{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:04:52Z","timestamp":1785488692998,"version":"3.56.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100013111","name":"Materials Research Science and Engineering Center, Harvard University","doi-asserted-by":"publisher","award":["DMR-2308691"],"award-info":[{"award-number":["DMR-2308691"]}],"id":[{"id":"10.13039\/100013111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR-1720139"],"award-info":[{"award-number":["DMR-1720139"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.actbio.2025.02.051","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T11:19:43Z","timestamp":1740568783000},"page":"257-270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Ex-vivo mechano-structural characterization of fresh diseased human esophagus"],"prefix":"10.1016","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-8825","authenticated-orcid":false,"given":"Nicolas A.","family":"Alderete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin W.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2558-9419","authenticated-orcid":false,"given":"Meisam","family":"Asgari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2486-3615","authenticated-orcid":false,"given":"Ryan","family":"Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8366-8860","authenticated-orcid":false,"given":"Sourav","family":"Halder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-7758","authenticated-orcid":false,"given":"Dustin","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-3322","authenticated-orcid":false,"given":"Eric","family":"Goudie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico A.","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-2753","authenticated-orcid":false,"given":"Daniel P.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen M.","family":"Witzenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-3454","authenticated-orcid":false,"given":"Neelesh A.","family":"Patankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Pandolfino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8212-0329","authenticated-orcid":false,"given":"Sevketcan","family":"Sarikaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio D.","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.02.051_bib0001","series-title":"Biomechanics: Mechanical Properties of Living Tissues","author":"Fung","year":"1993"},{"key":"10.1016\/j.actbio.2025.02.051_bib0002","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jmbbm.2015.12.028","article-title":"Quantification of effects of cancer on elastic properties of breast tissue by Atomic Force microscopy","volume":"60","author":"Ansardamavandi","year":"2016","journal-title":"J. Mech. Behav. Biomed."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.051_bib0003","article-title":"A quarter of a century biomechanical rupture risk assessment of abdominal aortic aneurysms. Achievements, clinical relevance, and ongoing developments","volume":"39","author":"Gasser","year":"2023","journal-title":"Int. J. Numer. Meth. Bio."},{"key":"10.1016\/j.actbio.2025.02.051_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1195067","article-title":"MRI-MECH: mechanics-informed MRI to estimate esophageal health","volume":"14","author":"Halder","year":"2023","journal-title":"Front. Physiol."},{"issue":"118","key":"10.1016\/j.actbio.2025.02.051_bib0005","article-title":"Biomechanical characterization of Human soft tissues using indentation and tensile testing","author":"Griffin","year":"2016","journal-title":"Jove-J. Vis. Exp."},{"key":"10.1016\/j.actbio.2025.02.051_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105581","article-title":"Characterization of mechanical properties of soft tissues using sub-microscale tensile testing and 3D-printed sample holder","volume":"138","author":"Kang","year":"2023","journal-title":"J. Mech. Behav. Biomed."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.051_bib0007","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1557\/s43578-021-00409-w","article-title":"3D Bioprinting for esophageal tissue regeneration: a review","volume":"37","author":"Vasanthan","year":"2022","journal-title":"J. Mater. Res."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0008","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/rcs.209","article-title":"An efficient soft tissue characterization algorithm from indentation experiments for medical simulation","volume":"4","author":"Kim","year":"2008","journal-title":"Int. J. Med. Robot. Comp."},{"issue":"6","key":"10.1016\/j.actbio.2025.02.051_bib0009","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jtcvs.2020.02.099","article-title":"A novel cervical esophagogastric anastomosis simulator","volume":"160","author":"Orringer","year":"2020","journal-title":"J. Thorac. Cardiov. Sur."},{"key":"10.1016\/j.actbio.2025.02.051_bib0010","article-title":"Physiology of oral, pharyngeal, and esophageal motility","author":"Goyal","year":"2006","journal-title":"GI Motility online"},{"key":"10.1016\/j.actbio.2025.02.051_bib0011","series-title":"Gray's anatomy: the Anatomical Basis of Clinical Practice","author":"Gray","year":"2005"},{"key":"10.1016\/j.actbio.2025.02.051_bib0012","series-title":"Biomechanics of the Gastrointestinal Tract: New Perspectives in Motility Research and Diagnostics","author":"Gregersen","year":"2003"},{"key":"10.1016\/j.actbio.2025.02.051_bib0013","series-title":"Esophageal Abnormalities","article-title":"Anatomy of esophagus","author":"Murat Ferhat","year":"2017"},{"issue":"9","key":"10.1016\/j.actbio.2025.02.051_bib0014","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3748\/wjg.v13.i9.1335","article-title":"Function of longitudinal circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling","volume":"13","author":"Brasseur","year":"2007","journal-title":"World J. Gastroentero."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0015","first-page":"G187","article-title":"Biomechanical and sensory parameters of the human esophagus at four levels","volume":"275","author":"Patel","year":"1998","journal-title":"Am. J. Physiol.-Gastr. L"},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0016","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1113\/jphysiol.2002.028795","article-title":"Effect of atropine on the biomechanical properties of the oesophageal wall in humans","volume":"547","author":"Takeda","year":"2003","journal-title":"J. Physiol. London"},{"issue":"5","key":"10.1016\/j.actbio.2025.02.051_bib0017","first-page":"G785","article-title":"A novel ultrasound technique to study the biomechanics of the human esophagus in vivo","volume":"282","author":"Takeda","year":"2002","journal-title":"Am. J. Physiol.-Gastr. L"},{"key":"10.1016\/j.actbio.2025.02.051_bib0018","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/nyas.13109","article-title":"Provocative testing of the esophagus and its future","volume":"1380","author":"Farmer","year":"2016","journal-title":"Ann. Ny. Acad. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.051_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/imammb\/dqt020","article-title":"The invalidity of the Laplace law for biological vessels and of estimating elastic modulus from total stress vs. strain: a new practical method","volume":"32","author":"Costanzo","year":"2015","journal-title":"Math. Med. Biol."},{"issue":"9","key":"10.1016\/j.actbio.2025.02.051_bib0020","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0021-9290(03)00160-X","article-title":"Biomechanical properties of oesophagus wall under loading","volume":"36","author":"Vanags","year":"2003","journal-title":"J. Biomech."},{"issue":"10","key":"10.1016\/j.actbio.2025.02.051_bib0021","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0021-9290(02)00084-2","article-title":"Mechanical properties of the human gastrointestinal tract","volume":"35","author":"Egorov","year":"2002","journal-title":"J. Biomech."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.051_bib0022","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10237-022-01583-4","article-title":"Experimental investigations of the human oesophagus: anisotropic properties of the embalmed muscular layer under large deformation","volume":"21","author":"Durcan","year":"2022","journal-title":"Biomech. Model. Mechan."},{"issue":"6","key":"10.1016\/j.actbio.2025.02.051_bib0023","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s10237-022-01613-1","article-title":"Experimental investigations of the human oesophagus: anisotropic properties of the embalmed mucosa-submucosa layer under large deformation","volume":"21","author":"Durcan","year":"2022","journal-title":"Biomech. Model. Mechan."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0024","first-page":"G338","article-title":"Mechanical-properties of isolated Human esophageal smooth-muscle","volume":"258","author":"Tottrup","year":"1990","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0025","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/jtbi.2002.3118","article-title":"A mathematical model for estimating muscle tension during esophageal bolus transport","volume":"219","author":"Nicosia","year":"2002","journal-title":"J. Theor. Biol."},{"issue":"213","key":"10.1016\/j.actbio.2025.02.051_bib0026","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2023.0592","article-title":"Characterization of the layer, direction and time-dependent mechanical behaviour of the human oesophagus and the effects of formalin preservation","volume":"21","author":"Durcan","year":"2024","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.actbio.2025.02.051_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2021.104914","article-title":"Coupled experimental and computational approach to stomach biomechanics: towards a validated characterization of gastric tissues mechanical properties","volume":"125","author":"Toniolo","year":"2022","journal-title":"J. Mech. Behav. Biomed."},{"issue":"7","key":"10.1016\/j.actbio.2025.02.051_bib0028","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jbiomech.2009.01.029","article-title":"Tissue softening of guinea pig oesophagus tested by the tri-axial test machine","volume":"42","author":"Liao","year":"2009","journal-title":"J. Biomech."},{"issue":"16","key":"10.1016\/j.actbio.2025.02.051_bib0029","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1016\/j.jbiomech.2009.08.018","article-title":"Biomechanical and histological characteristics of passive esophagus: experimental investigation and comparative constitutive modeling","volume":"42","author":"Stavropoulou","year":"2009","journal-title":"J. Biomech."},{"issue":"9","key":"10.1016\/j.actbio.2025.02.051_bib0030","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.compbiomed.2013.06.009","article-title":"Structurally-motivated characterization of the passive pseudo-elastic response of esophagus and its layers","volume":"43","author":"Sokolis","year":"2013","journal-title":"Comput. Biol. Med."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.051_bib0031","doi-asserted-by":"crossref","first-page":"e09312","DOI":"10.1016\/j.heliyon.2022.e09312","article-title":"Biomechanical analysis of sheep oesophagus subjected to biaxial testing including hyperelastic constitutive model fitting","volume":"8","author":"Ngwangwa","year":"2022","journal-title":"Heliyon"},{"issue":"12","key":"10.1016\/j.actbio.2025.02.051_bib0032","doi-asserted-by":"crossref","first-page":"9379","DOI":"10.1016\/j.actbio.2013.07.041","article-title":"Multiaxial mechanical response and constitutive modeling of esophageal tissues: impact on esophageal tissue engineering","volume":"9","author":"Sommer","year":"2013","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0033","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1115\/1.2187033","article-title":"Directional, regional, and layer variations of mechanical properties of esophageal tissue and its interpretation using a structure-based constitutive model","volume":"128","author":"Yang","year":"2006","journal-title":"J. Biomech. Eng."},{"issue":"6","key":"10.1016\/j.actbio.2025.02.051_bib0034","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1115\/1.2354206","article-title":"3D Mechanical properties of the layered esophagus: experiment and constitutive model","volume":"128","author":"Yang","year":"2006","journal-title":"J. Biomech. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0035","article-title":"3D reconstruction and fiber quantification in the pig lower esophageal sphincter region using diffusion tensor imaging","volume":"4","author":"Liao","year":"2018","journal-title":"Biomed. Phys. Eng. Expr."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.051_bib0036","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s10237-021-01476-y","article-title":"3D biomechanical properties of the layered esophagus: fung-type SEF and new constitutive model","volume":"20","author":"Ren","year":"2021","journal-title":"Biomech. Model. Mechan."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151223","article-title":"Acellularization-induced changes in tensile properties are organ specific - an In-vitro mechanical and structural analysis of porcine soft tissues","volume":"11","author":"Schleifenbaum","year":"2016","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.actbio.2025.02.051_bib0038","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI106630","article-title":"Mechanical properties of the esophageal wall","volume":"50","author":"Goyal","year":"1971","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.051_bib0039","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.jbiomech.2005.01.022","article-title":"Biomechanical properties of the layered oesophagus and its remodelling in experimental type-1 diabetes","volume":"39","author":"Yang","year":"2006","journal-title":"J. Biomech."},{"issue":"9","key":"10.1016\/j.actbio.2025.02.051_bib0040","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S1350-4533(03)00122-X","article-title":"Stress distribution in the layered wall of the rat oesophagus","volume":"25","author":"Liao","year":"2003","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.actbio.2025.02.051_bib0041","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jbiomech.2019.05.042","article-title":"Esophageal stress softening recovery is altered in STZ-induced diabetic rats","volume":"92","author":"Jiang","year":"2019","journal-title":"J. Biomech."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0042","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s10237-017-0873-y","article-title":"Reversible stress softening in layered rat esophagus in vitro after potassium chloride activation","volume":"16","author":"Jiang","year":"2017","journal-title":"Biomech. Model. Mechan."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0043","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade2522","article-title":"A magnetically actuated, optically sensed tensile testing method for mechanical characterization of soft biological tissues","volume":"9","author":"Rosalia","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2025.02.051_bib0044","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jcp.2017.07.025","article-title":"A continuum mechanics-based musculo-mechanical model for esophageal transport","volume":"348","author":"Kou","year":"2017","journal-title":"J. Comput. Phys."},{"issue":"7","key":"10.1016\/j.actbio.2025.02.051_bib0045","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.medengphy.2004.04.009","article-title":"Two-layered quasi-3D finite element model of the oesophagus","volume":"26","author":"Liao","year":"2004","journal-title":"Med. Eng. Phys."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0046","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10237-017-0963-x","article-title":"An in silico biomechanical analysis of the stent-esophagus interaction (vol 17, pg 111, 2017)","volume":"17","author":"Peirlinck","year":"2018","journal-title":"Biomech. Model. Mechan."},{"issue":"14","key":"10.1016\/j.actbio.2025.02.051_bib0047","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.jbiomech.2012.07.016","article-title":"On the specimen length dependency of tensile mechanical properties in soft tissues: gripping effects and the characteristic decay length","volume":"45","author":"Anssari-Benam","year":"2012","journal-title":"J. Biomech."},{"issue":"12","key":"10.1016\/j.actbio.2025.02.051_bib0048","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.jbiomech.2010.04.040","article-title":"Specimen dimensions influence the measurement of material properties in tendon fascicles","volume":"43","author":"Legerlotz","year":"2010","journal-title":"J. Biomech."},{"issue":"7","key":"10.1016\/j.actbio.2025.02.051_bib0049","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1002\/cpz1.493","article-title":"Combining unique planar biaxial testing with full-field thickness and displacement measurement for spatial characterization of soft tissues","volume":"2","author":"Pearce","year":"2022","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.actbio.2025.02.051_bib0050","unstructured":"T. Instruments, Discovery DMA Brochure, (2018)."},{"key":"10.1016\/j.actbio.2025.02.051_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106795","article-title":"Asymmetric sample shapes complicate planar biaxial testing assumptions by intensifying shear strains and stresses","volume":"161","author":"Pearce","year":"2025","journal-title":"J. Mech. Behav. Biomed."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0052","doi-asserted-by":"crossref","first-page":"H433","DOI":"10.1152\/ajpheart.1995.269.2.H433","article-title":"Biaxial mechanics of excised canine pulmonary-arteries","volume":"269","author":"Debes","year":"1995","journal-title":"Am. J. Physiol.-Heart. C"},{"issue":"6","key":"10.1016\/j.actbio.2025.02.051_bib0053","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s11340-015-0009-1","article-title":"Ncorr: open-source 2D digital image correlation matlab software","volume":"55","author":"Blaber","year":"2015","journal-title":"Exp. Mech."},{"issue":"8","key":"10.1016\/j.actbio.2025.02.051_bib0054","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1365-2982.2009.01311.x","article-title":"High-resolution manometry in clinical practice: utilizing pressure topography to classify oesophageal motility abnormalities","volume":"21","author":"Pandolfino","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.051_bib0055","doi-asserted-by":"crossref","first-page":"e14058","DOI":"10.1111\/nmo.14058","article-title":"Esophageal motility disorders on high-resolution manometry: chicago classification version 4.0\u00a9","volume":"33","author":"Yadlapati","year":"2021","journal-title":"Neurogastroenterol. Motil."},{"issue":"12","key":"10.1016\/j.actbio.2025.02.051_bib0056","article-title":"Classifying esophageal motility by FLIP panometry: a study of 722 subjects with manometry","volume":"116","author":"Carlson","year":"2021","journal-title":"Off. J. Am. Coll. Gastroenterol. ACG"},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0057","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00004836-198604000-00005","article-title":"Muscle anatomy of the Human esophagus","volume":"8","author":"Meyer","year":"1986","journal-title":"J. Clin. Gastroenterol."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0058","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cgh.2016.10.022","article-title":"Functional lumen imaging probe for the management of esophageal disorders: expert review from the Clinical Practice Updates Committee of the AGA Institute","volume":"15","author":"Hirano","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.051_bib0059","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.giec.2014.06.006","article-title":"Esophageal function testing: beyond manometry and impedance","volume":"24","author":"Mittal","year":"2014","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0060","first-page":"G431","article-title":"Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease","volume":"311","author":"Mittal","year":"2016","journal-title":"Am. J. Physiol.-Gastr. L"},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0061","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/0016-5085(92)90020-Y","article-title":"A wave of inhibition precedes primary peristaltic contractions in the human esophagus","volume":"103","author":"Sifrim","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.actbio.2025.02.051_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.artmed.2022.102435","article-title":"Virtual disease landscape using mechanics-informed machine learning: application to esophageal disorders","volume":"134","author":"Halder","year":"2022","journal-title":"Artif. Intell. Med."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0063","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jmps.2010.12.008","article-title":"A continuum constitutive model for the active behaviour of skeletal muscle","volume":"59","author":"Ehret","year":"2011","journal-title":"J. Mech. Phys. Solids."},{"issue":"1\u20133","key":"10.1016\/j.actbio.2025.02.051_bib0064","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1010835316564","article-title":"A new constitutive framework for arterial wall mechanics and a comparative study of material models","volume":"61","author":"Holzapfel","year":"2000","journal-title":"J. Elast."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0065","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10237-021-01420-0","article-title":"Mechanics informed fluoroscopy of esophageal transport","volume":"20","author":"Halder","year":"2021","journal-title":"Biomech. Model. Mechan."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0066","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2982.2005.00734.x","article-title":"Sensation and distribution of stress and deformation in the human oesophagus","volume":"18","author":"Frokj\u00e6r","year":"2006","journal-title":"Neurogastroenterol. Motil."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.051_bib0067","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s10388-020-00769-y","article-title":"Esophagus stretch tests: biomechanics for tissue engineering and possible implications on the outcome of esophageal atresia repairs performed under excessive tension","volume":"18","author":"Saxena","year":"2021","journal-title":"Esophagus-Tokyo"},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0068","article-title":"Effect of temperature and freezing on Human adipose tissue material properties characterized by high-rate indentation: puncture testing","volume":"144","author":"Sun","year":"2022","journal-title":"J. Biomech. Eng-T. Asme"},{"issue":"7","key":"10.1016\/j.actbio.2025.02.051_bib0069","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.jbiomech.2013.02.014","article-title":"Influence of preservation temperature on the measured mechanical properties of brain tissue","volume":"46","author":"Rashid","year":"2013","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.051_bib0070","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/02656736.2022.2028908","article-title":"Thermophysical and mechanical properties of biological tissues as a function of temperature: a systematic literature review","volume":"39","author":"Bianchi","year":"2022","journal-title":"Int. J. Hyperthermia"},{"issue":"6","key":"10.1016\/j.actbio.2025.02.051_bib0071","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1098\/rsif.2005.0073","article-title":"Hyperelastic modelling of arterial layers with distributed collagen fibre orientations","volume":"3","author":"Gasser","year":"2006","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.actbio.2025.02.051_bib0072","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.actbio.2022.01.003","article-title":"Biomechanics of mitral valve leaflets: second harmonic generation microscopy, biaxial mechanical tests and tissue modeling","volume":"141","author":"Sadeghinia","year":"2022","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.051_bib0073","doi-asserted-by":"crossref","DOI":"10.1115\/1.4033807","article-title":"Decay of tissue mechanical properties over a 24-hr period","volume":"10","author":"Stephens","year":"2016","journal-title":"J. Med. Devices"},{"issue":"12","key":"10.1016\/j.actbio.2025.02.051_bib0074","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1038\/ajg.2016.454","article-title":"Evaluation of esophageal motility utilizing the functional lumen imaging probe","volume":"111","author":"Carlson","year":"2016","journal-title":"Am. J. Gastroenterol."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125001497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125001497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:59:26Z","timestamp":1762556366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125001497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":74,"alternative-id":["S1742706125001497"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.02.051","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ex-vivo mechano-structural characterization of fresh diseased human esophagus","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.02.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}