{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:03:06Z","timestamp":1792101786944,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009397","name":"Eberhard-Karls-Universit\u00e4t T\u00fcbingen Medizinische Fakult\u00e4t","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.actbio.2024.05.002","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T09:16:58Z","timestamp":1714987018000},"page":"297-307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Proteolysis of the pericellular matrix: Pinpointing the role and involvement of matrix metalloproteinases in early osteoarthritic remodeling"],"prefix":"10.1016","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-2499","authenticated-orcid":false,"given":"Marina","family":"Danalache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-7492","authenticated-orcid":false,"given":"Felix","family":"Umrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Riester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik","family":"Schwitalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Guilak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0589-6654","authenticated-orcid":false,"given":"Ulf Krister","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2024.05.002_bib0001","doi-asserted-by":"crossref","unstructured":"B. Rolauffs, J. Williams, A. Grodzinsky, K. E Kuettner, A. A Cole, Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints, 2008.","DOI":"10.1016\/j.jsb.2008.01.010"},{"issue":"2","key":"10.1016\/j.actbio.2024.05.002_bib0002","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/art.27217","article-title":"Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis","volume":"62","author":"Rolauffs","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.actbio.2024.05.002_bib0003","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/art.27528","article-title":"Cartilage cell clusters","volume":"62","author":"Lotz","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.002_bib0004","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1504\/IJCIH.2012.046995","article-title":"A cell-matrix model of anabolic and catabolic dynamics during cartilage biomolecule regulation","volume":"1","author":"Saha","year":"2012","journal-title":"Int. J. Comput. Healthc."},{"key":"10.1016\/j.actbio.2024.05.002_bib0005","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1196\/annals.1346.011","article-title":"The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage","volume":"1068","author":"Guilak","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.002_bib0006","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/ar380","article-title":"Articular cartilage and changes in arthritis: collagen of articular cartilage","volume":"4","author":"Eyre","year":"2001","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.actbio.2024.05.002_bib0007","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/1941738109350438","article-title":"The basic science of articular cartilage: structure, composition, and function","volume":"1","author":"Sophia Fox","year":"2009","journal-title":"Sports Health"},{"issue":"4","key":"10.1016\/j.actbio.2024.05.002_bib0008","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/jor.1100050406","article-title":"Chondrons in cartilage: ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages","volume":"5","author":"Poole","year":"1987","journal-title":"J. Orthop. Res."},{"issue":"6","key":"10.1016\/j.actbio.2024.05.002_bib0009","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.matbio.2012.05.002","article-title":"A biomechanical role for perlecan in the pericellular matrix of articular cartilage","volume":"31","author":"Wilusz","year":"2012","journal-title":"Matrix. Biol."},{"issue":"39","key":"10.1016\/j.actbio.2024.05.002_bib0010","doi-asserted-by":"crossref","first-page":"37698","DOI":"10.1074\/jbc.M304638200","article-title":"Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan","volume":"278","author":"Wiberg","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.actbio.2024.05.002_bib0011","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1002\/term.2735","article-title":"Chondrocyte death after mechanically overloading degenerated human intervertebral disk explants is associated with a structurally impaired pericellular matrix","volume":"12","author":"Hofmann","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"15-16","key":"10.1016\/j.actbio.2024.05.002_bib0012","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1089\/ten.tea.2010.0601","article-title":"The protective role of the pericellular matrix in chondrocyte apoptosis","volume":"17","author":"Peters","year":"2011","journal-title":"Tissue Eng. Part A"},{"issue":"7","key":"10.1016\/j.actbio.2024.05.002_bib0013","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.joca.2016.02.001","article-title":"Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology","volume":"24","author":"Felka","year":"2016","journal-title":"Osteoarthritis Cartil."},{"issue":"76","key":"10.1016\/j.actbio.2024.05.002_bib0014","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1098\/rsif.2012.0314","article-title":"Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage","volume":"9","author":"Wilusz","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.actbio.2024.05.002_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2019.01.008","article-title":"Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage","volume":"27","author":"Danalache","year":"2019","journal-title":"Osteoarthritis Cartil."},{"issue":"13","key":"10.1016\/j.actbio.2024.05.002_bib0016","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.addr.2007.08.015","article-title":"Growth factor binding to the pericellular matrix and its importance in tissue engineering","volume":"59","author":"Macri","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2024.05.002_bib0017","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","article-title":"Osteoarthritis as a disease of the cartilage pericellular matrix","author":"Guilak","year":"2018","journal-title":"Matrix. Biol."},{"issue":"2","key":"10.1016\/j.actbio.2024.05.002_bib0018","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1172\/JCI108632","article-title":"Collagenase and collagenase inhibitors in osteoarthritic and normal cartilage","volume":"59","author":"Ehrlich","year":"1977","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.actbio.2024.05.002_bib0019","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/ar2013","article-title":"Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage","volume":"8","author":"Davidson","year":"2006","journal-title":"Arthritis Res. Ther."},{"issue":"70","key":"10.1016\/j.actbio.2024.05.002_bib0020","first-page":"115","article-title":"Proteolysis of the collagen fibril in osteoarthritis","author":"Poole","year":"2003","journal-title":"Biochem. Soc. Symp."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.002_bib0021","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00223-020-00739-7","article-title":"Targeting dysregulation of metalloproteinase activity in osteoarthritis","volume":"109","author":"Yamamoto","year":"2021","journal-title":"Calcif. Tissue Int."},{"issue":"7","key":"10.1016\/j.actbio.2024.05.002_bib0022","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI119316","article-title":"Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage","volume":"99","author":"Billinghurst","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.002_bib0023","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI118475","article-title":"Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage","volume":"97","author":"Mitchell","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.actbio.2024.05.002_bib0024","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1267\/ahc.13024","article-title":"Matrix metalloproteinase-2 degrades fibrillin-1 and fibrillin-2 of oxytalan fibers in the human eye and periodontal ligaments in vitro","volume":"46","author":"Kawagoe","year":"2013","journal-title":"Acta Histochem. Cytochem."},{"issue":"9","key":"10.1016\/j.actbio.2024.05.002_bib0025","doi-asserted-by":"crossref","first-page":"e24753","DOI":"10.1371\/journal.pone.0024753","article-title":"MMP mediated degradation of type VI collagen is highly associated with liver fibrosis\u2013identification and validation of a novel biochemical marker assay","volume":"6","author":"Veidal","year":"2011","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.actbio.2024.05.002_bib0026","doi-asserted-by":"crossref","first-page":"14713","DOI":"10.1038\/s41598-021-94321-2","article-title":"Endotrophin and C6Ma3, serological biomarkers of type VI collagen remodelling, reflect endoscopic and clinical disease activity in IBD","volume":"11","author":"Lindholm","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.002_bib0027","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1038\/s41598-018-25435-3","article-title":"Matrilysin\/MMP-7 cleavage of perlecan\/HSPG2 complexed with semaphorin 3A supports FAK-mediated stromal invasion by prostate cancer cells","volume":"8","author":"Grindel","year":"2018","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.actbio.2024.05.002_bib0028","doi-asserted-by":"crossref","first-page":"10079","DOI":"10.1074\/jbc.271.17.10079","article-title":"The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases","volume":"271","author":"Whitelock","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"188","key":"10.1016\/j.actbio.2024.05.002_bib0029","doi-asserted-by":"crossref","DOI":"10.3791\/64371","article-title":"Addressing practical issues in atomic force microscopy-based micro-indentation on human articular cartilage explants","author":"Daniel","year":"2022","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.actbio.2024.05.002_bib0030","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.joca.2019.01.008","article-title":"Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage","volume":"27","author":"Danalache","year":"2019","journal-title":"Osteoarthritis Cartil."},{"issue":"2","key":"10.1016\/j.actbio.2024.05.002_bib0033","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s002640000110","article-title":"Matrix metalloproteinases in patients with osteoarthritis of the hip","volume":"24","author":"Masuhara","year":"2000","journal-title":"Int. Orthop."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.002_bib0034","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1177\/039463201302600331","article-title":"Expression of gelatinases (MMP-2, MMP-9) in human articular cartilage","volume":"26","author":"Lipari","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.002_bib0035","doi-asserted-by":"crossref","first-page":"14409","DOI":"10.1038\/s41598-021-93744-1","article-title":"An in vitro investigation to understand the synergistic role of MMPs-1 and 9 on articular cartilage biomechanical properties","volume":"11","author":"Mixon","year":"2021","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.actbio.2024.05.002_bib0036","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/gb-2003-4-6-216","article-title":"Matrix metalloproteinases: old dogs with new tricks","volume":"4","author":"Somerville","year":"2003","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.002_bib0037","doi-asserted-by":"crossref","first-page":"9783","DOI":"10.1038\/s41598-021-89582-w","article-title":"Exploration of changes in spatial chondrocyte organisation in human osteoarthritic cartilage by means of 3D imaging","volume":"11","author":"Danalache","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.002_bib0038","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2474-15-93","article-title":"The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases","volume":"15","author":"Sun","year":"2014","journal-title":"BMC. Musculoskelet. Disord."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.002_bib0039","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"28","key":"10.1016\/j.actbio.2024.05.002_bib0040","doi-asserted-by":"crossref","first-page":"24292","DOI":"10.1021\/acsomega.2c01559","article-title":"Protease activity analysis: a toolkit for analyzing enzyme activity data","volume":"7","author":"Soleimany","year":"2022","journal-title":"ACS Omega"},{"issue":"8","key":"10.1016\/j.actbio.2024.05.002_bib0041","first-page":"9112","article-title":"Expression and correlation of matrix metalloproteinase-7 and interleukin-15 in human osteoarthritis","volume":"8","author":"Tao","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"10","key":"10.1016\/j.actbio.2024.05.002_bib0042","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1002\/art.22140","article-title":"Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of pro-matrix metalloproteinase 7 in osteoarthritic chondrocytes","volume":"54","author":"Fujita","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"12","key":"10.1016\/j.actbio.2024.05.002_bib0043","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/labinvest.3700351","article-title":"Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151","volume":"85","author":"Shiomi","year":"2005","journal-title":"Lab. Invest."},{"issue":"6484","key":"10.1016\/j.actbio.2024.05.002_bib0044","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/370061a0","article-title":"A matrix metalloproteinase expressed on the surface of invasive tumour cells","volume":"370","author":"Sato","year":"1994","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.actbio.2024.05.002_bib0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/excr.2000.5118","article-title":"MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells","volume":"263","author":"Deryugina","year":"2001","journal-title":"Exp. Cell Res."},{"issue":"35","key":"10.1016\/j.actbio.2024.05.002_bib0046","doi-asserted-by":"crossref","first-page":"24091","DOI":"10.1074\/jbc.M114.583443","article-title":"The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage","volume":"289","author":"Howes","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.002_bib0047","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bj1660021","article-title":"Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation","volume":"166","author":"Eeckhout","year":"1977","journal-title":"Biochem. J."},{"issue":"7","key":"10.1016\/j.actbio.2024.05.002_bib0048","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/bies.950140705","article-title":"The matrix-degrading metalloproteinases","volume":"14","author":"Matrisian","year":"1992","journal-title":"Bioessays"},{"issue":"8","key":"10.1016\/j.actbio.2024.05.002_bib0049","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1096\/fasebj.5.8.1850705","article-title":"Matrix metalloproteinases and their inhibitors in connective tissue remodeling","volume":"5","author":"Woessner","year":"1991","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.actbio.2024.05.002_bib0050","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0014-4827(92)90101-D","article-title":"Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator","volume":"202","author":"Keski-Oja","year":"1992","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.actbio.2024.05.002_bib0051","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1172\/JCI23977","article-title":"Synergy between a plasminogen cascade and MMP-9 in autoimmune disease","volume":"115","author":"Liu","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"47","key":"10.1016\/j.actbio.2024.05.002_bib0052","doi-asserted-by":"crossref","first-page":"45154","DOI":"10.1074\/jbc.M206354200","article-title":"Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity","volume":"277","author":"Netzel-Arnett","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2024.05.002_bib0053","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.actbio.2020.05.005","article-title":"Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis","volume":"111","author":"Chery","year":"2020","journal-title":"Acta Biomater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124002344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124002344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:34:25Z","timestamp":1736987665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124002344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":51,"alternative-id":["S1742706124002344"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.05.002","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteolysis of the pericellular matrix: Pinpointing the role and involvement of matrix metalloproteinases in early osteoarthritic remodeling","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}