{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:01:26Z","timestamp":1789041686621,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009401","name":"LMU Munich Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.actbio.2024.04.023","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:14:43Z","timestamp":1713312883000},"page":"128-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Inflammatory tissue response in human soft tissue is caused by a higher particle load near carbon fiber-reinforced PEEK compared to titanium plates"],"prefix":"10.1016","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-624X","authenticated-orcid":false,"given":"E","family":"Fleischhacker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CM","family":"Sprecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Milz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MM","family":"Saller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wirz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0811-7396","authenticated-orcid":false,"given":"R","family":"Zboray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Parrilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Gleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Siebenb\u00fcrger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"B\u00f6cker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Ockert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Helfen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.actbio.2024.04.023_bib0001","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12891-018-2223-3","article-title":"Open reduction internal fixation vs non-operative management in proximal humerus fractures: a prospective, randomized controlled trial protocol","volume":"19","author":"Howard","year":"2018","journal-title":"BMC Musculoskelet. Disord."},{"issue":"12","key":"10.1016\/j.actbio.2024.04.023_bib0002","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s00113-006-1165-7","article-title":"[Treatment of proximal humeral fractures with the PHILOS angular stable plate. Presentation of 225 cases of dislocated fractures]","volume":"109","author":"Kettler","year":"2006","journal-title":"Unfallchirurg"},{"issue":"8","key":"10.1016\/j.actbio.2024.04.023_bib0003","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.jse.2013.11.009","article-title":"Long-term functional outcomes (median 10 years) after locked plating for displaced fractures of the proximal humerus","volume":"23","author":"Ockert","year":"2014","journal-title":"J. Shoulder Elbow Surg."},{"key":"10.1016\/j.actbio.2024.04.023_bib0004","doi-asserted-by":"crossref","unstructured":"Thomsen, M. and P. Thomas, [Compatibility and allergies of osteosynthesis materials]. Unfallchirurg, 2017. 120(2): p. 116\u2013121.","DOI":"10.1007\/s00113-016-0309-7"},{"issue":"2","key":"10.1016\/j.actbio.2024.04.023_bib0005","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0142-9612(02)00312-5","article-title":"Immuno-inflammatory tissue reaction to stainless-steel and titanium plates used for internal fixation of long bones","volume":"24","author":"Voggenreiter","year":"2003","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2024.04.023_bib0006","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.dental.2020.01.013","article-title":"Titanium and zirconium release from titanium- and zirconia implants in mini pig maxillae and their toxicity in vitro","volume":"36","author":"He","year":"2020","journal-title":"Dent. Mater."},{"issue":"32","key":"10.1016\/j.actbio.2024.04.023_bib0007","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1016\/j.biomaterials.2007.07.013","article-title":"PEEK biomaterials in trauma, orthopedic, and spinal implants","volume":"28","author":"Kurtz","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.04.023_bib0008","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4137\/CMAMD.S20354","article-title":"The use of carbon-fiber-reinforced (CFR) PEEK material in orthopedic implants: a systematic review","volume":"8","author":"Li","year":"2015","journal-title":"Clin. Med. Insights Arthritis Musculoskelet. Disord."},{"issue":"2","key":"10.1016\/j.actbio.2024.04.023_bib0009","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1021\/acsbiomaterials.9b01148","article-title":"Mixed modification of the surface microstructure and chemical state of polyetheretherketone to improve its antimicrobial activity, hydrophilicity, cell adhesion, and bone integration","volume":"6","author":"Ding","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"8","key":"10.1016\/j.actbio.2024.04.023_bib0010","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/clr.13487","article-title":"Soft tissue response to dental implant closure caps made of either polyetheretherketone (PEEK) or titanium","volume":"30","author":"Caballe-Serrano","year":"2019","journal-title":"Clin. Oral Implants Res."},{"issue":"24","key":"10.1016\/j.actbio.2024.04.023_bib0011","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1097\/00007632-200112150-00025","article-title":"Bone graft incorporation in radiographically successful human intervertebral body fusion cages","volume":"26","author":"Togawa","year":"2001","journal-title":"Spine (Phila Pa 1976)"},{"issue":"16","key":"10.1016\/j.actbio.2024.04.023_bib0012","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1097\/00007632-199808150-00016","article-title":"Failure of a carbon fiber implant. A case report","volume":"23","author":"Tullberg","year":"1998","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"10.1016\/j.actbio.2024.04.023_bib0013","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10856-015-5664-3","article-title":"Debris of carbon-fibers originated from a CFRP (pEEK) wrist-plate triggered a destruent synovitis in human","volume":"27","author":"Merolli","year":"2016","journal-title":"J. Mater. Sci. Mater.. Med"},{"issue":"Pt 1","key":"10.1016\/j.actbio.2024.04.023_bib0014","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2818.2002.01010.x","article-title":"Simultaneous phase and amplitude extraction from a single defocused image of a homogeneous object","volume":"206","author":"Paganin","year":"2002","journal-title":"J. Microsc."},{"issue":"2","key":"10.1016\/j.actbio.2024.04.023_bib0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/jmi.12986","article-title":"Optimizing and applying high-resolution, in-line laboratory phase-contrast X-ray imaging for low-density material samples","volume":"282","author":"Zboray","year":"2021","journal-title":"J. Microsc."},{"key":"10.1016\/j.actbio.2024.04.023_bib0016","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1364\/JOSAA.1.000612","article-title":"Practical cone-beam algorithm","volume":"1","author":"Feldkamp","year":"1984","journal-title":"J. Opt. Soc. Am."},{"key":"10.1016\/j.actbio.2024.04.023_bib0017","doi-asserted-by":"crossref","first-page":"117","DOI":"10.22203\/eCM.v019a12","article-title":"Surface polishing positively influences ease of plate and screw removal","volume":"19","author":"Hayes","year":"2010","journal-title":"Eur. Cell Mater."},{"issue":"3","key":"10.1016\/j.actbio.2024.04.023_bib0018","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.injury.2016.01.004","article-title":"Influence of plate material and screw design on stiffness and ultimate load of locked plating in osteoporotic proximal humeral fractures","volume":"47","author":"Katthagen","year":"2016","journal-title":"Injury"},{"issue":"1","key":"10.1016\/j.actbio.2024.04.023_bib0019","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00402-016-2620-8","article-title":"PEEK versus titanium locking plates for proximal humerus fracture fixation: a comparative biomechanical study in two- and three-part fractures","volume":"137","author":"Schliemann","year":"2017","journal-title":"Arch. Orthop. Trauma Surg."},{"issue":"2","key":"10.1016\/j.actbio.2024.04.023_bib0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5435\/00124635-200602000-00006","article-title":"Hardware removal: indications and expectations","volume":"14","author":"Busam","year":"2006","journal-title":"J. Am. Acad. Orthop. Surg."},{"issue":"2","key":"10.1016\/j.actbio.2024.04.023_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/jfb13020064","article-title":"Computational contact pressure prediction of CoCrMo, SS 316L and Ti6Al4V femoral head against UHMWPE acetabular cup under gait cycle","volume":"13","author":"Jamari","year":"2022","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.actbio.2024.04.023_bib0022","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.actbio.2023.01.051","article-title":"Isolation and characterisation of wear debris surrounding failed total ankle replacements","volume":"159","author":"Stratton-Powell","year":"2023","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.actbio.2024.04.023_bib0023","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s10856-007-3256-6","article-title":"Pre-clinical studies to validate the MITCH PCR Cup: a flexible and anatomically shaped acetabular component with novel bearing characteristics","volume":"19","author":"Latif","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"6","key":"10.1016\/j.actbio.2024.04.023_bib0024","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1021\/acsbiomaterials.6b00006","article-title":"Macrophage polarization by titanium dioxide (TiO2) particles: size matters","volume":"2","author":"Schoenenberger","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2024.04.023_bib0025","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jbm.a.31310","article-title":"Amorphous and crystalline polyetheretherketone: mechanical properties and tissue reactions during a 3-year follow-up","volume":"84","author":"Nieminen","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2024.04.023_bib0026","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.actbio.2023.03.007","article-title":"Immune cell response to orthopedic and craniofacial biomaterials depends on biomaterial composition","volume":"161","author":"Avery","year":"2023","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.actbio.2024.04.023_bib0027","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/cmi.2013.39","article-title":"Macrophage polarization in response to wear particles in vitro","volume":"10","author":"Antonios","year":"2013","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.actbio.2024.04.023_bib0028","unstructured":"Tauro, J.A., R. L., The shoulder. AANA Advanced Arthroscopy Series, ed. R.K.N. Ryu 2010: Elsevier. 10."},{"issue":"13","key":"10.1016\/j.actbio.2024.04.023_bib0029","doi-asserted-by":"crossref","first-page":"11197","DOI":"10.18632\/oncotarget.23757","article-title":"Effects of wear particles of polyether-ether-ketone and cobalt-chromium-molybdenum on CD4- and CD8-T-cell responses","volume":"9","author":"Du","year":"2018","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.actbio.2024.04.023_bib0030","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1054\/ijom.2002.0283","article-title":"Surface analysis of titanium maxillofacial plates and screws retrieved from patients","volume":"31","author":"Langford","year":"2002","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2024.04.023_bib0031","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1054\/bjom.1998.0264","article-title":"Metallic fragments on the surface of miniplates and screws before insertion","volume":"37","author":"Ray","year":"1999","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.actbio.2024.04.023_bib0032","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.colsurfb.2018.10.081","article-title":"Influences of tantalum pentoxide and surface coarsening on surface roughness, hydrophilicity, surface energy, protein adsorption and cell responses to PEEK based biocomposite","volume":"174","author":"Mei","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.actbio.2024.04.023_bib0033","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.medengphy.2019.03.006","article-title":"Finite element investigation into the use of carbon fibre reinforced PEEK laminated composites for distal radius fracture fixation implants","volume":"67","author":"Gallagher","year":"2019","journal-title":"Med. Eng. Phys."},{"issue":"10","key":"10.1016\/j.actbio.2024.04.023_bib0034","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.spinee.2016.05.017","article-title":"Optimizing surface characteristics for cell adhesion and proliferation on titanium plasma spray coatings on polyetheretherketone","volume":"16","author":"Yoon","year":"2016","journal-title":"Spine J."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124001958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124001958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:14:25Z","timestamp":1716444865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124001958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":34,"alternative-id":["S1742706124001958"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.04.023","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory tissue response in human soft tissue is caused by a higher particle load near carbon fiber-reinforced PEEK compared to titanium plates","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}