{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:19:14Z","timestamp":1788520754047,"version":"build-2803163510"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE028919"],"award-info":[{"award-number":["R01DE028919"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.actbio.2024.11.040","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T12:49:48Z","timestamp":1732366188000},"page":"473-486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Obesity prolongs the pro-inflammatory response and attenuates bone healing on titanium implants"],"prefix":"10.1016","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3708-1935","authenticated-orcid":false,"given":"Derek","family":"Avery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais","family":"Morandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-0586","authenticated-orcid":false,"given":"Luke","family":"Sheakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9665-2737","authenticated-orcid":false,"given":"Asmaa","family":"Alajmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Bergey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9948-5463","authenticated-orcid":false,"given":"Rebecca K.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1232-9164","authenticated-orcid":false,"given":"Rene","family":"Olivares-Navarrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2024.11.040_bib0001","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.actbio.2024.11.040_bib0002","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S2213-8587(19)30026-9","article-title":"The obesity transition: stages of the global epidemic","volume":"7","author":"Jaacks","year":"2019","journal-title":"Lancet Diabetes. Endocrinol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbr.2014.03.017","article-title":"Diet-induced obesity attenuates cytokine production following an immune challenge","volume":"267","author":"Baumgarner","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.actbio.2024.11.040_bib0004","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1053\/meta.2000.9523","article-title":"Change of cytokine balance in diet-induced obese mice","volume":"49","author":"Mito","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.actbio.2024.11.040_bib0005","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1038\/oby.2009.113","article-title":"Neutrophil activation in morbid obesity, chronic activation of acute inflammation","volume":"17","author":"Nijhuis","year":"2009","journal-title":"Obesity"},{"key":"10.1016\/j.actbio.2024.11.040_bib0006","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.molimm.2019.11.002","article-title":"High-fat diet triggers obesity-related early infiltration of macrophages into adipose tissue and transient reduction of blood monocyte count","volume":"117","author":"Liu","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0007","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12020-017-1323-4","article-title":"Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice","volume":"57","author":"Ou","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.actbio.2024.11.040_bib0008","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2024.11.040_bib0009","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/sj.ijo.0803744","article-title":"Obesity in C57BL\/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration","volume":"32","author":"Rausch","year":"2008","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.actbio.2024.11.040_bib0010","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1038\/oby.2010.1","article-title":"T-Cell recruitment and th1 polarization in adipose tissue during diet-induced obesity in C57BL\/6 Mice","volume":"18","author":"Strissel","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.actbio.2024.11.040_bib0011","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2015.1009787","article-title":"Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization","volume":"11","author":"Liu","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.actbio.2024.11.040_bib0012","doi-asserted-by":"crossref","first-page":"10740","DOI":"10.1073\/pnas.0904412106","article-title":"Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses","volume":"106","author":"Zhou","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.actbio.2024.11.040_bib0013","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2337\/db06-1076","article-title":"Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity","volume":"56","author":"Lumeng","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.actbio.2024.11.040_bib0014","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1002\/eji.200838893","article-title":"Obesity predisposes to Th17 bias","volume":"39","author":"Winer","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0015","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12365","article-title":"Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations","volume":"50","author":"Magnuson","year":"2017","journal-title":"Cell Prolif."},{"key":"10.1016\/j.actbio.2024.11.040_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2018.08.013","article-title":"CD4+ T cells in obesity and obesity-associated diseases","volume":"332","author":"Zhao","year":"2018","journal-title":"Cell Immunol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0017","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.addr.2015.03.013","article-title":"Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair","volume":"94","author":"Agarwal","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2024.11.040_bib0018","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0022034515624444","article-title":"Implant surface design regulates mesenchymal stem cell differentiation and maturation","volume":"28","author":"Boyan","year":"2016","journal-title":"Adv. Dent. Res."},{"key":"10.1016\/j.actbio.2024.11.040_bib0019","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1016\/j.biomaterials.2009.12.029","article-title":"Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage","volume":"31","author":"Olivares-Navarrete","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.11.040_bib0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/rb\/rbw041","article-title":"An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration","volume":"4","author":"Selders","year":"2017","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2024.11.040_bib0021","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.actbio.2024.03.022","article-title":"CD4+ and CD8+ T cells reduce inflammation and promote bone healing in response to titanium implants","volume":"179","author":"Avery","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.11.040_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119920","article-title":"Wnt signaling modulates macrophage polarization and is regulated by biomaterial surface properties","volume":"243","author":"Abaricia","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.11.040_bib0023","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.actbio.2023.03.007","article-title":"Immune cell response to orthopedic and craniofacial biomaterials depends on biomaterial composition","volume":"161","author":"Avery","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.11.040_bib0024","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1021\/acsbiomaterials.6b00743","article-title":"Neutrophils at the Biological-Material Interface","volume":"4","author":"Jhunjhunwala","year":"2018","journal-title":"ACS. Biomater. Sci. Eng."},{"key":"10.1016\/j.actbio.2024.11.040_bib0025","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.biomaterials.2018.08.029","article-title":"Macrophage response to hydrophilic biomaterials regulates MSC recruitment and T-helper cell populations","volume":"182","author":"Hotchkiss","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.11.040_bib0026","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.actbio.2021.04.021","article-title":"Control of innate immune response by biomaterial surface topography, energy, and stiffness","volume":"133","author":"Abaricia","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.11.040_bib0027","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.actbio.2023.07.052","article-title":"Contribution of \u03b1\u03b2 T cells to macrophage polarization and MSC recruitment and proliferation on titanium implants","volume":"169","author":"Avery","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.11.040_bib0028","first-page":"52739","article-title":"Mouse Na\u00efve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets","volume":"2015","author":"Flaherty","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.actbio.2024.11.040_bib0029","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00223-021-00899-0","article-title":"Adipose tissue dysfunction: impact on bone and osseointegration","volume":"110","author":"King","year":"2022","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.actbio.2024.11.040_bib0030","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/cid.13234","article-title":"Influence of obesity on osseointegration of implants with different surface treatments: a preclinical study","volume":"25","author":"Silva","year":"2023","journal-title":"Clin. ImPlant Dent. Relat. Res."},{"key":"10.1016\/j.actbio.2024.11.040_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121797","article-title":"Canonical Wnt signaling enhances pro-inflammatory response to titanium by macrophages","volume":"289","author":"Avery","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.11.040_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2023.05.016","article-title":"Reduction of neutrophil extracellular traps accelerates inflammatory resolution and increases bone formation on titanium implants","author":"Morandini","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.11.040_bib0033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0293888","article-title":"Determination of progressive stages of type 2 diabetes in a 45 % high-fat diet-fed C57BL\/6J mouse model is achieved by utilizing both fasting blood glucose levels and a 2-hour oral glucose tolerance test","volume":"18","author":"Nguyen-Phuong","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2024.11.040_bib0034","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.actbio.2015.12.003","article-title":"Titanium surface characteristics, including topography and wettability, alter macrophage activation","volume":"31","author":"Hotchkiss","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.11.040_bib0035","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1039\/C9BM01474H","article-title":"Hydrophilic titanium surfaces reduce neutrophil inflammatory response and NETosis","volume":"8","author":"Abaricia","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.actbio.2024.11.040_bib0036","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.2337\/db14-1273","article-title":"Myeloperoxidase: a therapeutic target for preventing insulin resistance and the metabolic sequelae of obesity?","volume":"63","author":"Heinecke","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.actbio.2024.11.040_bib0037","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/imcb.12460","article-title":"Metabolic dysfunction induced by a high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice","volume":"99","author":"Mincham","year":"2021","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0038","doi-asserted-by":"crossref","first-page":"480","DOI":"10.7326\/0003-4819-93-3-480","article-title":"Oxygen metabolism and the toxic properties of phagocytes","volume":"93","author":"Klebanoff","year":"1980","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.actbio.2024.11.040_bib0039","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1074\/jbc.C116.758748","article-title":"Neutrophil elastase regulates emergency myelopoiesis preceding systemic inflammation in diet-induced obesity","volume":"292","author":"Huang","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2024.11.040_bib0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","article-title":"Myeloperoxidase: its role for host defense, inflammation, and neutrophil function","volume":"640","author":"Aratani","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.actbio.2024.11.040_bib0041","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/biof.1075","article-title":"Diet-induced obesity has a differential effect on adipose tissue and macrophage inflammatory responses of young and old mice","volume":"39","author":"Wu","year":"2013","journal-title":"Biofactors"},{"key":"10.1016\/j.actbio.2024.11.040_bib0042","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4162\/nrp.2011.5.3.219","article-title":"High fat diet-induced obesity leads to proinflammatory response associated with higher expression of NOD2 protein","volume":"5","author":"Kim","year":"2011","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.actbio.2024.11.040_bib0043","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ijo.2010.137","article-title":"C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization","volume":"35","author":"Timpson","year":"2011","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.actbio.2024.11.040_bib0044","article-title":"C-Reactive protein causes adult-onset obesity through chronic inflammatory mechanism","volume":"8","author":"Li","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0045","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/ATVBAHA.111.225508","article-title":"C-reactive protein polarizes human macrophages to an M1 Phenotype and inhibits transformation to the M2 phenotype","volume":"31","author":"Devaraj","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0046","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nm0809-846","article-title":"T-ing up inflammation in fat","volume":"15","author":"Lumeng","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2024.11.040_bib0047","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1017\/S0029665111000565","article-title":"Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue","volume":"70","author":"Harford","year":"2011","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.actbio.2024.11.040_bib0048","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004754","article-title":"Terminally differentiated CD8+ T cells negatively affect bone regeneration in humans","volume":"5","author":"Reinke","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2024.11.040_bib0049","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2016-000379","article-title":"Individuals with obesity and type 2 diabetes have additional immune dysfunction compared with obese individuals who are metabolically healthy","volume":"5","author":"Richard","year":"2017","journal-title":"BMJ Open Diabetes. Res. Care"},{"key":"10.1016\/j.actbio.2024.11.040_bib0050","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/j.dsx.2015.09.007","article-title":"Increased C-reactive protein and decreased Interleukin-2 content in serum from obese individuals with or without insulin resistance: associations with leukocyte count and insulin and adiponectin content","volume":"10","author":"Vargas","year":"2016","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"10.1016\/j.actbio.2024.11.040_bib0051","first-page":"568343","article-title":"Role of leptin in the activation of immune cells","author":"Fern\u00e1ndez-Riejos","year":"2010","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.actbio.2024.11.040_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.622468","article-title":"The role of the adipokine leptin in immune cell function in health and disease","volume":"11","author":"Kiernan","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0053","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.numecd.2019.08.004","article-title":"High fat diet downregulates regulatory T cells in the myocardium of spontaneous hypertensive rats","volume":"29","author":"Hong","year":"2019","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.actbio.2024.11.040_bib0054","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/5584_2015_147","article-title":"Regulatory T cells in obesity","volume":"866","author":"Kucharska","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0055","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.molmed.2010.04.002","article-title":"Regulatory T cells in obesity: the leptin connection","volume":"16","author":"Matarese","year":"2010","journal-title":"Trends. Mol. Med."},{"key":"10.1016\/j.actbio.2024.11.040_bib0056","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/jbmr.3408","article-title":"High-Fat diet\u2013induced obesity promotes expansion of bone marrow adipose tissue and impairs skeletal stem cell functions in mice","volume":"33","author":"Tencerova","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.actbio.2024.11.040_bib0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-13-450","article-title":"Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity","volume":"13","author":"Kwon","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.actbio.2024.11.040_bib0058","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.stem.2017.02.009","article-title":"Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration","volume":"20","author":"Ambrosi","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.actbio.2024.11.040_bib0059","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/JME-20-0229","article-title":"Obesity enhances the recruitment of mesenchymal stem cells to visceral adipose tissue","volume":"67","author":"De Assis-Ferreira","year":"2021","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0060","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1088508","article-title":"High-fat diet causes undesirable bone regeneration by altering the bone marrow environment in rats","volume":"14","author":"Cai","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.actbio.2024.11.040_bib0061","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1002\/oby.21660","article-title":"Obesity modifies bone marrow microenvironment and directs bone marrow mesenchymal cells to adipogenesis","volume":"24","author":"da Silva","year":"2016","journal-title":"Obesity"},{"key":"10.1016\/j.actbio.2024.11.040_bib0062","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/stem.1844","article-title":"Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway: an approach for treating bone disease in diabetes","volume":"33","author":"Yu","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2024.11.040_bib0063","article-title":"AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice","volume":"9","author":"Wu","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.actbio.2024.11.040_bib0064","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-018-0837-7","article-title":"Effects of obesity on the healing of bone fracture in mice","volume":"13","author":"Gao","year":"2018","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.actbio.2024.11.040_bib0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.exger.2010.09.014","article-title":"Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice","volume":"46","author":"Halade","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0066","first-page":"84","article-title":"Serum leptin levels negatively correlate with trabecular bone mineral density in high-fat diet-induced obesity mice","volume":"12","author":"Fujita","year":"2012","journal-title":"J. Musculoskeletal Neuronal Interact."},{"key":"10.1016\/j.actbio.2024.11.040_bib0067","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1749-6632.2009.05252.x","article-title":"Diet-induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice","volume":"1192","author":"Cao","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.actbio.2024.11.040_bib0068","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1126\/science.abj8894","article-title":"Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation","volume":"379","author":"Hata","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.actbio.2024.11.040_bib0069","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1741-7015-8-87","article-title":"Obesity related methylation changes in DNA of peripheral blood leukocytes","volume":"8","author":"Wang","year":"2010","journal-title":"BMC Med."},{"key":"10.1016\/j.actbio.2024.11.040_bib0070","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.tem.2016.06.008","article-title":"The emerging role of epigenetics in inflammation and immunometabolism","volume":"27","author":"Raghuraman","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.actbio.2024.11.040_bib0071","first-page":"175","article-title":"Nutrition in early life, immune-programming and allergies: the role of epigenetics","volume":"31","author":"Amarasekera","year":"2013","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0072","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.it.2023.01.002","article-title":"Metabolism and epigenetics at the heart of T cell function","volume":"44","author":"Soriano-Baguet","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.actbio.2024.11.040_bib0073","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3390\/biom12070982","article-title":"Epigenetic reprogramming of the inflammatory response in obesity and type 2 diabetes","volume":"12","author":"Zatterale","year":"2022","journal-title":"Biomolecules."},{"key":"10.1016\/j.actbio.2024.11.040_bib0074","doi-asserted-by":"crossref","first-page":"87748","DOI":"10.1172\/jci.insight.87748","article-title":"Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity","volume":"1","author":"Wang","year":"2016","journal-title":"JCI. Insight."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124006950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124006950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:59:17Z","timestamp":1762556357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124006950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":74,"alternative-id":["S1742706124006950"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.11.040","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity prolongs the pro-inflammatory response and attenuates bone healing on titanium implants","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.11.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Acta Materialia Inc. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}