{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:34:54Z","timestamp":1792010094300,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.actbio.2025.02.010","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T16:35:39Z","timestamp":1738773339000},"page":"157-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Endotoxin, not DNA, determines the host response and tissue regeneration behavior of acellular biologic scaffolds"],"prefix":"10.1016","volume":"195","author":[{"given":"Wenyue","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-8590","authenticated-orcid":false,"given":"Yonggang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meibiao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7251-3627","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3\u20134","key":"10.1016\/j.actbio.2025.02.010_bib0001","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.trim.2003.12.016","article-title":"Xenogeneic extracellular matrix as a scaffold for tissue reconstruction","volume":"12","author":"Badylak","year":"2004","journal-title":"Transpl. Immunol."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.010_bib0002","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10029-008-0362-4","article-title":"Mesh repair of common abdominal hernias: a review on experimental and clinical studies","volume":"12","author":"Penttinen","year":"2008","journal-title":"Hernia"},{"issue":"1","key":"10.1016\/j.actbio.2025.02.010_bib0003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jss.2008.02.013","article-title":"Quantification of DNA in biologic scaffold materials","volume":"152","author":"Gilbert","year":"2009","journal-title":"J. Surg. Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.010_bib0004","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/lary.25640","article-title":"Derivation and characterization of porcine vocal fold extracellular matrix scaffold","volume":"126","author":"Wrona","year":"2016","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.actbio.2025.02.010_bib0005","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00464-005-0568-9","article-title":"Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair","volume":"20","author":"Petter-Puchner","year":"2006","journal-title":"Surg. Endosc."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.010_bib0006","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.surg.2014.06.022","article-title":"A prospective, randomized, multicenter trial of surgisis gold, a biologic prosthetic, as a sublay reinforcement of the fascial closure after open bariatric surgery","volume":"156","author":"Sarr","year":"2014","journal-title":"Surgery"},{"issue":"3 Suppl","key":"10.1016\/j.actbio.2025.02.010_bib0007","first-page":"S21","article-title":"Comparison of three different mesh materials in tension-free inguinal hernia repair: prolene versus Vypro versus surgisis","volume":"90","author":"Puccio","year":"2005","journal-title":"Int. Surg."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.010_bib0008","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10029-016-1556-9","article-title":"Abdominal wall reinforcement: biologic vs. degradable synthetic devices","volume":"21","author":"Gruber-Blum","year":"2017","journal-title":"Hernia"},{"issue":"3","key":"10.1016\/j.actbio.2025.02.010_bib0009","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.amjsurg.2008.09.021","article-title":"Inguinal hernia repair with porcine small intestine submucosa: 3-year follow-up results of a randomized controlled trial of Lichtenstein's repair with polypropylene mesh versus Surgisis inguinal hernia matrix","volume":"198","author":"Ansaloni","year":"2009","journal-title":"Am. J. Surg."},{"issue":"9","key":"10.1016\/j.actbio.2025.02.010_bib0010","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1111\/tbj.13921","article-title":"Drain secretion and seroma formation after immediate breast reconstruction with a biological and a synthetic mesh, respectively: a randomized controlled study","volume":"26","author":"Hansson","year":"2020","journal-title":"Breast J."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.010_bib0011","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.surg.2022.12.002","article-title":"Biologic versus synthetic mesh in open ventral hernia repair: a systematic review and meta-analysis of randomized controlled trials","volume":"173","author":"Mazzola Poli de Figueiredo","year":"2023","journal-title":"Surgery"},{"issue":"12","key":"10.1016\/j.actbio.2025.02.010_bib0012","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1007\/s00268-020-05887-3","article-title":"Biologic mesh in surgery: a comprehensive review and meta-analysis of selected outcomes in 51 studies and 6079 patients","volume":"45","author":"Samson","year":"2021","journal-title":"World J. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.010_bib0013","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10029-011-0859-0","article-title":"Evaluation of crosslinked and non-crosslinked biologic prostheses for abdominal hernia repair","volume":"16","author":"de Castro Bras","year":"2012","journal-title":"Hernia"},{"issue":"1","key":"10.1016\/j.actbio.2025.02.010_bib0014","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40824-023-00348-z","article-title":"Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine","volume":"27","author":"Kasravi","year":"2023","journal-title":"Biomater. Res."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.010_bib0015","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1039\/C9BM01780A","article-title":"Regulation of decellularized matrix mediated immune response","volume":"8","author":"Chakraborty","year":"2020","journal-title":"Biomater. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.010_bib0016","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10561-005-1235-z","article-title":"Processing of whole femoral head allografts: validation methodology for the reliable removal of nucleated cells, lipid and soluble proteins using a multi-step washing procedure","volume":"6","author":"Yates","year":"2005","journal-title":"Cell Tissue Bank"},{"issue":"4","key":"10.1016\/j.actbio.2025.02.010_bib0017","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1001\/archsurg.1975.01360100058011","article-title":"A chemosterilized antigen-extracted autodigested alloimplant for bone banks","volume":"110","author":"Urist","year":"1975","journal-title":"Arch. Surg."},{"issue":"11\u201312","key":"10.1016\/j.actbio.2025.02.010_bib0018","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1089\/ten.tea.2011.0597","article-title":"The host response to endotoxin-contaminated dermal matrix","volume":"18","author":"Daly","year":"2012","journal-title":"Tissue Eng. A"},{"issue":"12","key":"10.1016\/j.actbio.2025.02.010_bib0019","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1525-1594.1993.tb03183.x","article-title":"Unusual inflammatory responses around a collagen-impregnated vascular prosthesis","volume":"17","author":"Yamamoto K","year":"1993","journal-title":"Artif. Organs"},{"issue":"4","key":"10.1016\/j.actbio.2025.02.010_bib0020","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/jbm.a.33144","article-title":"Endotoxin contamination delays the foreign body reaction","volume":"98","author":"van Putten","year":"2011","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"6","key":"10.1016\/j.actbio.2025.02.010_bib0021","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.biomaterials.2011.10.054","article-title":"Consequences of ineffective decellularization of biologic scaffolds on the host response","volume":"33","author":"Keane","year":"2012","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.actbio.2025.02.010_bib0022","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/15062","article-title":"Remodeling of an acellular collagen graft into a physiologically responsive neovessel","volume":"17","author":"Huynh","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2025.02.010_bib0023","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biomaterials.2016.02.040","article-title":"Perfusion-decellularized skeletal muscle as a three-dimensional scaffold with a vascular network template","volume":"89","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2025.02.010_bib0024","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/jbm.a.36055","article-title":"The effect of cell debris within biologic scaffolds upon the macrophage response","volume":"105","author":"Londono","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"34","key":"10.1016\/j.actbio.2025.02.010_bib0025","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1016\/j.biomaterials.2005.04.063","article-title":"Endotoxin: the uninvited guest","volume":"26","author":"Gorbet","year":"2005","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.actbio.2025.02.010_bib0026","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/ten.teb.2012.0636","article-title":"Endotoxins-the invisible companion in biomaterials research","volume":"19","author":"Lieder","year":"2013","journal-title":"Tissue Eng. B Rev."},{"issue":"6283","key":"10.1016\/j.actbio.2025.02.010_bib0027","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1126\/science.aad9272","article-title":"Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells","volume":"352","author":"Sadtler","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.actbio.2025.02.010_bib0028","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/jbm.b.31247","article-title":"Surface endotoxin contamination and hemocompatibility evaluation of materials","volume":"90","author":"Maitz","year":"2009","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.actbio.2025.02.010_bib0029","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biomaterials.2016.02.003","article-title":"Extracellular matrix-based biomaterial scaffolds and the host response","volume":"86","author":"Aamodt","year":"2016","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2025.02.010_bib0030","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/jor.1100170603","article-title":"Measurement and removal of adherent endotoxin from titanium particles and implant surfaces","volume":"17","author":"Ragab","year":"1999","journal-title":"J. Orthop. Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.010_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125078","article-title":"Detection of innate immune response modulating impurities in therapeutic proteins","volume":"10","author":"Haile","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2025.02.010_bib0032","doi-asserted-by":"crossref","first-page":"44750","DOI":"10.1038\/srep44750","article-title":"Biological activity of masked endotoxin","volume":"7","author":"Schwarz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.02.010_bib0033","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.dib.2016.04.018","article-title":"A panel data set on harvest and perfusion decellularization of porcine rectus abdominis","volume":"7","author":"Zhang","year":"2016","journal-title":"Data Br."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.010_bib0034","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/ten.tec.2014.0321","article-title":"Porcine liver decellularization under oscillating pressure conditions: a technical refinement to improve the homogeneity of the decellularization process","volume":"21","author":"Struecker","year":"2015","journal-title":"Tissue Eng. C Methods"},{"issue":"2","key":"10.1016\/j.actbio.2025.02.010_bib0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm1684","article-title":"Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart","volume":"14","author":"Ott","year":"2008","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.010_bib0036","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00383-012-3194-3","article-title":"Detergent enzymatic treatment for the development of a natural acellular matrix for oesophageal regeneration","volume":"29","author":"Totonelli","year":"2013","journal-title":"Pediatr. Surg. Int."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.010_bib0037","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/THC-2012-0672","article-title":"Decellularized ovine esophageal mucosa for esophageal tissue engineering","volume":"20","author":"Ackbar","year":"2012","journal-title":"Technol. Health Care"},{"issue":"1","key":"10.1016\/j.actbio.2025.02.010_bib0038","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/SAP.0000000000000157","article-title":"Decellularization of a fasciocutaneous flap for use as a perfusable scaffold","volume":"75","author":"Qu","year":"2015","journal-title":"Ann. Plast. Surg."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.010_bib0039","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jbiosc.2014.10.019","article-title":"Controlled processing of a full-sized porcine liver to a decellularized matrix in 24 h","volume":"119","author":"Buhler","year":"2015","journal-title":"J. Biosci. Bioeng."},{"issue":"11","key":"10.1016\/j.actbio.2025.02.010_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111591","article-title":"Bioartificial heart: a human-sized porcine model\u2013the way ahead","volume":"9","author":"Weymann","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2025.02.010_bib0041","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.sopen.2022.07.005","article-title":"Lack of immunogenicity of xenogeneic DNA from porcine biomaterials","volume":"10","author":"Record Ritchie","year":"2022","journal-title":"Surg. Open Sci."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125000959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125000959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T03:17:57Z","timestamp":1741922277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125000959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":41,"alternative-id":["S1742706125000959"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.02.010","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endotoxin, not DNA, determines the host response and tissue regeneration behavior of acellular biologic scaffolds","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}