{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:20:21Z","timestamp":1791822021415,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930020"],"award-info":[{"award-number":["81930020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82025007"],"award-info":[{"award-number":["82025007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170874"],"award-info":[{"award-number":["82170874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["23NSFTD0067"],"award-info":[{"award-number":["23NSFTD0067"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.actbio.2023.06.032","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T20:58:16Z","timestamp":1688072296000},"page":"484-496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["CREKA-modified liposomes target activated hepatic stellate cells to alleviate liver fibrosis by inhibiting collagen synthesis and angiogenesis"],"prefix":"10.1016","volume":"168","author":[{"given":"Rui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-7046","authenticated-orcid":false,"given":"Qingyi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.actbio.2023.06.032_bib0001","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.actbio.2023.06.032_bib0002","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.actbio.2023.06.032_bib0003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.05.016","article-title":"Pathophysiology of liver fibrosis and the methodological barriers to the development of anti-fibrogenic agents","volume":"121","author":"B\u00f6ttcher","year":"2017","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"2","key":"10.1016\/j.actbio.2023.06.032_bib0004","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bpg.2017.04.005","article-title":"Reversal of liver fibrosis: from fiction to reality","volume":"31","author":"Zoubek","year":"2017","journal-title":"Best Pract. Res. Baillieres Clin. Gastroenterol."},{"key":"10.1016\/j.actbio.2023.06.032_bib0005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.matbio.2018.04.006","article-title":"Liver fibrosis: direct antifibrotic agents and targeted therapies","author":"Schuppan","year":"2018","journal-title":"Matrix Biol."},{"issue":"6","key":"10.1016\/j.actbio.2023.06.032_bib0006","doi-asserted-by":"crossref","first-page":"821","DOI":"10.33549\/physiolres.934755","article-title":"Hepatic stellate cell: a double-edged sword in the liver","volume":"70","author":"Luo","year":"2021","journal-title":"Physiol. Res."},{"issue":"7","key":"10.1016\/j.actbio.2023.06.032_bib0007","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.actbio.2023.06.032_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111572","article-title":"Hepatic stellate cell senescence in liver fibrosis: characteristics, mechanisms and perspectives","volume":"199","author":"Zhang","year":"2021","journal-title":"Mech. Ageing Dev."},{"issue":"5","key":"10.1016\/j.actbio.2023.06.032_bib0009","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jhep.2006.11.011","article-title":"Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro","volume":"46","author":"Patsenker","year":"2007","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.actbio.2023.06.032_bib0010","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/hep.24427","article-title":"Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis","volume":"54","author":"Thabut","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.actbio.2023.06.032_bib0011","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"4","key":"10.1016\/j.actbio.2023.06.032_bib0012","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nbt1396","article-title":"Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone","volume":"26","author":"Sato","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2023.06.032_bib0013","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2019.04.022","article-title":"An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis","volume":"303","author":"Li","year":"2019","journal-title":"J. Control Release"},{"issue":"4","key":"10.1016\/j.actbio.2023.06.032_bib0014","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1021\/acsnano.8b06924","article-title":"Golgi apparatus-targeted chondroitin-modified nanomicelles suppress hepatic stellate cell activation for the management of liver fibrosis","volume":"13","author":"Luo","year":"2019","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.actbio.2023.06.032_bib0015","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/hepr.13040","article-title":"Vitamin A-coupled liposome system targeting free cholesterol accumulation in hepatic stellate cells offers a beneficial therapeutic strategy for liver fibrosis","volume":"48","author":"Furuhashi","year":"2018","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.actbio.2023.06.032_bib0016","doi-asserted-by":"crossref","unstructured":"R. Blomhoff, M.H. Green, J.B. Green, T. Berg, K.R.J.P.R. Norum, Vitamin A metabolism: new perspectives on absorption, transport, and storage, 71(4) (1991) 951\u2013990.","DOI":"10.1152\/physrev.1991.71.4.951"},{"issue":"4","key":"10.1016\/j.actbio.2023.06.032_bib0017","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.3892\/mmr.2016.5673","article-title":"Fibronectin expression is critical for liver fibrogenesis in vivo and in vitro","volume":"14","author":"Liu","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.actbio.2023.06.032_bib0018","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0168-8278(97)80322-4","article-title":"Expression, localization and alternative splicing pattern of fibronectin messenger RNA in fibrotic human liver and hepatocellular carcinoma","volume":"27","author":"Matsui","year":"1997","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.actbio.2023.06.032_bib0019","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1091\/mbc.e02-01-0048","article-title":"Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions","volume":"13","author":"Sottile","year":"2002","journal-title":"Mol. Biol. Cell"},{"issue":"30","key":"10.1016\/j.actbio.2023.06.032_bib0020","doi-asserted-by":"crossref","first-page":"33564","DOI":"10.1021\/acsami.0c10397","article-title":"Fibronectin-targeting and cathepsin B-activatable theranostic nanoprobe for MR\/fluorescence imaging and enhanced photodynamic therapy for triple negative breast cancer","volume":"12","author":"Wang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.actbio.2023.06.032_bib0021","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41392-019-0104-3","article-title":"Fibronectin-targeted dual-acting micelles for combination therapy of metastatic breast cancer","volume":"5","author":"Gong","year":"2020","journal-title":"Signal Transduc. Targeted Ther."},{"key":"10.1016\/j.actbio.2023.06.032_bib0022","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jconrel.2020.01.017","article-title":"Targeted delivery of celastrol to renal interstitial myofibroblasts using fibronectin-binding liposomes attenuates renal fibrosis and reduces systemic toxicity","volume":"320","author":"Li","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.actbio.2023.06.032_bib0023","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.biopha.2017.01.107","article-title":"Sorafenib: a potential therapeutic drug for hepatic fibrosis and its outcomes","volume":"88","author":"Ma","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.actbio.2023.06.032_bib0024","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.7150\/thno.54822","article-title":"Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma","volume":"11","author":"Kong","year":"2021","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.actbio.2023.06.032_bib0025","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.actbio.2023.06.032_bib0026","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2174\/1389201022666210826152311","article-title":"Human serum albumin nanoparticles as a carrier for on-demand sorafenib delivery","volume":"23","author":"Caputo","year":"2022","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.actbio.2023.06.032_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114687","article-title":"LC-MS\/MS monitoring of the colorectal carcinoma cellular uptake and entrapment of sorafenib and its N-oxide active metabolite","volume":"213","author":"Elawady","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"23","key":"10.1016\/j.actbio.2023.06.032_bib0028","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1016\/j.biomaterials.2014.04.037","article-title":"Hepatitis B virus preS1-derived lipopeptide functionalized liposomes for targeting of hepatic cells","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.actbio.2023.06.032_bib0029","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1016\/S0021-9258(17)41848-5","article-title":"Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis","volume":"269","author":"Lee","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.actbio.2023.06.032_bib0030","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/hep.27936","article-title":"Specific hepatic delivery of procollagen alpha1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis","volume":"62","author":"Jimenez Calvente","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.actbio.2023.06.032_bib0031","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jconrel.2022.04.002","article-title":"Sorafenib-loaded silica-containing redox nanoparticles for oral anti-liver fibrosis therapy","volume":"345","author":"Tran","year":"2022","journal-title":"J. Control Release"},{"issue":"3","key":"10.1016\/j.actbio.2023.06.032_bib0032","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/17474124.2021.1842732","article-title":"Angiogenesis in the progression from liver fibrosis to cirrhosis and hepatocelluar carcinoma","volume":"15","author":"Li","year":"2021","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.actbio.2023.06.032_bib0033","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-0040-1708876","article-title":"Hepatic stellate cell-macrophage crosstalk in liver fibrosis and carcinogenesis","volume":"40","author":"Matsuda","year":"2020","journal-title":"Semin. Liver Dis."},{"issue":"3","key":"10.1016\/j.actbio.2023.06.032_bib0034","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1073\/pnas.0610298104","article-title":"Biomimetic amplification of nanoparticle homing to tumors","volume":"104","author":"Simberg","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"31","key":"10.1016\/j.actbio.2023.06.032_bib0035","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1016\/j.biomaterials.2013.06.057","article-title":"Peptide targeted tripod macrocyclic Gd(III) chelates for cancer molecular MRI","volume":"34","author":"Zhou","year":"2013","journal-title":"Biomaterials"},{"issue":"15","key":"10.1016\/j.actbio.2023.06.032_bib0036","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1182\/blood-2010-03-274258","article-title":"Nanoparticle-induced vascular blockade in human prostate cancer","volume":"116","author":"Agemy","year":"2010","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.actbio.2023.06.032_bib0037","doi-asserted-by":"crossref","first-page":"6194","DOI":"10.1021\/acsnano.7b02308","article-title":"Fibrin-targeted and H(2)O(2)-responsive nanoparticles as a theranostics for thrombosed vessels","volume":"11","author":"Kang","year":"2017","journal-title":"ACS Nano"},{"issue":"15","key":"10.1016\/j.actbio.2023.06.032_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202106252","article-title":"Antithrombotic therapy by regulating the ROS-mediated thrombosis microenvironment and specific nonpharmaceutical thrombolysis using prussian blue nanodroplets","volume":"18","author":"Zhang","year":"2022","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.actbio.2023.06.032_bib0039","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jhep.2020.04.044","article-title":"Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis","volume":"73","author":"Gao","year":"2020","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.actbio.2023.06.032_bib0040","article-title":"Portal hypertension in cirrhosis: pathophysiological mechanisms and therapy","volume":"3","author":"Iwakiri","year":"2021","journal-title":"JHEP Rep."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.032_bib0041","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jhep.2010.02.027","article-title":"New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis","volume":"53","author":"Wang","year":"2010","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.actbio.2023.06.032_bib0042","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1158\/1535-7163.MCT-08-0013","article-title":"Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling","volume":"7","author":"Wilhelm","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.actbio.2023.06.032_bib0043","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2022.08.065","article-title":"Collagenase-I decorated co-delivery micelles potentiate extracellular matrix degradation and hepatic stellate cell targeting for liver fibrosis therapy","volume":"152","author":"Zhou","year":"2022","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.032_bib0044","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","article-title":"The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects","volume":"5","author":"Tang","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.actbio.2023.06.032_bib0045","doi-asserted-by":"crossref","unstructured":"C. Jian, J. Fu, X. Cheng, L.J. Shen, Y.X. Ji, X. Wang, S. Pan, H. Tian, S. Tian, R. Liao, K. Song, H.P. Wang, X. Zhang, Y. Wang, Z. Huang, Z.G. She, X.J. Zhang, L. Zhu, H. Li, Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis, Cell Metab. 31(5) (2020) 892\u2013908.e11.","DOI":"10.1016\/j.cmet.2020.04.011"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123003586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123003586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:27:28Z","timestamp":1781537248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706123003586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":45,"alternative-id":["S1742706123003586"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2023.06.032","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CREKA-modified liposomes target activated hepatic stellate cells to alleviate liver fibrosis by inhibiting collagen synthesis and angiogenesis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2023.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}