{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:43:42Z","timestamp":1791974622644,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008867","name":"Zhejiang Province Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Zhejiang Provincial Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.actbio.2024.02.044","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T17:33:58Z","timestamp":1709746438000},"page":"243-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Tumor-targeted delivery of copper-manganese biomineralized oncolytic adenovirus for colorectal cancer immunotherapy"],"prefix":"10.1016","volume":"179","author":[{"given":"Yi-Shu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Yi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Xi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Xing","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Ni","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-6325","authenticated-orcid":false,"given":"Tong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Zhou","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.actbio.2024.02.044_bib0001","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/17460441.2021.1850689","article-title":"The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy?","volume":"16","author":"Zhang","year":"2020","journal-title":"Expert Opin. Drug Discov."},{"issue":"1","key":"10.1016\/j.actbio.2024.02.044_bib0002","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/v2010078","article-title":"Oncolytic viruses for cancer therapy: overcoming the obstacles","volume":"2","author":"Wong","year":"2010","journal-title":"Viruses"},{"issue":"11","key":"10.1016\/j.actbio.2024.02.044_bib0003","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.3390\/v7112923","article-title":"Oncolytic adenovirus: strategies and insights for vector design and immuno-oncolytic applications","volume":"7","author":"Uusi-Kerttula","year":"2015","journal-title":"Viruses"},{"issue":"3","key":"10.1016\/j.actbio.2024.02.044_bib0004","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41571-022-00719-w","article-title":"Therapy with oncolytic viruses: progress and challenges","volume":"20","author":"Shalhout","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2024.02.044_bib0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrmicro3140","article-title":"New viruses for cancer therapy: meeting clinical needs","volume":"12","author":"Miest","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.actbio.2024.02.044_bib0006","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/2326-6066.CIR-19-0628","article-title":"Intratumoral delivery of a PD-1\u2013blocking scFv encoded in oncolytic HSV-1 promotes antitumor immunity and synergizes with TIGIT blockade","volume":"8","author":"Lin","year":"2020","journal-title":"Cancer Immunol. Res."},{"issue":"19","key":"10.1016\/j.actbio.2024.02.044_bib0007","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1158\/0008-5472.CAN-20-0471","article-title":"Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion","volume":"80","author":"Voli","year":"2020","journal-title":"Cancer Res."},{"issue":"36","key":"10.1016\/j.actbio.2024.02.044_bib0008","doi-asserted-by":"crossref","first-page":"11764","DOI":"10.1002\/anie.201807595","article-title":"Hybrid nanoreactors: enabling an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy","volume":"57","author":"Yang","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2024.02.044_bib0009","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.actbio.2019.09.030","article-title":"Activating macrophages for enhanced osteogenic and bactericidal performance by Cu ion release from micro\/nano-topographical coating on a titanium substrate","volume":"100","author":"Huang","year":"2019","journal-title":"Acta Biomater."},{"issue":"11","key":"10.1016\/j.actbio.2024.02.044_bib0010","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/sj.gt.3302448","article-title":"Effect of hypoxia on Ad5 infection, transgene expression and replication","volume":"12","author":"Shen","year":"2005","journal-title":"Gene Ther."},{"issue":"12","key":"10.1016\/j.actbio.2024.02.044_bib0011","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/sj.gt.3302736","article-title":"The effect of hypoxia on the uptake, replication and lytic potential of group B adenovirus type 3 (Ad3) and type 11p (Ad11p)","volume":"13","author":"Shen","year":"2006","journal-title":"Gene Ther."},{"issue":"11","key":"10.1016\/j.actbio.2024.02.044_bib0012","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1021\/acs.nanolett.9b03193","article-title":"MnCaCs-biomineralized oncolytic virus for bimodal imaging-guided and synergistically enhanced anticancer therapy","volume":"19","author":"Huang","year":"2019","journal-title":"Nano Lett."},{"issue":"7738","key":"10.1016\/j.actbio.2024.02.044_bib0013","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/d41586-018-07728-9","article-title":"Immune cells track hard-to-target brain tumours","volume":"565","author":"Zaidi","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.actbio.2024.02.044_bib0014","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1073\/pnas.1904022116","article-title":"Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer","volume":"117","author":"Newman","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"52","key":"10.1016\/j.actbio.2024.02.044_bib0015","doi-asserted-by":"crossref","first-page":"32962","DOI":"10.1073\/pnas.2011297117","article-title":"Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot","volume":"117","author":"Li","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.actbio.2024.02.044_bib0016","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s41565-021-00962-9","article-title":"Amplifying STING activation by cyclic dinucleotide\u2013manganese particles for local and systemic cancer metalloimmunotherapy","volume":"16","author":"Sun","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"4","key":"10.1016\/j.actbio.2024.02.044_bib0017","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.immuni.2018.03.017","article-title":"Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses","volume":"48","author":"Wang","year":"2018","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.actbio.2024.02.044_bib0018","doi-asserted-by":"crossref","first-page":"16909","DOI":"10.1021\/acsnano.2c06926","article-title":"Manganese coordination micelles that activate stimulator of interferon genes and capture in situ tumor antigens for cancer metalloimmunotherapy","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.actbio.2024.02.044_bib0019","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nrurol.2016.84","article-title":"Oncolytic virotherapy for urological cancers","volume":"13","author":"Delwar","year":"2016","journal-title":"Nat. Rev. Urol."},{"issue":"12","key":"10.1016\/j.actbio.2024.02.044_bib0020","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nrc1750","article-title":"Recent progress in the battle between oncolytic viruses and tumours","volume":"5","author":"Parato","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.actbio.2024.02.044_bib0021","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1021\/acs.nanolett.2c00699","article-title":"Boarding oncolytic viruses onto tumor-homing bacterium-vessels for augmented cancer immunotherapy","volume":"22","author":"Sun","year":"2022","journal-title":"Nano Lett"},{"issue":"4","key":"10.1016\/j.actbio.2024.02.044_bib0022","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1172\/JCI122287","article-title":"Oncolytic viruses: overcoming translational challenges","volume":"129","author":"Martinez-Quintanilla","year":"2019","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.actbio.2024.02.044_bib0023","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/sj.cgt.7701080","article-title":"A phase I trial of intravenous infusion of ONYX-015 and enbrel in solid tumor patients","volume":"14","author":"Nemunaitis","year":"2007","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.actbio.2024.02.044_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/805629","article-title":"Systemic delivery of oncolytic viruses: hopes and hurdles","volume":"2012","author":"Ferguson","year":"2012","journal-title":"Adv. Virol."},{"key":"10.1016\/j.actbio.2024.02.044_bib0025","doi-asserted-by":"crossref","first-page":"121089","DOI":"10.1016\/j.biomaterials.2021.121089","article-title":"Nanovaccine biomineralization for cancer immunotherapy: a NADPH oxidase-inspired strategy for improving antigen cross-presentation via lipid peroxidation","volume":"277","author":"Su","year":"2021","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.actbio.2024.02.044_bib0026","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1039\/C9RA90008J","article-title":"Correction: gold nanoparticle coatings as efficient adenovirus carriers to non-infectable stem cells","volume":"9","author":"Hernandez","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.actbio.2024.02.044_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119782","article-title":"Transdermal colorimetric patch for hyperglycemia sensing in diabetic mice","volume":"237","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2024.02.044_bib0028","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-38679-z","article-title":"Engineered bacterial outer membrane vesicles encapsulating oncolytic adenoviruses enhance the efficacy of cancer virotherapy by augmenting tumor cell autophagy","volume":"14","author":"Ban","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.actbio.2024.02.044_bib0029","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s12250-021-00434-3","article-title":"A self-biomineralized novel adenovirus vectored COVID-19 vaccine for boosting immunization of mice","volume":"36","author":"Luo","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.actbio.2024.02.044_bib0030","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jconrel.2015.10.009","article-title":"Polymeric oncolytic adenovirus for cancer gene therapy","volume":"219","author":"Choi","year":"2015","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.actbio.2024.02.044_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202006892","article-title":"Nanocatalytic theranostics with glutathione depletion and enhanced reactive oxygen species generation for efficient cancer therapy","volume":"33","author":"Fu","year":"2021","journal-title":"Adv. Mater."},{"issue":"12","key":"10.1016\/j.actbio.2024.02.044_bib0032","doi-asserted-by":"crossref","first-page":"13985","DOI":"10.1021\/acsnano.9b05836","article-title":"Biodegradable manganese-doped calcium phosphate nanotheranostics for traceable cascade reaction-enhanced anti-tumor therapy","volume":"13","author":"Fu","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2024.02.044_bib0033","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biomaterials.2019.03.014","article-title":"Ultrasmall Cu2-xS nanodots as photothermal-enhanced Fenton nanocatalysts for synergistic tumor therapy at NIR-II biowindow","volume":"206","author":"Hu","year":"2019","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2024.02.044_bib0034","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/jacs.8b08714","article-title":"Self-assembled copper\u2013amino acid nanoparticles for in situ glutathione \u201cAND\u201d H2O2 sequentially triggered chemodynamic therapy","volume":"141","author":"Ma","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"10.1016\/j.actbio.2024.02.044_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201801733","article-title":"Nanocatalytic tumor therapy by biomimetic dual inorganic nanozyme-catalyzed cascade reaction","volume":"6","author":"Gao","year":"2018","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2024.02.044_bib0036","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.micinf.2016.10.004","article-title":"Virus\u2013host interactions under hypoxia","volume":"19","author":"Vassilaki","year":"2017","journal-title":"Microbes Infect."},{"issue":"1","key":"10.1016\/j.actbio.2024.02.044_bib0037","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm1523","article-title":"Calreticulin exposure dictates the immunogenicity of cancer cell death","volume":"13","author":"Obeid","year":"2006","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.actbio.2024.02.044_bib0038","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.apsb.2021.02.001","article-title":"Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy","volume":"11","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"11","key":"10.1016\/j.actbio.2024.02.044_bib0039","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41565-019-0567-y","article-title":"Smart cancer nanomedicine","volume":"14","author":"van der Meel","year":"2019","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.actbio.2024.02.044_bib0040","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.apsb.2021.05.016","article-title":"Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy","volume":"12","author":"Ma","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"15","key":"10.1016\/j.actbio.2024.02.044_bib0041","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.7150\/thno.44569","article-title":"TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy","volume":"10","author":"Luo","year":"2020","journal-title":"Theranostics"},{"issue":"21","key":"10.1016\/j.actbio.2024.02.044_bib0042","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202201706","article-title":"Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy","volume":"34","author":"Chen","year":"2022","journal-title":"Adv. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2024.02.044_bib0043","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.celrep.2015.04.031","article-title":"Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity","volume":"11","author":"Corrales","year":"2015","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.actbio.2024.02.044_bib0044","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/nnano.2016.168","article-title":"Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues","volume":"11","author":"Zanganeh","year":"2016","journal-title":"Nat. Nanotechnol."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124001168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124001168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T09:16:04Z","timestamp":1714468564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124001168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":44,"alternative-id":["S1742706124001168"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.02.044","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor-targeted delivery of copper-manganese biomineralized oncolytic adenovirus for colorectal cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.02.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}