{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:13:52Z","timestamp":1793106832322,"version":"4.5.0"},"reference-count":223,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.actbio.2024.12.039","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T19:47:57Z","timestamp":1734464877000},"page":"65-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Impact of nanoparticle properties on immune cell interactions in the lymph node"],"prefix":"10.1016","volume":"193","author":[{"given":"Muhammad Asim","family":"Farooq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus P.R.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie L.","family":"Trevaskis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0001","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/ni.2039","article-title":"Immunological mechanisms of vaccination","volume":"12","author":"Pulendran","year":"2011","journal-title":"Nat. Immunol."},{"issue":"19","key":"10.1016\/j.actbio.2024.12.039_bib0002","doi-asserted-by":"crossref","first-page":"11109","DOI":"10.1021\/acs.chemrev.5b00109","article-title":"Synthetic nanoparticles for vaccines and immunotherapy","volume":"115","author":"Irvine","year":"2015","journal-title":"Chem. Rev."},{"issue":"44","key":"10.1016\/j.actbio.2024.12.039_bib0003","doi-asserted-by":"crossref","first-page":"5927","DOI":"10.1016\/j.vaccine.2015.07.100","article-title":"Polymeric micro\/nanoparticles: particle design and potential vaccine delivery applications","volume":"33","author":"Yue","year":"2015","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.actbio.2024.12.039_bib0004","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri2868","article-title":"Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns","volume":"10","author":"Bachmann","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0974-777X.77299","article-title":"Fundamentals of vaccine immunology","volume":"3","author":"Clem","year":"2011","journal-title":"J. Glob. Infect. Dis."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0006","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.virol.2010.12.016","article-title":"Contributions of humoral and cellular immunity to vaccine-induced protection in humans","volume":"411","author":"Amanna","year":"2011","journal-title":"Virology."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0007","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.immuni.2021.01.014","article-title":"B cell memory: understanding COVID-19","volume":"54","author":"Quast","year":"2021","journal-title":"Immunity."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0008","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0009","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41591-020-0858-8","article-title":"T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers","volume":"26","author":"Arunachalam","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2024.12.039_bib0010","doi-asserted-by":"crossref","first-page":"89534","DOI":"10.3389\/fimmu.2014.00202","article-title":"Induction of potent and long-lived antibody and cellular immune responses in the genitorectal mucosa could be the critical determinant of HIV vaccine efficacy","volume":"5","author":"Chanzu","year":"2014","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.actbio.2024.12.039_bib0011","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/CVI.00131-10","article-title":"Correlates of protection induced by vaccination","volume":"17","author":"Plotkin","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.actbio.2024.12.039_bib0012","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1038\/nm1216","article-title":"Can successful vaccines teach us how to induce efficient protective immune responses?","volume":"11","author":"Lambert","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.actbio.2024.12.039_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2021.11.001","article-title":"Mechanisms underpinning poor antibody responses to vaccines in ageing","volume":"241","author":"Lee","year":"2022","journal-title":"Immunol. Lett."},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0014","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/17425247.2024.2348656","article-title":"Multi-functional nanomedicines for combinational cancer immunotherapy that transform cold tumors to hot tumors","volume":"21","author":"Cho","year":"2024","journal-title":"Expert. Opin. Drug Deliv."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0015","doi-asserted-by":"crossref","DOI":"10.1080\/21645515.2024.2331486","article-title":"Unlocking cancer vaccine potential: what are the key factors?","volume":"20","author":"Grant","year":"2024","journal-title":"Hum. Vaccin. ImmunOther"},{"issue":"10","key":"10.1016\/j.actbio.2024.12.039_bib0016","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41568-019-0186-9","article-title":"Improving cancer immunotherapy through nanotechnology","volume":"19","author":"Goldberg","year":"2019","journal-title":"Nature Rev. Cancer"},{"key":"10.1016\/j.actbio.2024.12.039_bib0017","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2022.03.006","article-title":"Self-degradable poly (\u03b2-amino ester) s promote endosomal escape of antigen and agonist","volume":"345","author":"Liu","year":"2022","journal-title":"J. Controlled Release"},{"issue":"42","key":"10.1016\/j.actbio.2024.12.039_bib0018","article-title":"Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination","volume":"32","author":"Pan","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2024.12.039_bib0019","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s12274-020-2737-5","article-title":"Reverse immune suppressive microenvironment in tumor draining lymph nodes to enhance anti-PD1 immunotherapy via nanovaccine complexed microneedle","volume":"13","author":"Zhou","year":"2020","journal-title":"Nano Res."},{"issue":"19","key":"10.1016\/j.actbio.2024.12.039_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202001108","article-title":"Choice of nanovaccine delivery mode has profound impacts on the intralymph node spatiotemporal distribution and immunotherapy efficacy","volume":"7","author":"Wang","year":"2020","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0021","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41565-020-0663-z","article-title":"Targeting immune cells within lymph nodes","volume":"15","author":"Porter","year":"2020","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.actbio.2024.12.039_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.copbio.2016.02.001","article-title":"Biomaterials for enhancing anti-cancer immunity","volume":"40","author":"Koshy","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"issue":"7","key":"10.1016\/j.actbio.2024.12.039_bib0023","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1021\/acsbiomaterials.8b00511","article-title":"Peptide amphiphile micelle vaccine size and charge influence the host antibody response","volume":"4","author":"Zhang","year":"2018","journal-title":"ACS. Biomater. Sci. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0024","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1039\/C6BM00500D","article-title":"Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing","volume":"5","author":"Chang","year":"2017","journal-title":"Biomater. Sci."},{"issue":"13","key":"10.1016\/j.actbio.2024.12.039_bib0025","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1073\/pnas.0600997103","article-title":"Role of target geometry in phagocytosis","volume":"103","author":"Champion","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.actbio.2024.12.039_bib0026","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2147\/IJN.S28531","article-title":"Size-and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages","author":"Yu","year":"2012","journal-title":"Int. J. Nanomedicine"},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0027","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1021\/acsnano.7b00978","article-title":"Efficient nanovaccine delivery in cancer immunotherapy","volume":"11","author":"Zhu","year":"2017","journal-title":"ACS. Nano"},{"key":"10.1016\/j.actbio.2024.12.039_bib0028","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev-bioeng-101515-014413","article-title":"Implications of lymphatic transport to lymph nodes in immunity and immunotherapy","volume":"18","author":"Thomas","year":"2016","journal-title":"Annu Rev. Biomed. Eng."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0029","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41578-019-0110-7","article-title":"Material design for lymph node drug delivery","volume":"4","author":"Schudel","year":"2019","journal-title":"Nature Rev. Mater."},{"key":"10.1016\/j.actbio.2024.12.039_bib0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.addr.2020.10.004","article-title":"Lymphatic immunomodulation using engineered drug delivery systems for cancer immunotherapy","volume":"160","author":"Manspeaker","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.actbio.2024.12.039_bib0031","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1021\/acsptsci.9b00047","article-title":"Biomaterials for modulating lymphatic function in immunoengineering","volume":"2","author":"Sestito","year":"2019","journal-title":"ACS. Pharmacol. Transl. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0032","first-page":"247","article-title":"Recent advances in lymphatic targeted drug delivery system for tumor metastasis","volume":"11","author":"Zhang","year":"2014","journal-title":"Cancer Biol. Med."},{"issue":"10\u201311","key":"10.1016\/j.actbio.2024.12.039_bib0033","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.addr.2011.05.017","article-title":"Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles","volume":"63","author":"Cai","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"9","key":"10.1016\/j.actbio.2024.12.039_bib0034","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1021\/nn301949y","article-title":"Near-infrared emitting polymer nanogels for efficient sentinel lymph node mapping","volume":"6","author":"Noh","year":"2012","journal-title":"ACS. Nano"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0035","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nbt920","article-title":"Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping","volume":"22","author":"Kim","year":"2004","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"10.1016\/j.actbio.2024.12.039_bib0036","doi-asserted-by":"crossref","first-page":"686","DOI":"10.7150\/thno.11862","article-title":"Lymphatic imaging: focus on imaging probes","volume":"5","author":"Niu","year":"2015","journal-title":"Theranostics."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0037","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acs.bioconjchem.8b00812","article-title":"Fluorescence guided sentinel lymph node mapping: from current molecular probes to future multimodal nanoprobes","volume":"30","author":"Hameed","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.actbio.2024.12.039_bib0038","first-page":"610","article-title":"Nanoparticles in sentinel lymph node mapping","volume":"1","author":"Ravizzini","year":"2009"},{"key":"10.1016\/j.actbio.2024.12.039_bib0039","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.addr.2020.08.011","article-title":"Targeting and therapeutic peptide-based strategies for polycystic kidney disease","volume":"161","author":"Wang","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"8","key":"10.1016\/j.actbio.2024.12.039_bib0040","article-title":"Targeting lymphoid tissues to promote immune tolerance","volume":"4","author":"Chen","year":"2021","journal-title":"Adv. Ther. (Weinh)"},{"issue":"33","key":"10.1016\/j.actbio.2024.12.039_bib0041","doi-asserted-by":"crossref","first-page":"eaau6085","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.actbio.2024.12.039_bib0042","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jconrel.2024.05.007","article-title":"Spleen-targeted delivery systems and strategies for spleen-related diseases","volume":"370","author":"Huang","year":"2024","journal-title":"J. Controlled Release"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0043","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-immunol-041015-055354","article-title":"The lymphatic system: integral roles in immunity","volume":"35","author":"Randolph","year":"2017","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.actbio.2024.12.039_bib0044","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1021\/acs.molpharmaceut.0c00348","article-title":"High-density lipoprotein composition influences lymphatic transport after subcutaneous administration","volume":"17","author":"Gracia","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2024.12.039_bib0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2020.07.046","article-title":"Lymphatic targeting by albumin-hitchhiking: applications and optimisation","volume":"327","author":"Abdallah","year":"2020","journal-title":"J. Controlled Release"},{"issue":"11","key":"10.1016\/j.actbio.2024.12.039_bib0046","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrd4608","article-title":"From sewer to saviour\u2014Targeting the lymphatic system to promote drug exposure and activity","volume":"14","author":"Trevaskis","year":"2015","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.actbio.2024.12.039_bib0047","series-title":"Seminars in Cell & Developmental Biology","first-page":"83","article-title":"Lymphatic system: an active pathway for immune protection","author":"Liao","year":"2015"},{"issue":"35","key":"10.1016\/j.actbio.2024.12.039_bib0048","doi-asserted-by":"crossref","first-page":"9508","DOI":"10.1016\/j.biomaterials.2014.07.055","article-title":"Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG","volume":"35","author":"Yan","year":"2014","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.actbio.2024.12.039_bib0049","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3298","article-title":"HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes","volume":"12","author":"Girard","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0050","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2249.2012.04602.x","article-title":"Lymph node dissection\u2013understanding the immunological function of lymph nodes","volume":"169","author":"Buettner","year":"2012","journal-title":"Clin. Exp. Immunol."},{"issue":"12","key":"10.1016\/j.actbio.2024.12.039_bib0051","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/intimm\/dxn110","article-title":"The conduit system of the lymph node","volume":"20","author":"Roozendaal","year":"2008","journal-title":"Int. Immunol."},{"issue":"8","key":"10.1016\/j.actbio.2024.12.039_bib0052","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.it.2007.06.005","article-title":"Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node","volume":"28","author":"Baj\u00e9noff","year":"2007","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0053","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-065X.1997.tb00955.x","article-title":"Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex","volume":"156","author":"Gretz","year":"1997","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0054","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2004.11.013","article-title":"The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node","volume":"22","author":"Sixt","year":"2005","journal-title":"Immunity."},{"issue":"7166","key":"10.1016\/j.actbio.2024.12.039_bib0055","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature06287","article-title":"Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells","volume":"450","author":"Junt","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0056","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.immuni.2007.06.007","article-title":"B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node","volume":"27","author":"Carrasco","year":"2007","journal-title":"Immunity."},{"issue":"7754","key":"10.1016\/j.actbio.2024.12.039_bib0057","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41586-019-1125-3","article-title":"Compartmentalized gut lymph node drainage dictates adaptive immune responses","volume":"569","author":"Esterh\u00e1zy","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0058","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI71610","article-title":"Lymphatic transport of high-density lipoproteins and chylomicrons","volume":"124","author":"Randolph","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.actbio.2024.12.039_bib0059","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/CIRCRESAHA.109.207274","article-title":"Transmural flow modulates cell and fluid transport functions of lymphatic endothelium","volume":"106","author":"Miteva","year":"2010","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0060","doi-asserted-by":"crossref","first-page":"R6","DOI":"10.1152\/ajpregu.00097.2009","article-title":"Balance point characterization of interstitial fluid volume regulation","volume":"297","author":"Dongaonkar","year":"2009","journal-title":"Am. J. Physiol. Regulat. Integr. Compar. Physiol."},{"key":"10.1016\/j.actbio.2024.12.039_bib0061","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.addr.2020.10.002","article-title":"Lymph-directed immunotherapy\u2013Harnessing endogenous lymphatic distribution pathways for enhanced therapeutic outcomes in cancer","volume":"160","author":"Feeney","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7637","key":"10.1016\/j.actbio.2024.12.039_bib0062","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature21349","article-title":"Elements of cancer immunity and the cancer\u2013immune set point","volume":"541","author":"Chen","year":"2017","journal-title":"Nature"},{"issue":"6402","key":"10.1016\/j.actbio.2024.12.039_bib0063","first-page":"599","article-title":"Lacteal junction zippering protects against diet-induced obesity","volume":"361","author":"Zhang","year":"2018","journal-title":"Science (1979)"},{"key":"10.1016\/j.actbio.2024.12.039_bib0064","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1208\/s12248-014-9708-2","article-title":"Harnessing biomaterials to engineer the lymph node microenvironment for immunity or tolerance","volume":"17","author":"Andorko","year":"2015","journal-title":"AAPS. J."},{"key":"10.1016\/j.actbio.2024.12.039_bib0065","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fimmu.2019.00470","article-title":"Regulation of immune function by the lymphatic system in lymphedema","volume":"10","author":"Kataru","year":"2019","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.actbio.2024.12.039_bib0066","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.4049\/jimmunol.1302492","article-title":"Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells","volume":"192","author":"Hirosue","year":"2014","journal-title":"The Journal of Immunology"},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0067","doi-asserted-by":"crossref","first-page":"e87740","DOI":"10.1371\/journal.pone.0087740","article-title":"Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment","volume":"9","author":"Cohen","year":"2014","journal-title":"PLoS. One"},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0068","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1084\/jem.20092465","article-title":"Lymph node\u2013resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation","volume":"207","author":"Cohen","year":"2010","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0069","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20132000","article-title":"Lymph node stromal cells acquire peptide\u2013MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance","volume":"211","author":"Dubrot","year":"2014","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0070","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrc3186","article-title":"Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity","volume":"12","author":"Swartz","year":"2012","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/j.actbio.2024.12.039_bib0071","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00519","article-title":"Lymphatic function in autoimmune diseases","volume":"10","author":"Schwartz","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0072","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/0975-3583.85260","article-title":"An overview of lymphatic vessels and their emerging role in cardiovascular disease","volume":"2","author":"Jones","year":"2011","journal-title":"J. Cardiovasc. Dis. Res."},{"issue":"9","key":"10.1016\/j.actbio.2024.12.039_bib0073","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/s42255-021-00457-w","article-title":"Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity","volume":"3","author":"Cao","year":"2021","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0074","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3350\/cmh.2013.19.2.99","article-title":"The lymphatic vascular system in liver diseases: its role in ascites formation","volume":"19","author":"Chung","year":"2013","journal-title":"Clin. Mol. Hepatol."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0075","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1073\/pnas.1318249111","article-title":"Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues","volume":"111","author":"Fletcher","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"9","key":"10.1016\/j.actbio.2024.12.039_bib0076","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1021\/acs.biomac.7b00794","article-title":"An evaluation of optimal PEGylation strategies for maximizing the lymphatic exposure and antiviral activity of interferon after subcutaneous administration","volume":"18","author":"Chan","year":"2017","journal-title":"Biomacromolecules."},{"issue":"5","key":"10.1016\/j.actbio.2024.12.039_bib0077","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/ATVBAHA.123.319572","article-title":"Cardiac Lymphangiogenesis in CVDs","volume":"44","author":"Brakenhielm","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.actbio.2024.12.039_bib0078","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2147\/IJN.S440612","article-title":"The Application of Nanovaccines in Autoimmune Diseases","author":"Tang","year":"2024","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0079","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12964-024-01574-1","article-title":"Advances in lymphatic metastasis of non-small cell lung cancer","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0080","first-page":"62","article-title":"Immunodeficiency and immune reconstitution in pediatric HIV: mechanisms, challenges, and therapeutic strategies","volume":"2","author":"Obeagu","year":"2024","journal-title":"Elite J. Immunol."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0081","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1001\/jamasurg.2022.0654","article-title":"The gut-lymph model gives new treatment strategies for organ failure","volume":"157","author":"Windsor","year":"2022","journal-title":"JAMa Surg."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0082","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2022.12.031","article-title":"Lymphatic vessels in bone support regeneration after injury","volume":"186","author":"Biswas","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2024.12.039_bib0083","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2024.110788","article-title":"History of clinical intestinal transplantation","author":"Gondolesi","year":"2024","journal-title":"Hum. Immunol."},{"issue":"8","key":"10.1016\/j.actbio.2024.12.039_bib0084","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.stem.2022.07.007","article-title":"Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury","volume":"29","author":"Palikuqi","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"7839","key":"10.1016\/j.actbio.2024.12.039_bib0085","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41586-020-2998-x","article-title":"Lymphoangiocrine signals promote cardiac growth and repair","volume":"588","author":"Liu","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0086","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20171868","article-title":"Organ-specific lymphatic vasculature: from development to pathophysiology","volume":"215","author":"Petrova","year":"2018","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0087","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","article-title":"The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease","volume":"182","author":"Oliver","year":"2020","journal-title":"Cell"},{"issue":"34","key":"10.1016\/j.actbio.2024.12.039_bib0088","doi-asserted-by":"crossref","first-page":"12288","DOI":"10.1073\/pnas.1402981111","article-title":"Vaccines, new opportunities for a new society","volume":"111","author":"Rappuoli","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.actbio.2024.12.039_bib0089","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.h988","article-title":"Cancer vaccines","volume":"350","author":"Butterfield","year":"2015","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.actbio.2024.12.039_bib0090","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nri1222","article-title":"Homing and cellular traffic in lymph nodes","volume":"3","author":"von Andrian","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.actbio.2024.12.039_bib0091","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.addr.2017.07.005","article-title":"Exploiting lymphatic vessels for immunomodulation: rationale, opportunities, and challenges","volume":"114","author":"Maisel","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5808","key":"10.1016\/j.actbio.2024.12.039_bib0092","first-page":"107","article-title":"Differential antigen processing by dendritic cell subsets in vivo","volume":"315","author":"Dudziak","year":"2007","journal-title":"Science (1979)"},{"key":"10.1016\/j.actbio.2024.12.039_bib0093","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jconrel.2017.08.009","article-title":"Lymph node targeting strategies to improve vaccination efficacy","volume":"267","author":"Jiang","year":"2017","journal-title":"J. Controll. Release"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0094","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-065X.2006.00444.x","article-title":"The tumor-draining lymph node as an immune-privileged site","volume":"213","author":"Munn","year":"2006","journal-title":"Immunol. Rev."},{"issue":"7","key":"10.1016\/j.actbio.2024.12.039_bib0095","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.3390\/pharmaceutics14071372","article-title":"Nanomaterial-based drug delivery system targeting lymph nodes","volume":"14","author":"Cheng","year":"2022","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.actbio.2024.12.039_bib0096","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2022.09.015","article-title":"Lymph node-targeting nanovaccines for cancer immunotherapy","volume":"351","author":"Wang","year":"2022","journal-title":"J. Controll. Release"},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0097","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.apsb.2021.03.007","article-title":"Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0098","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","article-title":"Dendritic cells in cancer immunology and immunotherapy","volume":"20","author":"Wculek","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.actbio.2024.12.039_bib0099","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1080\/03639045.2019.1593442","article-title":"Mannose functionalized plain and endosomolytic nanocomposite-based approach for the induction of effective antitumor immune response in C57BL\/6 mice melanoma model","volume":"45","author":"Sharma","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"sup2","key":"10.1016\/j.actbio.2024.12.039_bib0100","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1080\/21691401.2018.1469137","article-title":"Release promoter-based systematically designed nanocomposite: a novel approach for site-specific delivery of tumor-associated antigen(TAAs)","volume":"46","author":"Sharma","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0101","first-page":"145","article-title":"Application of nano-delivery systems in lymph nodes for tumor immunotherapy","volume":"15","author":"Xia","year":"2023","journal-title":"Nanomicro Lett."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0102","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12951-023-01989-x","article-title":"Nanovaccine-based strategies for lymph node targeted delivery and imaging in tumor immunotherapy","volume":"21","author":"He","year":"2023","journal-title":"J. Nanobiotechnology."},{"issue":"46","key":"10.1016\/j.actbio.2024.12.039_bib0103","doi-asserted-by":"crossref","first-page":"17908","DOI":"10.1073\/pnas.0803725105","article-title":"Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial","volume":"105","author":"Senti","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"5","key":"10.1016\/j.actbio.2024.12.039_bib0104","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jaci.2012.02.026","article-title":"Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections","volume":"129","author":"Senti","year":"2012","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0105","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jaci.2012.10.056","article-title":"Intralymphatic allergen-specific immunotherapy: an effective and safe alternative treatment route for pollen-induced allergic rhinitis","volume":"131","author":"Hylander","year":"2013","journal-title":"Journal of allergy and clinical immunology"},{"issue":"5","key":"10.1016\/j.actbio.2024.12.039_bib0106","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jaci.2013.07.033","article-title":"Is intralymphatic immunotherapy ready for clinical use in patients with grass pollen allergy?","volume":"132","author":"Witten","year":"2013","journal-title":"Journal of allergy and clinical immunology"},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0107","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.anai.2015.11.010","article-title":"Three-injection intralymphatic immunotherapy in adolescents and young adults with grass pollen rhinoconjunctivitis","volume":"116","author":"Patterson","year":"2016","journal-title":"Asthma & Immunology"},{"key":"10.1016\/j.actbio.2024.12.039_bib0108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13601-016-0107-x","article-title":"Intralymphatic immunotherapy induces allergen specific plasmablasts and increases tolerance to skin prick testing in a pilot study","volume":"6","author":"Schmid","year":"2016","journal-title":"Clin. Transl. Allergy"},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0109","doi-asserted-by":"crossref","first-page":"272","DOI":"10.4168\/aair.2017.9.3.272","article-title":"A pilot study of intralymphatic immunotherapy for house dust mite, cat, and dog allergies","volume":"9","author":"Lee","year":"2017","journal-title":"Allergy Asthma Immunol. Res."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0110","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/eji.200425599","article-title":"Direct intralymphatic injection of peptide vaccines enhances immunogenicity","volume":"35","author":"Johansen","year":"2005","journal-title":"Eur. J. Immunol."},{"issue":"17","key":"10.1016\/j.actbio.2024.12.039_bib0111","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.1158\/1078-0432.CCR-11-1261","article-title":"Route of administration modulates the induction of dendritic cell vaccine\u2013induced antigen-specific T cells in advanced melanoma patients","volume":"17","author":"Lesterhuis","year":"2011","journal-title":"Clinical Cancer Research"},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0112","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1073\/pnas.051630798","article-title":"Intralymphatic immunization enhances DNA vaccination","volume":"98","author":"Maloy","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"15","key":"10.1016\/j.actbio.2024.12.039_bib0113","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1158\/1078-0432.CCR-08-3240","article-title":"Clinical and immunologic effects of intranodal autologous tumor lysate-dendritic cell vaccine with Aldesleukin (interleukin 2) and IFN-\u03b12a therapy in metastatic renal cell carcinoma patients","volume":"15","author":"Schwaab","year":"2009","journal-title":"Clinical Cancer Research"},{"issue":"7","key":"10.1016\/j.actbio.2024.12.039_bib0114","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1158\/1078-0432.CCR-08-2729","article-title":"Limited amounts of dendritic cells migrate into the T-cell area of lymph nodes but have high immune activating potential in melanoma patients","volume":"15","author":"Verdijk","year":"2009","journal-title":"Clinical Cancer Research"},{"issue":"9","key":"10.1016\/j.actbio.2024.12.039_bib0115","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1158\/1078-0432.CCR-10-3272","article-title":"Intra\u2013lymph node prime-boost vaccination against melan A and tyrosinase for the treatment of metastatic melanoma: results of a phase 1 clinical trial","volume":"17","author":"Ribas","year":"2011","journal-title":"Clinical Cancer Research"},{"issue":"22","key":"10.1016\/j.actbio.2024.12.039_bib0116","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1158\/0008-5472.CAN-10-0699","article-title":"Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity","volume":"70","author":"Kreiter","year":"2010","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0117","first-page":"641","article-title":"Intranodal immunization with tumor lysate-pulsed dendritic cells enhances protective antitumor immunity","volume":"61","author":"Lambert","year":"2001","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0118","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jconrel.2010.08.012","article-title":"Administration routes affect the quality of immune responses: a cross-sectional evaluation of particulate antigen-delivery systems","volume":"147","author":"Mohanan","year":"2010","journal-title":"J. Controll. Release"},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0119","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/CJI.0b013e3181611420","article-title":"Phase 1 trial of intranodal injection of a Melan-A\/MART-1 DNA plasmid vaccine in patients with stage IV melanoma","volume":"31","author":"Weber","year":"2008","journal-title":"Journal of immunotherapy"},{"issue":"38","key":"10.1016\/j.actbio.2024.12.039_bib0120","doi-asserted-by":"crossref","first-page":"15745","DOI":"10.1073\/pnas.1105200108","article-title":"In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles","volume":"108","author":"Jewell","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0121","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1152\/physrev.00037.2011","article-title":"Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer","volume":"92","author":"Wiig","year":"2012","journal-title":"Physiol. Rev."},{"issue":"11","key":"10.1016\/j.actbio.2024.12.039_bib0122","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nmat3775","article-title":"Engineering synthetic vaccines using cues from natural immunity","volume":"12","author":"Irvine","year":"2013","journal-title":"Nat. Mater."},{"issue":"10","key":"10.1016\/j.actbio.2024.12.039_bib0123","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/nbt1332","article-title":"Exploiting lymphatic transport and complement activation in nanoparticle vaccines","volume":"25","author":"Reddy","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0124","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jconrel.2006.01.006","article-title":"In vivo targeting of dendritic cells in lymph nodes with poly (propylene sulfide) nanoparticles","volume":"112","author":"Reddy","year":"2006","journal-title":"J. Controll. Release"},{"issue":"17","key":"10.1016\/j.actbio.2024.12.039_bib0125","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1016\/j.biomaterials.2013.02.024","article-title":"Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles","volume":"34","author":"Stano","year":"2013","journal-title":"Biomaterials"},{"issue":"49","key":"10.1016\/j.actbio.2024.12.039_bib0126","doi-asserted-by":"crossref","first-page":"19902","DOI":"10.1073\/pnas.1313152110","article-title":"Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose","volume":"110","author":"De Titta","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.actbio.2024.12.039_bib0127","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.biomaterials.2017.01.010","article-title":"Tailoring polymeric hybrid micelles with lymph node targeting ability to improve the potency of cancer vaccines","volume":"122","author":"Zeng","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.12.039_bib0128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2014.12.024","article-title":"Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses","volume":"200","author":"Zeng","year":"2015","journal-title":"J. Controll. Release"},{"issue":"42","key":"10.1016\/j.actbio.2024.12.039_bib0129","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/j.vaccine.2014.07.081","article-title":"Lymphatic-targeted cationic liposomes: a robust vaccine adjuvant for promoting long-term immunological memory","volume":"32","author":"Wang","year":"2014","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2011.12.017","article-title":"PEGylated cationic liposomes robustly augment vaccine-induced immune responses: role of lymphatic trafficking and biodistribution","volume":"159","author":"Zhuang","year":"2012","journal-title":"J. Controll. Release"},{"key":"10.1016\/j.actbio.2024.12.039_bib0131","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2018.04.003","article-title":"Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles","volume":"170","author":"Gondan","year":"2018","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0132","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41467-020-14906-9","article-title":"Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2024.12.039_bib0133","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.biomaterials.2018.05.025","article-title":"Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and co-delivery platform for enhanced cancer immunotherapy","volume":"175","author":"Lu","year":"2018","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0134","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1021\/acscentsci.8b00035","article-title":"Extra-large pore mesoporous silica nanoparticles enabling co-delivery of high amounts of protein antigen and toll-like receptor 9 agonist for enhanced cancer vaccine efficacy","volume":"4","author":"Cha","year":"2018","journal-title":"ACS. Cent. Sci."},{"issue":"51","key":"10.1016\/j.actbio.2024.12.039_bib0135","doi-asserted-by":"crossref","first-page":"12721","DOI":"10.1002\/anie.201205271","article-title":"Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Mode Imaging of Lymph Nodes with Metastatic Tumors","volume":"51","author":"Tang","year":"2012","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2024.12.039_bib0136","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120208","article-title":"Lymph node-targeted immune-activation mediated by imiquimod-loaded mesoporous polydopamine based-nanocarriers","volume":"255","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.12.039_bib0137","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.biomaterials.2018.10.031","article-title":"Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation","volume":"190","author":"Mottas","year":"2019","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0138","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1039\/C8BM01272E","article-title":"In vivo targeting of DNA vaccines to dendritic cells using functionalized gold nanoparticles","volume":"7","author":"Gulla","year":"2019","journal-title":"Biomater. Sci."},{"issue":"8","key":"10.1016\/j.actbio.2024.12.039_bib0139","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.nano.2015.08.002","article-title":"Optimization of dendrimer structure for sentinel lymph node imaging: effects of generation and terminal group","volume":"11","author":"Niki","year":"2015","journal-title":"Nanomedicine: Nanotechnology, Biology and Medicine"},{"key":"10.1016\/j.actbio.2024.12.039_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119021","article-title":"Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting","volume":"576","author":"Nishimoto","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"29","key":"10.1016\/j.actbio.2024.12.039_bib0141","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1073\/pnas.1600816113","article-title":"pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation","volume":"113","author":"Nuhn","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"45","key":"10.1016\/j.actbio.2024.12.039_bib0142","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201803397","article-title":"Nanoparticle-Conjugate TLR7\/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses","volume":"30","author":"Nuhn","year":"2018","journal-title":"Advanced Materials"},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0143","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/jps.21970","article-title":"Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery","volume":"99","author":"Rao","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.actbio.2024.12.039_bib0144","first-page":"2733","article-title":"Advanced drug delivery to the lymphatic system: lipid-based nanoformulations","author":"Khan","year":"2013","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0145","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12951-021-01232-5","article-title":"The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery","volume":"20","author":"Qi","year":"2022","journal-title":"J. Nanobiotechnology."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0146","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12951-024-02408-5","article-title":"Revolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives","volume":"22","author":"Cai","year":"2024","journal-title":"J. Nanobiotechnology."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11307-023-01827-4","article-title":"Current and developing lymphatic imaging approaches for elucidation of functional mechanisms and disease progression","volume":"26","author":"Aron","year":"2024","journal-title":"Mol. ImAging Biol."},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0148","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jconrel.2005.02.028","article-title":"Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice","volume":"105","author":"Reddy","year":"2005","journal-title":"J. Controll. Release"},{"issue":"1\u20132","key":"10.1016\/j.actbio.2024.12.039_bib0149","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ijpharm.2009.10.014","article-title":"LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors","volume":"385","author":"Luo","year":"2010","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0150","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0005-2736(97)00122-3","article-title":"Lymphatic uptake and biodistribution of liposomes after subcutaneous injection.: II. Influence of liposomal size, lipid composition and lipid dose","volume":"1328","author":"Oussoren","year":"1997","journal-title":"Biochimica et Biophysica Acta (BBA)-Biomembranes"},{"key":"10.1016\/j.actbio.2024.12.039_bib0151","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2017.04.024","article-title":"Effects of gold nanoparticle-based vaccine size on lymph node delivery and cytotoxic T-lymphocyte responses","volume":"256","author":"Kang","year":"2017","journal-title":"J. Controll. Release"},{"issue":"5","key":"10.1016\/j.actbio.2024.12.039_bib0152","doi-asserted-by":"crossref","first-page":"e1089","DOI":"10.1016\/j.nano.2014.01.007","article-title":"Optimizing retention of multimodal imaging nanostructures in sentinel lymph nodes by nanoscale size tailoring","volume":"10","author":"Kjellman","year":"2014","journal-title":"Nanomedicine: Nanotechnology, Biology and Medicine"},{"issue":"14","key":"10.1016\/j.actbio.2024.12.039_bib0153","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1016\/j.biomaterials.2010.01.136","article-title":"Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons","volume":"31","author":"Pan","year":"2010","journal-title":"Biomaterials"},{"issue":"10\u201311","key":"10.1016\/j.actbio.2024.12.039_bib0154","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.addr.2011.05.016","article-title":"Targeting the lymphatics using dendritic polymers (dendrimers)","volume":"63","author":"Kaminskas","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0155","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1021\/acs.molpharmaceut.9b01182","article-title":"The effect of size and charge of lipid nanoparticles prepared by microfluidic mixing on their lymph node transitivity and distribution","volume":"17","author":"Nakamura","year":"2020","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.actbio.2024.12.039_bib0156","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/eji.200737984","article-title":"Nanoparticles target distinct dendritic cell populations according to their size","volume":"38","author":"Manolova","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0157","doi-asserted-by":"crossref","first-page":"H324","DOI":"10.1152\/ajpheart.1996.270.1.H324","article-title":"Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory","volume":"270","author":"Swartz","year":"1996","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"13","key":"10.1016\/j.actbio.2024.12.039_bib0158","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1084\/jem.20091739","article-title":"Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels","volume":"206","author":"Pflicke","year":"2009","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0159","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0304-4165(84)90214-9","article-title":"Assessment of the potential uses of liposomes for lymphoscintigraphy and lymphatic drug delivery failure of 99m-technetium marker to represent intact liposomes in lymph nodes","volume":"801","author":"Patel","year":"1984","journal-title":"Biochimica et Biophysica Acta (BBA)-General Subjects"},{"issue":"1\u20132","key":"10.1016\/j.actbio.2024.12.039_bib0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0378-5173(87)90018-4","article-title":"Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities","volume":"37","author":"Takakura","year":"1987","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2024.12.039_bib0161","first-page":"1","article-title":"Anatomy and physiology of the lymphatics, Lymphatic transport of drugs","author":"O'Driscoll","year":"2019","journal-title":"Routledge"},{"issue":"10","key":"10.1016\/j.actbio.2024.12.039_bib0162","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1080\/10611860802475688","article-title":"Lymphatic targeting of zidovudine using surface-engineered liposomes","volume":"16","author":"Kaur","year":"2008","journal-title":"J. Drug Target."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0163","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0169-409X(95)00045-9","article-title":"Targeting of colloids to lymph nodes: influence of lymphatic physiology and colloidal characteristics","volume":"17","author":"Hawley","year":"1995","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0164","first-page":"333","article-title":"Drug delivery to the lymphatic system","volume":"14","author":"Porter","year":"1997","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0165","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jconrel.2009.09.005","article-title":"Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity","volume":"141","author":"van den Berg","year":"2010","journal-title":"J. Controll. Release"},{"issue":"12","key":"10.1016\/j.actbio.2024.12.039_bib0166","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1021\/acs.molpharmaceut.9b00855","article-title":"Lymphatic uptake of liposomes after intraperitoneal administration primarily occurs via the diaphragmatic lymphatics and is dependent on liposome surface properties","volume":"16","author":"Lee","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2024.12.039_bib0167","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jconrel.2014.04.051","article-title":"Nano-chemotherapeutics: maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers","volume":"193","author":"Ryan","year":"2014","journal-title":"J. Controll. Release"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0168","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-5793(94)00351-3","article-title":"Surface engineered nanospheres with enhanced drainage into lymphatics and uptake by macrophages of the regional lymph nodes","volume":"344","author":"Moghimi","year":"1994","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0169","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/ange.201508626","article-title":"Engineering Polymer Hydrogel Nanoparticles for Lymph Node-Targeted Delivery","volume":"128","author":"De Koker","year":"2016","journal-title":"Angewandte Chemie"},{"issue":"1\u20132","key":"10.1016\/j.actbio.2024.12.039_bib0170","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0169-409X(01)00154-5","article-title":"Liposomes to target the lymphatics by subcutaneous administration","volume":"50","author":"Oussoren","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2024.12.039_bib0171","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1023\/A:1012145410859","article-title":"Lymphatic uptake and biodistribution of liposomes after subcutaneous injection: III. Influence of surface modification with poly (ethyleneglycol)","volume":"14","author":"Oussoren","year":"1997","journal-title":"Pharm. Res."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0172","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2009.08.005","article-title":"PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats","volume":"140","author":"Kaminskas","year":"2009","journal-title":"J. Controll. Release"},{"issue":"8","key":"10.1016\/j.actbio.2024.12.039_bib0173","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.nano.2017.08.003","article-title":"Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site","volume":"13","author":"Ryan","year":"2017","journal-title":"Nanomedicine: Nanotechnology, Biology and Medicine"},{"key":"10.1016\/j.actbio.2024.12.039_bib0174","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jconrel.2017.12.031","article-title":"Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery","volume":"272","author":"Yadav","year":"2018","journal-title":"J. Controll. Release"},{"issue":"12","key":"10.1016\/j.actbio.2024.12.039_bib0175","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1124\/dmd.107.015669","article-title":"Lymphatic absorption of subcutaneously administered proteins: influence of different injection sites on the absorption of darbepoetin alfa using a sheep model","volume":"35","author":"Kota","year":"2007","journal-title":"Drug metabolism and disposition"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0176","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0005-2736(93)90115-G","article-title":"Subcutaneous administration of liposomes: a comparison with the intravenous and intraperitoneal routes of injection","volume":"1150","author":"Allen","year":"1993","journal-title":"Biochimica et Biophysica Acta (BBA)-Biomembranes"},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0177","first-page":"2528","article-title":"Pegylated liposomes have potential as vehicles for intratumoral and subcutaneous drug delivery","volume":"6","author":"Harrington","year":"2000","journal-title":"Clinical cancer research"},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0178","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1021\/acs.molpharmaceut.2c01041","article-title":"Intra-articular Injection of a B Cell Depletion Antibody Enhances Local Exposure to the Joint-Draining Lymph Node in Mice with Collagen-Induced Arthritis","volume":"20","author":"Lam","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2024.12.039_bib0179","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jconrel.2019.10.040","article-title":"Removal of interstitial hyaluronan with recombinant human hyaluronidase improves the systemic and lymphatic uptake of cetuximab in rats","volume":"315","author":"Styles","year":"2019","journal-title":"J. Controll. Release"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0180","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3109\/08982109709035487","article-title":"Lymphatic uptake and biodistribution of liposomes after subcutaneous injection I. Influence of the anatomical site of injection","volume":"7","author":"Oussoren","year":"1997","journal-title":"J. Liposome Res."},{"issue":"7","key":"10.1016\/j.actbio.2024.12.039_bib0181","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1021\/acs.biomac.0c00518","article-title":"PH-responsive biomimetic polymeric micelles as lymph node-targeting vaccines for enhanced antitumor immune responses","volume":"21","author":"Yang","year":"2020","journal-title":"Biomacromolecules."},{"issue":"1\u20133","key":"10.1016\/j.actbio.2024.12.039_bib0182","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-3659(01)00549-1","article-title":"Targeting to macrophages: role of physicochemical properties of particulate carriers\u2014Liposomes and microspheres\u2014On the phagocytosis by macrophages","volume":"79","author":"Ahsan","year":"2002","journal-title":"J. Controll. Release"},{"issue":"10","key":"10.1016\/j.actbio.2024.12.039_bib0183","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1021\/acs.accounts.0c00260","article-title":"Engineering strategies for lymph node targeted immune activation","volume":"53","author":"Chen","year":"2020","journal-title":"Acc. Chem. Res."},{"issue":"9","key":"10.1016\/j.actbio.2024.12.039_bib0184","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/ni1494","article-title":"Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells","volume":"8","author":"Phan","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.actbio.2024.12.039_bib0185","series-title":"Seminars in Immunology","first-page":"147","article-title":"Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design","author":"Swartz","year":"2008"},{"issue":"10\u201311","key":"10.1016\/j.actbio.2024.12.039_bib0186","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.addr.2011.05.018","article-title":"The role of the lymphatic system in vaccine trafficking and immune response","volume":"63","author":"Pal","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2024.12.039_bib0187","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.addr.2019.09.005","article-title":"Physical and chemical profiles of nanoparticles for lymphatic targeting","volume":"151","author":"Ke","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0188","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1182\/blood-2003-02-0513","article-title":"Most lymphoid organ dendritic cell types are phenotypically and functionally immature","volume":"102","author":"Wilson","year":"2003","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.actbio.2024.12.039_bib0189","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1084\/jem.192.10.1425","article-title":"Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex","volume":"192","author":"Gretz","year":"2000","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.actbio.2024.12.039_bib0190","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41565-020-0679-4","article-title":"Programmable multistage drug delivery to lymph nodes","volume":"15","author":"Schudel","year":"2020","journal-title":"Nat. Nanotechnol."},{"issue":"1\u20133","key":"10.1016\/j.actbio.2024.12.039_bib0191","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0014-5793(03)00273-4","article-title":"Modulation of lymphatic distribution of subcutaneously injected poloxamer 407-coated nanospheres: the effect of the ethylene oxide chain configuration","volume":"540","author":"Moghimi","year":"2003","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0192","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0169-409X(00)00121-6","article-title":"Lymphatic targeting with nanoparticulate system","volume":"47","author":"Nishioka","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0193","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0005-2736(97)00275-7","article-title":"Lymphatic uptake and biodistribution of liposomes after subcutaneous injection: IV. Fate of liposomes in regional lymph nodes","volume":"1370","author":"Oussoren","year":"1998","journal-title":"Biochimica et Biophysica Acta (BBA)-Biomembranes"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0194","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0378-5173(99)00040-X","article-title":"Role of macrophages in the localisation of liposomes in lymph nodes after subcutaneous administration","volume":"183","author":"Oussoren","year":"1999","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0195","doi-asserted-by":"crossref","first-page":"e61646","DOI":"10.1371\/journal.pone.0061646","article-title":"Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice","volume":"8","author":"Kourtis","year":"2013","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0196","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.immuni.2014.12.024","article-title":"Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens","volume":"42","author":"Gerner","year":"2015","journal-title":"Immunity."},{"issue":"10","key":"10.1016\/j.actbio.2024.12.039_bib0197","doi-asserted-by":"crossref","first-page":"7226","DOI":"10.1021\/acs.nanolett.9b02834","article-title":"Nanoparticle size influences antigen retention and presentation in lymph node follicles for humoral immunity","volume":"19","author":"Zhang","year":"2019","journal-title":"Nano Lett."},{"issue":"16","key":"10.1016\/j.actbio.2024.12.039_bib0198","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1016\/j.biomaterials.2014.02.030","article-title":"Lipid\u2013calcium phosphate nanoparticles for delivery to the lymphatic system and SPECT\/CT imaging of lymph node metastases","volume":"35","author":"Tseng","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2024.12.039_bib0199","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s12274-019-2301-3","article-title":"Critical size limit of biodegradable nanoparticles for enhanced lymph node trafficking and paracortex penetration","volume":"12","author":"Howard","year":"2019","journal-title":"Nano Res."},{"key":"10.1016\/j.actbio.2024.12.039_bib0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.coche.2014.11.003","article-title":"Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery","volume":"7","author":"Thomas","year":"2015","journal-title":"Curr. Opin. Chem. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2024.12.039_bib0201","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.immuni.2008.12.014","article-title":"Conduits mediate transport of low-molecular-weight antigen to lymph node follicles","volume":"30","author":"Roozendaal","year":"2009","journal-title":"Immunity."},{"key":"10.1016\/j.actbio.2024.12.039_bib0202","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jconrel.2023.03.006","article-title":"A liposomal vaccine promotes strong adaptive immune responses via dendritic cell activation in draining lymph nodes","volume":"356","author":"Agallou","year":"2023","journal-title":"J. Controll. Release"},{"issue":"3","key":"10.1016\/j.actbio.2024.12.039_bib0203","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1124\/jpet.108.148163","article-title":"Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy","volume":"328","author":"Sensken","year":"2009","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"9","key":"10.1016\/j.actbio.2024.12.039_bib0204","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ni.2085","article-title":"Afferent lymph\u2013derived T cells and DCs use different chemokine receptor CCR7\u2013dependent routes for entry into the lymph node and intranodal migration","volume":"12","author":"Braun","year":"2011","journal-title":"Nat. Immunol."},{"issue":"148","key":"10.1016\/j.actbio.2024.12.039_bib0205","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003763","article-title":"Engineering approaches to immunotherapy","volume":"4","author":"Swartz","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2024.12.039_bib0206","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107063","article-title":"IUPHAR ECR review: the cGAS-STING pathway: novel functions beyond innate immune and emerging therapeutic opportunities","author":"He","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.actbio.2024.12.039_bib0207","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.addr.2020.06.003","article-title":"Dawn of lipid nanoparticles in lymph node targeting: potential in cancer immunotherapy","volume":"167","author":"Nakamura","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0208","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-023-01557-7","article-title":"Vaccine adjuvants: mechanisms and platforms","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0209","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40364-023-00551-z","article-title":"Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy","volume":"12","author":"Chen","year":"2024","journal-title":"Biomark. Res."},{"issue":"12","key":"10.1016\/j.actbio.2024.12.039_bib0210","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1128\/JVI.02563-09","article-title":"Route of adenovirus-based HIV-1 vaccine delivery impacts the phenotype and trafficking of vaccine-elicited CD8+ T lymphocytes","volume":"84","author":"Kaufman","year":"2010","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.actbio.2024.12.039_bib0211","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.4049\/jimmunol.0901466","article-title":"What role does the route of immunization play in the generation of protective immunity against mucosal pathogens?","volume":"183","author":"Belyakov","year":"2009","journal-title":"The Journal of immunology"},{"key":"10.1016\/j.actbio.2024.12.039_bib0212","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2014.03.011","article-title":"Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site","volume":"182","author":"Kinnunen","year":"2014","journal-title":"J. Controll. Release"},{"issue":"21","key":"10.1016\/j.actbio.2024.12.039_bib0213","article-title":"An engineered nanosugar enables rapid and sustained glucose-responsive insulin delivery in diabetic mice","volume":"35","author":"Xu","year":"2023","journal-title":"Advanced Materials"},{"key":"10.1016\/j.actbio.2024.12.039_bib0214","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.addr.2016.02.003","article-title":"Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: insights for applications in HIV therapy","volume":"103","author":"Owen","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"22","key":"10.1016\/j.actbio.2024.12.039_bib0215","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1177\/15353702211010762","article-title":"Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes","volume":"246","author":"Trac","year":"2021","journal-title":"Exp. Biol. Med."},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0216","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41571-019-0308-z","article-title":"Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges","volume":"17","author":"Martin","year":"2020","journal-title":"Nature reviews Clinical oncology"},{"issue":"12","key":"10.1016\/j.actbio.2024.12.039_bib0217","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1016\/j.celrep.2020.02.111","article-title":"Route of vaccine administration alters antigen trafficking but not innate or adaptive immunity","volume":"30","author":"Ols","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.actbio.2024.12.039_bib0218","doi-asserted-by":"crossref","DOI":"10.1039\/D4BM00910J","article-title":"Different leukocyte subsets are targeted by systemic and locoregional administration despite conserved nanomaterial characteristics optimal for lymph node delivery","author":"Archer","year":"2024","journal-title":"Biomater. Sci."},{"issue":"12","key":"10.1016\/j.actbio.2024.12.039_bib0219","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1021\/mp300190g","article-title":"Effect of the poly (ethylene glycol)(PEG) density on the access and uptake of particles by antigen-presenting cells (APCs) after subcutaneous administration","volume":"9","author":"Zhan","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2024.12.039_bib0220","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.actbio.2022.03.054","article-title":"Nanoparticles with dense poly (ethylene glycol) coatings with near neutral charge are maximally transported across lymphatics and to the lymph nodes","volume":"145","author":"McCright","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2024.12.039_bib0221","article-title":"Cellular uptake and retention of nanoparticles: insights on particle properties and interaction with cellular components","volume":"25","author":"Augustine","year":"2020","journal-title":"Mater. Today Commun."},{"issue":"1","key":"10.1016\/j.actbio.2024.12.039_bib0222","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12951-022-01582-8","article-title":"Nanocarriers for effective delivery: modulation of innate immunity for the management of infections and the associated complications","volume":"20","author":"Ko","year":"2022","journal-title":"J. Nanobiotechnology."},{"issue":"4","key":"10.1016\/j.actbio.2024.12.039_bib0223","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1073\/pnas.1112648109","article-title":"Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction","volume":"109","author":"Moon","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270612400758X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270612400758X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T21:39:20Z","timestamp":1738445960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S174270612400758X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":223,"alternative-id":["S174270612400758X"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2024.12.039","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of nanoparticle properties on immune cell interactions in the lymph node","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2024.12.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}