{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:28:22Z","timestamp":1792978102056,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870617"],"award-info":[{"award-number":["81870617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100935"],"award-info":[{"award-number":["82100935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272532"],"award-info":[{"award-number":["82272532"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1456000"],"award-info":[{"award-number":["22ZR1456000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["202040350"],"award-info":[{"award-number":["202040350"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.actbio.2023.06.010","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T20:04:49Z","timestamp":1686859489000},"page":"401-415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["MicroRNA-224-5p nanoparticles balance homeostasis via inhibiting cartilage degeneration and synovial inflammation for synergistic alleviation of osteoarthritis"],"prefix":"10.1016","volume":"167","author":[{"given":"Haoyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqiong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nijiati","family":"Tulufu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-1629","authenticated-orcid":false,"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10182","key":"10.1016\/j.actbio.2023.06.010_bib0001","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"issue":"7743","key":"10.1016\/j.actbio.2023.06.010_bib0002","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-019-0920-1","article-title":"The CH25H-CYP7B1-ROR\u03b1 axis of cholesterol metabolism regulates osteoarthritis","volume":"566","author":"Choi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2023.06.010_bib0003","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"2","key":"10.1016\/j.actbio.2023.06.010_bib0004","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bone.2011.10.008","article-title":"Future therapeutics for osteoarthritis","volume":"51","author":"Martel-Pelletier","year":"2012","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.actbio.2023.06.010_bib0005","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1136\/ard.2006.058347","article-title":"Yet more evidence that osteoarthritis is not a cartilage disease","volume":"65","author":"Brandt","year":"2006","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.010_bib0006","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1038\/s41467-020-18208-y","article-title":"Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation","volume":"11","author":"Park","year":"2020","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.actbio.2023.06.010_bib0007","first-page":"1461","article-title":"What drives osteoarthritis?-synovial versus subchondral bone pathology","volume":"56","author":"Thomas","year":"2017","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.actbio.2023.06.010_bib0008","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tips.2014.03.005","article-title":"Targeting TGFN2 signaling in subchondral bone and articular cartilage homeostasis","volume":"35","author":"Zhen","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.actbio.2023.06.010_bib0009","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202106564","article-title":"Self-healing hydrogel embodied with macrophage-regulation and responsive-gene-silencing properties for synergistic prevention of peritendinous adhesion","volume":"34","author":"Cai","year":"2022","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.010_bib0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrrheum.2013.159","article-title":"Progress in intra-articular therapy","volume":"10","author":"Evans","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.010_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41427-021-00351-7","article-title":"Injectable \u201cnano-micron\u201d combined gene-hydrogel microspheres for local treatment of osteoarthritis","volume":"14","author":"Li","year":"2022","journal-title":"NPG Asia Mater."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.010_bib0012","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1038\/s41467-021-24460-7","article-title":"Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2\u03b1 expression and coordinately regulate cartilage homeostasis","volume":"12","author":"Ito","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.actbio.2023.06.010_bib0013","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/art.41552","article-title":"MicroRNA-34a-5p promotes joint destruction during osteoarthritis","volume":"73","author":"Endisha","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.010_bib0014","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/annrheumdis-2018-213629","article-title":"microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints","volume":"78","author":"Nakamura","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.actbio.2023.06.010_bib0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41419-022-04962-y","article-title":"Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32","volume":"13","author":"Yin","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.actbio.2023.06.010_bib0016","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jconrel.2019.10.007","article-title":"MicroRNA delivery through nanoparticles","volume":"313","author":"Lee","year":"2019","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.actbio.2023.06.010_bib0017","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/anie.201914264","article-title":"Functional Nanoparticles with a Reducible Tetrasulfide Motif to Upregulate mRNA Translation and Enhance Transfection in Hard-to-Transfect Cells","volume":"59","author":"Wang","year":"2020","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2023.06.010_bib0018","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jconrel.2016.12.017","article-title":"Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy","volume":"246","author":"Xie","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2023.06.010_bib0019","doi-asserted-by":"crossref","first-page":"13567","DOI":"10.1038\/srep13567","article-title":"Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells","volume":"5","author":"Santos-Carballal","year":"2015","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.actbio.2023.06.010_bib0020","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"33","key":"10.1016\/j.actbio.2023.06.010_bib0021","doi-asserted-by":"crossref","first-page":"9187","DOI":"10.1016\/j.biomaterials.2014.07.027","article-title":"Synergistic effect of amino acids modified on dendrimer surface in gene delivery","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2023.06.010_bib0022","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nprot.2008.95","article-title":"Primary culture and phenotyping of murine chondrocytes","volume":"3","author":"Gosset","year":"2008","journal-title":"Nat. Protoc."},{"issue":"26","key":"10.1016\/j.actbio.2023.06.010_bib0023","doi-asserted-by":"crossref","first-page":"eabf2665","DOI":"10.1126\/sciadv.abf2665","article-title":"Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis","volume":"7","author":"Kwon","year":"2021","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.010_bib0024","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10456-006-9060-y","article-title":"Regulation of endothelial cell migration by amphiphiles - are changes in cell membrane physical properties involved?","volume":"10","author":"Jensen","year":"2007","journal-title":"Angiogenesis"},{"issue":"9","key":"10.1016\/j.actbio.2023.06.010_bib0025","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.actbio.2023.06.010_bib0026","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/annrheumdis-2015-207923","article-title":"Halofuginone attenuates osteoarthritis by inhibition of TGF-N2 activity and H-type vessel formation in subchondral bone","volume":"75","author":"Cui","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.actbio.2023.06.010_bib0027","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1136\/annrheumdis-2014-205779","article-title":"Progranulin protects against osteoarthritis through interacting with TNF-\u03b1 and \u03b2-Catenin signalling","volume":"74","author":"Zhao","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.actbio.2023.06.010_bib0028","doi-asserted-by":"crossref","first-page":"906","DOI":"10.7150\/thno.20746","article-title":"Mesenchymal stromal\/stem cell-derived extracellular vesicles promote human cartilage regeneration in vitro","volume":"8","author":"Vonk","year":"2018","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.actbio.2023.06.010_bib0029","doi-asserted-by":"crossref","first-page":"20560","DOI":"10.3390\/ijms160920560","article-title":"Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis","volume":"16","author":"Musumeci","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.actbio.2023.06.010_bib0030","doi-asserted-by":"crossref","first-page":"15767","DOI":"10.3390\/ijms140815767","article-title":"Post-traumatic caspase-3 expression in the adjacent areas of growth plate injury site: a morphological study","volume":"14","author":"Musumeci","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2023.06.010_bib0031","doi-asserted-by":"crossref","first-page":"242","DOI":"10.5142\/jgr.2012.36.3.242","article-title":"Anti-apoptotic activity of ginsenoside Rb1 in hydrogen peroxide-treated chondrocytes: stabilization of mitochondria and the inhibition of caspase-3","volume":"36","author":"Na","year":"2012","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.actbio.2023.06.010_bib0032","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1196\/annals.1397.060","article-title":"Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro","volume":"1095","author":"Shakibaei","year":"2007","journal-title":"Ann. NY Acad. Sci."},{"issue":"16","key":"10.1016\/j.actbio.2023.06.010_bib0033","doi-asserted-by":"crossref","first-page":"8980","DOI":"10.3390\/ijms22168980","article-title":"A combination of celecoxib and glucosamine sulfate has anti-inflammatory and chondroprotective effects: results from an in vitro study on human osteoarthritic chondrocytes","volume":"22","author":"Cheleschi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.010_bib0034","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.joca.2020.08.014","article-title":"Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome C","volume":"29","author":"Ansari","year":"2021","journal-title":"Osteoarthr. Cartil."},{"issue":"10","key":"10.1016\/j.actbio.2023.06.010_bib0035","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.3390\/ijms21103653","article-title":"Hydrostatic pressure regulates oxidative stress through microRNA in human osteoarthritic chondrocytes","volume":"21","author":"Cheleschi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"428","key":"10.1016\/j.actbio.2023.06.010_bib0036","doi-asserted-by":"crossref","first-page":"eaan0746","DOI":"10.1126\/scitranslmed.aan0746","article-title":"FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis","volume":"10","author":"Matsuzaki","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.010_bib0037","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4161\/auto.26679","article-title":"Boning up on autophagy: the role of autophagy in skeletal biology","volume":"10","author":"Shapiro","year":"2014","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.actbio.2023.06.010_bib0038","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.semcdb.2003.12.004","article-title":"Two ubiquitin-like conjugation systems essential for autophagy","volume":"15","author":"Ohsumi","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.actbio.2023.06.010_bib0039","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1080\/15548627.2020.1871204","article-title":"BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes","volume":"17","author":"Yazdankhah","year":"2021","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.actbio.2023.06.010_bib0040","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1080\/15548627.2019.1586250","article-title":"TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1\/\u03b2-catenin degradation and is targeted for GSK3B\/GSK3\u03b2-mediated phosphorylation and degradation","volume":"15","author":"Wu","year":"2019","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.actbio.2023.06.010_bib0041","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nm.2153","article-title":"Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"issue":"576","key":"10.1016\/j.actbio.2023.06.010_bib0042","doi-asserted-by":"crossref","first-page":"eabb3946","DOI":"10.1126\/scitranslmed.abb3946","article-title":"Targeting cartilage EGFR pathway for osteoarthritis treatment","volume":"13","author":"Wei","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"10.1016\/j.actbio.2023.06.010_bib0043","doi-asserted-by":"crossref","first-page":"14475","DOI":"10.1021\/acsnano.1c04005","article-title":"Top-down fabricated microplates for prolonged, intra-articular matrix metalloproteinase 13 siRNA nanocarrier delivery to reduce post-traumatic osteoarthritis","volume":"15","author":"Bedingfield","year":"2021","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.actbio.2023.06.010_bib0044","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2012.80","article-title":"Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis","volume":"8","author":"Mapp","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.actbio.2023.06.010_bib0045","doi-asserted-by":"crossref","first-page":"970","DOI":"10.7150\/ijbs.39015","article-title":"Acute synovitis after trauma precedes and is associated with osteoarthritis onset and progression","volume":"16","author":"Liao","year":"2020","journal-title":"Int. J. Biol. Sci."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123003367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123003367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:06:24Z","timestamp":1761674784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706123003367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":45,"alternative-id":["S1742706123003367"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2023.06.010","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-224-5p nanoparticles balance homeostasis via inhibiting cartilage degeneration and synovial inflammation for synergistic alleviation of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2023.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}