{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:41:54Z","timestamp":1793108514363,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.actbio.2024.07.003","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:27:25Z","timestamp":1720657645000},"page":"441-455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Multifunctional cerium oxide nanozymes with high ocular surface retention for dry eye disease treatment achieved by restoring redox balance"],"prefix":"10.1016","volume":"185","author":[{"given":"Haoyu","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueze","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-6059","authenticated-orcid":false,"given":"Quankui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2024.07.003_bib0001","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/jama.2021.19963","article-title":"Dry eye disease: an update in 2022","volume":"327","author":"Hakim","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.actbio.2024.07.003_bib0002","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.151078","article-title":"Epithelial stem cell homeostasis in meibomian gland development, dysfunction, and dry eye disease","volume":"6","author":"Tchegnon","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.actbio.2024.07.003_bib0003","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.3390\/biomedicines10051160","article-title":"Altered ocular surface health status and tear film immune profile due to prolonged daily mask wear in health care workers","volume":"10","author":"D'Souza","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.actbio.2024.07.003_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.802302","article-title":"The association between dry eye disease with depression, anxiety and sleep disturbance during COVID-19","volume":"12","author":"He","year":"2022","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.actbio.2024.07.003_bib0005","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/ICO.0000000000001932","article-title":"The correlation between dry eyes, anxiety and depression: the sicca, anxiety and depression study","volume":"38","author":"Bitar","year":"2019","journal-title":"Cornea"},{"key":"10.1016\/j.actbio.2024.07.003_bib0006","first-page":"34","article-title":"IFN-\u03b3 facilitates corneal epithelial cell pyroptosis through the JAK2\/STAT1 pathway in dry eye","volume":"64","author":"Yang","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2024.07.003_bib0007","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jtos.2023.03.002","article-title":"MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1\/TAB2\/NF-kappaB pathway","volume":"28","author":"Wang","year":"2023","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.actbio.2024.07.003_bib0008","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1039\/C9NR00376B","article-title":"Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease","volume":"11","author":"Li","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.actbio.2024.07.003_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109418","article-title":"Cyclosporin A improves the hyperosmotic response in an experimental dry eye model by inhibiting the HMGB1\/TLR4\/NF-kappaB signaling pathway","volume":"229","author":"Shen","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.actbio.2024.07.003_bib0010","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.3390\/ijms24054754","article-title":"Dynasore protects corneal epithelial cells subjected to hyperosmolar stress in an in vitro model of dry eye epitheliopathy","volume":"24","author":"Martinez-Carrasco","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2024.07.003_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101093","article-title":"Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells","volume":"21","author":"Dai","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.actbio.2024.07.003_bib0012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.63.10.3","article-title":"AKR1C1 protects corneal epithelial cells against oxidative stress-mediated ferroptosis in dry eye","volume":"63","author":"Zuo","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2024.07.003_bib0013","article-title":"Anti-oxidative and mucin-compensating dual-functional nano eye drops for synergistic treatment of dry eye disease","volume":"27","author":"Jin","year":"2022","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.actbio.2024.07.003_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202200678","article-title":"In situ forming hydrogel as a tracer and degradable lacrimal plug for dry eye treatment","volume":"11","author":"Dai","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0015","article-title":"Antiangiogenic nanomicelles for the topical delivery of aflibercept to treat retinal neovascular disease","volume":"34","author":"Zhao","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0016","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1124\/jpet.119.256933","article-title":"Ocular drug delivery: present innovations and future challenges","volume":"370","author":"Gote","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.actbio.2024.07.003_bib0017","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1208\/s12249-023-02516-9","article-title":"Ocular drug delivery: a comprehensive review","volume":"24","author":"Ahmed","year":"2023","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.actbio.2024.07.003_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114817","article-title":"Smart contact lens systems for ocular drug delivery and therapy","volume":"196","author":"Kim","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2024.07.003_bib0019","first-page":"77","article-title":"Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye","volume":"9","author":"Han","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0020","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.actbio.2019.08.035","article-title":"Phenylboronic acid-tethered chondroitin sulfate-based mucoadhesive nanostructured lipid carriers for the treatment of dry eye syndrome","volume":"99","author":"Tan","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0021","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jcis.2021.03.151","article-title":"Biomass activated carbon-derived imprinted polymer with multi-boronic acid sites for selective capture of glycoprotein","volume":"596","author":"Ding","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.actbio.2024.07.003_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118082","article-title":"Dendrimer-assisted boronate affinity cellulose foams for the efficient and selective separation of glycoproteins","volume":"265","author":"Yao","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2024.07.003_bib0023","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1021\/acsabm.0c00080","article-title":"A bioadhesive nanoplatform enhances the permeation of drugs used to treat diabetic macular edema","volume":"3","author":"Zhang","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.colcom.2021.100429","article-title":"Anchoring polyethylene glycol to the ocular surface by phenylboronic acid functionalization: implications for fabrication of long-acting artificial tears","volume":"42","author":"Gong","year":"2021","journal-title":"Colloid Interface Sci. Commun."},{"key":"10.1016\/j.actbio.2024.07.003_bib0025","doi-asserted-by":"crossref","first-page":"9565","DOI":"10.1021\/acsami.5b11866","article-title":"Sialic acid-targeted nanovectors with phenylboronic acid-grafted polyethylenimine robustly enhance siRNA-based cancer therapy","volume":"8","author":"Ji","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2024.07.003_bib0026","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s12274-014-0547-3","article-title":"Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentally induced dry eye syndrome","volume":"8","author":"Liu","year":"2015","journal-title":"Nano Res."},{"key":"10.1016\/j.actbio.2024.07.003_bib0027","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1039\/C8CS00457A","article-title":"Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)","volume":"48","author":"Wu","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2024.07.003_bib0028","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3390\/biomimetics8050446","article-title":"Recent development and application of \u201cnanozyme\u201d artificial enzymes\u2013a review","volume":"8","author":"Jeyachandran","year":"2023","journal-title":"Biomimetics"},{"key":"10.1016\/j.actbio.2024.07.003_bib0029","doi-asserted-by":"crossref","first-page":"rbac070","DOI":"10.1093\/rb\/rbac070","article-title":"Regenerative cerium oxide nanozymes alleviate oxidative stress for efficient dry eye disease treatment","volume":"9","author":"Zou","year":"2022","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0030","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/acsnano.2c05447","article-title":"Repeated topical administration of 3 nm cerium oxide nanoparticles reverts disease atrophic phenotype and arrests neovascular degeneration in AMD mouse models","volume":"17","author":"Badia","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2024.07.003_bib0031","doi-asserted-by":"crossref","first-page":"rbac037","DOI":"10.1093\/rb\/rbac037","article-title":"Central nervous system injury meets nanoceria: opportunities and challenges","volume":"9","author":"Yang","year":"2022","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0032","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1039\/D1TB02689E","article-title":"An antioxidant nanodrug protects against hepatic ischemia-reperfusion injury by attenuating oxidative stress and inflammation","volume":"10","author":"Zhang","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2024.07.003_bib0033","doi-asserted-by":"crossref","first-page":"11937","DOI":"10.1021\/acsami.1c24686","article-title":"Density functional theory investigation of the biocatalytic mechanisms of pH-driven biomimetic behavior in CeO2","volume":"14","author":"Ma","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2024.07.003_bib0034","article-title":"Nanoceria for ocular diseases: recent advances and future prospects","volume":"18","author":"Cui","year":"2022","journal-title":"Mater. Today Nano"},{"key":"10.1016\/j.actbio.2024.07.003_bib0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1089\/jop.2019.0105","article-title":"Ophthalmic applications of cerium oxide nanoparticles","volume":"36","author":"Maccarone","year":"2020","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.actbio.2024.07.003_bib0036","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1039\/D2TA07917H","article-title":"A room temperature ammonia gas sensor based on cerium oxide\/MXene and self-powered by a freestanding-mode triboelectric nanogenerator and its multifunctional monitoring application","volume":"11","author":"Wang","year":"2023","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.actbio.2024.07.003_bib0037","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1021\/acsami.0c19074","article-title":"In vivo regenerable cerium oxide nanozyme-loaded pH\/H2O2-responsive nanovesicle for tumor-targeted photothermal and photodynamic therapies","volume":"13","author":"Zeng","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2024.07.003_bib0038","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jcis.2020.10.081","article-title":"Characterization of a nitric oxide (NO) donor molecule and cerium oxide nanoparticle (CNP) interactions and their synergistic antimicrobial potential for biomedical applications","volume":"586","author":"Estes","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.actbio.2024.07.003_bib0039","article-title":"Minocycline-loaded cerium oxide nanoparticles for the enhanced treatment of intracerebral hemorrhage","author":"Xu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.102044","article-title":"Metal polyphenol network\/cerium oxide artificial enzymes therapeutic nanoplatform for MRI\/CT-aided intestinal inflammation management","volume":"53","author":"Deng","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.actbio.2024.07.003_bib0041","doi-asserted-by":"crossref","first-page":"rbab074","DOI":"10.1093\/rb\/rbab074","article-title":"Injectable self-healing ceria-based nanocomposite hydrogel with ROS-scavenging activity for skin wound repair","volume":"9","author":"Gong","year":"2022","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2024.07.003_bib0042","doi-asserted-by":"crossref","first-page":"13759","DOI":"10.1021\/acsnano.1c05272","article-title":"Ceria nanozyme-integrated microneedles reshape the perifollicular microenvironment for androgenetic alopecia treatment","volume":"15","author":"Yuan","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2024.07.003_bib0043","article-title":"Anti-oxidative and anti-inflammatory micelles: break the dry eye vicious cycle","volume":"9","author":"Li","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2024.07.003_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.913648","article-title":"Mussel-inspired microgel encapsulated NLRP3 inhibitor as a synergistic strategy against dry eye","volume":"10","author":"Zha","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2024.07.003_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bj.2023.04.001","article-title":"Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy","volume":"46","author":"Cheon","year":"2023","journal-title":"Biomed. J."},{"key":"10.1016\/j.actbio.2024.07.003_bib0046","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1021\/acs.molpharmaceut.3c00068","article-title":"Hypoxia inhibitor combined with chemotherapeutic agents for antitumor and antimetastatic efficacy against osteosarcoma","volume":"20","author":"Zhao","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2024.07.003_bib0047","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1021\/acsnano.2c12614","article-title":"Single-atom nanocatalytic therapy for suppression of neuroinflammation by inducing autophagy of abnormal mitochondria","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2024.07.003_bib0048","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3892\/ijmm.2023.5239","article-title":"Metformin reverses oxidative stress\u2011induced mitochondrial dysfunction in pre\u2011osteoblasts via the EGFR\/GSK\u20113beta\/calcium pathway","volume":"51","author":"Cao","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.actbio.2024.07.003_bib0049","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1048177","article-title":"Current perspectives of mitochondria-targeted antioxidants in cancer prevention and treatment","volume":"11","author":"Zinovkin","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.actbio.2024.07.003_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114721","article-title":"Nano-based eye drop: topical and noninvasive therapy for ocular diseases","volume":"194","author":"Wang","year":"2023","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270612400374X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270612400374X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T15:00:16Z","timestamp":1725807616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S174270612400374X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":50,"alternative-id":["S174270612400374X"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.07.003","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multifunctional cerium oxide nanozymes with high ocular surface retention for dry eye disease treatment achieved by restoring redox balance","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Acta Materialia Inc. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}