{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:21:10Z","timestamp":1779337270355,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100017623","name":"Zhejiang Provincial Outstanding Youth Science Foundation","doi-asserted-by":"publisher","award":["LR23H180001"],"award-info":[{"award-number":["LR23H180001"]}],"id":[{"id":"10.13039\/501100017623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.actbio.2024.12.016","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T17:45:33Z","timestamp":1733420733000},"page":"248-259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Cascade catalytic multilayer modified intraocular lens for enhanced and safer posterior capsule opacification prevention"],"prefix":"10.1016","volume":"192","author":[{"given":"Qingqing","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youfei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-6059","authenticated-orcid":false,"given":"Quankui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2024.12.016_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100905","article-title":"Posterior capsule opacification: what's in the bag?","volume":"82","author":"Wormstone","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.actbio.2024.12.016_bib0002","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0140-6736(17)30544-5","volume":"390","author":"Liu","year":"2017","journal-title":"Cataracts, Lancet"},{"key":"10.1016\/j.actbio.2024.12.016_bib0003","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/ICU.0000000000000340","article-title":"The global state of cataract blindness","volume":"28","author":"Lee","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.actbio.2024.12.016_bib0004","doi-asserted-by":"crossref","first-page":"e1164","DOI":"10.1016\/S2214-109X(17)30412-6","article-title":"Global causes of vision loss in 2015: are we on track to achieve the Vision 2020 target?","volume":"5","author":"Sabanayagam","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.actbio.2024.12.016_bib0005","doi-asserted-by":"crossref","first-page":"15014","DOI":"10.1038\/nrdp.2015.14","article-title":"Cataract","volume":"1","author":"Lam","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.actbio.2024.12.016_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"B. Vision Loss Expert Grp Global, Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study","volume":"9","author":"Steinmetz","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.actbio.2024.12.016_bib0007","article-title":"Cataract: advances in surgery and whether surgery remains the only treatment in future","volume":"1","author":"Chen","year":"2021","journal-title":"Adv. Ophthalmol. Pract. Res."},{"key":"10.1016\/j.actbio.2024.12.016_bib0008","first-page":"343","article-title":"Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification","volume":"9","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2024.12.016_bib0009","doi-asserted-by":"crossref","first-page":"437","DOI":"10.7150\/ijbs.23946","article-title":"CTGF Contributes to the development of posterior capsule opacification: an in vitro and in vivo study","volume":"14","author":"Ma","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.actbio.2024.12.016_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.132716","article-title":"Photo-responsive intraocular lens with on demand drug release for posterior capsule opacification prevention and improved biosafety","volume":"430","author":"Xia","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2024.12.016_bib0011","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1167\/iovs.18-26248","article-title":"Resveratrol inhibits wound healing and lens fibrosis: a putative candidate for posterior capsule opacification prevention","volume":"60","author":"Smith","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2024.12.016_bib0012","first-page":"449","article-title":"Nd:YAG laser accidentally hitting the corneal layers during treatment of posterior capsule opacification after cataract surgery and its postoperative process","volume":"13","author":"Teshigawara","year":"2020","journal-title":"Int. Med. Case Rep. J."},{"key":"10.1016\/j.actbio.2024.12.016_bib0013","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12886-020-01428-7","article-title":"Acute retinal detachment after Nd:YAG treatment for vitreous floaters and postertior capsule opacification: a case report","volume":"20","author":"Liu","year":"2020","journal-title":"BMC. Ophthalmol."},{"key":"10.1016\/j.actbio.2024.12.016_bib0014","article-title":"Iris epithelium detachment - An uncommon complication of Nd:YAG laser capsulotomy","volume":"23","author":"Jakobsen","year":"2021","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"10.1016\/j.actbio.2024.12.016_bib0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/01.ICL.0000072833.79456.2D","article-title":"Biocompatibility of intraocular lenses","volume":"29","author":"McCulley","year":"2003","journal-title":"Eye Contact. Lens."},{"key":"10.1016\/j.actbio.2024.12.016_bib0016","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4103\/0366-6999.173496","article-title":"Surface modification of intraocular lenses","volume":"129","author":"Huang","year":"2016","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.actbio.2024.12.016_bib0017","doi-asserted-by":"crossref","DOI":"10.3390\/ph13120448","article-title":"A critical appraisal of new developments in intraocular lens modifications and drug delivery systems for the prevention of cataract surgery complications","volume":"13","author":"Mylona","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.actbio.2024.12.016_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13060860","article-title":"Factors affecting posterior capsule opacification in the development of intraocular lens materials","volume":"13","author":"Cooksley","year":"2021","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.actbio.2024.12.016_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-060418-052350","article-title":"Layer-by-layer biomaterials for drug delivery","volume":"22","author":"Alkekhia","year":"2020","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.actbio.2024.12.016_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202001474","article-title":"The Use of Layer-by-Layer Self-Assembly and Nanocellulose to Prepare Advanced Functional Materials","volume":"33","author":"W\u00e5gberg","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2024.12.016_bib0021","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.colsurfb.2009.07.036","article-title":"Hyaluronic acid and chitosan-DNA complex multilayered thin film as surface-mediated nonviral gene delivery system","volume":"74","author":"Lin","year":"2009","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.actbio.2024.12.016_bib0022","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1016\/j.biomaterials.2010.01.092","article-title":"In situ endothelialization of intravascular stents coated with an anti-CD34 antibody functionalized heparin-collagen multilayer","volume":"31","author":"Lin","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.12.016_bib0023","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/09205063.2020.1865691","article-title":"Antiproliferative drug-loaded multi-functionalized intraocular lens for reducing posterior capsular opacification","volume":"32","author":"Huang","year":"2021","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.actbio.2024.12.016_bib0024","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1039\/D0TB02530E","article-title":"Enhanced PCO prevention of drug eluting IOLs via endocytosis and autophagy effects of a PAMAM dendrimer","volume":"9","author":"Qin","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2024.12.016_bib0025","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1002\/smll.201600950","article-title":"Intracellular dual fluorescent lightup bioprobes for image-guided photodynamic cancer therapy","volume":"12","author":"Han","year":"2016","journal-title":"Small."},{"key":"10.1016\/j.actbio.2024.12.016_bib0026","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jconrel.2020.09.014","article-title":"Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis","volume":"327","author":"Han","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2024.12.016_bib0027","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1039\/D0TB02802A","article-title":"Surface modification of intraocular lenses via photodynamic coating for safe and effective PCO prevention","volume":"9","author":"Tang","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2024.12.016_bib0028","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1039\/C7CS00471K","article-title":"Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy","volume":"47","author":"Lin","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2024.12.016_bib0029","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/adma.201405105","article-title":"Bifunctionalized mesoporous silica-supported gold nanoparticles: intrinsic oxidase and peroxidase catalytic activities for antibacterial applications","volume":"27","author":"Tao","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2024.12.016_bib0030","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.cej.2018.11.156","article-title":"Mesoporous silica nanoparticles: synthesis, pharmaceutical applications, biodistribution, and biosafety assessment","volume":"359","author":"Farjadian","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2024.12.016_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.127862","article-title":"Synthesis, structural properties, biosafety and applications of chiral mesoporous silica nanostructures","volume":"421","author":"Gou","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2024.12.016_bib0032","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201801733","article-title":"Nanocatalytic tumor therapy by biomimetic dual inorganic nanozyme-catalyzed cascade reaction","volume":"6","author":"Gao","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2024.12.016_bib0033","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41467-017-00424-8","article-title":"Tumor-selective catalytic nanomedicine by nanocatalyst delivery","volume":"8","author":"Huo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2024.12.016_bib0034","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1039\/C7OB00391A","article-title":"Spatial organization of multi-enzyme biocatalytic cascades","volume":"15","author":"Quin","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.actbio.2024.12.016_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126054","article-title":"Wonton-like nanoparticles with dual enzyme-mimetic function for the multiple-imaging-guided cancer combined therapy","volume":"401","author":"Yi","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2024.12.016_bib0036","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.2147\/IJN.S195504","article-title":"Mesoporous silica nanoparticles as a delivery system for improving antiangiogenic therapy","volume":"14","author":"Sun","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2024.12.016_bib0037","article-title":"Cascade catalytic platform modified intraocular lens for high-efficient posterior capsule opacification prevention","volume":"427","author":"Huang","year":"2022","journal-title":"Che. Eng. J."},{"key":"10.1016\/j.actbio.2024.12.016_bib0038","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1021\/acsabm.0c00331","article-title":"Cellular microenvironment-sensitive drug eluting coating on intraocular lens for enhanced posterior capsular opacification prevention and in vivo biocompatibility","volume":"3","author":"Han","year":"2020","journal-title":"ACS Appl. Bio. Mater."},{"key":"10.1016\/j.actbio.2024.12.016_bib0039","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/00914037.2016.1190925","article-title":"Antiadhesive and antibacterial polysaccharide multilayer as IOL coating for prevention of postoperative infectious endophthalmitis","volume":"66","author":"Lin","year":"2017","journal-title":"Int. J. Polym. Mater."},{"key":"10.1016\/j.actbio.2024.12.016_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8458752","article-title":"Bottom-up fabrication of PEG brush on poly(dimethylsiloxane) for antifouling surface construction","author":"Tang","year":"2016","journal-title":"Int. J. Polym. Sci."},{"key":"10.1016\/j.actbio.2024.12.016_bib0041","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.2147\/IJN.S215802","article-title":"Anti-adhesive and antiproliferative synergistic surface modification of intraocular lens for reduced posterior capsular opacification","volume":"14","author":"Han","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2024.12.016_bib0042","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1177\/0885328220977605","article-title":"Surface functionalized mesoporous silica nanoparticles for intravitreal application of tacrolimus","volume":"35","author":"Paiva","year":"2021","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.actbio.2024.12.016_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138620","article-title":"Amination-mediated nano eye-drops with enhanced corneal permeability and effective burst release for acute glaucoma treatment","volume":"451","author":"Nguyen","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2024.12.016_bib0044","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202170034","article-title":"Lollipop-inspired multilayered drug delivery hydrogel for dual effective, long-term, and NIR-defined glaucoma reatment","volume":"21","author":"Wang","year":"2021","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.actbio.2024.12.016_bib0045","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad020","article-title":"Non-viral gene coating modified IOL delivering PDGFR-alpha shRNA interferes with the fibrogenic process to prevent posterior capsular opacification","volume":"10","author":"Wang","year":"2023","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2024.12.016_bib0046","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.colsurfb.2016.12.028","article-title":"Hydrophilic modification of intraocular lens via surface initiated reversible addition-fragmentation chain transfer polymerization for reduced posterior capsular opacification","volume":"151","author":"Lin","year":"2017","journal-title":"Colloid. Surface. B."},{"key":"10.1016\/j.actbio.2024.12.016_bib0047","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/1120672119891042","article-title":"Development of a drug-eluting intraocular lens to deliver epidermal growth factor receptor inhibitor gefitinib for posterior capsule opacification prophylaxis","volume":"31","author":"Kassumeh","year":"2021","journal-title":"Eur. J. Ophthalmol."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124007256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706124007256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:58:39Z","timestamp":1762556319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706124007256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":47,"alternative-id":["S1742706124007256"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.12.016","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cascade catalytic multilayer modified intraocular lens for enhanced and safer posterior capsule opacification prevention","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Acta Materialia Inc. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}