fiber orientation","volume":"37","author":"Cochran","year":"1991","journal-title":"ASAIO transactions"},{"issue":"12","key":"10.1016\/j.actbio.2023.03.029_bib0046","doi-asserted-by":"crossref","first-page":"e3142","DOI":"10.1002\/cnm.3142","article-title":"A noninvasive method for the determination of in vivo mitral valve leaflet strains","volume":"34","author":"Rego","year":"2018","journal-title":"Int. J. Numer. Method. Biomed. Eng."},{"key":"10.1016\/j.actbio.2023.03.029_bib0047","first-page":"491","article-title":"Anatomic basis for mitral valve modelling","volume":"3 5","author":"Kunzelman","year":"1994","journal-title":"J. Heart Valve Dis."},{"issue":"6","key":"10.1016\/j.actbio.2023.03.029_bib0048","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1098\/rsif.2005.0073","article-title":"Hyperelastic modelling of arterial layers with distributed collagen fibre orientations","volume":"3","author":"Gasser","year":"2006","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.actbio.2023.03.029_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjon.2023.01.007","article-title":"In silico analysis provides insights for patient-specific annuloplasty in barlow disease","author":"Aguilera","year":"2023","journal-title":"JTCVS Open"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123001666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123001666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:08:02Z","timestamp":1761674882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706123001666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":49,"alternative-id":["S1742706123001666"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2023.03.029","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical behavior and collagen structure of degenerative mitral valve leaflets and a finite element model of primary mitral regurgitation","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2023.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}