{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:37:51Z","timestamp":1792593471412,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1C1B5039286"],"award-info":[{"award-number":["NRF-2018R1C1B5039286"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1A2C2084535"],"award-info":[{"award-number":["NRF-2019R1A2C2084535"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1F1A1075564"],"award-info":[{"award-number":["NRF-2020R1F1A1075564"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1A2C3003496"],"award-info":[{"award-number":["NRF-2021R1A2C3003496"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A2C3004609"],"award-info":[{"award-number":["NRF-2022R1A2C3004609"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009624","name":"Yonsei University College of Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.actbio.2023.08.031","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:31:11Z","timestamp":1692653471000},"page":"360-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Micellized protein transduction domain-bone morphogenetic protein-2 accelerates bone healing in a rat tibial distraction osteogenesis model"],"prefix":"10.1016","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-076X","authenticated-orcid":false,"given":"Cheol Hee","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Yi","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Eun","family":"Um","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Won","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Ho","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong-Mee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Seop","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7381-3972","authenticated-orcid":false,"given":"Jong-Ki","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-1764","authenticated-orcid":false,"given":"Hyun Sil","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong In","family":"Yook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0596-1228","authenticated-orcid":false,"given":"Yoon Hae","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2023.08.031_bib0001","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tice.2019.08.003","article-title":"Fabrication of vascularized and scaffold-free bone tissue using endothelial and osteogenic cells differentiated from bone marrow derived mesenchymal stem cells","volume":"61","author":"Xu","year":"2019","journal-title":"Tissue Cell"},{"key":"10.1016\/j.actbio.2023.08.031_bib0002","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jare.2017.02.004","article-title":"iPS cell technologies and their prospect for bone regeneration and disease modeling: a mini review","volume":"8","author":"Csobonyeiova","year":"2017","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.actbio.2023.08.031_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.503524","article-title":"Total flavonoids of rhizoma drynariae enhances angiogenic-osteogenic coupling during distraction osteogenesis by promoting type H vessel formation through PDGF-BB\/PDGFR-beta instead of HIF-1 alpha \/VEGF axis","volume":"11","author":"Shen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.actbio.2023.08.031_bib0004","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13287-018-1115-7","article-title":"Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis","volume":"10","author":"Jia","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.actbio.2023.08.031_bib0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1600-051X.2009.01522.x","article-title":"Ex vivo bone morphogenetic protein-2 gene delivery using gingival fibroblasts promotes bone regeneration in rats","volume":"37","author":"Shin","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.actbio.2023.08.031_bib0006","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/pharmaceutics11080393","article-title":"BMP-2 gene delivery-based bone regeneration in dentistry","volume":"11","author":"Park","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.actbio.2023.08.031_bib0007","series-title":"Premarket Approval (PMA) \u2013 Infuse Bone Graft for Spinal Fusion Procedures","year":"2002"},{"key":"10.1016\/j.actbio.2023.08.031_bib0008","series-title":"Premarket Approval (PMA) \u2013 Infuse Bone Graft for Acute Open Tibial Shaft Fractures","year":"2004"},{"key":"10.1016\/j.actbio.2023.08.031_bib0009","series-title":"Premarket Approval (PMA) \u2013 Infuse Bone Graft for Alternative to Autogeneous Bone Graft for Sinus Augmentations, and Localized Alveolar Ridge Augmentations","year":"2007"},{"key":"10.1016\/j.actbio.2023.08.031_bib0010","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00264-007-0418-6","article-title":"A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft)","volume":"31","author":"McKay","year":"2007","journal-title":"Int. Orthop."},{"key":"10.1016\/j.actbio.2023.08.031_bib0011","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1874210601206010051","article-title":"Protein-signaled guided bone regeneration using titanium mesh and Rh-BMP2 in oral surgery: a case report involving left mandibular reconstruction after tumor resection","volume":"6","author":"Cicci\u00f9","year":"2012","journal-title":"Open Dent. J."},{"key":"10.1016\/j.actbio.2023.08.031_bib0012","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1055\/s-0035-1555660","article-title":"The use of bone morphogenetic protein in pediatric cervical spine fusion surgery: case reports and review of the literature","volume":"6","author":"Molinari","year":"2016","journal-title":"Glob. Spine J."},{"key":"10.1016\/j.actbio.2023.08.031_bib0013","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1097\/SCS.0000000000005049","article-title":"Use of recombinant human bone morphogenetic protein-2 associated with lyophilized bovine bone in reconstruction of atrophic maxilla","volume":"29","author":"Zanettini","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.actbio.2023.08.031_bib0014","unstructured":"Global bone morphogenetic protein (BMP) 2 market insights and forcast to 2028, Precision Reports. (2022). https:\/\/www.precisionreports.co\/global-bone-morphogenetic-protein-bmp-2-market-19951590. (Accessed 23 May 2023)"},{"key":"10.1016\/j.actbio.2023.08.031_bib0015","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2106\/00004623-199905000-00004","article-title":"Distraction osteogenesis for lengthening of the tibia in patients who have limb-length discrepancy or short stature","volume":"81","author":"Aldegheri","year":"1999","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.actbio.2023.08.031_bib0016","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2106\/00004623-200008000-00019","article-title":"Distraction osteogenesis for tibial lengthening","volume":"82","author":"Meiss","year":"2000","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.actbio.2023.08.031_bib0017","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00264-006-0236-2","article-title":"Complications of Ilizarov leg lengthening: a comparative study between patients with leg length discrepancy and short stature","volume":"31","author":"Vargas Barreto","year":"2007","journal-title":"Int. Orthop."},{"key":"10.1016\/j.actbio.2023.08.031_bib0018","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1302\/0301-620X.95B12.32385","article-title":"Distraction osteogenesis in the treatment of long bone defects of the lower limbs: effectiveness, complications and clinical results; a systematic review and meta-analysis","volume":"95\u2013B","author":"Papakostidis","year":"2013","journal-title":"Bone Joint J."},{"key":"10.1016\/j.actbio.2023.08.031_bib0019","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13018-018-0907-x","article-title":"Effect of low-intensity pulsed ultrasound on distraction osteogenesis: a systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Lou","year":"2018","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.actbio.2023.08.031_bib0020","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10103-009-0691-2","article-title":"Effects of low-level laser therapy on bone formed after distraction osteogenesis","volume":"25","author":"H\u00fcbler","year":"2010","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.actbio.2023.08.031_bib0021","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jormas.2018.05.006","article-title":"Investigation of effects of low level laser therapy in distraction osteogenesis","volume":"119","author":"Gurler","year":"2018","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"10.1016\/j.actbio.2023.08.031_bib0022","first-page":"170","article-title":"Injected calcium sulfate for consolidation of distraction osteogenesis in rabbit tibia","volume":"13","author":"Song","year":"2004","journal-title":"J. Pediatr. Orthop. B."},{"key":"10.1016\/j.actbio.2023.08.031_bib0023","first-page":"158","article-title":"The effects of rhBMP-2 injection at distraction osteogenesis of rats\u2019 tibia","volume":"8","author":"Song","year":"2011","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.actbio.2023.08.031_bib0024","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11832-012-0477-0","article-title":"Epidemiology and treatment outcome of congenital pseudarthrosis of the tibia","volume":"7","author":"Horn","year":"2013","journal-title":"J. Child. Orthop."},{"key":"10.1016\/j.actbio.2023.08.031_bib0025","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1302\/1863-2548.13.180147","article-title":"Congenital pseudarthrosis of the tibia: biological and biomechanical considerations to achieve union and prevent refracture","volume":"13","author":"Paley","year":"2019","journal-title":"J. Child. Orthop."},{"key":"10.1016\/j.actbio.2023.08.031_bib0026","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.spinee.2007.06.014","article-title":"Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF\/TLIF use of bone morphogenetic protein-2 (BMP-2)","volume":"8","author":"Wong","year":"2008","journal-title":"Spine J."},{"key":"10.1016\/j.actbio.2023.08.031_bib0027","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.spinee.2009.10.016","article-title":"High-dose bone morphogenetic protein-induced ectopic abdomen bone growth","volume":"10","author":"Deutsch","year":"2010","journal-title":"Spine J."},{"key":"10.1016\/j.actbio.2023.08.031_bib0028","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3171\/2009.4.SPINE0876","article-title":"Symptomatic ectopic bone formation after off-label use of recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion","volume":"12","author":"Chen","year":"2010","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.actbio.2023.08.031_bib0029","first-page":"37","article-title":"BMP-2: biological challenges to its clinical use","volume":"78","author":"Razzouk","year":"2012","journal-title":"N. Y. State Dent. J."},{"key":"10.1016\/j.actbio.2023.08.031_bib0030","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.spinee.2011.04.023","article-title":"A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned","volume":"11","author":"Carragee","year":"2011","journal-title":"Spine J."},{"key":"10.1016\/j.actbio.2023.08.031_bib0031","first-page":"919","article-title":"In vivo release of rhBMP-2 loaded porous calcium phosphate cement pretreated with albumin","volume":"17","author":"Ruh\u00e9","year":"2006","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.actbio.2023.08.031_bib0032","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.addr.2012.03.014","article-title":"Studies of bone morphogenetic protein-based surgical repair","volume":"64","author":"Lo","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2023.08.031_bib0033","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1016\/j.biomaterials.2014.08.005","article-title":"A platform technique for growth factor delivery with novel mode of action","volume":"35","author":"Kim","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2023.08.031_bib0034","doi-asserted-by":"crossref","first-page":"14536","DOI":"10.1073\/pnas.93.25.14536","article-title":"Pharmacologic shifting of a balance between protein refolding and degradation mediated by\u2009Hsp90","volume":"93","author":"Schneider","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.actbio.2023.08.031_bib0035","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1126\/science.285.5433.1569","article-title":"In vivo protein transduction: delivery of a biologically active protein into the mouse","volume":"285","author":"Schwarze","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.actbio.2023.08.031_bib0036","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nm996","article-title":"Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis","volume":"10","author":"Wadia","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2023.08.031_bib0037","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1091\/mbc.e03-12-0921","article-title":"HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses","volume":"15","author":"Vendeville","year":"2004","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.actbio.2023.08.031_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.591275","article-title":"Micellized protein transduction domain-bone morphogenetic protein-7 efficiently blocks renal fibrosis via inhibition of transforming growth factor-beta-mediated epithelial-mesenchymal transition","volume":"11","author":"Kim","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.actbio.2023.08.031_bib0039","first-page":"763","article-title":"A micellized bone morphogenetic protein-7 prodrug ameliorates liver fibrosis by suppressing transforming growth factor-\u03b2 signaling","volume":"12","author":"Cho","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.actbio.2023.08.031_bib0040","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/aps.2017.178","article-title":"Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.actbio.2023.08.031_bib0041","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12951-021-00986-2","article-title":"Artificial exosomes for translational nanomedicine","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2023.08.031_bib0042","doi-asserted-by":"crossref","first-page":"17802","DOI":"10.1021\/acsnano.2c08774","article-title":"Exosomes\u2013nature's lipid nanoparticles, a rising star in drug delivery and diagnostics","volume":"16","author":"Tenchov","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2023.08.031_bib0043","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S8756-3282(98)00076-3","article-title":"Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia","volume":"23","author":"J\u00e4ms\u00e4","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2023.08.031_bib0044","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bone.2005.07.028","article-title":"The use of micro-CT to evaluate cortical bone geometry and strength in nude rats: correlation with mechanical testing, pQCT and DXA","volume":"38","author":"Bagi","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2023.08.031_bib0045","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.bone.2012.03.008","article-title":"Micro-computed tomography assessment of the progression of fracture healing in mice","volume":"50","author":"O'Neill","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2023.08.031_bib0046","series-title":"Conn's Biological stains: a Handbook of Dyes, Stains and Fluorochromes for Use in Biology and Medicine","author":"Horobin","year":"2020"},{"key":"10.1016\/j.actbio.2023.08.031_bib0047","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-5173(99)00174-X","article-title":"Characterization of absorbable collagen sponges as rhBMP-2 carriers","volume":"187","author":"Friess","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2023.08.031_bib0048","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1532-950X.2007.00242.x","article-title":"Recombinant human bone morphogenetic protein-2 in absorbable collagen sponge enhances bone healing of tibial osteotomies in dogs","volume":"36","author":"Faria","year":"2007","journal-title":"Vet. Surg."},{"key":"10.1016\/j.actbio.2023.08.031_bib0049","doi-asserted-by":"crossref","first-page":"16924","DOI":"10.1038\/s41598-021-96484-4","article-title":"A novel BMP-2-loaded hydroxyapatite\/beta-tricalcium phosphate microsphere\/hydrogel composite for bone regeneration","volume":"11","author":"Tateiwa","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2023.08.031_bib0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.actbio.2017.06.028","article-title":"Enhanced in vivo retention of low dose BMP-2 via heparin microparticle delivery does not accelerate bone healing in a critically sized femoral defect","volume":"59","author":"Hettiaratchi","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.08.031_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121117","article-title":"Enhanced bone regeneration via spatiotemporal and controlled delivery of a genetically engineered BMP-2 in a composite Hydrogel","volume":"277","author":"Chen","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2023.08.031_bib0052","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1096\/fba.2018-00023","article-title":"Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion","volume":"1","author":"Khattar","year":"2019","journal-title":"FASEB Bioadv"},{"key":"10.1016\/j.actbio.2023.08.031_bib0053","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/ten.teb.2015.0357","article-title":"A review of the clinical side effects of bone morphogenetic protein-2","volume":"22","author":"James","year":"2016","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.actbio.2023.08.031_bib0054","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.spinee.2006.04.010","article-title":"Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study","volume":"7","author":"Perri","year":"2007","journal-title":"Spine J."},{"key":"10.1016\/j.actbio.2023.08.031_bib0055","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00776-005-0934-4","article-title":"Efficacy of rhBMP-2 during distraction osteogenesis","volume":"10","author":"Nunotani","year":"2005","journal-title":"J. Orthop. Sci."},{"key":"10.1016\/j.actbio.2023.08.031_bib0056","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.injury.2009.10.010","article-title":"Rh-BMP-2 in distraction osteogenesis: dose effect and premature consolidation","volume":"41","author":"Sailhan","year":"2010","journal-title":"Injury"},{"key":"10.1016\/j.actbio.2023.08.031_bib0057","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/14653249.2011.630728","article-title":"The effect of bone morphogenic protein-2-coated tri-calcium phosphate\/hydroxyapatite on new bone formation in a rat model of femoral distraction osteogenesis","volume":"14","author":"Yang","year":"2012","journal-title":"Cytotherapy"},{"key":"10.1016\/j.actbio.2023.08.031_bib0058","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.injury.2010.11.012","article-title":"Local BMP-2 application can rescue the delayed osteotomy healing in a rat model","volume":"42","author":"Wildemann","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.actbio.2023.08.031_bib0059","doi-asserted-by":"crossref","first-page":"8539","DOI":"10.3390\/ijms15058539","article-title":"Stimulation of bone healing by sustained bone morphogenetic protein 2 (BMP-2) delivery","volume":"15","author":"Fa\u00dfbender","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2023.08.031_bib0060","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1089\/ten.tea.2010.0555","article-title":"High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo","volume":"17","author":"Zara","year":"2011","journal-title":"Tissue Eng. A"},{"key":"10.1016\/j.actbio.2023.08.031_bib0061","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/230152","article-title":"Bone formation in a rat tibial defect model using carboxymethyl cellulose\/BioC\/bone morphogenic protein-2 hybrid materials","volume":"2014","author":"Song","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.actbio.2023.08.031_bib0062","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2106\/JBJS.H.01667","article-title":"The use of rhBMP-2 for the treatment of congenital pseudarthrosis of the tibia: a case series","volume":"92","author":"Richards","year":"2010","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.actbio.2023.08.031_bib0063","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/BPO.0000000000000789","article-title":"rhBMP-2 and intramedullary fixation in congenital pseudarthrosis of the tibia","volume":"38","author":"Richards","year":"2018","journal-title":"J. Pediatr. Orthop."},{"key":"10.1016\/j.actbio.2023.08.031_bib0064","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jbm.a.35900","article-title":"Accelerated bony defect healing based on chitosan thermosensitive hydrogel scaffolds embedded with chitosan nanoparticles for the delivery of BMP2 plasmid DNA","volume":"105","author":"Li","year":"2017","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.actbio.2023.08.031_bib0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1902\/jop.2017.170328","article-title":"Non-surgical model for alveolar bone regeneration by bone morphogenetic protein-2\/7 gene therapy","volume":"89","author":"Kawai","year":"2018","journal-title":"J. Periodontol."},{"key":"10.1016\/j.actbio.2023.08.031_bib0066","first-page":"2985","article-title":"Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2\/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo","volume":"8","author":"Qiao","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2023.08.031_bib0067","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/jbm.a.35773","article-title":"A novel nonviral gene delivery tool of BMP-2 for the reconstitution of critical-size bone defects in rats","volume":"104","author":"Kolk","year":"2016","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.actbio.2023.08.031_bib0068","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0022034513483771","article-title":"Advanced BMP gene therapies for temporal and spatial control of bone regeneration","volume":"92","author":"Wilson","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.actbio.2023.08.031_bib0069","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40510-018-0216-2","article-title":"Role of osteopontin in bone remodeling and orthodontic tooth movement: a review","volume":"19","author":"Singh","year":"2018","journal-title":"Prog. Orthod."},{"key":"10.1016\/j.actbio.2023.08.031_bib0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/10408369109106867","article-title":"Osteocalcin: diagnostic methods and clinical applications","volume":"28","author":"Power","year":"1991","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.actbio.2023.08.031_bib0071","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00223-009-9275-1","article-title":"Bone turnover and the osteoprotegerin\u2013RANKL pathway in tumor-induced osteomalacia: a longitudinal study of five cases","volume":"85","author":"Rendina","year":"2009","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.actbio.2023.08.031_bib0072","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1055\/s-0033-1349842","article-title":"Osteoprotegerin, RANKL, and bone turnover in primary hyperparathyroidism: the effect of parathyroidectomy and treatment with alendronate","volume":"45","author":"Szymczak","year":"2013","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.actbio.2023.08.031_bib0073","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/children8070547","article-title":"Cross-union surgery for congenital pseudarthrosis of the tibia","volume":"8","author":"Shannon","year":"2021","journal-title":"Children"},{"key":"10.1016\/j.actbio.2023.08.031_bib0074","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1097\/BPO.0000000000002138","article-title":"Combination treatment by cross-union of the tibia and fibula, autogenic iliac bone grafting, reliable fixation and bone morphogenetic proteins for the treatment of refractory congenital pseudarthrosis of the tibia","volume":"42","author":"Wu","year":"2022","journal-title":"J. Pediatr. Orthop."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123004956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123004956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:11:26Z","timestamp":1761675086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706123004956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":74,"alternative-id":["S1742706123004956"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2023.08.031","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Micellized protein transduction domain-bone morphogenetic protein-2 accelerates bone healing in a rat tibial distraction osteogenesis model","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2023.08.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}