{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:39:54Z","timestamp":1791772794632,"version":"4.3.4"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200559"],"award-info":[{"award-number":["82200559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["496695"],"award-info":[{"award-number":["496695"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-22-0032119"],"award-info":[{"award-number":["G-22-0032119"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A04J0586"],"award-info":[{"award-number":["2023A04J0586"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.actbio.2025.02.058","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T03:23:38Z","timestamp":1740626618000},"page":"123-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["A conductive polymer restores connexin43 expression through the suppression of mitogen-activated protein kinases to improve intercellular communication and alleviate atrial fibrillation"],"prefix":"10.1016","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0747-9028","authenticated-orcid":false,"given":"Chong-yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2505-9533","authenticated-orcid":false,"given":"Cheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6998-2055","authenticated-orcid":false,"given":"Shu-hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Ziyi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing-wen","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2584-060X","authenticated-orcid":false,"given":"Ren-Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.actbio.2025.02.058_bib0001","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.cell.2017.03.050","article-title":"Macrophages facilitate electrical conduction in the heart","volume":"169","author":"Hulsmans","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.actbio.2025.02.058_bib0002","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1161\/CIRCEP.112.976787","article-title":"Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death","volume":"6","author":"Sovari","year":"2013","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.058_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021174","article-title":"The involvement of Cx43 in JNK1\/2-mediated endothelial mechanotransduction and Human plaque progression","volume":"24","author":"Tauchi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.actbio.2025.02.058_bib0004","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/CIRCRESAHA.111.259705","article-title":"Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43","volume":"110","author":"Beauchamp","year":"2012","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.058_bib0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/cvr\/cvs025","article-title":"Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current","volume":"94","author":"Desplantez","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.058_bib0006","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00395-021-00846-y","article-title":"AMPKalpha1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism","volume":"116","author":"Dufeys","year":"2021","journal-title":"Basic Res. Cardiol."},{"issue":"11","key":"10.1016\/j.actbio.2025.02.058_bib0007","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1002\/cbin.11864","article-title":"Interaction of KCNA5, CX43, and CX40 proteins in the atrial muscle of patients with atrial fibrillation","volume":"46","author":"Wang","year":"2022","journal-title":"Cell Biol. Int."},{"issue":"23","key":"10.1016\/j.actbio.2025.02.058_bib0008","first-page":"e199","article-title":"AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American heart association task force on practice guidelines and the heart rhythm society","volume":"130","author":"January","year":"2014","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.actbio.2025.02.058_bib0009","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/eurheartj\/ehy171","article-title":"Epidemiology of atrial fibrillation","volume":"39","author":"Conen","year":"2018","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.058_bib0010","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.ahj.2007.06.035","article-title":"Outpatient use of anticoagulants, rate-controlling drugs, and antiarrhythmic drugs for atrial fibrillation","volume":"154","author":"Allen LaPointe","year":"2007","journal-title":"Am. Heart J."},{"issue":"23","key":"10.1016\/j.actbio.2025.02.058_bib0011","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1161\/01.CIR.0000072769.17295.B1","article-title":"Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction","volume":"107","author":"Sweeney","year":"2003","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.actbio.2025.02.058_bib0012","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/jama.2009.2029","article-title":"Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial","volume":"303","author":"Wilber","year":"2010","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.actbio.2025.02.058_bib0013","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/archinte.164.1.55","article-title":"National trends in antiarrhythmic and antithrombotic medication use in atrial fibrillation","volume":"164","author":"Fang","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.actbio.2025.02.058_bib0014","series-title":"Handbook of Surfaces and Interfaces of Materials","author":"Nalwa","year":"2001"},{"key":"10.1016\/j.actbio.2025.02.058_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119672","article-title":"A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function","volume":"231","author":"Zhang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.02.058_bib0016","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jconrel.2022.09.062","article-title":"Epicardial delivery of a conductive membrane synchronizes conduction to reduce atrial fibrillation","volume":"351","author":"Zhang","year":"2022","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.actbio.2025.02.058_bib0017","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00018-019-03285-0","article-title":"Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications","volume":"77","author":"Totland","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.actbio.2025.02.058_bib0018","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bioelechem.2016.07.003","article-title":"Transient suppression of gap junctional intercellular communication after exposure to 100-nanosecond pulsed electric fields","volume":"112","author":"Steuer","year":"2016","journal-title":"Bioelectrochemistry"},{"issue":"1","key":"10.1016\/j.actbio.2025.02.058_bib0019","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/cvr\/cvz340","article-title":"RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes","volume":"117","author":"Lissoni","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.actbio.2025.02.058_bib0020","doi-asserted-by":"crossref","DOI":"10.1172\/JCI137752","article-title":"Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability","volume":"131","author":"De Smet","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.058_bib0021","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cmet.2021.01.009","article-title":"Global spread of a local fire: transmission of endoplasmic reticulum stress via connexin 43","volume":"33","author":"Yang","year":"2021","journal-title":"Cell. Metab."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.058_bib0022","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cmet.2020.11.009","article-title":"Intercellular transmission of hepatic ER stress in obesity disrupts systemic metabolism","volume":"33","author":"Tirosh","year":"2021","journal-title":"Cell. Metab."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.058_bib0023","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00418-018-1736-z","article-title":"Anisomycin, a JNK and p38 activator, suppresses cell-cell junction formation in 2D cultures of K38 mouse keratinocyte cells and reduces claudin-7 expression, with an increase of paracellular permeability in 3D cultures","volume":"151","author":"Nikaido","year":"2019","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.actbio.2025.02.058_bib0024","article-title":"The prognostic significance of anisomycin-activated phospho-c-Jun NH2-terminal kinase (p-JNK) in predicting breast cancer patients'","volume":"9","author":"Chen","year":"2021","journal-title":"Survival Time, Front Cell. Dev. Biol."},{"issue":"10","key":"10.1016\/j.actbio.2025.02.058_bib0025","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1242\/jcs.01056","article-title":"Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway","volume":"117","author":"Ogawa","year":"2004","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.058_bib0026","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/cvr\/cvs366","article-title":"c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias","volume":"97","author":"Yan","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.actbio.2025.02.058_bib0027","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.biopha.2018.09.111","article-title":"Sevoflurane induces neurotoxicity in the developing rat hippocampus by upregulating connexin 43 via the JNK\/c-Jun\/AP-1 pathway","volume":"108","author":"Bi","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.058_bib0028","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jid.2018.07.032","article-title":"IL-22 down-regulates Cx43 expression and decreases gap junctional intercellular communication by activating the JNK pathway in psoriasis","volume":"139","author":"Liang","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.actbio.2025.02.058_bib0029","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yjmcc.2017.11.006","article-title":"The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart","volume":"114","author":"Yan","year":"2018","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.actbio.2025.02.058_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.108979","article-title":"Uremic toxin indoxyl sulfate suppresses myocardial Cx43 assembly and expression via JNK activation","volume":"319","author":"Changchien","year":"2020","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.058_bib0031","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0022-5223(99)70018-8","article-title":"Fetal cell transplantation: a comparison of three cell types","volume":"118","author":"Sakai","year":"1999","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.actbio.2025.02.058_bib0032","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yjmcc.2022.04.007","article-title":"Methods of mouse cardiomyocyte isolation from postnatal heart","volume":"168","author":"Feng","year":"2022","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.actbio.2025.02.058_bib0033","series-title":"Cardiovascular Signaling in Health and Disease","first-page":"39","article-title":"Organization of Ca(2+) signaling microdomains in cardiac myocytes","author":"Li","year":"2022"},{"issue":"2","key":"10.1016\/j.actbio.2025.02.058_bib0034","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/toxsci\/kfy110","article-title":"Cross-site reliability of Human induced pluripotent stem cell-derived cardiomyocyte based safety assays using microelectrode arrays: results from a blinded CiPA pilot study","volume":"164","author":"Millard","year":"2018","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.058_bib0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1172\/JCI7798","article-title":"Wnt-1 regulation of connexin43 in cardiac myocytes","volume":"105","author":"Ai","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.actbio.2025.02.058_bib0036","article-title":"Role of connexin 43 phosphorylation on serine-368 by PKC in cardiac function and disease","volume":"9","author":"Pun","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.058_bib0037","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0735-1097(98)00317-9","article-title":"Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes","volume":"32","author":"Dodge","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.actbio.2025.02.058_bib0038","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/01.RES.0000035854.11082.01","article-title":"c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes","volume":"91","author":"Petrich","year":"2002","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.058_bib0039","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.nlm.2007.10.006","article-title":"Protein synthesis inhibition and memory: formation vs amnesia","volume":"89","author":"Gold","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"issue":"7","key":"10.1016\/j.actbio.2025.02.058_bib0040","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/aps.2012.46","article-title":"Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro","volume":"33","author":"Li","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.058_bib0041","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22030987","article-title":"Importance of Cx43 for right ventricular function","volume":"22","author":"Boengler","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.actbio.2025.02.058_bib0042","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.bbamem.2011.07.039","article-title":"Functional consequences of abnormal Cx43 expression in the heart","volume":"1818","author":"Fontes","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.actbio.2025.02.058_bib0043","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061659","article-title":"Cx43 Channel gating and permeation: multiple phosphorylation-dependent roles of the carboxyl terminus","volume":"19","author":"Ek-Vitorin","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.actbio.2025.02.058_bib0044","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28134914","article-title":"Connexin 43 phosphorylation: implications in multiple diseases","volume":"28","author":"Zhang","year":"2023","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.actbio.2025.02.058_bib0045","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.hrthm.2011.11.025","article-title":"Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice","volume":"9","author":"Jansen","year":"2012","journal-title":"Heart. Rhythm."},{"issue":"11","key":"10.1016\/j.actbio.2025.02.058_bib0046","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nnano.2011.160","article-title":"Nanowired three-dimensional cardiac patches","volume":"6","author":"Dvir","year":"2011","journal-title":"Nat. Nanotechnol."},{"issue":"10","key":"10.1016\/j.actbio.2025.02.058_bib0047","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.7150\/thno.22599","article-title":"Polypyrrole-chitosan conductive biomaterial synchronizes cardiomyocyte contraction and improves myocardial electrical impulse propagation","volume":"8","author":"Cui","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.02.058_bib0048","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biomaterials.2017.01.012","article-title":"A pi-pi conjugation-containing soft and conductive injectable polymer hydrogel highly efficiently rebuilds cardiac function after myocardial infarction","volume":"122","author":"Bao","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.02.058_bib0049","doi-asserted-by":"crossref","first-page":"10312","DOI":"10.1038\/ncomms10312","article-title":"Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes","volume":"7","author":"Eng","year":"2016","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.actbio.2025.02.058_bib0050","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.4103\/1673-5374.221151","article-title":"Conductive polymer scaffolds to improve neural recovery","volume":"12","author":"Song","year":"2017","journal-title":"Neural. Regen. Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.058_bib0051","doi-asserted-by":"crossref","DOI":"10.1063\/1.5138587","article-title":"Actively controlled local drug delivery using conductive polymer-based devices","volume":"116","author":"Chapman","year":"2020","journal-title":"Appl. Phys. Lett."},{"issue":"18","key":"10.1016\/j.actbio.2025.02.058_bib0052","doi-asserted-by":"crossref","DOI":"10.3390\/polym15183783","article-title":"Conductive polymers and their nanocomposites: application features in biosensors and biofuel cells","volume":"15","author":"Kuznetsova","year":"2023","journal-title":"Polymers (Basel)"},{"issue":"8","key":"10.1016\/j.actbio.2025.02.058_bib0053","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1161\/CIRCULATIONAHA.114.014937","article-title":"A conductive polymer hydrogel supports cell electrical signaling and improves cardiac function after implantation into myocardial infarct","volume":"132","author":"Mihic","year":"2015","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.actbio.2025.02.058_bib0054","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1039\/C4TB00142G","article-title":"Influence of conductive polymer doping on the viability of cardiac progenitor cells","volume":"2","author":"Gelmi","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2025.02.058_bib0055","series-title":"Conducting Polymer Based Flexible and Conductible Heart Patch, Institut de G\u00e9nie Biom\u00e9dical","author":"Sauvage","year":"2022"},{"key":"10.1016\/j.actbio.2025.02.058_bib0056","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jconrel.2020.01.027","article-title":"A conductive cell-delivery construct as a bioengineered patch that can improve electrical propagation and synchronize cardiomyocyte contraction for heart repair","volume":"320","author":"Chen","year":"2020","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.actbio.2025.02.058_bib0057","article-title":"Bio-conductive polymers for treating myocardial conductive defects: long-term efficacy study","volume":"11","author":"Fu","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2025.02.058_bib0058","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10010001","article-title":"JNK, p38, ERK, and SGK1 inhibitors in cancer","volume":"10","author":"Cicenas","year":"2017","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.actbio.2025.02.058_bib0059","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fphar.2017.00464","article-title":"Attenuation of TNF-alpha-induced inflammatory injury in endothelial cells by ginsenoside Rb1 via inhibiting NF-kappaB, JNK and p38 signaling pathways","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.actbio.2025.02.058_bib0060","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1111\/jcmm.13631","article-title":"Up-regulated Cx43 phosphorylation at Ser368 prolongs QRS duration in myocarditis","volume":"22","author":"Zhong","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.058_bib0061","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-019-0748-8","article-title":"Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia\/reperfusion hearts","volume":"114","author":"Xue","year":"2019","journal-title":"Basic Res. Cardiol."},{"issue":"19","key":"10.1016\/j.actbio.2025.02.058_bib0062","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197412","article-title":"p 38 MAPK pathway in the heart: new insights in health and disease","volume":"21","author":"Romero-Becerra","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.actbio.2025.02.058_bib0063","first-page":"1317","article-title":"SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice","volume":"68","author":"Su","year":"2010","journal-title":"J. Trauma"},{"key":"10.1016\/j.actbio.2025.02.058_bib0064","article-title":"Selective HDAC8 inhibition attenuates isoproterenol-induced cardiac hypertrophy and fibrosis via p38 MAPK pathway","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.actbio.2025.02.058_bib0065","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s00395-004-0478-3","article-title":"p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes","volume":"99","author":"Engelbrecht","year":"2004","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.actbio.2025.02.058_bib0066","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/475152","article-title":"Peripheral injection of SB203580 inhibits the inflammatory-dependent synthesis of proinflammatory cytokines in the hypothalamus","author":"Herman","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.actbio.2025.02.058_bib0067","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.3389\/fimmu.2018.01556","article-title":"The p38 MAPK inhibitor SB203580 abrogates tumor necrosis factor-induced proliferative expansion of mouse CD4(+)Foxp3(+) regulatory T cells","volume":"9","author":"He","year":"2018","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2025.02.058_bib0068","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/00005344-200003000-00019","article-title":"Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death","volume":"35","author":"Barancik","year":"2000","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.actbio.2025.02.058_bib0069","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149486","article-title":"SB203580 Modulates p38 MAPK signaling and dengue virus-induced liver injury by reducing MAPKAPK2, HSP27, and ATF2 phosphorylation","volume":"11","author":"Sreekanth","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.actbio.2025.02.058_bib0070","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1152\/physrev.00054.2009","article-title":"Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale","volume":"90","author":"Rose","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.actbio.2025.02.058_bib0071","doi-asserted-by":"crossref","DOI":"10.1007\/s12265-024-10515-9","article-title":"The activation of P38MAPK signaling pathway impedes the delivery of the Cx43 to the intercalated discs during cardiac ischemia-reperfusion injury","author":"Huang","year":"2024","journal-title":"J. Cardiovasc Transl. Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.02.058_bib0072","article-title":"Atrial fibrillation: focus on myocardial connexins and gap junctions","volume":"11","author":"Guo","year":"2022","journal-title":"Biology (Basel)"},{"issue":"1","key":"10.1016\/j.actbio.2025.02.058_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2022.100004","article-title":"Adipose triglyceride lipase deficiency aggravates angiotensin II-induced atrial fibrillation by reducing peroxisome proliferator-activated receptor alpha activation in mice","volume":"103","author":"Han","year":"2023","journal-title":"Lab. Invest."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125001540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125001540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:59:48Z","timestamp":1778824788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125001540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":73,"alternative-id":["S1742706125001540"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.02.058","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A conductive polymer restores connexin43 expression through the suppression of mitogen-activated protein kinases to improve intercellular communication and alleviate atrial fibrillation","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.02.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}