{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:41:03Z","timestamp":1791394863085,"version":"4.3.3"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.actbio.2024.10.050","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T12:34:59Z","timestamp":1731414899000},"page":"189-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Harnessing synergistic effects of MMP-2 Inhibition and bFGF to simultaneously preserve and vascularize cardiac extracellular matrix after myocardial infarction"],"prefix":"10.1016","volume":"191","author":[{"given":"Hong","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-3864","authenticated-orcid":false,"given":"Zhongting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-4966","authenticated-orcid":false,"given":"Ya","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-7765","authenticated-orcid":false,"given":"Jiaxing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.actbio.2024.10.050_bib0009","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/CIRCRESAHA.114.302533","article-title":"Myocardial extracellular matrix: an ever-changing and diverse entity","volume":"114","author":"Rienks","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2024.10.050_bib0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/bs.pmbts.2017.02.001","article-title":"Matrix metalloproteinases in myocardial infarction and heart failure","volume":"147","author":"DeLeon-Pennell","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"8","key":"10.1016\/j.actbio.2024.10.050_bib0011","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41569-018-0022-z","article-title":"Assigning matrix metalloproteinase roles in ischaemic cardiac remodelling","volume":"15","author":"Lindsey","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"10","key":"10.1016\/j.actbio.2024.10.050_bib0012","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1161\/CIRCULATIONAHA.105.600353","article-title":"Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling","volume":"114","author":"Webb","year":"2006","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.actbio.2024.10.050_bib0013","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1054-8807(98)00008-8","article-title":"Early activation of metalloproteinases after experimental myocardial infarction occurs in infarct and non-infarct zones","volume":"7","author":"Herzog","year":"1998","journal-title":"Cardiovasc. Pathol."},{"issue":"14","key":"10.1016\/j.actbio.2024.10.050_bib0014","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1161\/01.CIR.0000160936.91849.9F","article-title":"Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction","volume":"111","author":"Chen","year":"2005","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.actbio.2024.10.050_bib0015","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0008-6363(00)00029-8","article-title":"Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat","volume":"46","author":"Peterson","year":"2000","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1023\/B:HREV.0000011392.03037.7e","article-title":"The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling","volume":"9","author":"Janicki","year":"2004","journal-title":"Heart. Fail. Rev."},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0002","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/CIRCRESAHA.112.266882","article-title":"Membrane-associated matrix proteolysis and heart failure","volume":"112","author":"Spinale","year":"2013","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0003","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/B:HREV.0000011394.34355.bb","article-title":"Matrix metalloproteinases: pathways of induction by bioactive molecules","volume":"9","author":"Tsuruda","year":"2004","journal-title":"Heart. Fail. Rev."},{"issue":"8","key":"10.1016\/j.actbio.2024.10.050_bib0016","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/ph15080920","article-title":"Matrix metalloproteinase 2 as a pharmacological target in heart failure","volume":"15","author":"Gon\u00e7alves","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.actbio.2024.10.050_bib0017","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.matbio.2017.12.001","article-title":"Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes","volume":"75","author":"Nielsen","year":"2019","journal-title":"Matrix Biol."},{"issue":"11","key":"10.1016\/j.actbio.2024.10.050_bib0018","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41419-020-03211-4","article-title":"Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction","volume":"11","author":"Yang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0019","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.119.311148","article-title":"The extracellular matrix in ischemic and nonischemic heart failure","volume":"125","author":"Frangogiannis","year":"2019","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.actbio.2024.10.050_bib0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/01.fjc.0000200989.23987.b8","article-title":"Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling","volume":"47","author":"Apple","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.actbio.2024.10.050_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107465","article-title":"The past, present and future perspectives of matrix metalloproteinase inhibitors","volume":"207","author":"Li","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.actbio.2024.10.050_bib0021","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1124\/pharmrev.121.000349","article-title":"Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology","volume":"74","author":"de Almeida","year":"2022","journal-title":"Pharmacol. Rev."},{"issue":"12","key":"10.1016\/j.actbio.2024.10.050_bib0022","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/jnci\/djq179","article-title":"chemoradiotherapy With or Without Ae-941 in Stage iii Non\u2013Small cell lung cancer: a randomized Phase iii trial","volume":"102","author":"Lu","year":"2010","journal-title":"JNCI J. Natl. Cancer Inst."},{"issue":"5","key":"10.1016\/j.actbio.2024.10.050_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127063","article-title":"Selective allosteric inhibition of MMP9 is efficacious in preclinical models of ulcerative colitis and colorectal cancer","volume":"10","author":"Marshall","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.actbio.2024.10.050_bib0024","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1021\/acs.bioconjchem.3c00266","article-title":"Matrix metalloproteinase-responsive drug delivery systems","volume":"34","author":"Zhang","year":"2023","journal-title":"Bioconjug. Chem."},{"issue":"9","key":"10.1016\/j.actbio.2024.10.050_bib0025","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3390\/cells8090984","article-title":"The Rebirth of Matrix Metalloproteinase Inhibitors: moving Beyond the Dogma","volume":"8","author":"Fields","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.actbio.2024.10.050_bib0026","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201801217","article-title":"Decellularized extracellular matrix materials for cardiac repair and regeneration","volume":"8","author":"Bejleri","year":"2019","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.actbio.2024.10.050_bib0004","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/hc0602.103674","article-title":"Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction","volume":"105","author":"Lindsey","year":"2002","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0006","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/B:HREV.0000011390.44039.b7","article-title":"MMP induction and inhibition in myocardial infarction","volume":"9","author":"Lindsey","year":"2004","journal-title":"Heart. Fail. Rev."},{"issue":"223","key":"10.1016\/j.actbio.2024.10.050_bib0007","doi-asserted-by":"crossref","first-page":"223ra21","DOI":"10.1126\/scitranslmed.3007244","article-title":"Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction","volume":"6","author":"Eckhouse","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"17","key":"10.1016\/j.actbio.2024.10.050_bib0027","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.jacc.2020.03.020","article-title":"Extracellular matrix in ischemic heart disease, part 4\/4: JACC focus seminar","volume":"75","author":"Frangogiannis","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.actbio.2024.10.050_bib0028","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.biomaterials.2016.02.033","article-title":"Engineering a growth factor embedded nanofiber matrix niche to promote vascularization for functional cardiac regeneration","volume":"97","author":"Lakshmanan","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.10.050_bib0029","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.biomaterials.2017.01.037","article-title":"Perivascular extracellular matrix hydrogels mimic native matrix microarchitecture and promote angiogenesis via basic fibroblast growth factor","volume":"123","author":"Fercana","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.10.050_bib0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.addr.2015.06.001","article-title":"Vascularization strategies of engineered tissues and their application in cardiac regeneration","volume":"96","author":"Sun","year":"2016","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"8","key":"10.1016\/j.actbio.2024.10.050_bib0031","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.7150\/thno.29552","article-title":"Engineering stem cell cardiac patch with microvascular features representative of native myocardium","volume":"9","author":"Qian","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2024.10.050_bib0032","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biomaterials.2017.09.001","article-title":"Extracellular matrix-derived extracellular vesicles promote cardiomyocyte growth and electrical activity in engineered cardiac atria","volume":"146","author":"An","year":"2017","journal-title":"Biomaterials"},{"issue":"584","key":"10.1016\/j.actbio.2024.10.050_bib0033","doi-asserted-by":"crossref","first-page":"eabb0202","DOI":"10.1126\/scitranslmed.abb0202","article-title":"Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates","volume":"13","author":"Li","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.actbio.2024.10.050_bib0034","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1021\/acsami.9b19452","article-title":"Local delivery of dual microRNAs in trilayered electrospun grafts for vascular regeneration","volume":"12","author":"Wen","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2024.10.050_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115301","article-title":"Vascular endothelial growth factor (VEGF) delivery approaches in regenerative medicine","volume":"166","author":"Beheshtizadeh","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.actbio.2024.10.050_bib0036","doi-asserted-by":"crossref","first-page":"541","DOI":"10.7150\/thno.3682","article-title":"Vascular endothelial growth factor-delivery systems for cardiac repair: an overview","volume":"2","author":"Sim\u00f3n-Yarza","year":"2012","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.actbio.2024.10.050_bib0037","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.stemcr.2015.10.019","article-title":"Fibroblast growth factors and vascular endothelial growth factor promote cardiac reprogramming under defined conditions","volume":"5","author":"Yamakawa","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.actbio.2024.10.050_bib0038","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijcard.2021.08.022","article-title":"Platelet-derived growth factor (PDGF) therapy in myocardial infarction: challenges and opportunities","volume":"341","author":"Frangogiannis","year":"2021","journal-title":"Int. J. Cardiol."},{"issue":"5","key":"10.1016\/j.actbio.2024.10.050_bib0039","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1161\/01.RES.0000122042.51161.B6","article-title":"Platelet-derived growth factor-AB promotes the generation of adult bone marrow\u2013derived cardiac myocytes","volume":"94","author":"Xaymardan","year":"2004","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.actbio.2024.10.050_bib0008","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nmat3922","article-title":"Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition","volume":"13","author":"Purcell","year":"2014","journal-title":"Nat. Mater."},{"issue":"12","key":"10.1016\/j.actbio.2024.10.050_bib0040","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.eng.2021.08.011","article-title":"Research and progress of implantable cardiovascular materials and devices","volume":"7","author":"Wang","year":"2021","journal-title":"Engineering"},{"key":"10.1016\/j.actbio.2024.10.050_bib0041","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jconrel.2024.03.050","article-title":"Remodeling brain pathological microenvironment to lessen cerebral ischemia injury by multifunctional injectable hydrogels","volume":"369","author":"Zhang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2024.10.050_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121849","article-title":"Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis properties","volume":"290","author":"Hu","year":"2022","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0043","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jss.2006.04.034","article-title":"Application of bFGF and BDNF to improve angiogenesis and cardiac function","volume":"136","author":"Liu","year":"2006","journal-title":"J. Surg. Res."},{"issue":"7","key":"10.1016\/j.actbio.2024.10.050_bib0044","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3390\/nano9071037","article-title":"Sustained release of basic fibroblast growth factor (bFGF) encapsulated polycaprolactone (PCL) microspheres promote angiogenesis in vivo","volume":"9","author":"Arunkumar","year":"2019","journal-title":"Nanomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-020-00555-4","article-title":"TGF-\u03b2 and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus","volume":"18","author":"Yousefi","year":"2020","journal-title":"Cell Commun. Signal."},{"issue":"7","key":"10.1016\/j.actbio.2024.10.050_bib0046","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3390\/cells10071716","article-title":"Cardiac fibrosis and fibroblasts","volume":"10","author":"Kurose","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.actbio.2024.10.050_bib0047","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.18632\/oncotarget.23795","article-title":"Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-\u03b2 receptor type I inhibitor","volume":"9","author":"Yingling","year":"2018","journal-title":"Oncotarget."},{"issue":"536","key":"10.1016\/j.actbio.2024.10.050_bib0048","doi-asserted-by":"crossref","first-page":"eaay8456","DOI":"10.1126\/scitranslmed.aay8456","article-title":"Selective inhibition of TGF\u03b21 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape","volume":"12","author":"Martin","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2024.10.050_bib0049","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00262-011-1119-y","article-title":"The small molecule TGF-\u03b2 signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis","volume":"61","author":"Garrison","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"issue":"8","key":"10.1016\/j.actbio.2024.10.050_bib0050","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/11703","article-title":"Tumor targeting with a selective gelatinase inhibitor","volume":"17","author":"Koivunen","year":"1999","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.actbio.2024.10.050_bib0051","doi-asserted-by":"crossref","first-page":"14230","DOI":"10.3390\/molecules171214230","article-title":"Peptide-based selective inhibitors of matrix metalloproteinase-mediated activities","volume":"17","author":"Ndinguri","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.actbio.2024.10.050_bib0052","doi-asserted-by":"crossref","DOI":"10.1021\/acs.biomac.7b00760","article-title":"Sustained release of a peptide-based matrix metalloproteinase-2 inhibitor to attenuate adverse cardiac remodeling and improve cardiac function following myocardial infarction","author":"Fan","year":"2017","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2024.10.050_bib0053","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jconrel.2019.09.005","article-title":"Spatiotemporal delivery of basic fibroblast growth factor to directly and simultaneously attenuate cardiac fibrosis and promote cardiac tissue vascularization following myocardial infarction","volume":"311","author":"Fan","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2024.10.050_bib0054","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.actbio.2015.12.021","article-title":"A prosurvival and proangiogenic stem cell delivery system to promote ischemic limb regeneration","volume":"31","author":"Xu","year":"2016","journal-title":"Acta Biomater."},{"issue":"35","key":"10.1016\/j.actbio.2024.10.050_bib0055","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj0153","article-title":"Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation","volume":"7","author":"Guan","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2024.10.050_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2022.03.021","article-title":"Delivery of VEGF and Delta-like 4 to Synergistically Regenerate Capillaries and Arterioles in Ischemic Limbs","author":"Niu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.10.050_bib0057","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.actbio.2018.10.038","article-title":"Thermosensitive, fast gelling, photoluminescent, highly flexible, and degradable hydrogels for stem cell delivery","volume":"83","author":"Niu","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.10.050_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2020.01.017","article-title":"High Oxygen Preservation Hydrogels to Augment Cell Survival under Hypoxic Condition","author":"Niu","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.10.050_bib0059","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","article-title":"Cell sensitivity assays: the MTT assay","author":"Van Meerloo","year":"2011","journal-title":"Cancer Cell Cult. Methods Protoc."},{"issue":"2","key":"10.1016\/j.actbio.2024.10.050_bib0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/ceo.12374","article-title":"Bevacizumab modulates the process of fibrosis in vitro","volume":"43","author":"Zhang","year":"2015","journal-title":"Clin. Experiment. Ophthalmol."},{"issue":"2","key":"10.1016\/j.actbio.2024.10.050_bib0061","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/cvr\/cvm102","article-title":"Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead","volume":"78","author":"Van Hinsbergh","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.actbio.2024.10.050_bib0062","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022210","article-title":"TGF-\u03b2 signaling in control of cardiovascular function","volume":"10","author":"Goumans","year":"2018","journal-title":"Cold. Spring. Harb. Perspect. Biol."},{"issue":"4","key":"10.1016\/j.actbio.2024.10.050_bib0063","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S1097-2765(03)00386-1","article-title":"Activin receptor-like kinase (ALK) 1 is an antagonistic mediator of lateral TGF\u03b2\/ALK5 signaling","volume":"12","author":"Goumans","year":"2003","journal-title":"Mol. Cell"},{"issue":"18","key":"10.1016\/j.actbio.2024.10.050_bib0064","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1242\/jcs.048942","article-title":"VEGF and inhibitors of TGF\u03b2 type-I receptor kinase synergistically promote blood-vessel formation by inducing \u03b15-integrin expression","volume":"122","author":"Liu","year":"2009","journal-title":"J. Cell. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2024.10.050_bib0065","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/carcin\/bgp327","article-title":"ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1\/5\/8 signaling and endothelial cell migration","volume":"31","author":"Ray","year":"2010","journal-title":"Carcinogenesis"},{"issue":"11","key":"10.1016\/j.actbio.2024.10.050_bib0066","doi-asserted-by":"crossref","first-page":"19551","DOI":"10.1021\/acsnano.2c10043","article-title":"Rescuing cardiac cells and improving cardiac function by targeted delivery of oxygen-releasing nanoparticles after or even before acute myocardial infarction","volume":"16","author":"Guan","year":"2022","journal-title":"ACS. Nano"},{"issue":"5","key":"10.1016\/j.actbio.2024.10.050_bib0067","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1021\/acsami.0c19271","article-title":"Targeted delivery of a matrix metalloproteinases-2 specific inhibitor using multifunctional nanogels to attenuate ischemic skeletal muscle degeneration and promote revascularization","volume":"13","author":"Dang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.actbio.2024.10.050_bib0068","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3390\/polym3020740","article-title":"Hydrogels for cardiac tissue engineering","volume":"3","author":"Li","year":"2011","journal-title":"Polymers (Basel)"},{"issue":"9","key":"10.1016\/j.actbio.2024.10.050_bib0069","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1021\/acs.biomac.7b00760","article-title":"Sustained release of a peptide-based matrix metalloproteinase-2 inhibitor to attenuate adverse cardiac remodeling and improve cardiac function following myocardial infarction","volume":"18","author":"Fan","year":"2017","journal-title":"Biomacromolecules"},{"issue":"2","key":"10.1016\/j.actbio.2024.10.050_bib0070","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jconrel.2012.11.004","article-title":"Controlled delivery of heparin-binding EGF-like growth factor yields fast and comprehensive wound healing","volume":"166","author":"Johnson","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2024.10.050_bib0071","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.reth.2020.10.002","article-title":"Heparin-conjugated collagen as a potent growth factor-localizing and stabilizing scaffold for regenerative medicine","volume":"15","author":"Ikegami","year":"2020","journal-title":"Regen. Ther."},{"issue":"7","key":"10.1016\/j.actbio.2024.10.050_bib0072","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/gels9070589","article-title":"Controlled release of growth factor from heparin embedded poly (aldehyde guluronate) hydrogels and its effect on vascularization","volume":"9","author":"Zhao","year":"2023","journal-title":"Gels"},{"issue":"10","key":"10.1016\/j.actbio.2024.10.050_bib0073","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1161\/CIRCULATIONAHA.105.600353","article-title":"Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling","volume":"114","author":"Webb","year":"2006","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.actbio.2024.10.050_bib0074","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201500122","article-title":"Injectable hydrogels for cardiac tissue repair after myocardial infarction","volume":"2","author":"Hasan","year":"2015","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2024.10.050_bib0075","first-page":"339","article-title":"An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair","volume":"20","author":"Zhang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"11","key":"10.1016\/j.actbio.2024.10.050_bib0076","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1139\/cjpp-2018-0670","article-title":"Sitagliptin protects diabetic rats with acute myocardial infarction through induction of angiogenesis: role of IGF-1 and VEGF","volume":"97","author":"Khodeer","year":"2019","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"15","key":"10.1016\/j.actbio.2024.10.050_bib0077","doi-asserted-by":"crossref","first-page":"12298","DOI":"10.3390\/ijms241512298","article-title":"New Insights into the Reparative Angiogenesis after Myocardial Infarction","volume":"24","author":"Mart\u00edn-B\u00f3rnez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2024.10.050_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122006","article-title":"Roles of long non-coding RNAs in angiogenesis-related diseases: focusing on non-neoplastic aspects","author":"Li","year":"2023","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0079","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","article-title":"Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling","volume":"18","author":"Wong","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2024.10.050_bib0080","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.660145","article-title":"Hydrogel scaffolds to deliver cell therapies for wound healing","volume":"9","author":"Sivaraj","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"9","key":"10.1016\/j.actbio.2024.10.050_bib0081","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0828-282X(07)70818-8","article-title":"Matrix metalloproteinases and myocardial infarction","volume":"23","author":"Phatharajaree","year":"2007","journal-title":"Can. J. Cardiol."},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0082","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/17460441.2020.1819235","article-title":"Challenges with matrix metalloproteinase inhibition and future drug discovery avenues","volume":"16","author":"Fischer","year":"2021","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.actbio.2024.10.050_bib0083","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12989-021-00427-w","article-title":"Pulmonary delivery of the broad-spectrum matrix metalloproteinase inhibitor marimastat diminishes multiwalled carbon nanotube-induced circulating bioactivity without reducing pulmonary inflammation","volume":"18","author":"Young","year":"2021","journal-title":"Part. Fibre. Toxicol."},{"issue":"40","key":"10.1016\/j.actbio.2024.10.050_bib0084","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201902900","article-title":"Myocardial-infarction-responsive smart hydrogels targeting matrix metalloproteinase for on-demand growth factor delivery","volume":"31","author":"Fan","year":"2019","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.actbio.2024.10.050_bib0085","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/01.ATV.0000059406.92165.31","article-title":"Osteo\/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification","volume":"23","author":"Tyson","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"13","key":"10.1016\/j.actbio.2024.10.050_bib0086","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202209041","article-title":"A Matrix-metalloproteinase-responsive hydrogel system for modulating the immune microenvironment in myocardial infarction","volume":"35","author":"Chen","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2024.10.050_bib0087","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ehf2.13144","article-title":"Heart failure after myocardial infarction: incidence and predictors","volume":"8","author":"Jen\u010da","year":"2021","journal-title":"ESC Heart. Fail."},{"issue":"2","key":"10.1016\/j.actbio.2024.10.050_bib0088","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1161\/CIR.0000000000000985","article-title":"Mechanical complications of acute myocardial infarction: a scientific statement from the American Heart Association","volume":"144","author":"Damluji","year":"2021","journal-title":"Circulation"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124006421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124006421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T02:21:14Z","timestamp":1734402074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124006421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":88,"alternative-id":["S1742706124006421"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.10.050","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing synergistic effects of MMP-2 Inhibition and bFGF to simultaneously preserve and vascularize cardiac extracellular matrix after myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.10.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}