{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:48:04Z","timestamp":1793144884770,"version":"4.5.0"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP210101862"],"award-info":[{"award-number":["DP210101862"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010083","name":"Hunan Provincial Innovation Foundation for Postgraduate","doi-asserted-by":"publisher","award":["XDCX2021B130"],"award-info":[{"award-number":["XDCX2021B130"]}],"id":[{"id":"10.13039\/501100010083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"publisher","award":["LGF22H140008"],"award-info":[{"award-number":["LGF22H140008"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012279","name":"Zhejiang Xinmiao Talents Program","doi-asserted-by":"publisher","award":["2021R413083"],"award-info":[{"award-number":["2021R413083"]}],"id":[{"id":"10.13039\/501100012279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.actbio.2023.07.061","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T21:28:49Z","timestamp":1691011729000},"page":"641-660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"special_numbering":"C","title":["Mechanical properties, corrosion and degradation behaviors, and in vitro cytocompatibility of a biodegradable Zn\u20135La alloy for bone-implant applications"],"prefix":"10.1016","volume":"169","author":[{"given":"Xian","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-185X","authenticated-orcid":false,"given":"Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-4772","authenticated-orcid":false,"given":"Yuncang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-3536","authenticated-orcid":false,"given":"Cuie","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.actbio.2023.07.061_bib0001","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202002236","article-title":"Bioresorbable metals for biomedical applications: from mechanical components to electronic devices","volume":"10","author":"Ryu","year":"2021","journal-title":"Adv. Healthc. Mater."},{"issue":"12","key":"10.1016\/j.actbio.2023.07.061_bib0002","first-page":"4607","article-title":"Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties","volume":"6","author":"Qu","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0003","article-title":"ZnP-coated Zn-1Cu-0.1Ti membrane with high strength-ductility, antibacterial ability, cytocompatibility, and osteogenesis for biodegradable guided bone regeneration applications","author":"Tong","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"8","key":"10.1016\/j.actbio.2023.07.061_bib0004","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/0196-9781(94)90110-4","article-title":"Effect of zinc-chelating dipeptides on osteoblastic MC3T3\u2013E1 cells: activation of aminoacyl-tRNA synthetase","volume":"15","author":"Yamaguchi","year":"1994","journal-title":"Peptides"},{"issue":"6","key":"10.1016\/j.actbio.2023.07.061_bib0005","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrn1671","article-title":"The neurobiology of zinc in health and disease","volume":"6","author":"Frederickson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0006","first-page":"1","article-title":"Critical role of zinc as either an antioxidant or a prooxidant in cellular systems","volume":"2018","author":"Ryul","year":"2018","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.actbio.2023.07.061_bib0007","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.actbio.2018.10.015","article-title":"Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn\u20135Ge alloy for biodegradable implant materials","volume":"82","author":"Tong","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2019.01.035","article-title":"The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: a comprehensive review","volume":"87","author":"Venezuela","year":"2019","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.actbio.2023.07.061_bib0009","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1007\/s11837-019-03357-3","article-title":"Comparative studies on degradation behavior of pure zinc in various simulated body fluids","volume":"71","author":"Liu","year":"2019","journal-title":"Jom"},{"issue":"6","key":"10.1016\/j.actbio.2023.07.061_bib0010","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0022-3913(08)60259-0","article-title":"The influence of implant diameter and length on stress distribution of osseointegrated implants related to crestal bone geometry: a three-dimensional finite element analysis","volume":"100","author":"Baggi","year":"2008","journal-title":"J. Prosthet. Dent."},{"key":"10.1016\/j.actbio.2023.07.061_bib0011","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.msec.2016.06.082","article-title":"Research on a Zn\u2013Cu alloy as a biodegradable material for potential vascular stents application","volume":"69","author":"Niu","year":"2016","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1016\/j.actbio.2023.07.061_bib0012","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.matdes.2016.12.075","article-title":"Design and characterizations of novel biodegradable Zn\u2013Cu\u2013Mg alloys for potential biodegradable implants","volume":"117","author":"Tang","year":"2017","journal-title":"Mater. Des."},{"key":"10.1016\/j.actbio.2023.07.061_bib0013","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.actbio.2020.02.017","article-title":"A biodegradable Zn\u20131Cu\u20130.1Ti alloy with antibacterial properties for orthopedic applications","volume":"106","author":"Lin","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0014","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1038\/srep10719","article-title":"Development of biodegradable Zn\u20131X binary alloys with nutrient alloying elements Mg, Ca and Sr","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1016\/j.actbio.2023.07.061_bib0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.msec.2015.08.015","article-title":"Structure, mechanical characteristics and in vitro degradation, cytotoxicity, genotoxicity and mutagenicity of novel biodegradable Zn\u2013Mg alloys","volume":"58","author":"Kub\u00e1sek","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2023.07.061_bib0016","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jmst.2020.10.076","article-title":"Hierarchical microstructure and two-stage corrosion behavior of a high-performance near-eutectic Zn\u2013Li alloy","volume":"80","author":"Li","year":"2021","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.actbio.2023.07.061_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120905","article-title":"Zn0.8Li0.1Sr\u2014a biodegradable metal with high mechanical strength comparable to pure Ti for the treatment of osteoporotic bone fractures: in vitro and in vivo studies","volume":"275","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2023.07.061_bib0018","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3390\/ijms19030755","article-title":"Mechanical characteristics, in vitro degradation, cytotoxicity, and antibacterial evaluation of Zn\u20134.0Ag alloy as a biodegradable material","volume":"19","author":"Li","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.actbio.2023.07.061_bib0019","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1007\/s11661-020-05797-y","article-title":"A novel high-strength Zn\u20133Ag\u20130.5Mg alloy processed by hot extrusion, cold rolling, or high-pressure torsion","volume":"51","author":"W\u0105troba","year":"2020","journal-title":"Metall. Mater. Trans."},{"key":"10.1016\/j.actbio.2023.07.061_bib0020","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.matdes.2018.02.049","article-title":"Microalloyed Zn\u2013Mn alloys: from extremely brittle to extraordinarily ductile at room temperature","volume":"144","author":"Shi","year":"2018","journal-title":"Mater. Des."},{"key":"10.1016\/j.actbio.2023.07.061_bib0021","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.matdes.2015.12.128","article-title":"Microalloying with Mn in Zn\u2013Mg alloy for future biodegradable metals application","volume":"94","author":"Liu","year":"2016","journal-title":"Mater. Des."},{"key":"10.1016\/j.actbio.2023.07.061_bib0022","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jmst.2020.10.031","article-title":"Binary Zn\u2013Ti alloys for orthopedic applications: corrosion and degradation behaviors, friction and wear performance, and cytotoxicity","volume":"74","author":"Wang","year":"2021","journal-title":"J. Mater. Sci. Technol."},{"issue":"4","key":"10.1016\/j.actbio.2023.07.061_bib0023","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s12613-022-2468-6","article-title":"Second phase refining induced optimization of Fe alloying in Zn: significantly enhanced strengthening effect and corrosion uniformity","volume":"29","author":"Shi","year":"2022","journal-title":"Int. J. Miner. Metall. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2023.07.061_bib0024","first-page":"1436","article-title":"The influence of Ca and Cu additions on the microstructure, mechanical and degradation properties of Zn\u2013Ca\u2013Cu alloys for absorbable wound closure device applications","volume":"6","author":"Yang","year":"2021","journal-title":"Bioact. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2023.07.061_bib0025","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S1003-6326(20)65346-8","article-title":"Effects of Sr addition on microstructure, mechanical properties and in vitro degradation behavior of as-extruded Zn\u2013Sr binary alloys","volume":"30","author":"Ke","year":"2020","journal-title":"Trans. Nonferrous Met. Soc. China"},{"key":"10.1016\/j.actbio.2023.07.061_bib0026","first-page":"243","article-title":"Blending with transition metals improves bioresorbable zinc as better medical implants","volume":"20","author":"Su","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.matlet.2022.132516","article-title":"Microstructure, mechanical and corrosion properties of biodegradable Zn\u2013Mg\u2013Zr alloys for biomedical applications","volume":"323","author":"Hua","year":"2022","journal-title":"Mater. Lett."},{"key":"10.1016\/j.actbio.2023.07.061_bib0028","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.actbio.2019.11.013","article-title":"Comparative in vitro study on binary Mg\u2013RE (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu) alloy systems","volume":"102","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0029","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fmats.2019.00201","article-title":"Wide range mechanical customization of Mg\u2013Gd alloys with low degradation rates by extrusion","volume":"6","author":"Harmuth","year":"2019","journal-title":"Front. Mater."},{"issue":"11","key":"10.1016\/j.actbio.2023.07.061_bib0030","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1016\/j.actbio.2014.07.005","article-title":"Recent advances on the development of magnesium alloys for biodegradable implants","volume":"10","author":"Chen","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0031","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.actbio.2020.09.036","article-title":"Development of biodegradable Zn\u20131Mg\u20130.1RE (RE= Er, Dy, and Ho) alloys for biomedical applications","volume":"117","author":"Tong","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0032","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.actbio.2022.02.015","article-title":"Impact of gadolinium on mechanical properties, corrosion resistance, and biocompatibility of Zn\u20131Mg\u2013xGd alloys for biodegradable bone-implant applications","volume":"142","author":"Tong","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0033","article-title":"Modifiedbiodegradation behavior induced beneficial microenvironments for bone regeneration by low addition of gadolinium in zinc","author":"Yang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2021.108882","article-title":"Rare earth improves strength and creep resistance of additively manufactured Zn implants","volume":"216","author":"Yang","year":"2021","journal-title":"Compos. Part B-Eng"},{"key":"10.1016\/j.actbio.2023.07.061_bib0035","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ccr.2018.05.012","article-title":"Lanthanides: Schiff base complexes, applications in cancer diagnosis, therapy, and antibacterial activity","volume":"370","author":"Kaczmarek","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.actbio.2023.07.061_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.127311","article-title":"Unraveling the effects of light rare-earth element (lanthanum (III)) on the efficacy of partial-nitritation process and its responsible functional genera","volume":"408","author":"Su","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"8","key":"10.1016\/j.actbio.2023.07.061_bib0037","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1093\/ndt\/gfr144","article-title":"Lanthanum carbonate reduces FGF23 in chronic kidney disease Stage 3 patients","volume":"26","author":"Gonzalez-Parra","year":"2011","journal-title":"Nephrol. Dial. Transplant"},{"issue":"1","key":"10.1016\/j.actbio.2023.07.061_bib0038","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0272-6386(03)00554-7","article-title":"Randomized, double-blind, placebo-controlled, dose-titration, phase III study assessing the efficacy and tolerability of lanthanum carbonate: a new phosphate binder for the treatment of hyperphosphatemia","volume":"42","author":"Joy","year":"2003","journal-title":"Am. J. Kidney Dis."},{"issue":"6","key":"10.1016\/j.actbio.2023.07.061_bib0039","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10534-010-9368-3","article-title":"Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells","volume":"23","author":"Shen","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.actbio.2023.07.061_bib0040","series-title":"Nature's Building Blocks: An AZ Guide to the Elements","author":"Emsley","year":"2011"},{"issue":"22","key":"10.1016\/j.actbio.2023.07.061_bib0041","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.2174\/0929867326666190104165311","article-title":"Lanthanum, Gallium and their impact on oxidative stress","volume":"26","author":"Todorov","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.actbio.2023.07.061_bib0042","first-page":"507","article-title":"Systematic in vitro and in vivo study on biodegradable binary Zn\u20130.2 at% Rare Earth alloys (Zn\u2013RE: Sc, Y, La\u2013Nd, Sm\u2013Lu)","volume":"24","author":"Du","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0043","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.actbio.2022.10.053","article-title":"Biodegradable Zn\u2013Dy binary alloys with high strength, ductility, cytocompatibility, and antibacterial ability for bone-implant applications","volume":"155","author":"Tong","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0044","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.colsurfb.2019.01.038","article-title":"Role of protein adsorption in the bio corrosion of metallic implants-a review","volume":"176","author":"Talha","year":"2019","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.actbio.2023.07.061_bib0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.22203\/eCM.v033a07","article-title":"In vivo and in vitro degradation comparison of pure Mg, Mg\u201310Gd and Mg\u20132Ag: a short term study","volume":"33","author":"Marco","year":"2017","journal-title":"Eur. Cells Mater."},{"issue":"6","key":"10.1016\/j.actbio.2023.07.061_bib0046","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/4\/6\/065011","article-title":"Influence of artificial biological fluid composition on the biocorrosion of potential orthopedic Mg\u2013Ca, AZ31, AZ91 alloys","volume":"4","author":"Gu","year":"2009","journal-title":"Biomed. Mater."},{"issue":"11","key":"10.1016\/j.actbio.2023.07.061_bib0047","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1016\/j.corsci.2007.05.018","article-title":"Nucleation of corrosion pits in Ringer's solution containing bovine serum","volume":"49","author":"Burstein","year":"2007","journal-title":"Corros. Sci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0048","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.matchemphys.2018.08.060","article-title":"Serum albumin can influence magnesium alloy degradation in simulated blood plasma for cardiovascular stenting","volume":"220","author":"Heakal","year":"2018","journal-title":"Mater. Chem. Phys."},{"issue":"5","key":"10.1016\/j.actbio.2023.07.061_bib0049","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.msec.2008.12.015","article-title":"Effect of inorganic salts, amino acids and proteins on the degradation of pure magnesium in vitro","volume":"29","author":"Yamamoto","year":"2009","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2023.07.061_bib0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.corsci.2015.07.010","article-title":"The effects of L-cysteine on the inhibition and accelerated dissolution processes of zinc metal","volume":"100","author":"Shkirskiy","year":"2015","journal-title":"Corros. Sci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0051","series-title":"Standard Test Methods for Tension Testing of Metallic Materials","year":"2011"},{"key":"10.1016\/j.actbio.2023.07.061_bib0052","series-title":"Standard Test Methods of Compression Testing of Metallic Materials at Room Temperature","year":"2018"},{"key":"10.1016\/j.actbio.2023.07.061_bib0053","series-title":"Standard Practice for Calculation of Corrosion Rates and Related Information from Electrochemical Measurements","year":"2015"},{"key":"10.1016\/j.actbio.2023.07.061_bib0054","series-title":"Standard Guide for Laboratory Immersion Corrosion Testing of metals","year":"2013"},{"key":"10.1016\/j.actbio.2023.07.061_bib0055","series-title":"Biological Evaluation of Medical Devices. Part 5: Tests for In Vitro Cytotoxicity","year":"2009"},{"key":"10.1016\/j.actbio.2023.07.061_bib0056","series-title":"Biological Evaluation of Medical Devices. Part 12: Sample Preparation and Reference Materials","year":"2012"},{"key":"10.1016\/j.actbio.2023.07.061_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.137946","article-title":"Zinc phosphate, zinc oxide, and their dual-phase coatings on pure Zn foam with good corrosion resistance, cytocompatibility, and antibacterial ability for potential biodegradable bone-implant applications","volume":"450","author":"Zhu","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2023.07.061_bib0058","unstructured":"DIN EN ISO 20645\u20132004, Textile fabrics-determination of antibacterial activity-agar diffusion plate test."},{"key":"10.1016\/j.actbio.2023.07.061_bib0059","series-title":"Microbiology of the Food Chain\u2013Horizontal Method for the Enumeration of Coagulase-Positive Staphylococci (Staphylococcus aureus and other species)\u2013Part 1: Method Using Baird-Parker Agar Medium","year":"2021"},{"key":"10.1016\/j.actbio.2023.07.061_bib0060","series-title":"Binary Alloy Phase Diagrams","author":"Massalski","year":"1990"},{"key":"10.1016\/j.actbio.2023.07.061_bib0061","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.msea.2017.08.095","article-title":"Evolution of microstructure and its influence on tensile properties in thermo-mechanically controlled processed (TMCP) quench and partition (Q&P) steel","volume":"705","author":"Parthiban","year":"2017","journal-title":"Mater. Sci. Eng. A"},{"issue":"1","key":"10.1016\/j.actbio.2023.07.061_bib0062","first-page":"1","article-title":"Alloying design of biodegradable zinc as promising bone implants for load-bearing applications","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2023.07.061_bib0063","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jallcom.2015.03.140","article-title":"Critical assessment and optimization of phase diagrams and thermodynamic properties of RE\u2013Zn systems-part I: Sc\u2013Zn, La\u2013Zn, Ce\u2013Zn, Pr\u2013Zn, Nd\u2013Zn, Pm\u2013Zn and Sm\u2013Zn","volume":"641","author":"Zhu","year":"2015","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.actbio.2023.07.061_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchar.2019.109870","article-title":"Investigations of the peritectic reaction and transformation in a hypo-peritectic steel: using high-temperature confocal scanning laser microscopy and differential scanning calorimetry","volume":"156","author":"Liu","year":"2019","journal-title":"Mater. Charact."},{"key":"10.1016\/j.actbio.2023.07.061_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.03.005","article-title":"Zinc-based alloys for degradable vascular stent applications","volume":"71","author":"Mostaed","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0066","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.msea.2012.10.044","article-title":"Dynamic recrystallization behavior during hot deformation and mechanical properties of 0.2 \u03bcm SiCp reinforced Mg matrix composite","volume":"560","author":"Deng","year":"2013","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.actbio.2023.07.061_bib0067","series-title":"Modern Aspects of Bulk Crystal and Thin Film Preparation","first-page":"141","article-title":"Controlling the morphology and distribution of an intermetallic Zn16Ti phase in single crystals of Zn\u2013Ti\u2013Cu","author":"Boczkal","year":"2012"},{"key":"10.1016\/j.actbio.2023.07.061_bib0068","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.msea.2014.03.126","article-title":"Effect of stacking fault energy on mechanical properties of nanostructured FCC materials processed by the ARB process","volume":"606","author":"Jamaati","year":"2014","journal-title":"Mater. Sci. Eng. A"},{"issue":"5","key":"10.1016\/j.actbio.2023.07.061_bib0069","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.scriptamat.2010.10.045","article-title":"High-ductility magnesium-zinc-erium extrusion alloys","volume":"64","author":"Luo","year":"2011","journal-title":"Scr. Mater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0070","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jallcom.2019.05.087","article-title":"Improving the room-temperature formability of Mg\u20133Al\u20131Zn alloy sheet by introducing an orthogonal four-peak texture","volume":"797","author":"He","year":"2019","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.actbio.2023.07.061_bib0071","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.corsci.2019.05.018","article-title":"Comparative studies of Tris-HCl, HEPES and NaHCO3\/CO2 buffer systems on the biodegradation behaviour of pure Zn in NaCl and SBF solutions","volume":"157","author":"Liu","year":"2019","journal-title":"Corros. Sci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.corsci.2021.109278","article-title":"Corrosion behavior of biodegradable metals in two different simulated physiological solutions: comparison of Mg, Zn and Fe","volume":"182","author":"Dong","year":"2021","journal-title":"Corros. Sci."},{"issue":"44","key":"10.1016\/j.actbio.2023.07.061_bib0073","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.1021\/la402710r","article-title":"Diazonium cation-exchanged clay: an efficient, unfrequented route for making clay\/polymer nanocomposites","volume":"29","author":"Salmi","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2023.07.061_bib0074","series-title":"Electrochemical series","author":"Van\u00fdsek","year":"2008"},{"issue":"8","key":"10.1016\/j.actbio.2023.07.061_bib0075","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0013-4686(81)85079-7","article-title":"Mixed potential measurements in the elucidation of corrosion mechanisms\u20141. Introductory theory","volume":"26","author":"Power","year":"1981","journal-title":"Electrochim. Acta"},{"issue":"12","key":"10.1016\/j.actbio.2023.07.061_bib0076","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1016\/j.corsci.2010.08.006","article-title":"Susceptibility of rare-earth-magnesium alloys to micro-galvanic corrosion","volume":"52","author":"Coy","year":"2010","journal-title":"Corros. Sci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0077","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.corsci.2013.05.008","article-title":"Influence of alloyed chromium on the atmospheric corrosion resistance of weathering steels","volume":"74","author":"Qian","year":"2013","journal-title":"Corros. Sci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0078","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jmbbm.2017.05.013","article-title":"Potential biodegradable Zn\u2013Cu binary alloys developed for cardiovascular implant applications","volume":"72","author":"Tang","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0079","article-title":"Biodegradable Zn\u2013Cu\u2013Li alloys with ultrahigh strength, ductility, antibacterial ability, cytocompatibility, and suitable degradation rate for potential bone-implant applications","volume":"1","author":"Tong","year":"2023","journal-title":"Smart Mater. Manuf."},{"key":"10.1016\/j.actbio.2023.07.061_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.matlet.2022.133569","article-title":"Development of biodegradable in situ Zn\u2013Mg2Sn composites for bone-implant applications","volume":"333","author":"Han","year":"2023","journal-title":"Mater. Lett."},{"key":"10.1016\/j.actbio.2023.07.061_bib0081","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jmbbm.2016.03.018","article-title":"Novel Zn-based alloys for biodegradable stent applications: design, development and in vitro degradation","volume":"60","author":"Mostaed","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0082","doi-asserted-by":"crossref","DOI":"10.1016\/j.matlet.2023.134276","article-title":"In situ development of a Zn\u2013Mg\u2013Mg2Si alloy for a biodegradable bone implant applications","volume":"342","author":"Li","year":"2023","journal-title":"Mater. Lett."},{"key":"10.1016\/j.actbio.2023.07.061_bib0083","series-title":"TMS Magnesium Technology 2009","first-page":"209","article-title":"Applicability of existing magnesium alloys as biomedical implant materials","author":"Erinc","year":"2009"},{"issue":"6","key":"10.1016\/j.actbio.2023.07.061_bib0084","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1016\/j.actbio.2011.03.004","article-title":"Chemical surface alteration of biodegradable magnesium exposed to corrosion media","volume":"7","author":"Willumeit","year":"2011","journal-title":"Acta Biomater."},{"issue":"22","key":"10.1016\/j.actbio.2023.07.061_bib0085","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1016\/j.electacta.2010.05.087","article-title":"Influence of chloride ion concentration on the electrochemical corrosion behaviour of plasma electrolytic oxidation coated AM50 magnesium alloy","volume":"55","author":"Liang","year":"2010","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.actbio.2023.07.061_bib0086","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.clay.2013.06.003","article-title":"Adsorption of proteins and nucleic acids on clay minerals and their interactions: a review","volume":"80","author":"Yu","year":"2013","journal-title":"Appl. Clay Sci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.corsci.2019.108363","article-title":"Effect of p-toluenesulfonyl hydrazide on copper corrosion in hydrochloric acid solution","volume":"165","author":"Laggoun","year":"2020","journal-title":"Corros. Sci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0088","doi-asserted-by":"crossref","first-page":"C839","DOI":"10.1149\/2.0401614jes","article-title":"Effects of solute Zn on corrosion film of Mg\u2013Sn\u2013Zn alloy formed in NaCl solution","volume":"163","author":"Yang","year":"2016","journal-title":"J. Electrochem. Soc."},{"key":"10.1016\/j.actbio.2023.07.061_bib0089","first-page":"87","article-title":"Initial formation of corrosion products on pure zinc in saline solution","volume":"4","author":"Meng","year":"2019","journal-title":"Bioact. Mater."},{"issue":"10","key":"10.1016\/j.actbio.2023.07.061_bib0090","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/maco.202112485","article-title":"Comparison of the in vitro corrosion behavior of biodegradable pure Zn in SBF, 0.9% NaCl, and DMEM","volume":"72","author":"Zhu","year":"2021","journal-title":"Mater. Corros"},{"key":"10.1016\/j.actbio.2023.07.061_bib0091","doi-asserted-by":"crossref","DOI":"10.1016\/j.corsci.2020.109071","article-title":"Insight into the corrosion behaviour and degradation mechanism of pure zinc in simulated body fluid","volume":"178","author":"Huang","year":"2021","journal-title":"Corros. Sci."},{"key":"10.1016\/j.actbio.2023.07.061_bib0092","doi-asserted-by":"crossref","DOI":"10.1016\/j.corsci.2020.108661","article-title":"Exploring the effect of amino acid and glucose on the biodegradation of pure Zn","volume":"170","author":"Liu","year":"2020","journal-title":"Corros. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2023.07.061_bib0093","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1021\/acsbiomaterials.6b00035","article-title":"In vitro cytotoxicity, adhesion, and proliferation of human vascular cells exposed to zinc","volume":"2","author":"Shearier","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2023.07.061_bib0094","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1073\/pnas.68.1.229","article-title":"pH as a determinant of cellular growth and contact inhibition","volume":"68","author":"Ceccarini","year":"1971","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2023.07.061_bib0095","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/5\/4\/045005","article-title":"Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation","volume":"5","author":"Yang","year":"2010","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.actbio.2023.07.061_bib0096","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.actbio.2015.04.011","article-title":"Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials","volume":"21","author":"Wang","year":"2015","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.actbio.2023.07.061_bib0097","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1016\/j.actbio.2009.05.026","article-title":"Characterization, physicochemical properties and biocompatibility of La-incorporated apatites","volume":"5","author":"Guo","year":"2009","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2023.07.061_bib0098","first-page":"210","article-title":"Design biodegradable Zn alloys: second phases and their significant influences on alloy properties","volume":"5","author":"Shi","year":"2020","journal-title":"Bioact. Mater."},{"issue":"7-8","key":"10.1016\/j.actbio.2023.07.061_bib0099","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1439-0396.2001.00327.x","article-title":"Study on the performance enhancing effect of rare earth elements in growing and fattening pigs","volume":"85","author":"He","year":"2001","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"issue":"1","key":"10.1016\/j.actbio.2023.07.061_bib0100","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jbm.a.34322","article-title":"In vitro antibacterial evaluation of sol-gel-derived Zn-, Ag-, and (Zn+Ag)-doped hydroxyapatite coatings against methicillin-resistant Staphylococcus aureus","volume":"101","author":"Samani","year":"2013","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.actbio.2023.07.061_bib0101","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2147\/IJN.S121956","article-title":"The antimicrobial activity of nanoparticles: present situation and prospects for the future","volume":"12","author":"Wang","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"Pt 6","key":"10.1016\/j.actbio.2023.07.061_bib0102","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1099\/jmm.0.068130-0","article-title":"Aminoglycoside inhibition of Staphylococcus aureus biofilm formation is nutrient dependent","volume":"63","author":"Henry-Stanley","year":"2014","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.actbio.2023.07.061_bib0103","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.actbio.2021.06.004","article-title":"A review of the physiological impact of rare earth elements and their uses in biomedical Mg alloys","volume":"130","author":"Weng","year":"2021","journal-title":"Acta Biomater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123004531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123004531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:07:37Z","timestamp":1761674857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706123004531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":103,"alternative-id":["S1742706123004531"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2023.07.061","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical properties, corrosion and degradation behaviors, and in vitro cytocompatibility of a biodegradable Zn\u20135La alloy for bone-implant applications","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2023.07.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}