{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:23:07Z","timestamp":1792668187205,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002581","name":"School of Medicine, CHA University","doi-asserted-by":"publisher","award":["2022SKLS-KFKT001"],"award-info":[{"award-number":["2022SKLS-KFKT001"]}],"id":[{"id":"10.13039\/501100002581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JZ-48"],"award-info":[{"award-number":["2022JZ-48"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272141"],"award-info":[{"award-number":["82272141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.actbio.2023.04.036","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T21:35:01Z","timestamp":1682717701000},"page":"485-495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Intelligent gold nanoparticles for malignant tumor treatment via spontaneous copper manipulation and on-demand photothermal therapy based on copper induced click chemistry"],"prefix":"10.1016","volume":"166","author":[{"given":"Tian","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1224-0285","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2023.04.036_bib0001","doi-asserted-by":"crossref","unstructured":"S. Wang, L. Zhang, J. Zhao, M. He, Y. Huang, S. Zhao, A tumor microenvironment\u2013induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy, Sci. Adv. 7(12) eabe3588.","DOI":"10.1126\/sciadv.abe3588"},{"issue":"2","key":"10.1016\/j.actbio.2023.04.036_bib0002","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1021\/acsnano.6b06658","article-title":"Overcoming the heat endurance of tumor cells by interfering with the anaerobic glycolysis metabolism for improved photothermal therapy","volume":"11","author":"Chen","year":"2017","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0003","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1021\/acsnano.8b05982","article-title":"Multifunctional two-dimensional core\u2013shell MXene@gold nanocomposites for enhanced photo\u2013radio combined therapy in the second biological window","volume":"13","author":"Tang","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2023.04.036_bib0004","doi-asserted-by":"crossref","unstructured":"S. Hong, D.-W. Zheng, C. Zhang, Q.-X. Huang, S.-X. Cheng, X.-Z. Zhang, Vascular disrupting agent induced aggregation of gold nanoparticles for photothermally enhanced tumor vascular disruption, Sci. Adv. 6(23) eabb0020.","DOI":"10.1126\/sciadv.abb0020"},{"key":"10.1016\/j.actbio.2023.04.036_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120921","article-title":"PolyTLR7\/8a-conjugated, antigen-trapping gold nanorods elicit anticancer immunity against abscopal tumors by photothermal therapy-induced in situ vaccination","volume":"275","author":"Liu","year":"2021","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2023.04.036_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201705451","article-title":"Porphyrinic metal\u2013organic frameworks coated gold nanorods as a versatile nanoplatform for combined photodynamic\/photothermal\/chemotherapy of tumor","volume":"28","author":"Zeng","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2023.04.036_bib0007","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.carbon.2019.10.105","article-title":"Graphene oxide \/BaHoF5 \/ PEG nanocomposite for dual-modal imaging and heat shock protein inhibitor-sensitized tumor photothermal therapy","volume":"158","author":"Chang","year":"2020","journal-title":"Carbon"},{"key":"10.1016\/j.actbio.2023.04.036_bib0008","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biomaterials.2015.06.043","article-title":"Radionuclide 131I labeled reduced graphene oxide for nuclear imaging guided combined radio- and photothermal therapy of cancer","volume":"66","author":"Chen","year":"2015","journal-title":"Biomaterials"},{"issue":"18","key":"10.1016\/j.actbio.2023.04.036_bib0009","doi-asserted-by":"crossref","first-page":"21653","DOI":"10.1021\/acsami.1c04608","article-title":"Synergistic chemo-thermal therapy of cancer by DNA-templated silver nanoclusters and polydopamine nanoparticles","volume":"13","author":"Jiang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"50","key":"10.1016\/j.actbio.2023.04.036_bib0010","doi-asserted-by":"crossref","first-page":"46626","DOI":"10.1021\/acsami.9b18730","article-title":"JQ1-Loaded polydopamine nanoplatform inhibits c-MYC\/programmed cell death ligand 1 to enhance photothermal therapy for triple-negative breast cancer","volume":"11","author":"Tian","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.actbio.2023.04.036_bib0011","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201604894","article-title":"Light-triggered assembly of gold nanoparticles for photothermal therapy and photoacoustic imaging of tumors in vivo","volume":"29","author":"Cheng","year":"2017","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0012","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1038\/ncomms10437","article-title":"Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature","volume":"7","author":"Zhu","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0013","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/acs.nanolett.1c04369","article-title":"Driving DNA Origami Assembly with a Terahertz Wave","volume":"22","author":"Zhang","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2023.04.036_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.133850","article-title":"Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy","volume":"433","author":"Guo","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"32","key":"10.1016\/j.actbio.2023.04.036_bib0015","doi-asserted-by":"crossref","first-page":"28621","DOI":"10.1021\/acsami.9b05943","article-title":"Intracellular enzyme-triggered assembly of amino acid-modified gold nanoparticles for accurate cancer therapy with multimode","volume":"11","author":"Liu","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"44","key":"10.1016\/j.actbio.2023.04.036_bib0016","doi-asserted-by":"crossref","first-page":"23805","DOI":"10.1002\/anie.202109863","article-title":"Aggregation of gold nanoparticles triggered by hydrogen peroxide-initiated chemiluminescence for activated tumor theranostics","volume":"60","author":"Mao","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"issue":"17","key":"10.1016\/j.actbio.2023.04.036_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100074","article-title":"HOCl-activated aggregation of gold nanoparticles for multimodality therapy of tumors","volume":"8","author":"Liu","year":"2021","journal-title":"Advanced Science"},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0018","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1038\/s41467-019-12142-4","article-title":"Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2023.04.036_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2020.213529","article-title":"Endogenous tumor microenvironment-responsive multifunctional nanoplatforms for precision cancer theranostics","volume":"426","author":"Wang","year":"2021","journal-title":"Coord. Chem. Rev."},{"issue":"5","key":"10.1016\/j.actbio.2023.04.036_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202000834","article-title":"Tumor microenvironment sensitive nanocarriers for bioimaging and therapeutics","volume":"10","author":"Park","year":"2021","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.actbio.2023.04.036_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100851","article-title":"Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics","volume":"32","author":"Gong","year":"2020","journal-title":"Nano Today"},{"issue":"26","key":"10.1016\/j.actbio.2023.04.036_bib0022","doi-asserted-by":"crossref","first-page":"9277","DOI":"10.1021\/acs.analchem.1c01713","article-title":"Furin enzyme and pH synergistically triggered aggregation of gold nanoparticles for activated photoacoustic imaging and photothermal therapy of tumors","volume":"93","author":"Cheng","year":"2021","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0023","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41467-018-03473-9","article-title":"Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer","volume":"9","author":"Nam","year":"2018","journal-title":"Nat. Commun."},{"issue":"7501","key":"10.1016\/j.actbio.2023.04.036_bib0024","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature13180","article-title":"Copper is required for oncogenic BRAF signalling and tumorigenesis","volume":"509","author":"Brady","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.actbio.2023.04.036_bib0025","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10911-006-9003-7","article-title":"The role of copper in tumour angiogenesis","volume":"10","author":"Lowndes","year":"2005","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0026","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ctrv.2008.07.004","article-title":"Elevated copper and oxidative stress in cancer cells as a target for cancer treatment","volume":"35","author":"Gupte","year":"2009","journal-title":"Cancer Treat Rev"},{"issue":"12","key":"10.1016\/j.actbio.2023.04.036_bib0027","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nchem.2381","article-title":"Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation","volume":"7","author":"Wang","year":"2015","journal-title":"Nat. Chem."},{"issue":"6","key":"10.1016\/j.actbio.2023.04.036_bib0028","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1177\/000456329303000603","article-title":"Serum ultrafiltrable copper, total copper and caeruloplasmin concentrations in gynaecological carcinomas","volume":"30","author":"Chan","year":"1993","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.actbio.2023.04.036_bib0029","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biomaterials.2019.01.007","article-title":"Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer","volume":"195","author":"Zhou","year":"2019","journal-title":"Biomaterials"},{"issue":"48","key":"10.1016\/j.actbio.2023.04.036_bib0030","doi-asserted-by":"crossref","first-page":"19507","DOI":"10.1073\/pnas.1318431110","article-title":"Bioavailable copper modulates oxidative phosphorylation and growth of tumors","volume":"110","author":"Ishida","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.actbio.2023.04.036_bib0031","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1039\/C5MT00149H","article-title":"Targeting copper in cancer therapy: \u2018Copper That Cancer\u2019","volume":"7","author":"Denoyer","year":"2015","journal-title":"Metallomics"},{"issue":"3","key":"10.1016\/j.actbio.2023.04.036_bib0032","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0009-8981(80)90390-3","article-title":"The zinc and copper content of blood leucocytes and plasma from patients with benign and malignant prostates","volume":"104","author":"Habib","year":"1980","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0033","doi-asserted-by":"crossref","DOI":"10.1159\/000499261","article-title":"Serum levels of selenium, zinc, copper, manganese, and iron in prostate cancer patients","volume":"14","author":"Saleh","year":"2020","journal-title":"Current Urology"},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0034","first-page":"1","article-title":"Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study","volume":"6","author":"Brewer","year":"2000","journal-title":"Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.actbio.2023.04.036_bib0035","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ccr.2010.04.011","article-title":"Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator","volume":"17","author":"Ishida","year":"2010","journal-title":"Cancer Cell"},{"issue":"22","key":"10.1016\/j.actbio.2023.04.036_bib0036","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1158\/0008-5472.CAN-16-1190","article-title":"Copper chelation inhibits BRAFV600E-driven melanomagenesis and counters resistance to BRAFV600E and MEK1\/2 inhibitors","volume":"77","author":"Brady","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.actbio.2023.04.036_bib0037","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.freeradbiomed.2013.02.003","article-title":"The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies","volume":"60","author":"Lee","year":"2013","journal-title":"Free Radical Biol. Med."},{"issue":"9","key":"10.1016\/j.actbio.2023.04.036_bib0038","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41551-017-0130-9","article-title":"A non-cytotoxic dendrimer with innate and potent anticancer and anti-metastatic activities","volume":"1","author":"Shao","year":"2017","journal-title":"Nat Biomed Eng"},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0039","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0022-1902(80)80049-2","article-title":"Studies on the reaction of copper(II) with thiourea\u2014II: The modification of bjerrum's method. The determination of equilibrium in simultaneous redox and complexation reactions","volume":"42","author":"Krzewska","year":"1980","journal-title":"J. Inorg. Nucl. Chem."},{"issue":"5","key":"10.1016\/j.actbio.2023.04.036_bib0040","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/zaac.201400605","article-title":"Synthesis and characterization of N,N-Di-substituted acylthiourea copper(II) complexes","volume":"641","author":"Wu","year":"2015","journal-title":"Z Anorg Allg Chem"},{"issue":"1","key":"10.1016\/j.actbio.2023.04.036_bib0041","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1021\/ja0471525","article-title":"Copper(I)-catalyzed synthesis of azoles. DFT Study predicts unprecedented reactivity and intermediates","volume":"127","author":"Himo","year":"2005","journal-title":"J. Am. Chem. Soc."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123002362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123002362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:13:13Z","timestamp":1761675193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706123002362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":41,"alternative-id":["S1742706123002362"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2023.04.036","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intelligent gold nanoparticles for malignant tumor treatment via spontaneous copper manipulation and on-demand photothermal therapy based on copper induced click chemistry","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2023.04.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}