{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:55:52Z","timestamp":1792036552247,"version":"4.4.0"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP210101862"],"award-info":[{"award-number":["DP210101862"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"publisher","award":["LGF22H140008"],"award-info":[{"award-number":["LGF22H140008"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"publisher","award":["LTGY23H140002"],"award-info":[{"award-number":["LTGY23H140002"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.actbio.2024.01.018","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T03:26:56Z","timestamp":1705807616000},"page":"538-559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["A biodegradable Zn-5Gd alloy with biomechanical compatibility, cytocompatibility, antibacterial ability, and in vitro and in vivo osteogenesis for orthopedic applications"],"prefix":"10.1016","volume":"177","author":[{"given":"Xian","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinkun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-4772","authenticated-orcid":false,"given":"Yuncang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-3536","authenticated-orcid":false,"given":"Cuie","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2024.01.018_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2014.01.001","article-title":"Biodegradable metals","volume":"77","author":"Zheng","year":"2014","journal-title":"J. Mater. Sci. Eng. R"},{"key":"10.1016\/j.actbio.2024.01.018_bib0002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fmats.2019.00201","article-title":"Wide range mechanical customization of Mg-Gd alloys with low degradation rates by extrusion","volume":"6","author":"Harmuth","year":"2019","journal-title":"Front. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2024.01.018_bib0003","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/jbm.b.33470","article-title":"Comparison of magnesium alloys and poly-l-lactide screws as degradable implants in a canine fracture model","volume":"104","author":"Marukawa","year":"2016","journal-title":"J. Biomed. Mater. Res. Part B"},{"key":"10.1016\/j.actbio.2024.01.018_bib0004","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.actbio.2021.09.047","article-title":"Multimodal ex vivo methods reveal that Gd-rich corrosion byproducts remain at the implant site of biodegradable Mg-Gd screws","volume":"136","author":"Peruzzi","year":"2021","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.actbio.2024.01.018_bib0005","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.jmst.2019.03.006","article-title":"Diameter-dependent in vitro performance of biodegradable pure zinc wires for suture application","volume":"35","author":"Guo","year":"2019","journal-title":"J. Mater. Sci. Technol."},{"issue":"5","key":"10.1016\/j.actbio.2024.01.018_bib0006","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.actbio.2009.07.039","article-title":"Design strategy for biodegradable Fe-based alloys for medical applications","volume":"6","author":"Schinhammer","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0007","series-title":"Electrochemical Series","first-page":"8","author":"Van\u00fdsek","year":"2008"},{"key":"10.1016\/j.actbio.2024.01.018_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchemphys.2020.123257","article-title":"Comparative study on performance and microstructure of composite water-soluble salt core material for manufacturing hollow zinc alloy castings","volume":"252","author":"Liu","year":"2020","journal-title":"Mater. Chem. Phys."},{"issue":"2","key":"10.1016\/j.actbio.2024.01.018_bib0009","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1039\/C5MT00251F","article-title":"The contribution of zinc to platelet behaviour during haemostasis and thrombosis","volume":"8","author":"Taylor","year":"2016","journal-title":"Metallomics"},{"issue":"11","key":"10.1016\/j.actbio.2024.01.018_bib0010","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.dental.2010.07.006","article-title":"The requirement of zinc and calcium ions for functional MMP activity in demineralized dentin matrices","volume":"26","author":"Tezvergil-Mutluay","year":"2010","journal-title":"Dent. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0011","article-title":"Advanced nutrition and human metabolism","author":"Gropper","year":"2012","journal-title":"Cengage Learn."},{"issue":"4","key":"10.1016\/j.actbio.2024.01.018_bib0012","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1017\/S0029665100000781","article-title":"Zinc and the immune system","volume":"59","author":"Rink","year":"2000","journal-title":"Proc. Nutr. Soc."},{"issue":"9","key":"10.1016\/j.actbio.2024.01.018_bib0013","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0753-3322(03)00081-7","article-title":"Trace elements in human physiology and pathology: zinc and metallothioneins","volume":"57","author":"Tapiero","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actbio.2024.01.018_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111172","article-title":"Biodegradable Zn-1.5Cu-1.5Ag alloy with anti-aging ability and strain hardening behavior for cardiovascular stents","volume":"116","author":"Chen","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2024.01.018_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2019.01.035","article-title":"The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: a comprehensive review","volume":"87","author":"Venezuela","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0016","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1038\/srep10719","article-title":"Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2024.01.018_bib0017","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jmbbm.2017.05.013","article-title":"Potential biodegradable Zn-Cu binary alloys developed for cardiovascular implant applications","volume":"72","author":"Tang","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0018","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.msec.2017.02.167","article-title":"Zn-Li alloy after extrusion and drawing: structural, mechanical characterization, and biodegradation in abdominal aorta of rat","volume":"76","author":"Zhao","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2024.01.018_bib0019","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.actbio.2020.03.009","article-title":"In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications","volume":"108","author":"Jia","year":"2020","journal-title":"Acta Biomater."},{"issue":"12","key":"10.1016\/j.actbio.2024.01.018_bib0020","first-page":"4607","article-title":"Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties","volume":"6","author":"Qu","year":"2021","journal-title":"Bioact. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2024.01.018_bib0021","first-page":"1436","article-title":"The influence of Ca and Cu additions on the microstructure, mechanical and degradation properties of Zn-Ca-Cu alloys for absorbable wound closure device applications","volume":"6","author":"Yang","year":"2021","journal-title":"Bioact. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2024.01.018_bib0022","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S1003-6326(20)65346-8","article-title":"Effects of Sr addition on microstructure, mechanical properties and in vitro degradation behavior of as-extruded Zn-Sr binary alloys","volume":"30","author":"Ke","year":"2020","journal-title":"Trans. Nonferrous Met. Soc. China"},{"issue":"4","key":"10.1016\/j.actbio.2024.01.018_bib0023","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s12613-022-2468-6","article-title":"Second phase refining induced optimization of Fe alloying in Zn: significantly enhanced strengthening effect and corrosion uniformity","volume":"29","author":"Shi","year":"2022","journal-title":"Int. J. Miner., Metall. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0024","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.actbio.2018.10.015","article-title":"Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn-5Ge alloy for biodegradable implant materials","volume":"82","author":"Tong","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0025","first-page":"243","article-title":"Blending with transition metals improves bioresorbable zinc as better medical implants","volume":"20","author":"Su","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.matlet.2022.132516","article-title":"Microstructure, mechanical and corrosion properties of biodegradable Zn-Mg-Zr alloys for biomedical applications","volume":"323","author":"Hua","year":"2022","journal-title":"Mater. Lett."},{"issue":"18","key":"10.1016\/j.actbio.2024.01.018_bib0027","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201901715","article-title":"The application of the rare earths to magnesium and titanium metallurgy in Australia","volume":"32","author":"Biesiekierski","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0028","series-title":"Datensammlung Chemie in Si-Einheiten","author":"Aylward","year":"2014"},{"key":"10.1016\/j.actbio.2024.01.018_bib0029","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/978-1-4684-8748-0_9","article-title":"Past, present, and possible future clinical applications of the lanthanides","author":"Evans","year":"1990","journal-title":"Biochem. Lanthanides"},{"issue":"24","key":"10.1016\/j.actbio.2024.01.018_bib0030","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1002\/smll.201000418","article-title":"Small upconverting fluorescent nanoparticles for biomedical applications","volume":"6","author":"Chatterjee","year":"2010","journal-title":"Small"},{"issue":"19","key":"10.1016\/j.actbio.2024.01.018_bib0031","doi-asserted-by":"crossref","first-page":"10725","DOI":"10.1021\/acs.chemrev.5b00091","article-title":"Lanthanide nanoparticles: from design toward bioimaging and therapy","volume":"115","author":"Dong","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.actbio.2024.01.018_bib0032","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.actbio.2021.05.014","article-title":"The role of rare earth elements in biodegradable metals: a review","volume":"129","author":"Li","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0033","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.actbio.2018.01.018","article-title":"The degradation and transport mechanism of a Mg-Nd-Zn-Zr stent in rabbit common carotid artery: a 20-month study","volume":"69","author":"Zhang","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0034","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.biomaterials.2015.02.096","article-title":"Enhanced antibacterial properties, biocompatibility, and corrosion resistance of degradable Mg-Nd-Zn-Zr alloy","volume":"53","author":"Qin","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.01.018_bib0035","first-page":"508","article-title":"Comparative in vitro study on binary Mg-RE (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu) alloy systems","volume":"102","author":"Liu","year":"2020"},{"key":"10.1016\/j.actbio.2024.01.018_bib0036","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.actbio.2022.02.015","article-title":"Impact of gadolinium on mechanical properties, corrosion resistance, and biocompatibility of Zn-1Mg-xGd alloys for biodegradable bone-implant applications","volume":"142","author":"Tong","year":"2022","journal-title":"Acta Biomater."},{"issue":"21","key":"10.1016\/j.actbio.2024.01.018_bib0037","article-title":"Modified biodegradation behavior induced beneficial microenvironments for bone regeneration by low addition of gadolinium in zinc","volume":"11","author":"Yang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0038","first-page":"507","article-title":"Systematic in vitro and in vivo study on biodegradable binary Zn-0.2 at% rare earth alloys (Zn-RE: Sc, Y, La-Nd, Sm-Lu)","volume":"24","author":"Du","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0039","doi-asserted-by":"crossref","unstructured":"C.J. Shuai, M.L. Yang, F. Deng, Y.W. Yang, S.P. Peng, F.W. Qi, H.X. Liang, Forming quality, mechanical properties, and anti-inflammatory activity of additive manufactured Zn-Nd alloy, J. Zhejiang Univ.\u2013Sci. A 21(11) (2020) 876\u2013891.","DOI":"10.1631\/jzus.A2000186"},{"key":"10.1016\/j.actbio.2024.01.018_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2021.108882","article-title":"Rare earth improves strength and creep resistance of additively manufactured Zn implants","volume":"216","author":"Yang","year":"2021","journal-title":"Compos. Part B-Eng"},{"key":"10.1016\/j.actbio.2024.01.018_bib0041","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.actbio.2022.10.053","article-title":"Biodegradable Zn-Dy binary alloys with high strength, ductility, cytocompatibility, and antibacterial ability for bone-implant applications","volume":"155","author":"Tong","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0042","series-title":"Standard Test Methods for Tension Testing of Metallic Materials","year":"2011"},{"key":"10.1016\/j.actbio.2024.01.018_bib0043","series-title":"Standard Practice for Calculation of Corrosion Rates and Related Information from Electrochemical Measurements","year":"2015"},{"key":"10.1016\/j.actbio.2024.01.018_bib0044","series-title":"Standard Guide for Laboratory Immersion Corrosion Testing of Metals","year":"2013"},{"key":"10.1016\/j.actbio.2024.01.018_bib0045","series-title":"Biological Evaluation of Medical Devices. Part 5: Tests For In Vitro Cytotoxicity","year":"2009"},{"key":"10.1016\/j.actbio.2024.01.018_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.137946","article-title":"Zinc phosphate, zinc oxide, and their dual-phase coatings on pure Zn foam with good corrosion resistance, cytocompatibility, and antibacterial ability for potential biodegradable bone-implant applications","volume":"450","author":"Zhu","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2024.01.018_bib0047","series-title":"Biological Evaluation of Medical Devices. Part 12: Sample Preparation and Reference Materials","year":"2012"},{"key":"10.1016\/j.actbio.2024.01.018_bib0048","series-title":"Textile Fabrics-Determination of Antibacterial Activity-Agar Diffusion Plate Test","year":"2004"},{"key":"10.1016\/j.actbio.2024.01.018_bib0049","series-title":"Microbiology of the Food Chain\u2013Horizontal Method for the Enumeration of Coagulase-Positive Staphylococci (Staphylococcus Aureus and Other Species)\u2013Part 1: Method Using Baird-Parker Agar Medium","year":"2021"},{"key":"10.1016\/j.actbio.2024.01.018_bib0050","article-title":"ZnP-coated Zn-1Cu-0.1Ti membrane with high strength-ductility, antibacterial ability, cytocompatibility, and osteogenesis for biodegradable guided bone regeneration applications","author":"Tong","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2024.01.018_bib0051","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.vacuum.2010.04.007","article-title":"Influence of CH4 fraction on the composition, structure, and internal stress of the TiCN coatings deposited by LAFAD technique","volume":"85","author":"Cheng","year":"2010","journal-title":"Vacuum"},{"key":"10.1016\/j.actbio.2024.01.018_bib0052","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.msea.2017.08.095","article-title":"Evolution of microstructure and its influence on tensile properties in thermo-mechanically controlled processed (TMCP) quench and partition (Q&P) steel","volume":"705","author":"Parthiban","year":"2017","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.actbio.2024.01.018_bib0053","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.actbio.2020.09.036","article-title":"Development of biodegradable Zn-1Mg-0.1RE (RE= Er, Dy, and Ho) alloys for biomedical applications","volume":"117","author":"Tong","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0054","article-title":"Effect of Y content on properties of extruded Zn-1.5Mg-xY alloys for medical applications","volume":"22","author":"Zhang","year":"2019","journal-title":"Mater. Res."},{"issue":"3","key":"10.1016\/j.actbio.2024.01.018_bib0055","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bone.2008.08.112","article-title":"Peri-graft bone mass and connectivity as predictors for the strength of tendon-to-bone attachment after anterior cruciate ligament reconstruction","volume":"45","author":"Wen","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2024.01.018_bib0056","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.corsci.2019.05.018","article-title":"Comparative studies of Tris-HCl, HEPES and NaHCO3\/CO2 buffer systems on the biodegradation behaviour of pure Zn in NaCl and SBF solutions","volume":"157","author":"Liu","year":"2019","journal-title":"Corros. Sci."},{"issue":"6","key":"10.1016\/j.actbio.2024.01.018_bib0057","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0924-8579(02)00115-2","article-title":"Antibacterial effect of intraprostatic zinc injection in a rat model of chronic bacterial prostatitis","volume":"19","author":"Cho","year":"2002","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"3\u20134","key":"10.1016\/j.actbio.2024.01.018_bib0058","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0022-1902(61)80142-5","article-title":"Electronegativity values from thermochemical data","volume":"17","author":"Allred","year":"1961","journal-title":"J. Inorg. Nucl. Chem."},{"issue":"10","key":"10.1016\/j.actbio.2024.01.018_bib0059","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1063\/1.1725697","article-title":"Atomic radii in crystals","volume":"41","author":"Slater","year":"1964","journal-title":"J. Chem. Phys."},{"issue":"6","key":"10.1016\/j.actbio.2024.01.018_bib0060","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/adem.200700240","article-title":"Solid-solution phase formation rules for multi-component alloys","volume":"10","author":"Zhang","year":"2008","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0061","series-title":"Binary Alloy Phase Diagrams","first-page":"12","author":"Okamoto","year":"1990"},{"key":"10.1016\/j.actbio.2024.01.018_bib0062","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jallcom.2015.02.227","article-title":"Critical assessment and optimization of phase diagrams and thermodynamic properties of RE-Zn systems-Part II-Y-Zn, Eu-Zn, Gd-Zn, Tb-Zn, Dy-Zn, Ho-Zn, Er-Zn, Tm-Zn, Yb-Zn and Lu-Zn","volume":"641","author":"Zhu","year":"2015","journal-title":"J. Alloys Compd."},{"issue":"12","key":"10.1016\/j.actbio.2024.01.018_bib0063","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.scriptamat.2009.02.048","article-title":"Effects of Sm addition on microstructure and mechanical properties of Mg-6Al-0.6Zn alloy","volume":"60","author":"Li","year":"2009","journal-title":"Scr. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0064","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.scriptamat.2017.11.004","article-title":"The effect of rare earth element segregation on grain boundary energy and mobility in magnesium and ensuing texture weakening","volume":"146","author":"Barrett","year":"2018","journal-title":"Scr. Mater."},{"issue":"10","key":"10.1016\/j.actbio.2024.01.018_bib0065","doi-asserted-by":"crossref","DOI":"10.1088\/2053-1591\/ab35bd","article-title":"Effects of rare earth modification on microstructure refinement and mechanical properties of Al-2 wt% Fe alloys","volume":"6","author":"Liang","year":"2019","journal-title":"Mater. Res. Express"},{"key":"10.1016\/j.actbio.2024.01.018_bib0066","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.actbio.2022.11.060","article-title":"Microstructures, mechanical and corrosion properties of graphene nanoplatelet-reinforced zinc matrix composites for implant applications","volume":"157","author":"Kabir","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.03.005","article-title":"Zinc-based alloys for degradable vascular stent applications","volume":"71","author":"Mostaed","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0068","series-title":"Materials Science and Engineering: An Introduction","first-page":"665","author":"Callister","year":"2007"},{"key":"10.1016\/j.actbio.2024.01.018_bib0069","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.msea.2019.01.117","article-title":"Can zinc alloys be strengthened by grain refinement? A critical evaluation of the processing of low-alloyed binary zinc alloys using ECAP","volume":"748","author":"Bednarczyk","year":"2019","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.actbio.2024.01.018_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jallcom.2020.157958","article-title":"Role of second phases and grain boundaries on dynamic recrystallization behavior in ZK60 magnesium alloy","volume":"861","author":"Peng","year":"2021","journal-title":"J. Alloys Compd."},{"issue":"3","key":"10.1016\/j.actbio.2024.01.018_bib0071","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jma.2020.09.018","article-title":"Effect of Ce-base mischmetal addition on the microstructure and mechanical properties of hot-rolled ZK60 alloy","volume":"9","author":"Silva","year":"2021","journal-title":"J. Magnes. Alloy"},{"key":"10.1016\/j.actbio.2024.01.018_bib0072","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.msea.2012.10.044","article-title":"Dynamic recrystallization behavior during hot deformation and mechanical properties of 0.2\u00b5m SiCp reinforced Mg matrix composite","volume":"560","author":"Deng","year":"2013","journal-title":"Mater. Sci. Eng. A"},{"issue":"1\u20132","key":"10.1016\/j.actbio.2024.01.018_bib0073","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.msea.2005.06.009","article-title":"Microstructure evolution during FSW\/FSP of high strength aluminum alloys","volume":"405","author":"Su","year":"2005","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.actbio.2024.01.018_bib0074","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jmst.2019.08.027","article-title":"Improvement of elevated-temperature strength and recrystallization resistance via Mn-containing dispersoid strengthening in Al-Mg-Si 6082 alloys","volume":"39","author":"Li","year":"2020","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.actbio.2024.01.018_bib0075","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.msea.2014.03.126","article-title":"Effect of stacking fault energy on mechanical properties of nanostructured FCC materials processed by the ARB process","volume":"606","author":"Jamaati","year":"2014","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.actbio.2024.01.018_bib0076","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fmats.2020.00198","article-title":"A review on developments in magnesium alloys","volume":"7","author":"Kaya","year":"2020","journal-title":"Front. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.msea.2020.139611","article-title":"Combination effects of Yb addition and cryogenic-rolling on microstructure and mechanical properties of LA141 alloy","volume":"788","author":"Jin","year":"2020","journal-title":"Mater. Sci. Eng. A"},{"issue":"1","key":"10.1016\/j.actbio.2024.01.018_bib0078","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jma.2020.06.021","article-title":"Recent developments and applications on high-performance cast magnesium rare-earth alloys","volume":"9","author":"Wu","year":"2021","journal-title":"J. Magnes. Alloy"},{"issue":"5","key":"10.1016\/j.actbio.2024.01.018_bib0079","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.scriptamat.2010.10.045","article-title":"High-ductility magnesium-zinc-cerium extrusion alloys","volume":"64","author":"Luo","year":"2011","journal-title":"Scr. Mater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0080","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jallcom.2019.05.087","article-title":"Improving the room-temperature formability of Mg-3Al-1Zn alloy sheet by introducing an orthogonal four-peak texture","volume":"797","author":"He","year":"2019","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.actbio.2024.01.018_bib0081","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.scriptamat.2020.08.017","article-title":"Stiff, strong and ductile heterostructured aluminum composites reinforced with oriented nanoplatelets","volume":"189","author":"Nie","year":"2020","journal-title":"Scr. Mater."},{"issue":"8","key":"10.1016\/j.actbio.2024.01.018_bib0082","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmst.2016.01.004","article-title":"Enhanced strength and ductility due to microstructure refinement and texture weakening of the GW102K alloy by cyclic extrusion compression","volume":"32","author":"Lin","year":"2016","journal-title":"J. Mater. Sci. Technol."},{"issue":"15","key":"10.1016\/j.actbio.2024.01.018_bib0083","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1016\/j.actamat.2011.06.005","article-title":"A microcantilever investigation of size effect, solid-solution strengthening and second-phase strengthening for <a>prism slip in alpha-Ti","volume":"59","author":"Gong","year":"2011","journal-title":"Acta Mater"},{"issue":"1\u20132","key":"10.1016\/j.actbio.2024.01.018_bib0084","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.msea.2004.05.027","article-title":"High strain rate response of aluminum 6092\/B4C composites","volume":"384","author":"Zhang","year":"2004","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.actbio.2024.01.018_bib0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jmps.2015.12.012","article-title":"The inverse hall-petch relation in nanocrystalline metals: a discrete dislocation dynamics analysis","volume":"88","author":"Quek","year":"2016","journal-title":"J. Mech. Phys. Solids"},{"issue":"9","key":"10.1016\/j.actbio.2024.01.018_bib0086","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.corsci.2010.04.037","article-title":"Influence of steel-concrete interface condition on galvanic corrosion currents in carbonated concrete","volume":"52","author":"Nasser","year":"2010","journal-title":"Corros. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2024.01.018_bib0087","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.matlet.2010.11.015","article-title":"Homogeneous corrosion of high pressure torsion treated Mg-Zn-Ca alloy in simulated body fluid","volume":"65","author":"Gao","year":"2011","journal-title":"Mater. Lett."},{"issue":"3","key":"10.1016\/j.actbio.2024.01.018_bib0088","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jma.2013.10.003","article-title":"Effect of rare earth and Mn elements on the corrosion behavior of extruded AZ61 system in 3.5 wt% NaCl solution and salt spray test","volume":"1","author":"Zhu","year":"2013","journal-title":"J. Magnes. Alloy"},{"key":"10.1016\/j.actbio.2024.01.018_bib0089","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jallcom.2017.06.269","article-title":"Effect of texture symmetry on mechanical performance and corrosion resistance of magnesium alloy sheet","volume":"723","author":"He","year":"2017","journal-title":"J. Alloys Compd."},{"issue":"11","key":"10.1016\/j.actbio.2024.01.018_bib0090","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1021\/acsbiomaterials.5b00319","article-title":"Endothelial cellular responses to biodegradable metal zinc","volume":"1","author":"Ma","year":"2015","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2024.01.018_bib0091","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1073\/pnas.68.1.229","article-title":"pH as a determinant of cellular growth and contact inhibition","volume":"68","author":"Ceccarini","year":"1971","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.actbio.2024.01.018_bib0092","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.actbio.2015.04.011","article-title":"Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials","volume":"21","author":"Wang","year":"2015","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.actbio.2024.01.018_bib0093","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3390\/ijerph17041399","article-title":"The accumulation and metabolism characteristics of rare earth elements in Sprague-Dawley rats","volume":"17","author":"Cao","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"10","key":"10.1016\/j.actbio.2024.01.018_bib0094","first-page":"1197","article-title":"The different fluorescent response of quin 2 to the binding of Ca2+ and La3+ and its application","volume":"15","author":"Jian","year":"2004","journal-title":"Chin. Chem. Lett."},{"issue":"1","key":"10.1016\/j.actbio.2024.01.018_bib0095","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jinorgbio.2003.08.012","article-title":"Study on biological effect of La3+ on Escherichia coli by atomic force microscopy","volume":"98","author":"Liu","year":"2004","journal-title":"J. Inorg. Biochem."},{"issue":"2","key":"10.1016\/j.actbio.2024.01.018_bib0096","first-page":"210","article-title":"Design biodegradable Zn alloys: second phases and their significant influences on alloy properties","volume":"5","author":"Shi","year":"2020","journal-title":"Bioact. Mater."},{"issue":"14","key":"10.1016\/j.actbio.2024.01.018_bib0097","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJMra035415","article-title":"Treatment of infections associated with surgical implants","volume":"350","author":"Darouiche","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.actbio.2024.01.018_bib0098","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jbm.a.34322","article-title":"In vitro antibacterial evaluation of sol-gel-derived Zn-, Ag-, and (Zn+Ag)-doped hydroxyapatite coatings against methicillin-resistant Staphylococcus aureus","volume":"101","author":"Samani","year":"2013","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.actbio.2024.01.018_bib0099","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2147\/IJN.S121956","article-title":"The antimicrobial activity of nanoparticles: present situation and prospects for the future","volume":"12","author":"Wang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2024.01.018_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119531","article-title":"Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens","volume":"586","author":"Pardhi","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"Pt 6","key":"10.1016\/j.actbio.2024.01.018_bib0101","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1099\/jmm.0.068130-0","article-title":"Aminoglycoside inhibition of Staphylococcus aureus biofilm formation is nutrient dependent","volume":"63","author":"Henry-Stanley","year":"2014","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.actbio.2024.01.018_bib0102","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.actbio.2021.06.004","article-title":"A review of the physiological impact of rare earth elements and their uses in biomedical Mg alloys","volume":"130","author":"Weng","year":"2021","journal-title":"Acta Biomater."},{"issue":"17","key":"10.1016\/j.actbio.2024.01.018_bib0103","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00128-18","article-title":"Reduce, induce, thrive: bacterial redox sensing during pathogenesis","volume":"200","author":"Reniere","year":"2018","journal-title":"J. Bacteriol."},{"issue":"9","key":"10.1016\/j.actbio.2024.01.018_bib0104","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S1357-2725(03)00107-9","article-title":"Osteoblasts: novel roles in orchestration of skeletal architecture","volume":"35","author":"Mackie","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"17","key":"10.1016\/j.actbio.2024.01.018_bib0105","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1557\/s43578-022-00663-6","article-title":"Fabrication of magnesium phosphate bone cement with enhanced osteogenic properties by employing zeolitic imidazolate framework-8","volume":"37","author":"Wang","year":"2022","journal-title":"J. Mater. Res."},{"issue":"25","key":"10.1016\/j.actbio.2024.01.018_bib0106","doi-asserted-by":"crossref","first-page":"14915","DOI":"10.1039\/D0RA01465F","article-title":"Double-edged effects and mechanisms of Zn2+ microenvironments on osteogenic activity of BMSCs: osteogenic differentiation or apoptosis","volume":"10","author":"Yu","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.actbio.2024.01.018_bib0107","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cej.2018.11.071","article-title":"Gadolinium phosphate\/chitosan scaffolds promote new bone regeneration via Smad\/Runx2 pathway","volume":"359","author":"Zhao","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2024.01.018_bib0108","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109999","article-title":"Gadolinium-doped mesoporous calcium silicate\/chitosan scaffolds enhanced bone regeneration ability","volume":"104","author":"Liao","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2024.01.018_bib0109","first-page":"2170","article-title":"Effects of the rare earth ions on bone resorbing function of rabbit mature osteoclasts in vitro","volume":"48","author":"Zhang","year":"2003","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.actbio.2024.01.018_bib0110","series-title":"Nature's Building Blocks: An AZ Guide to the Elements","author":"Emsley","year":"2011"},{"issue":"5","key":"10.1016\/j.actbio.2024.01.018_bib0111","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0160-4120(01)00097-6","article-title":"Rare earth element content in various waste ashes and the potential risk to Japanese soils","volume":"27","author":"Zhang","year":"2001","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.actbio.2024.01.018_bib0112","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.actbio.2009.09.024","article-title":"Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines","volume":"6","author":"Feyerabend","year":"2010","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.actbio.2024.01.018_bib0113","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1476-5381.1961.tb01139.x","article-title":"Toxicological and pharmacological effects of gadolinium and samarium chlorides","volume":"17","author":"Haley","year":"1961","journal-title":"Br. J. Pharmacol. Chemother."},{"issue":"5","key":"10.1016\/j.actbio.2024.01.018_bib0114","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/jps.2600540502","article-title":"Pharmacology and toxicology of the rare earth elements","volume":"54","author":"Haley","year":"1965","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.actbio.2024.01.018_bib0115","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.actbio.2016.11.024","article-title":"Gadolinium accumulation in organs of Sprague-Dawley\u00ae rats after implantation of a biodegradable magnesium-gadolinium alloy","volume":"48","author":"Myrissa","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.01.018_bib0116","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jallcom.2014.02.175","article-title":"Formation of profuse long period stacking ordered microcells in Mg-Gd-Zn-Zr alloy during multipass ECAP process","volume":"601","author":"Lu","year":"2014","journal-title":"J. Alloys Compd."},{"issue":"5","key":"10.1016\/j.actbio.2024.01.018_bib0117","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1089\/ars.2008.2318","article-title":"The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase","volume":"11","author":"Tibodeau","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.actbio.2024.01.018_bib0118","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.actbio.2017.05.045","article-title":"Long-term surveillance of zinc implant in murine artery: surprisingly steady biocorrosion rate","volume":"58","author":"Drelich","year":"2017","journal-title":"Acta Biomater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T01:39:27Z","timestamp":1762393167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":118,"alternative-id":["S1742706124000199"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.01.018","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A biodegradable Zn-5Gd alloy with biomechanical compatibility, cytocompatibility, antibacterial ability, and in vitro and in vivo osteogenesis for orthopedic applications","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}