{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:46:46Z","timestamp":1792716406111,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.actbio.2024.03.021","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T18:07:29Z","timestamp":1711649249000},"page":"220-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Injectable microspheres adhering to the cartilage matrix promote rapid reconstruction of partial-thickness cartilage defects"],"prefix":"10.1016","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-9830","authenticated-orcid":false,"given":"Xiaoyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2024.03.021_bib0001","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.actbio.2024.03.021_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121169","article-title":"Injectable mussel-inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration","volume":"278","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.actbio.2024.03.021_bib0003","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41584-023-00979-5","article-title":"Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies","volume":"19","author":"Muthu","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.actbio.2024.03.021_bib0004","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.addr.2006.01.012","article-title":"Cartilage tissue engineering for degenerative joint disease","volume":"58","author":"Nesic","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2024.03.021_bib0005","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5690252","article-title":"Clinical application status of articular cartilage regeneration techniques: tissue-engineered cartilage brings new hope","volume":"2020","author":"Jiang","year":"2020","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.actbio.2024.03.021_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114647","article-title":"Protein-engineered biomaterials for cartilage therapeutics and repair","volume":"192","author":"Haq-Siddiqi","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2024.03.021_bib0007","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.actbio.2021.01.003","article-title":"Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis","volume":"123","author":"Rahimi","year":"2021","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0008","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20220014","article-title":"Functional biomaterials for osteoarthritis treatment: from research to application","volume":"1","author":"Lei","year":"2022","journal-title":"Smart Med."},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0009","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrrheum.2014.157","article-title":"Repair and tissue engineering techniques for articular cartilage","volume":"11","author":"Makris","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2024.03.021_bib0010","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.2147\/IJN.S382737","article-title":"Advances in the treatment of partial-thickness cartilage defect","volume":"17","author":"Sun","year":"2022","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"10.1016\/j.actbio.2024.03.021_bib0011","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s11427-014-4673-7","article-title":"Treatment of osteoarthritis with mesenchymal stem cells","volume":"57","author":"Wang","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.actbio.2024.03.021_bib0012","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.actbio.2021.12.034","article-title":"Sodium alginate microencapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis","volume":"141","author":"McKinney","year":"2022","journal-title":"Acta Biomater."},{"issue":"12","key":"10.1016\/j.actbio.2024.03.021_bib0013","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrrheum.2017.182","article-title":"Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis","volume":"13","author":"McGonagle","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2024.03.021_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101684","article-title":"Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis","volume":"80","author":"Yu","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0015","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/s13287-020-01885-3","article-title":"Synovial membrane mesenchymal stem cells: past life, current situation, and application in bone and joint diseases","volume":"11","author":"Li","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0016","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1089\/ten.teb.2018.0119","article-title":"Advances in porous scaffold design for bone and cartilage tissue engineering and regeneration","volume":"25","author":"Cheng","year":"2019","journal-title":"Tissue Eng. Part B"},{"key":"10.1016\/j.actbio.2024.03.021_bib0017","first-page":"47","article-title":"Biomedical applications of gelatin methacryloyl hydrogels","volume":"2","author":"Piao","year":"2021","journal-title":"Eng. Regen."},{"issue":"36","key":"10.1016\/j.actbio.2024.03.021_bib0018","doi-asserted-by":"crossref","first-page":"40711","DOI":"10.1021\/acsami.2c12703","article-title":"Nanoarchitectonics of cartilage-targeting hydrogel microspheres with reactive oxygen species responsiveness for the repair of osteoarthritis","volume":"14","author":"Yu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"46","key":"10.1016\/j.actbio.2024.03.021_bib0019","doi-asserted-by":"crossref","first-page":"54801","DOI":"10.1021\/acsami.1c17629","article-title":"Biomimetic joint paint for efficient cartilage repair by simultaneously regulating cartilage degeneration and regeneration in pigs","volume":"13","author":"Wei","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"20","key":"10.1016\/j.actbio.2024.03.021_bib0020","doi-asserted-by":"crossref","first-page":"22467","DOI":"10.1021\/acsami.0c01776","article-title":"Tissue-adhesive paint of silk microparticles for articular surface cartilage regeneration","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"11","key":"10.1016\/j.actbio.2024.03.021_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering10111315","article-title":"Controlled-release hydrogel microspheres to deliver multipotent stem cells for treatment of knee osteoarthritis","volume":"10","author":"Hamilton","year":"2023","journal-title":"Bioengineering"},{"issue":"18","key":"10.1016\/j.actbio.2024.03.021_bib0022","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1039\/D3TB00105A","article-title":"Functional injectable hydrogel with spatiotemporal sequential release for recruitment of endogenous stem cells and in situ cartilage regeneration","volume":"11","author":"Dai","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2024.03.021_bib0023","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bmt.2022.11.002","article-title":"Injectable hydrogel microspheres in cartilage repair","volume":"1","author":"Lin","year":"2023","journal-title":"Biomed. Technol."},{"key":"10.1016\/j.actbio.2024.03.021_bib0024","article-title":"Enhanced cartilage regeneration by icariin and mesenchymal stem cell-derived extracellular vesicles combined in alginate-hyaluronic acid hydrogel","volume":"55","author":"Li","year":"2024","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0025","article-title":"Functionalizing PLGA and PLGA derivatives for drug delivery and tissue regeneration applications","volume":"7","author":"Martins","year":"2018","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0026","first-page":"110","article-title":"Microfluidic bioscaffolds for regenerative engineering","volume":"3","author":"Zhuge","year":"2022","journal-title":"Eng. Regener."},{"key":"10.1016\/j.actbio.2024.03.021_bib0027","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actbio.2021.03.067","article-title":"Recent advances in PLGA-based biomaterials for bone tissue regeneration","volume":"127","author":"Jin","year":"2021","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0028","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s40824-023-00411-9","article-title":"Multifunctional hydrogels: advanced therapeutic tools for osteochondral regeneration","volume":"27","author":"Zhang","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.actbio.2024.03.021_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120539","article-title":"Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration","volume":"269","author":"Xu","year":"2021","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.actbio.2024.03.021_bib0030","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1021\/acsami.8b22123","article-title":"Functionalization of silk fibroin electrospun scaffolds via bmsc affinity peptide grafting through oxidative self-polymerization of dopamine for bone regeneration","volume":"11","author":"Wu","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2024.03.021_bib0031","article-title":"3D printed poly(epsilon-caprolactone)\/meniscus extracellular matrix composite scaffold functionalized with kartogenin-releasing PLGA microspheres for meniscus tissue engineering","volume":"9","author":"Li","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2024.03.021_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.600103","article-title":"Cartilage Extracellular matrix Scaffold with kartogenin-encapsulated PLGA microspheres for cartilage regeneration","volume":"8","author":"Zhao","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.actbio.2024.03.021_bib0033","article-title":"Stem cells expansion vector via bioadhesive porous microspheres for accelerating articular cartilage regeneration","volume":"13","author":"Bai","year":"2024","journal-title":"Adv. Healthc. Mater."},{"issue":"40","key":"10.1016\/j.actbio.2024.03.021_bib0034","doi-asserted-by":"crossref","first-page":"47341","DOI":"10.1021\/acsami.1c11772","article-title":"Polydopamine-decorated microcomposites promote functional recovery of an injured spinal cord by inhibiting neuroinflammation","volume":"13","author":"Wei","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"40","key":"10.1016\/j.actbio.2024.03.021_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202202156","article-title":"Injectable double positively charged hydrogel microspheres for targeting-penetration-phagocytosis","volume":"18","author":"Lin","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.actbio.2024.03.021_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121545","article-title":"Nanofat functionalized injectable super-lubricating microfluidic microspheres for treatment of osteoarthritis","volume":"285","author":"Han","year":"2022","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0037","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2024.03.021_bib0038","first-page":"485","article-title":"Functional microspheres for tissue regeneration","volume":"25","author":"Li","year":"2023","journal-title":"Bioact. Mater."},{"issue":"8","key":"10.1016\/j.actbio.2024.03.021_bib0039","doi-asserted-by":"crossref","first-page":"8537","DOI":"10.1021\/acsnano.9b04436","article-title":"Versatile polydopamine platforms: synthesis and promising applications for surface modification and advanced nanomedicine","volume":"13","author":"Cheng","year":"2019","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.actbio.2024.03.021_bib0040","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1021\/acsami.7b19865","article-title":"Polydopamine surface chemistry: a decade of discovery","volume":"10","author":"Ryu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2024.03.021_bib0041","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.actbio.2023.07.024","article-title":"Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineering","volume":"168","author":"Xu","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.03.021_bib0042","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.12659\/MSM.916918","article-title":"Lithium chloride-releasing 3D printed scaffold for enhanced cartilage regeneration","volume":"25","author":"Li","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"36","key":"10.1016\/j.actbio.2024.03.021_bib0043","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1016\/j.biomaterials.2014.08.020","article-title":"A functional biphasic biomaterial homing mesenchymal stem cells for in vivo cartilage regeneration","volume":"35","author":"Huang","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0044","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1021\/acsnano.5b06663","article-title":"Photo-cross-linked scaffold with kartogenin-encapsulated nanoparticles for cartilage regeneration","volume":"10","author":"Shi","year":"2016","journal-title":"ACS Nano"},{"issue":"17","key":"10.1016\/j.actbio.2024.03.021_bib0045","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.scib.2023.07.050","article-title":"Enhanced osteochondral repair with hyaline cartilage formation using an extracellular matrix-inspired natural scaffold","volume":"68","author":"Dai","year":"2023","journal-title":"Sci. Bull."},{"issue":"48","key":"10.1016\/j.actbio.2024.03.021_bib0046","article-title":"Stem cell-recruiting injectable microgels for repairing osteoarthritis","volume":"31","author":"Lei","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2024.03.021_bib0047","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/1061186X.2018.1464011","article-title":"Recent advances in kartogenin for cartilage regeneration","volume":"27","author":"Cai","year":"2019","journal-title":"J. Drug Target."},{"issue":"18","key":"10.1016\/j.actbio.2024.03.021_bib0048","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202005513","article-title":"Recent progress in cartilage lubrication","volume":"33","author":"Lin","year":"2021","journal-title":"Adv. Mater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124001491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124001491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T09:17:33Z","timestamp":1714468653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124001491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":48,"alternative-id":["S1742706124001491"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.03.021","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injectable microspheres adhering to the cartilage matrix promote rapid reconstruction of partial-thickness cartilage defects","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}