{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:15:39Z","timestamp":1793772939832,"version":"4.6.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2022C03127"],"award-info":[{"award-number":["2022C03127"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371630"],"award-info":[{"award-number":["82371630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370750"],"award-info":[{"award-number":["82370750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370762"],"award-info":[{"award-number":["82370762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200850"],"award-info":[{"award-number":["82200850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZCLQN25H1606"],"award-info":[{"award-number":["ZCLQN25H1606"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M733083"],"award-info":[{"award-number":["2023M733083"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.actbio.2025.03.032","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:35:19Z","timestamp":1742304919000},"page":"460-475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Effective delivery of CRISPR\/dCas9-SAM for multiplex gene activation based on mesoporous silica nanoparticles for bladder cancer therapy"],"prefix":"10.1016","volume":"197","author":[{"given":"Jinming","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-847X","authenticated-orcid":false,"given":"Jiaju","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5369-7205","authenticated-orcid":false,"given":"Xuhong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huangfu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiyu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-5011","authenticated-orcid":false,"given":"Bohan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.actbio.2025.03.032_bib0001","doi-asserted-by":"crossref","first-page":"216","DOI":"10.6004\/jnccn.2024.0024","article-title":"Bladder Cancer, Version 3.2024","volume":"22","author":"Flaig","year":"2024","journal-title":"J. Natl. Compr. Canc. Netw."},{"issue":"28","key":"10.1016\/j.actbio.2025.03.032_bib0002","doi-asserted-by":"crossref","first-page":"eabb1777","DOI":"10.1126\/sciadv.abb1777","article-title":"Engineering a far-red light-activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors","volume":"6","author":"Yu","year":"2020","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.actbio.2025.03.032_bib0003","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1097\/HEP.0000000000000700","article-title":"Base editing of the mutated TERT promoter inhibits liver tumor growth","volume":"79","author":"Zhao","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.actbio.2025.03.032_bib0004","article-title":"Bidirectional epigenetic editing reveals hierarchies in gene regulation","author":"Pacalin","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.actbio.2025.03.032_bib0005","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.cell.2013.02.022","article-title":"Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression","volume":"152","author":"Qi","year":"2013","journal-title":"Cell"},{"issue":"7536","key":"10.1016\/j.actbio.2025.03.032_bib0006","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature14136","article-title":"Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex","volume":"517","author":"Konermann","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0007","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41392-021-00645-w","article-title":"Spatiotemporal control of CRISPR\/Cas9 gene editing","volume":"6","author":"Zhuo","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"13","key":"10.1016\/j.actbio.2025.03.032_bib0008","article-title":"Engineered Nanomaterials to Potentiate CRISPR\/Cas9 Gene Editing for Cancer Therapy","volume":"36","author":"Yi","year":"2024","journal-title":"Adv. Mater."},{"issue":"2","key":"10.1016\/j.actbio.2025.03.032_bib0009","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20210081","article-title":"Carrier strategies boost the application of CRISPR\/Cas system in gene therapy","volume":"2","author":"Xu","year":"2022","journal-title":"Exploration"},{"issue":"4","key":"10.1016\/j.actbio.2025.03.032_bib0010","article-title":"Together is Better: mRNA Co-Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co-Delivery and Protein Expression on the Single Cell Level","volume":"9","author":"Zhang","year":"2022","journal-title":"Adv. Sci. (Weinh)"},{"issue":"3","key":"10.1016\/j.actbio.2025.03.032_bib0011","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12033-022-00567-0","article-title":"A Review on the Mechanism and Applications of CRISPR\/Cas9\/Cas12\/Cas13\/Cas14 Proteins Utilized for Genome Engineering","volume":"65","author":"Hillary","year":"2023","journal-title":"Mol. Biotechnol."},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0012","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ymthe.2022.10.009","article-title":"Screening DNA aptamers that control the DNA cleavage, homology-directed repair, and transcriptional regulation of the CRISPR-(d)Cas9 system","volume":"31","author":"Huang","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.actbio.2025.03.032_bib0013","article-title":"Gene Therapy Advances: A Meta-Analysis of AAV Usage in Clinical Settings","volume":"8","author":"Au","year":"2021","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0014","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s11658-024-00569-7","article-title":"CRISPR-based gene expression platform for precise regulation of bladder cancer","volume":"29","author":"Zhan","year":"2024","journal-title":"Cell Mol. Biol. Lett."},{"issue":"6","key":"10.1016\/j.actbio.2025.03.032_bib0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd.2016.280","article-title":"Delivery technologies for genome editing","volume":"16","author":"Yin","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"issue":"20","key":"10.1016\/j.actbio.2025.03.032_bib0016","doi-asserted-by":"crossref","first-page":"19740","DOI":"10.1021\/acsnano.3c03195","article-title":"Reactive oxygen species-sensitive biodegradable mesoporous silica nanoparticles harboring theravac elicit tumor-specific immunity for colon tumor treatment","volume":"17","author":"Huang","year":"2023","journal-title":"ACS. Nano"},{"issue":"46","key":"10.1016\/j.actbio.2025.03.032_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202003537","article-title":"A Versatile Nonviral Delivery System for Multiplex Gene-Editing in the Liver","volume":"32","author":"Gong","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.03.032_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122349","article-title":"A LIGHTFUL nanomedicine overcomes EGFR-mediated drug resistance for enhanced tyrosine-kinase-inhibitor-based hepatocellular carcinoma therapy","volume":"302","author":"Yi","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.03.032_bib0019","first-page":"392","article-title":"C176-loaded and phosphatidylserine-modified nanoparticles treat retinal neovascularization by promoting M2 macrophage polarization","volume":"39","author":"Shao","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.03.032_bib0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2018.03.014","article-title":"Silica based hybrid materials for drug delivery and bioimaging","volume":"277","author":"Bagheri","year":"2018","journal-title":"J. Control Release"},{"issue":"3","key":"10.1016\/j.actbio.2025.03.032_bib0021","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10456-024-09913-z","article-title":"Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism","volume":"27","author":"Yang","year":"2024","journal-title":"Angiogenesis."},{"issue":"4","key":"10.1016\/j.actbio.2025.03.032_bib0022","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41565-023-01563-4","article-title":"Strategies for non-viral vectors targeting organs beyond the liver","volume":"19","author":"Kim","year":"2024","journal-title":"Nat. Nanotechnol."},{"issue":"45","key":"10.1016\/j.actbio.2025.03.032_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202401499","article-title":"Delivery of Synthetic Interleukin-22 mRNA to Hepatocytes via Lipid Nanoparticles Alleviates Liver Injury","volume":"20","author":"Ouyang","year":"2024","journal-title":"Small."},{"issue":"6","key":"10.1016\/j.actbio.2025.03.032_bib0024","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3390\/pharmaceutics12060505","article-title":"Particle-Size-Dependent Delivery of Antitumoral miRNA Using Targeted Mesoporous Silica Nanoparticles","volume":"12","author":"Haddick","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.actbio.2025.03.032_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120763","article-title":"Effective and safe delivery of GLP-1AR and FGF-21 plasmids using amino-functionalized dual-mesoporous silica nanoparticles in vitro and in vivo","volume":"271","author":"Geng","year":"2021","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2025.03.032_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189111","article-title":"Gene regulation by the tumor suppressor p53 - The omics era","volume":"1879","author":"Fischer","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"3","key":"10.1016\/j.actbio.2025.03.032_bib0027","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/carcin\/bgad011","article-title":"ARID1A mutations in cancer development: mechanism and therapy","volume":"44","author":"Zhang","year":"2023","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/ijbs.77181","article-title":"Vimentin epigenetic deregulation in Bladder Cancer associates with acquisition of invasive and metastatic phenotype through epithelial-to-mesenchymal transition","volume":"19","author":"Monteiro-Reis","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.actbio.2025.03.032_bib0029","article-title":"KMT2D inhibits the growth and metastasis of bladder Cancer cells by maintaining the tumor suppressor genes","volume":"115","author":"Sun","year":"2019","journal-title":"Biomed. Pharmac Other"},{"issue":"2","key":"10.1016\/j.actbio.2025.03.032_bib0030","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1021\/jacs.2c11111","article-title":"Ruthenium(II) Polypyridyl Complexes as FRET Donors: Structure- and Sequence-Selective DNA-Binding and Anticancer Properties","volume":"145","author":"Elgar","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2025.03.032_bib0031","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.biomaterials.2016.07.026","article-title":"Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer","volume":"104","author":"Lin","year":"2016","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.actbio.2025.03.032_bib0032","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.urolonc.2010.06.011","article-title":"Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach","volume":"30","author":"Zhang","year":"2012","journal-title":"Urol. Oncol."},{"issue":"68","key":"10.1016\/j.actbio.2025.03.032_bib0033","doi-asserted-by":"crossref","first-page":"9422","DOI":"10.1039\/C7CC04816E","article-title":"Endonuclease IV based competitive DNA probe assay for differentiation of low-abundance point mutations by discriminating stable single-base mismatches","volume":"53","author":"Xu","year":"2017","journal-title":"Chem. Commun."},{"issue":"48","key":"10.1016\/j.actbio.2025.03.032_bib0034","doi-asserted-by":"crossref","first-page":"27016","DOI":"10.1039\/C8RA04552F","article-title":"Endonuclease IV recognizes single base mismatch on the eighth base 3? to the abasic site in DNA strands for ultra-selective and sensitive mutant-type DNA detection","volume":"8","author":"Xu","year":"2018","journal-title":"RSC. Adv."},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0035","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12967-023-03913-1","article-title":"ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR\/ERK signaling pathway","volume":"21","author":"Xu","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0036","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401142RR","article-title":"Mechanosensitive Ca2+ channel TRPV1 activated by low-intensity pulsed ultrasound ameliorates acute kidney injury through Notch1-Akt-eNOS signaling","volume":"39","author":"Huangfu","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.actbio.2025.03.032_bib0037","article-title":"Low Expression Levels of SLC22A12 indicates a poor prognosis and progresses clear cell renal cell carcinoma","volume":"11","author":"Xu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.actbio.2025.03.032_bib0038","doi-asserted-by":"crossref","first-page":"44838","DOI":"10.1038\/srep44838","article-title":"Silicon and carbon nanocomposite spheres with enhanced electrochemical performance for full cell lithium ion batteries","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"41","key":"10.1016\/j.actbio.2025.03.032_bib0039","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1002\/adma.201302189","article-title":"Developing functionalized dendrimer-like silica nanoparticles with hierarchical pores as advanced delivery nanocarriers","volume":"25","author":"Du","year":"2013","journal-title":"Adv. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2025.03.032_bib0040","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1021\/nn103130q","article-title":"Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery","volume":"5","author":"Kim","year":"2011","journal-title":"ACS. Nano"},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0041","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/acsbiomaterials.2c01142","article-title":"NIR-Activated Thermosensitive Liposome-Gold Nanorod Hybrids for Enhanced Drug Delivery and Stimulus Sensitivity","volume":"9","author":"Zhang","year":"2023","journal-title":"ACS. Biomater. Sci. Eng."},{"issue":"51","key":"10.1016\/j.actbio.2025.03.032_bib0042","doi-asserted-by":"crossref","first-page":"57362","DOI":"10.1021\/acsami.0c17660","article-title":"Co-delivery of Sorafenib and CRISPR\/Cas9 Based on Targeted Core-Shell Hollow Mesoporous Organosilica Nanoparticles for Synergistic HCC Therapy","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS. Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0043","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1021\/acs.chemmater.7b03128","article-title":"Multifunctional Protocells for Enhanced Penetration in 3D Extracellular Tumoral Matrices","volume":"30","author":"Villegas","year":"2017","journal-title":"Chem. Mater."},{"issue":"48","key":"10.1016\/j.actbio.2025.03.032_bib0044","doi-asserted-by":"crossref","first-page":"53598","DOI":"10.1021\/acsami.0c13023","article-title":"Virus Mimetic Shell-Sheddable Chitosan Micelles for siVEGF Delivery and FRET-Traceable Acid-Triggered Release","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS. Appl. Mater. Interfaces"},{"issue":"46","key":"10.1016\/j.actbio.2025.03.032_bib0045","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1002\/anie.201403036","article-title":"Engineered nanoparticles for drug delivery in cancer therapy","volume":"53","author":"Sun","year":"2014","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"16","key":"10.1016\/j.actbio.2025.03.032_bib0046","doi-asserted-by":"crossref","first-page":"7995","DOI":"10.1021\/am402082d","article-title":"One-pot construction of functional mesoporous silica nanoparticles for the tumor-acidity-activated synergistic chemotherapy of glioblastoma","volume":"5","author":"Li","year":"2013","journal-title":"ACS. Appl. Mater. Interfaces"},{"issue":"9","key":"10.1016\/j.actbio.2025.03.032_bib0047","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1021\/acsnano.6b02819","article-title":"Mesoporous silica nanoparticle-supported lipid bilayers (protocells) for active targeting and delivery to individual leukemia cells","volume":"10","author":"Durfee","year":"2016","journal-title":"ACS. Nano"},{"key":"10.1016\/j.actbio.2025.03.032_bib0048","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.actbio.2020.07.027","article-title":"Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery","volume":"114","author":"Noureddine","year":"2020","journal-title":"Acta Biomater."},{"issue":"24","key":"10.1016\/j.actbio.2025.03.032_bib0049","doi-asserted-by":"crossref","first-page":"10371","DOI":"10.1021\/acs.chemmater.3c01174","article-title":"Metallic cation-mediated entrapment of nucleic acids on mesoporous silica surface: application in castration-resistant prostate cancer","volume":"35","author":"Maestas-Olguin","year":"2023","journal-title":"Chem. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2025.03.032_bib0050","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1021\/acs.nanolett.0c01387","article-title":"Engineered interactions with mesoporous silica facilitate intracellular delivery of proteins and gene editing","volume":"20","author":"Liu","year":"2020","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0051","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1038\/s41467-021-22465-w","article-title":"An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer","volume":"12","author":"Lindskrog","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.actbio.2025.03.032_bib0052","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrc3817","article-title":"Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity","volume":"15","author":"Knowles","year":"2015","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.actbio.2025.03.032_bib0053","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4161\/cbt.28411","article-title":"The emerging roles of ARID1A in tumor suppression","volume":"15","author":"Wu","year":"2014","journal-title":"Cancer Biol. Ther."},{"issue":"4","key":"10.1016\/j.actbio.2025.03.032_bib0054","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/2211-5463.12600","article-title":"Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer","volume":"9","author":"Ding","year":"2019","journal-title":"FEBS. Open. Bio"},{"issue":"3","key":"10.1016\/j.actbio.2025.03.032_bib0055","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMoa2031054","article-title":"CRISPR-Cas9 Gene Editing for Sickle Cell Disease and \u03b2-Thalassemia","volume":"384","author":"Frangoul","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.actbio.2025.03.032_bib0056","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41587-020-0561-9","article-title":"Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors","volume":"38","author":"Anzalone","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"6121","key":"10.1016\/j.actbio.2025.03.032_bib0057","first-page":"819","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science (1979)"},{"issue":"42","key":"10.1016\/j.actbio.2025.03.032_bib0058","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/27\/42\/425103","article-title":"Disulfide-crosslinked nanomicelles confer cancer-specific drug delivery and improve efficacy of paclitaxel in bladder cancer","volume":"27","author":"Pan","year":"2016","journal-title":"Nanotechnology"},{"issue":"5","key":"10.1016\/j.actbio.2025.03.032_bib0059","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nature Rev. Mater."},{"issue":"42","key":"10.1016\/j.actbio.2025.03.032_bib0060","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1039\/C4TB01316F","article-title":"The liposome-protein corona in mice and humans and its implications for in vivo delivery","volume":"2","author":"Caracciolo","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2025.03.032_bib0061","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jcis.2023.03.048","article-title":"Protein adsorption determines pulmonary cell uptake of lipid-based nanoparticles","volume":"641","author":"Subramaniam","year":"2023","journal-title":"J. Colloid. Interface Sci."},{"issue":"40","key":"10.1016\/j.actbio.2025.03.032_bib0062","doi-asserted-by":"crossref","first-page":"18806","DOI":"10.1039\/C9NR05788A","article-title":"The role of apolipoprotein- and vitronectin-enriched protein corona on lipid nanoparticles for in vivo targeted delivery and transfection of oligonucleotides in murine tumor models","volume":"11","author":"Chen","year":"2019","journal-title":"Nanoscale"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125002053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125002053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:30:18Z","timestamp":1777793418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125002053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":62,"alternative-id":["S1742706125002053"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.03.032","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effective delivery of CRISPR\/dCas9-SAM for multiplex gene activation based on mesoporous silica nanoparticles for bladder cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.03.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}