{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:39:52Z","timestamp":1740141592857,"version":"3.37.3"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017585","name":"First Hospital of Jilin University","doi-asserted-by":"publisher","award":["JDYY-DEP-2022013"],"award-info":[{"award-number":["JDYY-DEP-2022013"]}],"id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20210101276JC","20210204157YY"],"award-info":[{"award-number":["20210101276JC","20210204157YY"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.actbio.2024.05.045","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T16:22:03Z","timestamp":1717431723000},"page":"306-317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dual-molecular targeting nanomedicine upregulates synergistic therapeutic efficacy in preclinical hepatoma models"],"prefix":"10.1016","volume":"183","author":[{"given":"Qilong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xizhu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haodong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.actbio.2024.05.045_bib0001","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1021\/acsnano.8b01729","article-title":"Locally deployable nanofiber patch for sequential drug delivery in treatment of primary and advanced orthotopic hepatomas","volume":"12","author":"Li","year":"2018","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.actbio.2024.05.045_bib0002","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.gendis.2023.02.050","article-title":"WNT\/I3-catenin signaling in hepatocellular carcinoma: the aberrant activation, pathogenic roles, and therapeutic opportunities","volume":"11","author":"Gajos-Michniewicz","year":"2024","journal-title":"Genes Dis."},{"issue":"2","key":"10.1016\/j.actbio.2024.05.045_bib0003","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3350\/cmh.2022.0402","article-title":"Clinical practice guidelines and real-life practice in hepatocellular carcinoma: a Chinese perspective","volume":"29","author":"Xie","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"issue":"10","key":"10.1016\/j.actbio.2024.05.045_bib0004","doi-asserted-by":"crossref","first-page":"8774","DOI":"10.3390\/curroncol30100633","article-title":"The new era of systemic treatment for hepatocellular carcinoma: from the first line to the optimal sequence","volume":"30","author":"Cerreto","year":"2023","journal-title":"Curr. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.045_bib0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41420-023-01469-z","article-title":"PLEKHG5 is stabilized by HDAC2-related deacetylation and confers sorafenib resistance in hepatocellular carcinoma","volume":"9","author":"Sha","year":"2023","journal-title":"Cell Death Discov."},{"issue":"Suppl 1","key":"10.1016\/j.actbio.2024.05.045_bib0006","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.14701\/ahbps.LV-DB-4","article-title":"Non-systemic non-surgical therapy for hepatocellular carcinoma with portal vein tumor thrombosis","volume":"25","author":"Jang","year":"2021","journal-title":"Ann. Hepato-Biliary-Pancreat. Surg."},{"issue":"12","key":"10.1016\/j.actbio.2024.05.045_bib0007","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1002\/cam4.1228","article-title":"Phosphorylated ERK is a potential prognostic biomarker for Sorafenib response in hepatocellular carcinoma","volume":"6","author":"Liang","year":"2017","journal-title":"Cancer Med."},{"issue":"2","key":"10.1016\/j.actbio.2024.05.045_bib0008","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3233\/BD-201063","article-title":"Mini review: the FDA-approved prescription drugs that target the MAPK signaling pathway in women with breast cancer","volume":"40","author":"Khojasteh Poor","year":"2021","journal-title":"Breast Dis."},{"issue":"15","key":"10.1016\/j.actbio.2024.05.045_bib0009","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.18632\/aging.102165","article-title":"The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells","volume":"11","author":"Wang","year":"2019","journal-title":"Aging"},{"issue":"7","key":"10.1016\/j.actbio.2024.05.045_bib0010","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S1470-2045(18)30351-6","article-title":"Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial","volume":"19","author":"Zhu","year":"2018","journal-title":"Lancet Oncol."},{"issue":"7","key":"10.1016\/j.actbio.2024.05.045_bib0011","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/cancers12071900","article-title":"Efficacy and safety of the combination of pravastatin and sorafenib for the treatment of advanced hepatocellular carcinoma (ESTAHEP Clinical Trial)","volume":"12","author":"Ria\u00f1o","year":"2020","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.actbio.2024.05.045_bib0012","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3892\/br.2021.1425","article-title":"Effects of obesity and 10 weeks metformin treatment on liver steatosis","volume":"14","author":"Hakkak","year":"2021","journal-title":"Biomed. Rep."},{"issue":"2","key":"10.1016\/j.actbio.2024.05.045_bib0013","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/biom13020250","article-title":"Action mechanism of metformin and its application in hematological malignancy treatments: a review","volume":"13","author":"Zhang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.actbio.2024.05.045_bib0014","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/circ.146.suppl_1.11469","article-title":"Effects of metformin and donepezil on the prevention of doxorubicin-induced cardiotoxicity in breast cancer patient: a randomized controlled trial","volume":"146","author":"Osataphan","year":"2022","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.actbio.2024.05.045_bib0015","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/1753-0407.13310","article-title":"Is metformin a possible treatment for diabetic neuropathy?","volume":"14","author":"Wei","year":"2022","journal-title":"J. Diabetes"},{"issue":"5","key":"10.1016\/j.actbio.2024.05.045_bib0016","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/ph15050626","article-title":"Metformin and cancer, an ambiguanidous relationship","volume":"15","author":"Skuli","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"13","key":"10.1016\/j.actbio.2024.05.045_bib0017","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.4161\/cc.8.13.8814","article-title":"Metformin induces unique biological and molecular responses in triple negative breast cancer cells","volume":"8","author":"Liu","year":"2009","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.actbio.2024.05.045_bib0018","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1063\/5.0061530","article-title":"Smart transformable nanoparticles for enhanced tumor theranostics","volume":"8","author":"Chen","year":"2021","journal-title":"Appl. Phys. Rev."},{"issue":"5","key":"10.1016\/j.actbio.2024.05.045_bib0019","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1021\/acs.nanolett.0c04778","article-title":"Ultrasound-augmented mitochondrial calcium ion overload by calcium nanomodulator to induce immunogenic cell death","volume":"21","author":"Zheng","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2024.05.045_bib0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jconrel.2021.02.005","article-title":"Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer","volume":"332","author":"Duro-Castano","year":"2021","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.actbio.2024.05.045_bib0021","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/hep.28735","article-title":"Extracellular vesicles carry MicroRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model","volume":"65","author":"Li","year":"2017","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.actbio.2024.05.045_bib0022","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.7150\/thno.31683","article-title":"Evaluation of polymer nanoformulations in hepatoma therapy by established rodent models","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.actbio.2024.05.045_bib0023","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12951-021-01096-9","article-title":"Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy","volume":"19","author":"Wang","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.actbio.2024.05.045_bib0024","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/acsabm.2c00891","article-title":"Chlorin e6: a promising photosensitizer in photo-based cancer nanomedicine","volume":"6","author":"Hak","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.045_bib0025","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12951-023-01857-8","article-title":"Combining nanotechnology with monoclonal antibody drugs for rheumatoid arthritis treatments","volume":"21","author":"Chi","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"24","key":"10.1016\/j.actbio.2024.05.045_bib0026","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1016\/j.biomaterials.2006.03.039","article-title":"Parameters influencing the stealthiness of colloidal drug delivery systems","volume":"27","author":"Vonarbourg","year":"2006","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.actbio.2024.05.045_bib0027","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1021\/am303073u","article-title":"Nanoscaled poly(L-glutamic acid)\/doxorubicin-amphiphile complex as ph-responsive drug delivery system for effective treatment of nonsmall cell lung cancer","volume":"5","author":"Li","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2024.05.045_bib0028","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41467-017-01646-6","article-title":"Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys","volume":"8","author":"Peng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2024.05.045_bib0029","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.addr.2012.09.013","article-title":"Block copolymer micelles for drug delivery: design, characterization and biological significance","volume":"64","author":"Kataoka","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2024.05.045_bib0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejps.2020.105693","article-title":"Size-shrinkable and protein kinase C\u03b1-recognizable nanoparticles for deep tumor penetration and cellular internalization","volume":"159","author":"Ma","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"issue":"22","key":"10.1016\/j.actbio.2024.05.045_bib0031","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1016\/j.polymer.2008.08.052","article-title":"Synthesis and characterization of star-shaped block copolymer of poly(\u03b5-caprolactone) and poly(ethyl ethylene phosphate) as drug carrier","volume":"49","author":"Cheng","year":"2008","journal-title":"Polymer"},{"issue":"12","key":"10.1016\/j.actbio.2024.05.045_bib0032","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.1016\/j.actbio.2013.08.015","article-title":"Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy","volume":"9","author":"Lv","year":"2013","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.actbio.2024.05.045_bib0033","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1021\/acsnano.7b02675","article-title":"A pH-responsive yolk-like nanoplatform for tumor targeted dual-mode magnetic resonance imaging and chemotherapy","volume":"11","author":"Sun","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2024.05.045_bib0034","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biomaterials.2021.121003","article-title":"Combined anti-hepatocellular carcinoma therapy inhibit drug-resistance and metastasis via targeting \"substance P-hepatic stellate cells-hepatocellular carcinoma\" axis","volume":"276","author":"Li","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.05.045_bib0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fonc.2022.1043479","article-title":"Screening of an individualized treatment strategy for an advanced gallbladder cancer using patient-derived tumor xenograft and organoid models","volume":"12","author":"Tan","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.045_bib0036","doi-asserted-by":"crossref","first-page":"184","DOI":"10.20892\/j.issn.2095-3941.2020.0012","article-title":"Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity","volume":"18","author":"Chen","year":"2021","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.actbio.2024.05.045_bib0037","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/2022\/5211368","article-title":"Jujuboside B reverse CUMS-promoted tumor progression via blocking PI3K\/Akt and MAPK\/ERK and dephosphorylating CREB signaling","volume":"2022","author":"Yang","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.actbio.2024.05.045_bib0038","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1016\/j.biopha.2018.11.109","article-title":"Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells","volume":"109","author":"Ryabaya","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actbio.2024.05.045_bib0039","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.lfs.2023.121735","article-title":"Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7","volume":"324","author":"Yousef","year":"2023","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.actbio.2024.05.045_bib0040","first-page":"799","article-title":"Mesenchymal stem cells versus their conditioned medium in the treatment of ischemia\/reperfusion injury: evaluation of efficacy and hepatic specific gene expression in mice","volume":"25","author":"Khosravi-Farsani","year":"2022","journal-title":"Iran J. Basic Med. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.045_bib0041","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/8755122517747295","article-title":"Monitoring patients on metformin: recent changes and rationales","volume":"34","author":"Wooley","year":"2018","journal-title":"J. Pharm. Technol."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124002940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124002940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T11:58:54Z","timestamp":1720612734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124002940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":41,"alternative-id":["S1742706124002940"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.05.045","relation":{},"ISSN":["1742-7061"],"issn-type":[{"type":"print","value":"1742-7061"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-molecular targeting nanomedicine upregulates synergistic therapeutic efficacy in preclinical hepatoma models","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.05.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}