{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:57:01Z","timestamp":1783997821272,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.actbio.2024.05.051","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T16:22:07Z","timestamp":1717431727000},"page":"278-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["A gene delivery system with autophagy blockade for enhanced anti-angiogenic therapy against Fusobacterium nucleatum-associated colorectal cancer"],"prefix":"10.1016","volume":"183","author":[{"given":"Na","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-1726","authenticated-orcid":false,"given":"Xiongwei","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-9999","authenticated-orcid":false,"given":"Hui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0002","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","article-title":"Angiogenic signaling pathways and anti-angiogenic therapy for cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.actbio.2024.05.051_bib0003","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.3390\/ijms22073765","article-title":"Anti-angiogenic therapy: current challenges and future perspectives","volume":"22","author":"Lopes-Coelho","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0004","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41392-020-0116-z","article-title":"Comprehensive review of targeted therapy for colorectal cancer","volume":"5","author":"Xie","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1158\/1078-0432.CCR-22-1366","article-title":"Molecular mechanisms and future implications of VEGF\/VEGFR in cancer therapy","volume":"29","author":"Patel","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.actbio.2024.05.051_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102017","article-title":"Bevacizumab (Avastin\u00ae) in cancer treatment: a review of 15 years of clinical experience and future outlook","volume":"86","author":"Garcia","year":"2020","journal-title":"Cancer Treat. Rev."},{"issue":"6","key":"10.1016\/j.actbio.2024.05.051_bib0007","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrd.2015.17","article-title":"Ten years of anti-vascular endothelial growth factor therapy","volume":"15","author":"Ferrara","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9863","key":"10.1016\/j.actbio.2024.05.051_bib0008","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0140-6736(12)61900-X","article-title":"Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial","volume":"381","author":"Grothey","year":"2013","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.actbio.2024.05.051_bib0009","first-page":"99","article-title":"Should we move beyond VEGF inhibition in metastatic colorectal cancer? Lessons from early phase clinical trials","volume":"5","author":"Patel","year":"2014","journal-title":"J. Gastrointest. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0010","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1629865","article-title":"Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis","volume":"8","author":"Zeng","year":"2019","journal-title":"J. Extracell. Vesicles"},{"issue":"11","key":"10.1016\/j.actbio.2024.05.051_bib0011","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1158\/1078-0432.CCR-12-1542","article-title":"Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy","volume":"19","author":"Selvakumaran","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.actbio.2024.05.051_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108866","article-title":"Autophagy represses fascaplysin-induced apoptosis and angiogenesis inhibition via ROS and p8 in vascular endothelia cells","volume":"114","author":"Meng","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.actbio.2024.05.051_bib0013","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1080\/15548627.2017.1336277","article-title":"Autophagy-induced KDR\/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells","volume":"13","author":"Wu","year":"2017","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.actbio.2024.05.051_bib0014","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1158\/0008-5472.CAN-11-3831","article-title":"Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma","volume":"72","author":"Hu","year":"2012","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.actbio.2024.05.051_bib0015","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1158\/1078-0432.CCR-10-2634","article-title":"Principles and current strategies for targeting autophagy for cancer treatment","volume":"17","author":"Amaravadi","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.actbio.2024.05.051_bib0016","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s41418-019-0290-0","article-title":"Therapeutic modulation of autophagy: which disease comes first?","volume":"26","author":"Maiuri","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.actbio.2024.05.051_bib0017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.semcancer.2019.08.031","article-title":"Autophagy as a mechanism for anti-angiogenic therapy resistance","volume":"66","author":"Chandra","year":"2020","journal-title":"Semin. Cancer Biol."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.051_bib0018","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy","volume":"170","author":"Yu","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.actbio.2024.05.051_bib0019","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1101\/gr.126516.111","article-title":"Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma","volume":"22","author":"Castellarin","year":"2012","journal-title":"Genome Res."},{"issue":"2","key":"10.1016\/j.actbio.2024.05.051_bib0020","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1101\/gr.126573.111","article-title":"Genomic analysis identifies association of Fusobacterium with colorectal carcinoma","volume":"22","author":"Kostic","year":"2012","journal-title":"Genome Res."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.051_bib0021","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41579-018-0129-6","article-title":"Fusobacterium nucleatum-symbiont, opportunist and oncobacterium","volume":"17","author":"Brennan","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0022","doi-asserted-by":"crossref","first-page":"323","DOI":"10.7150\/thno.38870","article-title":"Fusobacterium nucleatum promotes metastasis in colorectal cancer by activating autophagy signaling via the upregulation of CARD3 expression","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"15_suppl","key":"10.1016\/j.actbio.2024.05.051_bib0023","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2017.35.15_suppl.3545","article-title":"Phase II trial of the autophagy inhibitor hydroxychloroquine with FOLFOX and bevacizumab in front line treatment of metastatic colorectal cancer","volume":"35","author":"O'Hara","year":"2017","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.actbio.2024.05.051_bib0024","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/neuonc\/not119","article-title":"Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma","volume":"15","author":"Lobo","year":"2013","journal-title":"Neuro-oncology"},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mam.2006.12.005","article-title":"Anti-angiogenic gene therapy of cancer: current status and future prospects","volume":"28","author":"Persano","year":"2007","journal-title":"Mol. Asp. Med."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-020-00610-9","article-title":"Lipoplex-based targeted gene therapy for the suppression of tumours with VEGFR expression by producing anti-angiogenic molecules","volume":"18","author":"Ho","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2024.05.051_bib0027","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jconrel.2013.10.003","article-title":"RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system","volume":"173","author":"Sakurai","year":"2014","journal-title":"J. Control. Rel."},{"issue":"6801","key":"10.1016\/j.actbio.2024.05.051_bib0028","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.actbio.2024.05.051_bib0029","doi-asserted-by":"crossref","first-page":"10705","DOI":"10.1073\/pnas.90.22.10705","article-title":"Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor","volume":"90","author":"Kendall","year":"1993","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.051_bib0030","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1006\/bbrc.2002.6478","article-title":"Soluble Flt-1 (Soluble VEGFR-1), a potent natural antiangiogenic molecule in mammals, is phylogenetically conserved in avians","volume":"291","author":"Yamaguchi","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"13","key":"10.1016\/j.actbio.2024.05.051_bib0031","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1016\/j.biomaterials.2009.11.072","article-title":"Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity","volume":"31","author":"Itaka","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.05.051_bib0032","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jconrel.2016.05.042","article-title":"Jumping the nuclear envelope barrier: improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306","volume":"234","author":"Zhou","year":"2016","journal-title":"J. Control. Rel."},{"key":"10.1016\/j.actbio.2024.05.051_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120156","article-title":"Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability","volume":"255","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.actbio.2024.05.051_bib0034","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1021\/bm200807s","article-title":"Effects of base polymer hydrophobicity and end-group modification on polymeric gene delivery","volume":"12","author":"Sunshine","year":"2011","journal-title":"Biomacromolecules"},{"issue":"32","key":"10.1016\/j.actbio.2024.05.051_bib0035","doi-asserted-by":"crossref","first-page":"7971","DOI":"10.1016\/j.biomaterials.2013.07.005","article-title":"Hydrophobic modification of low molecular weight polyethylenimine for improved gene transfection","volume":"34","author":"Teo","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.05.051_bib0036","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.2147\/IJN.S266514","article-title":"Design and fabrication of dual redox responsive nanoparticles with diselenide linkage combined photodynamically to effectively enhance gene expression","volume":"15","author":"Fang","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.actbio.2024.05.051_bib0037","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jconrel.2008.06.022","article-title":"Effect of chemical functionalities in poly(amido amine)s for non-viral gene transfection","volume":"132","author":"Lin","year":"2008","journal-title":"J. Control. Rel."},{"key":"10.1016\/j.actbio.2024.05.051_bib0038","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1021\/bk-2004-0879.ch011","article-title":"Clinically available endosomolytic agent for gene delivery","volume":"879","author":"Itaka","year":"2004","journal-title":"ACS Symp. Ser."},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0039","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0168-3659(97)00249-6","article-title":"Effects of membrane-active agents in gene delivery","volume":"53","author":"Wagner","year":"1998","journal-title":"J. Control. Rel."},{"key":"10.1016\/j.actbio.2024.05.051_bib0040","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.actbio.2023.11.019","article-title":"Amphiphilic polymeric nanodrug integrated with superparamagnetic iron oxide nanoparticles for synergistic antibacterial and antitumor therapy of colorectal cancer","volume":"173","author":"Li","year":"2024","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.actbio.2024.05.051_bib0041","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4161\/auto.4734","article-title":"Autophagy and angiogenesis inhibition","volume":"3","author":"Ramakrishnan","year":"2007","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0042","article-title":"Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: systematic review, improvements and future challenges","volume":"4","author":"Liu","year":"2023","journal-title":"Exploration"},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0043","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/15548627.2023.2249762","article-title":"Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer","volume":"20","author":"Li","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.actbio.2024.05.051_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.137605","article-title":"Construction of size-transformable supramolecular nano-platform against drug-resistant colorectal cancer caused by Fusobacterium nucleatum","volume":"450","author":"Yan","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2024.05.051_bib0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jconrel.2023.05.034","article-title":"In situ-activated photothermal nanoplatform for on-demand NO gas delivery and enhanced colorectal cancer treatment","volume":"359","author":"Xin","year":"2023","journal-title":"J. Control. Rel."},{"issue":"18","key":"10.1016\/j.actbio.2024.05.051_bib0046","doi-asserted-by":"crossref","first-page":"7658","DOI":"10.1021\/acs.chemmater.7b01982","article-title":"Bioinspired design of stereospecific D-protein nanomimics for high-efficiency autophagy induction","volume":"29","author":"Hu","year":"2017","journal-title":"Chem. Mater."},{"issue":"31","key":"10.1016\/j.actbio.2024.05.051_bib0047","doi-asserted-by":"crossref","first-page":"eabb8725","DOI":"10.1126\/sciadv.abb8725","article-title":"Development of a pH-responsive polymersome inducing endoplasmic reticulum stress and autophagy blockade","volume":"6","author":"Xu","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2024.05.051_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105582","article-title":"Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms","volume":"168","author":"Ferreira","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"22","key":"10.1016\/j.actbio.2024.05.051_bib0049","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/pola.29512","article-title":"Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration","volume":"57","author":"Yu","year":"2019","journal-title":"J. Polym. Sci., Part A: Polym. Chem."},{"key":"10.1016\/j.actbio.2024.05.051_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-018-0930-x","article-title":"Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLC\u03b5-NF-\u03baB signaling pathway and VEGF-C\/Bcl-2 expression","volume":"18","author":"Chen","year":"2019","journal-title":"Mol. Cancer"},{"issue":"27","key":"10.1016\/j.actbio.2024.05.051_bib0051","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.1016\/j.biomaterials.2013.04.030","article-title":"Gene transfection efficacy and biocompatibility of polycation\/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"issue":"35","key":"10.1016\/j.actbio.2024.05.051_bib0052","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1016\/j.biomaterials.2010.08.043","article-title":"Amphoteric hyaluronic acid derivative for targeting gene delivery","volume":"31","author":"Yao","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.05.051_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121257","article-title":"The role of hyaluronic acid in the design and functionalization of nanoparticles for the treatment of colorectal cancer","volume":"320","author":"de Paula","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2024.05.051_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121312","article-title":"Polymeric PD-L1 blockade nanoparticles for cancer photothermal-immunotherapy","volume":"280","author":"Yu","year":"2022","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.actbio.2024.05.051_bib0055","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.1021\/nn403325f","article-title":"Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity","volume":"7","author":"Nelson","year":"2013","journal-title":"ACS Nano"},{"issue":"18","key":"10.1016\/j.actbio.2024.05.051_bib0056","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1016\/j.biomaterials.2012.03.017","article-title":"Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2024.05.051_bib0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/29934168.2023.2268943","article-title":"Green Biomaterials: fundamental principles","volume":"1","author":"Rabiee","year":"2023","journal-title":"Green Biomater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124002988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124002988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T11:59:10Z","timestamp":1720612750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124002988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":57,"alternative-id":["S1742706124002988"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.05.051","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A gene delivery system with autophagy blockade for enhanced anti-angiogenic therapy against Fusobacterium nucleatum-associated colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.05.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Acta Materialia Inc. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}