{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:03:16Z","timestamp":1785582196734,"version":"3.56.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["809831"],"award-info":[{"award-number":["809831"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008767","name":"Fundaci\u00f3n Agencia Aragonesa para la Investigaci\u00f3n y el Desarrollo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00242"],"award-info":[{"award-number":["PI21\/00242"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.actbio.2024.09.002","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T11:17:48Z","timestamp":1725707868000},"page":"157-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Thermosensitive chitosan-based hydrogel: A vehicle for overcoming the limitations of nose-to-brain cell therapy"],"prefix":"10.1016","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7005-8019","authenticated-orcid":false,"given":"Doddy Denise","family":"Ojeda-Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-6750","authenticated-orcid":false,"given":"Susana","family":"Velasco-Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-5138","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Fraile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-6654","authenticated-orcid":false,"given":"J.C.","family":"Mateos-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9517-0050","authenticated-orcid":false,"given":"Francisco J.","family":"Rojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-6426","authenticated-orcid":false,"given":"Mar\u00eda Soledad","family":"Benito-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-5558","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Selma-Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6241-5795","authenticated-orcid":false,"given":"Sarah de la","family":"Fuente-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8007-3586","authenticated-orcid":false,"given":"Marina","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4843-324X","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Larriba-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-0360","authenticated-orcid":false,"given":"Mercedes Azucena","family":"Hern\u00e1ndez-Sapi\u00e9ns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro A.","family":"Canales-Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi A.","family":"Matias-Guiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Matias-Guiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-5557","authenticated-orcid":false,"given":"Ulises","family":"Gomez-Pinedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2024.09.002_bib0001","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41582-022-00736-4","article-title":"Cell-based therapies for neurological disorders \u2014 The bioreactor hypothesis","volume":"19","author":"Savitz","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.actbio.2024.09.002_bib0002","series-title":"International Review of Neurobiology","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/bs.irn.2023.04.003","article-title":"Chapter six - advances in neurorestoratology\u2014current status and future developments","author":"Huang","year":"2023"},{"key":"10.1016\/j.actbio.2024.09.002_bib0003","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.reth.2023.03.004","article-title":"Clinical results of neurorestorative cell therapies and therapeutic indications according to cellular bio-proprieties","volume":"23","author":"Huang","year":"2023","journal-title":"Regenerat. Therapy"},{"key":"10.1016\/j.actbio.2024.09.002_bib0004","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.14336\/AD.2021.0416","article-title":"Oligodendrocyte precursor cells transplantation improves stroke recovery via oligodendrogenesis, neurite growth and synaptogenesis","volume":"12","author":"Li","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.actbio.2024.09.002_bib0005","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.stem.2012.12.002","article-title":"Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination","volume":"12","author":"Wang","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.actbio.2024.09.002_bib0006","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/stem.245","article-title":"Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury","volume":"28","author":"Sharp","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2024.09.002_bib0007","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13287-021-02274-0","article-title":"Advances in intranasal application of stem cells in the treatment of central nervous system diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.actbio.2024.09.002_bib0008","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.3390\/cells11193095","article-title":"Nose-to-brain: the next step for stem cell and biomaterial therapy in neurological disorders","volume":"11","author":"Villar-G\u00f3mez","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.actbio.2024.09.002_bib0009","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/pharmaceutics10030116","article-title":"Tailoring formulations for intranasal nose-to-brain delivery: a review on architecture, physico-chemical characteristics and mucociliary clearance of the nasal olfactory mucosa","volume":"10","author":"G\u00e4nger","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.actbio.2024.09.002_bib0010","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ijbiomac.2016.05.054","article-title":"Why Chitosan? From properties to perspective of mucosal drug delivery","volume":"91","author":"Kumar","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2024.09.002_bib0011","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.3390\/polym13193256","article-title":"Chitosan: an overview of its properties and applications","volume":"13","author":"Aranaz","year":"2021","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.actbio.2024.09.002_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2023.105634","article-title":"Chitosan: a review on properties, biological activities and recent progress in biomedical applications","volume":"191","author":"Harugade","year":"2023","journal-title":"Reactive Funct. Polym."},{"key":"10.1016\/j.actbio.2024.09.002_bib0013","doi-asserted-by":"crossref","unstructured":"D.D. Ojeda-Hern\u00e1ndez, A.A. Canales-Aguirre, J. Matias-Guiu, U. Gomez-Pinedo, J.C. Mateos-D\u00edaz, Potential of chitosan and its derivatives for biomedical applications in the central nervous system, Front. Bioeng. Biotechnol., 8 (2020) 389.","DOI":"10.3389\/fbioe.2020.00389"},{"key":"10.1016\/j.actbio.2024.09.002_bib0014","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.3390\/pharmaceutics14122680","article-title":"Enhanced nasal deposition and anti-coronavirus effect of favipiravir-loaded mucoadhesive chitosan\u2013alginate nanoparticles","volume":"14","author":"Alcantara","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.actbio.2024.09.002_bib0015","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/17425247.2019.1597051","article-title":"Smart thermosensitive chitosan hydrogel for nasal delivery of ibuprofen to treat neurological disorders","volume":"16","author":"Gholizadeh","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.actbio.2024.09.002_bib0016","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.ijbiomac.2018.05.079","article-title":"Temozolomide loaded nano lipid based chitosan hydrogel for nose to brain delivery: characterization, nasal absorption, histopathology and cell line study","volume":"116","author":"Khan","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2024.09.002_bib0017","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.3390\/polym15071615","article-title":"The role of mucoadhesion and mucopenetration in the immune response induced by polymer-based mucosal adjuvants","volume":"15","author":"Vasquez-Mart\u00ednez","year":"2023","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.actbio.2024.09.002_bib0018","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3390\/md20050335","article-title":"Multiple roles of chitosan in mucosal drug delivery: an updated review","volume":"20","author":"Mura","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.actbio.2024.09.002_bib0019","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.3390\/polym13234118","article-title":"Chitosan functionalization: covalent and non-covalent interactions and their characterization","volume":"13","author":"Nicolle","year":"2021","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.actbio.2024.09.002_bib0020","doi-asserted-by":"crossref","first-page":"12473","DOI":"10.3390\/ijms232012473","article-title":"Chitosan-hydroxycinnamic acids conjugates: emerging biomaterials with rising applications in biomedicine","volume":"23","author":"Ojeda-Hern\u00e1ndez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"251","key":"10.1016\/j.actbio.2024.09.002_bib0021","article-title":"Ionic and covalent crosslinking in chitosan-succinic acid membranes: effect on physicochemical properties","author":"Gabriele","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2024.09.002_bib0022","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1134\/S0965545X16030123","article-title":"Enhanced functional properties of chitosan films cross-linked by biosourced dicarboxylic acids","volume":"58","author":"Medimagh","year":"2016","journal-title":"Polym. Sci. Ser. A"},{"key":"10.1016\/j.actbio.2024.09.002_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111806","article-title":"Biocompatibility of ferulic\/succinic acid-grafted chitosan hydrogels for implantation after brain injury: a preliminary study","volume":"121","author":"Ojeda-Hern\u00e1ndez","year":"2021","journal-title":"Mater. Sci. Eng.: C"},{"key":"10.1016\/j.actbio.2024.09.002_bib0024","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/macp.200900385","article-title":"Exploring the factors affecting the solubility of chitosan in water","volume":"211","author":"Sogias","year":"2010","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.actbio.2024.09.002_bib0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13233-015-3006-4","article-title":"Injectable in situ forming chitosan-based hydrogels for curcumin delivery","volume":"23","author":"Songkroh","year":"2015","journal-title":"Macromol. Res."},{"key":"10.1016\/j.actbio.2024.09.002_bib0026","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.carbpol.2015.03.039","article-title":"The dramatic effect of small pH changes on the properties of chitosan hydrogels crosslinked with genipin","volume":"127","author":"Delmar","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2024.09.002_bib0027","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/abio.1993.1263","article-title":"Quantitative determination of chitosan and the percentage of free amino groups","volume":"211","author":"Curotto","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.actbio.2024.09.002_bib0028","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.05.001","article-title":"Evaluation of the safety and efficacy of the therapeutic potential of adipose-derived stem cells injected in the cerebral ischemic penumbra","volume":"27","author":"G\u00f3mez-Pinedo","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.actbio.2024.09.002_bib0029","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF03218961","article-title":"Regioselective succinylation and gelation behavior of glycol chitosan","volume":"16","author":"Jeong","year":"2008","journal-title":"Macromol. Res."},{"key":"10.1016\/j.actbio.2024.09.002_bib0030","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.carbpol.2013.04.006","article-title":"Preparation, characterization and antioxidant property of water-soluble ferulic acid grafted chitosan","volume":"96","author":"Woranuch","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2024.09.002_bib0031","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ijbiomac.2019.03.006","article-title":"Preparation of crosslinked active bilayer film based on chitosan and alginate for regulating ascorbate-glutathione cycle of postharvest cherry tomato (Lycopersicon esculentum)","volume":"130","author":"Zhu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"251","key":"10.1016\/j.actbio.2024.09.002_bib0032","article-title":"Acid-base evaluation of chitosan-ferulic acid conjugate by a free radical grafting method","author":"Anwar","year":"2019","journal-title":"IOP Conf. Ser.: Earth Environ. Sci."},{"key":"10.1016\/j.actbio.2024.09.002_bib0033","doi-asserted-by":"crossref","first-page":"10056","DOI":"10.1021\/acsomega.1c06101","article-title":"Amphiphilic chitosan bearing double palmitoyl chains and quaternary ammonium moieties as a nanocarrier for plasmid DNA","volume":"7","author":"Pol","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.actbio.2024.09.002_bib0034","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1002\/pola.20669","article-title":"Characterization of ring-opening polymerization of genipin and pH-dependent cross-linking reactions between chitosan and genipin","volume":"43","author":"Mi","year":"2005","journal-title":"J. Polym. Sci. Part A: Polym. Chem."},{"key":"10.1016\/j.actbio.2024.09.002_bib0035","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.carbpol.2017.08.029","article-title":"CotA laccase-ABTS\/hydrogen peroxide system: an efficient approach to produce active and decolorized chitosan-genipin films","volume":"175","author":"Gon\u00e7alves","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2024.09.002_bib0036","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/app.1602","article-title":"Release of indomethacin from a novel chitosan microsphere prepared by a naturally occurring crosslinker: examination of crosslinking and polycation\u2013anionic drug interaction","volume":"81","author":"Mi","year":"2001","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.actbio.2024.09.002_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128886","article-title":"Decoupling diffusion and macromolecular relaxation in the release of vitamin B6 from genipin-crosslinked whey protein networks","volume":"346","author":"Teimouri","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.actbio.2024.09.002_bib0038","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ijbiomac.2022.01.193","article-title":"Wound healing and antibacterial chitosan-genipin hydrogels with controlled drug delivery for synergistic anti-inflammatory activity","volume":"203","author":"Andrade del Olmo","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2024.09.002_bib0039","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.carbpol.2013.01.082","article-title":"Biodegradable chitosan nanogels crosslinked with genipin","volume":"94","author":"Arteche Pujana","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2024.09.002_bib0040","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/1099-0518(20000801)38:15<2804::AID-POLA210>3.0.CO;2-Y","article-title":"Synthesis and characterization of a novel chitosan-based network prepared using naturally occurring crosslinker","volume":"38","author":"Mi","year":"2000","journal-title":"J. Polym. Sci. Part A: Polym. Chem."},{"key":"10.1016\/j.actbio.2024.09.002_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2020.104210","article-title":"Preparation of an environmentally friendly lead adsorbent. A contribution to the rational design of heavy metal adsorbents","volume":"8","author":"Rossi","year":"2020","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.actbio.2024.09.002_bib0042","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s12272-013-0139-x","article-title":"Caffeic acid-conjugated chitosan derivatives and their anti-tumor activity","volume":"36","author":"Lee","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.actbio.2024.09.002_bib0043","doi-asserted-by":"crossref","first-page":"9128","DOI":"10.1021\/jf503207s","article-title":"Grafting of gallic acid onto chitosan enhances antioxidant activities and alters rheological properties of the copolymer","volume":"62","author":"Xie","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.actbio.2024.09.002_bib0044","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.foodhyd.2010.08.019","article-title":"Physicochemical properties of gelatin gels from walleye pollock (Theragra chalcogramma) skin cross-linked by gallic acid and rutin","volume":"25","author":"Yan","year":"2011","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.actbio.2024.09.002_bib0045","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.1021\/acs.jafc.6b02468","article-title":"Effect of protocatechuic acid-grafted-chitosan coating on the postharvest quality of Pleurotus eryngii","volume":"64","author":"Liu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.actbio.2024.09.002_bib0046","series-title":"Nanotechnology and Polymers","article-title":"Applications of carboxylic acids in organic synthesis","author":"S\u00e1enz-Galindo","year":"2018"},{"key":"10.1016\/j.actbio.2024.09.002_bib0047","first-page":"84","article-title":"Preparation, structural characterization and functional properties of chitosan derivative","volume":"3","author":"Guo Q","year":"2018","journal-title":"J. Food Technol."},{"key":"10.1016\/j.actbio.2024.09.002_bib0048","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejcb.2009.02.001","article-title":"Intranasal delivery of cells to the brain","volume":"88","author":"Danielyan","year":"2009","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.actbio.2024.09.002_bib0049","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/0963689718754561","article-title":"The route by which intranasally delivered stem cells enter the central nervous system","volume":"27","author":"Galeano","year":"2018","journal-title":"Cell Transplant"},{"key":"10.1016\/j.actbio.2024.09.002_bib0050","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijpharm.2019.02.026","article-title":"How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods","volume":"561","author":"Salade","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2024.09.002_bib0051","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.actbio.2016.10.018","article-title":"Human-derived extracellular matrix from Wharton's jelly: an untapped substrate to build up a standardized and homogeneous coating for vascular engineering","volume":"48","author":"Dan","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.09.002_bib0052","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s40204-019-0108-7","article-title":"A silk fibroin\/decellularized extract of Wharton's jelly hydrogel intended for cartilage tissue engineering","volume":"8","author":"Basiri","year":"2019","journal-title":"Prog. Biomater."},{"key":"10.1016\/j.actbio.2024.09.002_bib0053","doi-asserted-by":"crossref","first-page":"e58314","DOI":"10.1371\/journal.pone.0058314","article-title":"Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a\/pRb pathways","volume":"8","author":"Hao","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2024.09.002_bib0054","article-title":"C-shaped cartilage development using Wharton's jelly-derived hydrogels to assemble a highly biomimetic neotrachea for use in circumferential tracheal reconstruction","volume":"33","author":"Gao","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2024.09.002_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0290095","article-title":"Successful 3D culture and transplantation of mouse isolated preantral follicles in hydrogel of bioengineered Wharton's jelly","volume":"18","author":"Zand","year":"2023","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2024.09.002_bib0056","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000244392","article-title":"Collagen and glycosaminoglycans of Wharton's jelly","volume":"71","author":"Sobolewski","year":"1997","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.actbio.2024.09.002_bib0057","series-title":"Nanostructures for Oral Medicine","first-page":"409","article-title":"Chapter 14 - Polysaccharide based nano\/microformulation: an effective and versatile oral drug delivery system","author":"Nurunnabi","year":"2017"},{"key":"10.1016\/j.actbio.2024.09.002_bib0058","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/polb.21475","article-title":"Dissociation behaviors of carboxyl and amine groups on carboxymethyl-chitosan in aqueous system","volume":"46","author":"Wang","year":"2008","journal-title":"J. Polym. Sci. Part B: Polym. Phys."},{"key":"10.1016\/j.actbio.2024.09.002_bib0059","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.3390\/biomedicines10112724","article-title":"Exogenous FGF-1 differently regulates oligodendrocyte replenishment in an SCI repair model and cultured cells","volume":"10","author":"Meng-Jen","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.actbio.2024.09.002_bib0060","first-page":"10435","article-title":"Nose-to-brain delivery by nanosuspensions-based in situ gel for breviscapine","volume":"15","author":"Y","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2024.09.002_bib0061","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1080\/17425247.2018.1517741","article-title":"In situ gelling and mucoadhesive polymers: why do they need each other?","volume":"15","author":"Zahir-Jouzdani","year":"2018","journal-title":"Expert Opin. Drug Deliv."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124005105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124005105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:55:16Z","timestamp":1728953716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124005105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":61,"alternative-id":["S1742706124005105"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.09.002","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thermosensitive chitosan-based hydrogel: A vehicle for overcoming the limitations of nose-to-brain cell therapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}