{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:19:10Z","timestamp":1793823550445,"version":"4.6.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102215"],"award-info":[{"award-number":["82102215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.actbio.2023.06.036","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T20:58:21Z","timestamp":1688072301000},"page":"195-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["A biomimetic peptide\u2013drug supramolecular hydrogel as eyedrops enables controlled release of ophthalmic drugs"],"prefix":"10.1016","volume":"167","author":[{"given":"Minmengqi","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0368-4538","authenticated-orcid":false,"given":"Xingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-9496","authenticated-orcid":false,"given":"Jiaqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.actbio.2023.06.036_bib0001","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/jama.296.8.953","article-title":"Fusarium keratitis investigation team, multistate outbreak of fusarium keratitis associated with use of a contact lens solution","volume":"296","author":"Chang","year":"2006","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.actbio.2023.06.036_bib0002","first-page":"447","article-title":"Wound infection after cataract surgery","volume":"40","author":"Valenton","year":"1996","journal-title":"Japanese J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.actbio.2023.06.036_bib0003","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3928\/1081-597X-19960101-25","article-title":"Eye infections after refractive keratotomy","volume":"12","author":"Jain","year":"1996","journal-title":"J. Refract. Surgery"},{"issue":"10","key":"10.1016\/j.actbio.2023.06.036_bib0004","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1167\/iovs.18-24428","article-title":"The Corneal Basement Membranes and Stromal Fibrosis","volume":"59","author":"Medeiros","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2023.06.036_bib0005","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/aos.12684","article-title":"Antibiotic prevention of postcataract endophthalmitis: a systematic review and meta-analysis","volume":"93","author":"Kessel","year":"2015","journal-title":"Acta Ophthalmol"},{"issue":"2","key":"10.1016\/j.actbio.2023.06.036_bib0006","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.preteyeres.2006.12.001","article-title":"Bacterial endophthalmitis: therapeutic challenges and host\u2013pathogen interactions","volume":"26","author":"Callegan","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.actbio.2023.06.036_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119133","article-title":"Nanocomplexes based polyvinylpyrrolidone K-17PF for ocular drug delivery of naringenin","volume":"578","author":"Wang","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2023.06.036_bib0008","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2019.05.034","article-title":"Hydrogel-based ocular drug delivery systems: emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations","volume":"306","author":"Cooper","year":"2019","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.actbio.2023.06.036_bib0009","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/17434440.2018.1435271","article-title":"The tear turnover and tear clearance tests- a review","volume":"15","author":"Garaszczuk","year":"2018","journal-title":"Expert Rev. Med. Devices"},{"issue":"5073","key":"10.1016\/j.actbio.2023.06.036_bib0010","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.257.5073.1064","article-title":"The Crisis in Antibiotic Resistance","volume":"257","author":"Neu","year":"1992","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.actbio.2023.06.036_bib0011","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijmm.2013.02.001","article-title":"Plasmids and the spread of resistance","volume":"303","author":"Carattoli","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.actbio.2023.06.036_bib0012","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.actbio.2021.06.027","article-title":"Cationic self-assembled peptide-based molecular hydrogels for extended ocular drug delivery","volume":"131","author":"Liu","year":"2021","journal-title":"Acta Biomater"},{"issue":"4","key":"10.1016\/j.actbio.2023.06.036_bib0013","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202104657","article-title":"A rapid corneal healing microneedle for efficient ocular drug delivery","volume":"18","author":"Shi","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.actbio.2023.06.036_bib0014","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jconrel.2022.03.011","article-title":"Enzyme-instructed self-assembly of peptide-drug conjugates in tear fluids for ocular drug delivery","volume":"344","author":"Hu","year":"2022","journal-title":"J. Control. Release"},{"issue":"1\u20133","key":"10.1016\/j.actbio.2023.06.036_bib0015","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0168-3659(02)00284-5","article-title":"Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI\u00ae) for the treatment of external ocular infections in dogs","volume":"85","author":"Baeyens","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2023.06.036_bib0016","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejpb.2019.06.008","article-title":"Topical semifluorinated alkane-based azithromycin suspension for the management of ocular infections","volume":"142","author":"Agarwal","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.actbio.2023.06.036_bib0017","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ejps.2017.04.013","article-title":"Nanoemulsion-based electrolyte triggered in situ gel for ocular delivery of acetazolamide","volume":"104","author":"Morsi","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.actbio.2023.06.036_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119020","article-title":"New nanoparticles for topical ocular delivery of erythropoietin","volume":"576","author":"Silva","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.actbio.2023.06.036_bib0019","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/jop.2015.0047","article-title":"Recent advances in topical ocular drug delivery","volume":"32","author":"Yellepeddi","year":"2016","journal-title":"J. Ocul. Pharmacol. Th."},{"key":"10.1016\/j.actbio.2023.06.036_bib0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.addr.2017.12.017","article-title":"Ophthalmic gels: past, present and future","volume":"126","author":"Al-Kinani","year":"2018","journal-title":"Adv. Drug Deliver. Rev."},{"issue":"6","key":"10.1016\/j.actbio.2023.06.036_bib0021","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201900001","article-title":"Stimulus-responsive hydrogel for ophthalmic drug delivery","volume":"19","author":"Lin","year":"2019","journal-title":"Macromol. Biosci."},{"issue":"3","key":"10.1016\/j.actbio.2023.06.036_bib0022","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0939-6411(02)00080-2","article-title":"Systematic study of the flow behaviour and mechanical properties of Carbopol\u00ae Ultrez\u2122 10 hydroalcoholic gels","volume":"54","author":"Fresno","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"4","key":"10.1016\/j.actbio.2023.06.036_bib0023","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.1111\/aos.13526","article-title":"Dry eye disease and oxidative stress","volume":"96","author":"Seen","year":"2018","journal-title":"Acta Ophthalmol"},{"issue":"9","key":"10.1016\/j.actbio.2023.06.036_bib0024","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1021\/am100484c","article-title":"Peptide hydrogel as an intraocular drug delivery system for inhibition of postoperative scarring formation","volume":"2","author":"Xu","year":"2010","journal-title":"ACS Appl. Mater. Inter."},{"key":"10.1016\/j.actbio.2023.06.036_bib0025","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.addr.2021.05.010","article-title":"Peptide-based supramolecular hydrogels for local drug delivery","volume":"174","author":"Zhang","year":"2021","journal-title":"Adv. Drug Deliver. Rev."},{"issue":"12","key":"10.1016\/j.actbio.2023.06.036_bib0026","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1016\/j.cclet.2021.03.037","article-title":"Bioinspired self-assembly supramolecular hydrogel for ocular drug delivery","volume":"32","author":"Li","year":"2021","journal-title":"Chinese Chem. Lett."},{"issue":"2","key":"10.1016\/j.actbio.2023.06.036_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.chempr.2016.07.003","article-title":"Enzyme-instructed self-assembly for spatiotemporal profiling of the activities of alkaline phosphatases on live cells","volume":"1","author":"Zhou","year":"2016","journal-title":"Chem"},{"issue":"6","key":"10.1016\/j.actbio.2023.06.036_bib0028","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1021\/acsnano.0c01388","article-title":"Perimitochondrial enzymatic self-assembly for selective targeting the mitochondria of cancer cells","volume":"14","author":"He","year":"2020","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.actbio.2023.06.036_bib0029","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/jacs.7b11582","article-title":"Enzymatic cleavage of branched peptides for targeting mitochondria","volume":"140","author":"He","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"10.1016\/j.actbio.2023.06.036_bib0030","article-title":"Enzymatic noncovalent synthesis for mitochondrial genetic engineering of cancer cells","volume":"1","author":"He","year":"2020","journal-title":"Cell Rep. Phys. Sci."},{"issue":"14","key":"10.1016\/j.actbio.2023.06.036_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201707140","article-title":"Supramolecular nanofibers of curcumin for highly amplified radiosensitization of colorectal cancers to ionizing radiation","volume":"28","author":"Xu","year":"2018","journal-title":"Adv. Funct. Mater."},{"issue":"45","key":"10.1016\/j.actbio.2023.06.036_bib0032","doi-asserted-by":"crossref","first-page":"21459","DOI":"10.1039\/C8NR07534D","article-title":"Responsive peptide-based supramolecular hydrogels constructed by self-immolative chemistry","volume":"10","author":"Zheng","year":"2018","journal-title":"Nanoscale"},{"issue":"3","key":"10.1016\/j.actbio.2023.06.036_bib0033","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cclet.2020.09.009","article-title":"Detection of amyloid-beta by Fmoc-KLVFF self-assembled fluorescent nanoparticles for Alzheimer's disease diagnosis","volume":"32","author":"Liu","year":"2021","journal-title":"Chinese Chem. Lett."},{"issue":"4","key":"10.1016\/j.actbio.2023.06.036_bib0034","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.cclet.2021.10.058","article-title":"Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery","volume":"33","author":"Li","year":"2022","journal-title":"Chinese Chem. Lett."},{"issue":"11","key":"10.1016\/j.actbio.2023.06.036_bib0035","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1016\/j.cclet.2021.04.039","article-title":"Supramolecular hydrogels of self-assembled zwitterionic-peptides","volume":"32","author":"Zhang","year":"2021","journal-title":"Chinese Chem. Lett."},{"key":"10.1016\/j.actbio.2023.06.036_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.130979","article-title":"Sequential drug release of co-assembled supramolecular hydrogel as synergistic therapy against Staphylococcus aureus endophthalmitis","volume":"427","author":"Yu","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2023.06.036_bib0037","first-page":"420","article-title":"Drug-peptide supramolecular hydrogel boosting transcorneal permeability and pharmacological activity via ligand-receptor interaction","volume":"10","author":"Chen","year":"2022","journal-title":"Bioact. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2023.06.036_bib0038","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/ACI.0000000000000770","article-title":"Autologous serum eye drops for ocular surface disorders","volume":"21","author":"Cui","year":"2021","journal-title":"Curr. Opin. Allergy Cl."},{"issue":"4","key":"10.1016\/j.actbio.2023.06.036_bib0039","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/adfm.200500161","article-title":"Intermolecular forces in the self-assembly of peptide amphiphile nanofibers","volume":"16","author":"Stendahl","year":"2006","journal-title":"Adv. Funct. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2023.06.036_bib0040","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1021\/la9030969","article-title":"Tunable mechanics of peptide nanofiber gels","volume":"26","author":"Greenfield","year":"2010","journal-title":"Langmuir"},{"issue":"23","key":"10.1016\/j.actbio.2023.06.036_bib0041","doi-asserted-by":"crossref","first-page":"14425","DOI":"10.1021\/la2033862","article-title":"Calcium ions to cross-link supramolecular nanofibers to tune the elasticity of hydrogels over orders of magnitude","volume":"27","author":"Shi","year":"2011","journal-title":"Langmuir"},{"issue":"31","key":"10.1016\/j.actbio.2023.06.036_bib0042","doi-asserted-by":"crossref","first-page":"10631","DOI":"10.1002\/anie.201905230","article-title":"Diglycine enables rapid intrabacterial hydrolysis for activating anbiotics against gram-negative bacteria","volume":"58","author":"Wang","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2023.06.036_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101031","article-title":"Bacterial keratitis: identifying the areas of clinical uncertainty","volume":"89","author":"Tuft","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"issue":"12","key":"10.1016\/j.actbio.2023.06.036_bib0045","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1021\/acs.molpharmaceut.7b00524","article-title":"Interactions between chloramphenicol, carrier polymers, and bacteria\u2013implications for designing electrospun drug delivery systems countering wound infection","volume":"14","author":"Preem","year":"2017","journal-title":"Mol. Pharmaceut."},{"issue":"2","key":"10.1016\/j.actbio.2023.06.036_bib0046","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1128\/CMR.00117-14","article-title":"The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria","volume":"28","author":"Li","year":"2015","journal-title":"Clin. Microbiol. Rev."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123003616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123003616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:05:16Z","timestamp":1761674716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706123003616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":45,"alternative-id":["S1742706123003616"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2023.06.036","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A biomimetic peptide\u2013drug supramolecular hydrogel as eyedrops enables controlled release of ophthalmic drugs","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2023.06.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}