{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:22:01Z","timestamp":1785734521661,"version":"3.56.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["21XD1420900"],"award-info":[{"award-number":["21XD1420900"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018558","name":"Shanghai Shuguang Program","doi-asserted-by":"publisher","award":["19SG06"],"award-info":[{"award-number":["19SG06"]}],"id":[{"id":"10.13039\/501100018558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971598"],"award-info":[{"award-number":["81971598"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071456"],"award-info":[{"award-number":["82071456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102111"],"award-info":[{"award-number":["82102111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J011020"],"award-info":[{"award-number":["2020J011020"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010120","name":"Huashan Hospital Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.actbio.2023.11.027","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T23:08:07Z","timestamp":1701212887000},"page":"314-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Targeted nanotheranostics for the treatment of epilepsy through in vivo hijacking of locally activated macrophages"],"prefix":"10.1016","volume":"174","author":[{"given":"Lin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoying","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejun","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Kuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.actbio.2023.11.027_bib0001","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1212\/WNL.0000000000003509","article-title":"Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international studies","volume":"88","author":"Fiest","year":"2017","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.actbio.2023.11.027_bib0002","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrd4126","article-title":"New avenues for anti-epileptic drug discovery and development","volume":"12","author":"L\u00f6scher","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"issue":"46","key":"10.1016\/j.actbio.2023.11.027_bib0003","doi-asserted-by":"crossref","first-page":"12436","DOI":"10.1002\/anie.201403846","article-title":"Angiopep-conjugated electro-responsive hydrogel nanoparticles: therapeutic potential for epilepsy","volume":"53","author":"Ying","year":"2014","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2023.11.027_bib0004","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biomaterials.2015.09.041","article-title":"Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery","volume":"74","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2023.11.027_bib0005","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.biomaterials.2016.04.021","article-title":"Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy","volume":"97","author":"Fang","year":"2016","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2023.11.027_bib0006","doi-asserted-by":"crossref","first-page":"7847","DOI":"10.1021\/acsnano.3c01140","article-title":"ROS\/electro dual-reactive nanogel for targeting epileptic foci to remodel aberrant circuits and inflammatory microenvironment","volume":"17","author":"Zhou","year":"2023","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.actbio.2023.11.027_bib0007","doi-asserted-by":"crossref","first-page":"eaau8301","DOI":"10.1126\/sciadv.aau8301","article-title":"Accessing neuroinflammation sites: monocyte\/neutrophil-mediated drug delivery for cerebral ischemia","volume":"5","author":"Hou","year":"2019","journal-title":"Sci. Adv."},{"issue":"10","key":"10.1016\/j.actbio.2023.11.027_bib0008","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/epi.14550","article-title":"Activation of the innate immune system is evident throughout epileptogenesis and is associated with blood-brain barrier dysfunction and seizure progression","volume":"59","author":"Broekaart","year":"2018","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.actbio.2023.11.027_bib0009","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/glia.20208","article-title":"CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation","volume":"51","author":"Fabriek","year":"2005","journal-title":"Glia"},{"issue":"15","key":"10.1016\/j.actbio.2023.11.027_bib0010","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.3390\/ijms21155497","article-title":"Targeting of CD163(+) macrophages in inflammatory and malignant diseases","volume":"21","author":"Skytthe","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.actbio.2023.11.027_bib0011","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3390\/ijms17091383","article-title":"CTHRSSVVC peptide as a possible early molecular imaging target for atherosclerosis","volume":"17","author":"Silva","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"10172","key":"10.1016\/j.actbio.2023.11.027_bib0012","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.actbio.2023.11.027_bib0013","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/WNL.0b013e3182a35193","article-title":"MRI-identified pathology in adults with new-onset seizures","volume":"81","author":"Hakami","year":"2013","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.actbio.2023.11.027_bib0014","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S1474-4422(15)00383-X","article-title":"Brain imaging in the assessment for epilepsy surgery","volume":"15","author":"Duncan","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.actbio.2023.11.027_bib0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/epi.12189","article-title":"Can we develop pathology-specific MRI contrast for \"MR-negative\" epilepsy?","volume":"54","author":"Feindel","year":"2013","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.actbio.2023.11.027_bib0016","doi-asserted-by":"crossref","first-page":"110","DOI":"10.7326\/M20-0299","article-title":"Risk for nephrogenic systemic fibrosis after exposure to newer gadolinium agents: a systematic review","volume":"173","author":"Lunyera","year":"2020","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.actbio.2023.11.027_bib0017","doi-asserted-by":"crossref","first-page":"990","DOI":"10.7150\/thno.22465","article-title":"O2-generating MnO2 nanoparticles for enhanced photodynamic therapy of bladder cancer by ameliorating hypoxia","volume":"8","author":"Lin","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2023.11.027_bib0018","doi-asserted-by":"crossref","unstructured":"J. Dai, Z. Liu, L. Wang, A telomerase-activated magnetic resonance imaging probe for consecutively monitoring tumor growth kinetics and in situ screening inhibitors, 145(2) (2023) 1108-1117.","DOI":"10.1021\/jacs.2c10749"},{"issue":"10","key":"10.1016\/j.actbio.2023.11.027_bib0019","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1007\/s12274-022-4542-9","article-title":"Versatile nanocomposite augments high-intensity focused ultrasound for high-efficacy sonodynamic therapy of glioma","volume":"15","author":"Zheng","year":"2022","journal-title":"Nano Res."},{"issue":"3","key":"10.1016\/j.actbio.2023.11.027_bib0020","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41551-020-00618-4","article-title":"An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy","volume":"5","author":"Wang","year":"2021","journal-title":"Nat. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.actbio.2023.11.027_bib0021","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0306-4522(00)00038-5","article-title":"Similar increases in extracellular lactic acid in the limbic system during epileptic and\/or olfactory stimulation","volume":"97","author":"Fornai","year":"2000","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.actbio.2023.11.027_bib0022","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/jcbfm.1988.17","article-title":"Extracellular lactic acid as an indicator of brain metabolism: continuous on-line measurement in conscious, freely moving rats with intrastriatal dialysis","volume":"8","author":"Kuhr","year":"1988","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"5","key":"10.1016\/j.actbio.2023.11.027_bib0023","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2010.07013.x","article-title":"Persistent impairment of mitochondrial and tissue redox status during lithium-pilocarpine-induced epileptogenesis","volume":"115","author":"Waldbaum","year":"2010","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.actbio.2023.11.027_bib0024","first-page":"3","article-title":"Mitochondrial dysfunction and oxidative stress in seizure-induced neuronal cell death","volume":"19","author":"Chuang","year":"2010","journal-title":"Acta Neurol. Taiwan"},{"key":"10.1016\/j.actbio.2023.11.027_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119581","article-title":"Construction of pepstatin A-conjugated ultrasmall SPIONs for targeted positive MR imaging of epilepsy-overexpressed P-glycoprotein","volume":"230","author":"Du","year":"2020","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2023.11.027_bib0026","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.bbrc.2018.03.175","article-title":"Comparative toxicity and contrast enhancing assessments of Gd2O3@BSA and MnO2@BSA nanoparticles for MR imaging of brain glioma","volume":"499","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.actbio.2023.11.027_bib0027","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","article-title":"Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy","volume":"15","author":"Vezzani","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.actbio.2023.11.027_bib0028","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3389\/fneur.2019.00685","article-title":"Advances in the potential biomarkers of epilepsy","volume":"10","author":"Kobylarek","year":"2019","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.actbio.2023.11.027_bib0029","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/nan.12444","article-title":"Review: neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies","volume":"44","author":"van Vliet","year":"2018","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"Pt A","key":"10.1016\/j.actbio.2023.11.027_bib0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.expneurol.2017.08.009","article-title":"Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation","volume":"298","author":"McElroy","year":"2017","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.actbio.2023.11.027_bib0031","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1124\/pr.110.003046","article-title":"Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research","volume":"62","author":"Loscher","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"5","key":"10.1016\/j.actbio.2023.11.027_bib0032","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/14737175.2018.1465410","article-title":"Oxidative stress in epilepsy","volume":"18","author":"Geronzi","year":"2018","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.actbio.2023.11.027_bib0033","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6687185","article-title":"Antioxidants targeting mitochondrial oxidative stress: promising neuroprotectants for epilepsy","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.actbio.2023.11.027_bib0034","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.actbio.2023.11.027_bib0035","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/acs.chemrev.8b00672","article-title":"Nanozymes: classification, catalytic mechanisms, activity regulation, and applications","volume":"119","author":"Huang","year":"2019","journal-title":"Chem. Rev."},{"issue":"44","key":"10.1016\/j.actbio.2023.11.027_bib0036","doi-asserted-by":"crossref","first-page":"13661","DOI":"10.1002\/anie.201706910","article-title":"Manganese dioxide nanozymes as responsive cytoprotective shells for individual living cell encapsulation","volume":"56","author":"Li","year":"2017","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2023.11.027_bib0037","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.colsurfb.2017.07.081","article-title":"Synthesis and characterization of hyaluronic acid coated manganese dioxide microparticles that act as ROS scavengers","volume":"159","author":"Bizeau","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.actbio.2023.11.027_bib0038","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.actbio.2017.07.006","article-title":"Manganese oxide particles as cytoprotective, oxygen generating agents","volume":"59","author":"Tootoonchi","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2023.11.027_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119467","article-title":"Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress","volume":"224","author":"Kumar","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2023.11.027_bib0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biomaterials.2017.06.017","article-title":"Macrophages with cellular backpacks for targeted drug delivery to the brain","volume":"140","author":"Klyachko","year":"2017","journal-title":"Biomaterials"},{"issue":"10 Pt 2","key":"10.1016\/j.actbio.2023.11.027_bib0041","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/j.neubiorev.2013.10.011","article-title":"The kainic acid model of temporal lobe epilepsy","volume":"37","author":"Levesque","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"33","key":"10.1016\/j.actbio.2023.11.027_bib0042","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1002\/adma.201601902","article-title":"Intelligent albumin-MnO2 nanoparticles as pH-\/H2 O2 -responsive dissociable nanocarriers to modulate tumor hypoxia for effective combination therapy","volume":"28","author":"Chen","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2023.11.027_bib0043","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.biomaterials.2015.10.050","article-title":"A multimodal Pepstatin A peptide-based nanoagent for the molecular imaging of P-glycoprotein in the brains of epilepsy rats","volume":"76","author":"Yu","year":"2016","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2023.11.027_bib0044","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/acsnano.5b06779","article-title":"Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and attenuating tumor hypoxia","volume":"10","author":"Song","year":"2016","journal-title":"ACS Nano"},{"issue":"41","key":"10.1016\/j.actbio.2023.11.027_bib0045","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1002\/adma.201402572","article-title":"Break-up of two-dimensional MnO2 nanosheets promotes ultrasensitive pH-triggered theranostics of cancer","volume":"26","author":"Chen","year":"2014","journal-title":"Adv. Mater."},{"issue":"8","key":"10.1016\/j.actbio.2023.11.027_bib0046","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nnano.2016.72","article-title":"A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy","volume":"11","author":"Mi","year":"2016","journal-title":"Nat. Nanotechnol."},{"issue":"2","key":"10.1016\/j.actbio.2023.11.027_bib0047","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1021\/nn406197c","article-title":"Dual-targeting upconversion nanoprobes across the blood-brain barrier for magnetic resonance\/fluorescence imaging of intracranial glioblastoma","volume":"8","author":"Ni","year":"2014","journal-title":"ACS Nano"},{"issue":"18","key":"10.1016\/j.actbio.2023.11.027_bib0048","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1016\/j.biomaterials.2011.02.044","article-title":"Angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma","volume":"32","author":"Xin","year":"2011","journal-title":"Biomaterials"},{"issue":"28","key":"10.1016\/j.actbio.2023.11.027_bib0049","doi-asserted-by":"crossref","first-page":"6832","DOI":"10.1016\/j.biomaterials.2011.05.064","article-title":"Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma","volume":"32","author":"Huang","year":"2011","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.actbio.2023.11.027_bib0050","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2217\/nnm.13.115","article-title":"Macrophages offer a paradigm switch for CNS delivery of therapeutic proteins","volume":"9","author":"Klyachko","year":"2014","journal-title":"Nanomedicine"},{"issue":"5","key":"10.1016\/j.actbio.2023.11.027_bib0051","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1084\/jem.168.5.1865","article-title":"The selective binding and transmigration of monocytes through the junctional complexes of human endothelium","volume":"168","author":"Pawlowski","year":"1988","journal-title":"J. Exp. Med."},{"issue":"13","key":"10.1016\/j.actbio.2023.11.027_bib0052","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.7150\/thno.19979","article-title":"Direct macromolecular drug delivery to cerebral ischemia area using neutrophil-mediated nanoparticles","volume":"7","author":"Zhang","year":"2017","journal-title":"Theranostics"},{"issue":"50","key":"10.1016\/j.actbio.2023.11.027_bib0053","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201805557","article-title":"Nanoparticle-laden macrophages for tumor-tropic drug delivery","volume":"30","author":"Zhang","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2023.11.027_bib0054","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7897584","article-title":"Antiepileptic effects of protein-rich extract from bombyx batryticatus on mice and its protective effects against H2O2-induced oxidative damage in PC12 cells via regulating PI3K\/Akt signaling pathways","volume":"2019","author":"Hu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.actbio.2023.11.027_bib0055","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.3390\/ijms18112365","article-title":"Metabolic dysfunction and oxidative stress in epilepsy","volume":"18","author":"Pearson-Smith","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.actbio.2023.11.027_bib0056","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1002\/anie.201802309","article-title":"Custom-made ceria nanoparticles show a neuroprotective effect by modulating phenotypic polarization of the microglia","volume":"57","author":"Zeng","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"20","key":"10.1016\/j.actbio.2023.11.027_bib0057","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101526","article-title":"Macrophage-disguised manganese dioxide nanoparticles for neuroprotection by reducing oxidative stress and modulating inflammatory microenvironment in acute ischemic stroke","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2023.11.027_bib0058","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s13311-018-0653-0","article-title":"Inhibition of MyD88 signaling skews microglia\/macrophage polarization and attenuates neuronal apoptosis in the hippocampus after status epilepticus in mice","volume":"15","author":"Liu","year":"2018","journal-title":"Neurotherapeutics"},{"issue":"38","key":"10.1016\/j.actbio.2023.11.027_bib0059","doi-asserted-by":"crossref","first-page":"E5665","DOI":"10.1073\/pnas.1604263113","article-title":"Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus","volume":"113","author":"Varvel","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.actbio.2023.11.027_bib0060","doi-asserted-by":"crossref","first-page":"17135","DOI":"10.1038\/srep17135","article-title":"Targeted gold-coated iron oxide nanoparticles for CD163 detection in atherosclerosis by MRI","volume":"5","author":"Tarin","year":"2015","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.actbio.2023.11.027_bib0061","doi-asserted-by":"crossref","first-page":"896","DOI":"10.7150\/thno.14915","article-title":"CD163-macrophages are involved in rhabdomyolysis-induced kidney injury and may be detected by MRI with targeted gold-coated iron oxide nanoparticles","volume":"6","author":"Rubio-Navarro","year":"2016","journal-title":"Theranostics"},{"issue":"36","key":"10.1016\/j.actbio.2023.11.027_bib0062","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1523\/JNEUROSCI.1636-16.2016","article-title":"Anti-inflammatory modulation of microglia via CD163-targeted glucocorticoids protects dopaminergic neurons in the 6-OHDA Parkinson's disease model","volume":"36","author":"Tentillier","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.actbio.2023.11.027_bib0063","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.omtm.2016.11.004","article-title":"Antibody-directed glucocorticoid targeting to CD163 in M2-type macrophages attenuates fructose-induced liver inflammatory changes","volume":"4","author":"Svendsen","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123006839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706123006839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:13:36Z","timestamp":1761675216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706123006839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":63,"alternative-id":["S1742706123006839"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2023.11.027","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted nanotheranostics for the treatment of epilepsy through in vivo hijacking of locally activated macrophages","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2023.11.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}