{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:25:54Z","timestamp":1786983954723,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.actbio.2024.05.001","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T11:54:45Z","timestamp":1714737285000},"page":"117-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Hyaluronan improves photoreceptor differentiation and maturation in human retinal organoids"],"prefix":"10.1016","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-6638","authenticated-orcid":false,"given":"Kotoe","family":"Kawai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret T.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1915-3116","authenticated-orcid":false,"given":"Yui","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhana","family":"Abdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4705-7587","authenticated-orcid":false,"given":"Hidenori","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Honma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-3475","authenticated-orcid":false,"given":"Molly S.","family":"Shoichet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2024.05.001_bib0001","doi-asserted-by":"crossref","DOI":"10.1242\/dev.189746","article-title":"Retinal organoids: a window into human retinal development","volume":"147","author":"O'Hara-Wright","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.actbio.2024.05.001_bib0002","article-title":"Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines","volume":"146","author":"Capowski","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.actbio.2024.05.001_bib0003","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.stem.2012.05.009","article-title":"Self-formation of optic cups and storable stratified neural retina from human ESCs","volume":"10","author":"Nakano","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.actbio.2024.05.001_bib0004","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1038\/ncomms5047","article-title":"Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs","volume":"5","author":"Zhong","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2024.05.001_bib0005","first-page":"97","article-title":"A simple and efficient method for generating human retinal organoids","volume":"26","author":"Regent","year":"2020","journal-title":"Mol. Vis."},{"key":"10.1016\/j.actbio.2024.05.001_bib0006","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41598-017-00774-9","article-title":"Photoreceptor outer segment-like structures in long-term 3d retinas from human pluripotent stem cells","volume":"7","author":"Wahlin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2024.05.001_bib0007","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1002\/stem.2023","article-title":"IGF-1 signaling plays an important role in the formation of three-dimensional laminated neural retina and other ocular structures from human embryonic stem cells","volume":"33","author":"Mellough","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2024.05.001_bib0008","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.stemcr.2017.07.022","article-title":"Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors","volume":"9","author":"Gonzalez-Cordero","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2024.05.001_bib0009","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/stem.2586","article-title":"Generation of storable retinal organoids and retinal pigmented epithelium from adherent human iPS cells in xeno-free and feeder-free conditions","volume":"35","author":"Reichman","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2024.05.001_bib0010","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/stem.2974","article-title":"CRX expression in pluripotent stem cell-derived photoreceptors marks a transplantable subpopulation of early cones","volume":"37","author":"Collin","year":"2019","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2024.05.001_bib0011","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41467-019-08961-0","article-title":"Organoid-derived C-Kit+\/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2024.05.001_bib0012","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.stemcr.2018.07.005","article-title":"Characterization and transplantation of CD73-positive photoreceptors isolated from human iPSC-derived retinal organoids","volume":"11","author":"Gagliardi","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2024.05.001_bib0013","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/stcltm\/szab010","article-title":"Human retinal organoids provide a suitable tool for toxicological investigations: a comprehensive validation using drugs and compounds affecting the retina","volume":"11","author":"Dorgau","year":"2022","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.actbio.2024.05.001_bib0014","doi-asserted-by":"crossref","DOI":"10.3791\/62269-v","article-title":"Toxicity screens in human retinal organoids for pharmaceutical discovery","author":"Eade","year":"2021","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.actbio.2024.05.001_bib0015","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1242\/dev.146290","article-title":"Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids","volume":"144","author":"Vergara","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.actbio.2024.05.001_bib0016","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.stemcr.2019.09.010","article-title":"Morphological and molecular defects in human three-dimensional retinal organoid model of X-linked juvenile retinoschisis","volume":"13","author":"Huang","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2024.05.001_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2019.00212","article-title":"Generation and characterization of induced pluripotent stem cells and retinal organoids from a leber's congenital amaurosis patient with novel RPE65 mutations","volume":"12","author":"Li","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00128","article-title":"Patient-specific retinal organoids recapitulate disease features of late-onset retinitis pigmentosa","volume":"8","author":"Gao","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.actbio.2024.05.001_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-62047-2","article-title":"Retinal organoids derived from hiPSCs of an AIPL1-LCA patient maintain cytoarchitecture despite reduced levels of mutant AIPL1","volume":"10","author":"Lukovic","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2024.05.001_bib0020","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay5247","article-title":"Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids","volume":"6","author":"Xie","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2024.05.001_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ydbio.2020.03.011","article-title":"Role of RB1 in human embryonic stem cell-derived retinal organoids","author":"Zheng","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.actbio.2024.05.001_bib0022","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.stemcr.2018.02.003","article-title":"Gene correction reverses ciliopathy and photoreceptor loss in iPSC-derived retinal organoids from retinitis pigmentosa patients","volume":"10","author":"Deng","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2024.05.001_bib0023","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ajo.2019.04.033","article-title":"The role of FGF9 in the production of neural retina and RPE in a pluripotent stem cell model of early human retinal development","volume":"206","author":"Gamm","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2024.05.001_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00361","article-title":"Modeling retinitis pigmentosa: retinal organoids generated from the iPSCs of a patient with the USH2A mutation show early developmental abnormalities","volume":"13","author":"Guo","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0025","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.actbio.2024.05.001_bib0026","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biomaterials.2019.01.028","article-title":"Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids","volume":"199","author":"Dorgau","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.05.001_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.stemcr.2022.02.019","article-title":"Antioxidant and lipid supplementation improve the development of photoreceptor outer segments in pluripotent stem cell-derived retinal organoids","author":"West","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2024.05.001_bib0028","article-title":"Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform","volume":"8","author":"Achberger","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.actbio.2024.05.001_bib0029","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.3390\/ijms21175988","article-title":"Diverse roles for hyaluronan and hyaluronan receptors in the developing and adult nervous system","volume":"21","author":"Peters","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0030","first-page":"2767","article-title":"Hyaluronan and the functional organization of the interphotoreceptor matrix","volume":"40","author":"Hollyfield","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0031","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/exer.1997.0422","article-title":"Hyaluronan in the interphotoreceptor matrix of the eye: species differences in content, distribution, ligand binding and degradation","volume":"66","author":"Hollyfield","year":"1998","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.actbio.2024.05.001_bib0032","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1242\/jcs.114.1.199","article-title":"Glycosaminoglycan synthesis and secretion by the retinal pigment epithelium: polarized delivery of hyaluronan from the apical surface","volume":"114","author":"deS Senanayake","year":"2001","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0033","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2008.12.023","article-title":"Hyaluronan dynamics during retinal development","volume":"1256","author":"Inoue","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.actbio.2024.05.001_bib0034","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1002\/adfm.201504024","article-title":"Hyaluronic acid-based hydrogels enable rod photoreceptor survival and maturation in vitro through activation of the mTOR pathway","volume":"26","author":"Mitrousis","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2024.05.001_bib0035","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.stemcr.2015.04.008","article-title":"A hyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation","volume":"4","author":"Ballios","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2024.05.001_bib0036","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.actbio.2018.05.023","article-title":"Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix","volume":"74","author":"Felemban","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.05.001_bib0037","series-title":"Principles and Techniques of Electron Microscopy: Biological Applications","author":"Hayat","year":"1981"},{"key":"10.1016\/j.actbio.2024.05.001_bib0038","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1038\/s41467-022-33848-y","article-title":"HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids","volume":"13","author":"V\u00f6lkner","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2024.05.001_bib0039","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.tins.2012.05.004","article-title":"Cell fate determination in the vertebrate retina","volume":"35","author":"Bassett","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0040","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-021-03917-4","article-title":"A look into retinal organoids: methods, analytical techniques, and applications","author":"Afanasyeva","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0041","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.00092","article-title":"Photoreceptor disc enclosure occurs in the absence of normal peripherin-2\/rds oligomerization","volume":"14","author":"Lewis","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0042","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1083\/jcb.201608081","article-title":"Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release","volume":"216","author":"Salinas","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.actbio.2024.05.001_bib0043","doi-asserted-by":"crossref","first-page":"27043","DOI":"10.1073\/pnas.1913518117","article-title":"Photoreceptor disc membranes are formed through an Arp2\/3-dependent lamellipodium-like mechanism","volume":"116","author":"Spencer","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0044","doi-asserted-by":"crossref","first-page":"20615","DOI":"10.1073\/pnas.2010751117","article-title":"Syntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival","volume":"117","author":"Kakakhel","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.actbio.2024.05.001_bib0045","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/jmg.34.8.620","article-title":"RDS\/peripherin gene mutations are frequent causes of central retinal dystrophies","volume":"34","author":"Kohl","year":"1997","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.actbio.2024.05.001_bib0046","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1136\/bjo.2007.115659","article-title":"Mutations in the peripherin\/RDS gene are an important cause of multifocal pattern dystrophy simulating STGD1\/fundus flavimaculatus","volume":"91","author":"Boon","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2024.05.001_bib0047","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/cne.901880204","article-title":"Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy","volume":"188","author":"Carter-Dawson","year":"1979","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.actbio.2024.05.001_bib0048","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4641902","article-title":"The distribution of the photoreceptor outer segment length in a healthy population","volume":"2017","author":"Maden","year":"2017","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.actbio.2024.05.001_bib0049","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41586-022-05394-6","article-title":"Extracellular fluid viscosity enhances cell migration and cancer dissemination","volume":"611","author":"Bera","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2024.05.001_bib0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.actbio.2016.11.016","article-title":"3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development","volume":"49","author":"Hunt","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.05.001_bib0051","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.cell.2020.08.013","article-title":"Cell types of the human retina and its organoids at single-cell resolution","volume":"182","author":"Cowan","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2024.05.001_bib0052","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1002\/cpsc.120","article-title":"Differentiation protocol for 3D retinal organoids, immunostaining and signal quantitation","volume":"55","author":"D\u00f6pper","year":"2020","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"10.1016\/j.actbio.2024.05.001_bib0053","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1038\/ncomms7286","article-title":"Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue","volume":"6","author":"Kuwahara","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2024.05.001_bib0054","series-title":"Stem Cells","article-title":"Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent","author":"Chichagova","year":"2019"},{"key":"10.1016\/j.actbio.2024.05.001_bib0055","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201803550","article-title":"3D microstructured scaffolds to support photoreceptor polarization and maturation","volume":"30","author":"Jung","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2024.05.001_bib0056","doi-asserted-by":"crossref","first-page":"eabf0344","DOI":"10.1126\/sciadv.abf0344","article-title":"Ultrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction","volume":"7","author":"Lee","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2024.05.001_bib0057","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/acc761","article-title":"One-stop assembly of adherent 3D retinal organoids from hiPSCs based on 3D-printed derived PDMS microwell platform","volume":"15","author":"Sun","year":"2023","journal-title":"Biofabrication"},{"key":"10.1016\/j.actbio.2024.05.001_bib0058","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-018-0907-0","article-title":"Use of bioreactors for culturing human retinal organoids improves photoreceptor yields","volume":"9","author":"Ovando-Roche","year":"2018","journal-title":"Stem Cell Res. Ther."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124002332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124002332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T19:34:11Z","timestamp":1736969651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124002332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":58,"alternative-id":["S1742706124002332"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.05.001","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyaluronan improves photoreceptor differentiation and maturation in human retinal organoids","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}