{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:47:08Z","timestamp":1792259228860,"version":"4.4.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000124","name":"National Institutes of Health Office of Research on Women's Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD083383"],"award-info":[{"award-number":["HD083383"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"National Institutes of Health Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.actbio.2025.04.003","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T02:17:07Z","timestamp":1743819427000},"page":"207-218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Polypropylene surgical mesh induces lipid oxidation in a nonhuman primate model"],"prefix":"10.1016","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-9221","authenticated-orcid":false,"given":"Amanda M.","family":"Artsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Rytel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-3824","authenticated-orcid":false,"given":"Pamela A.","family":"Moalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.04.003_bib0001","article-title":"Surgery for women with apical vaginal prolapse","volume":"7","author":"Maher","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.actbio.2025.04.003_bib0002","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1056\/NEJM200008103430603","article-title":"A comparison of suture repair with mesh repair for incisional hernia","volume":"343","author":"Luijendijk","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actbio.2025.04.003_bib0003","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1007\/s00268-012-1523-2","article-title":"Risk factors for chronic pain after open ventral hernia repair by underlay mesh placement","volume":"36","author":"Gronnier","year":"2012","journal-title":"World J. Surg."},{"key":"10.1016\/j.actbio.2025.04.003_bib0004","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/01.gco.0000242961.48114.b0","article-title":"Mesh augmentation during pelvic-floor reconstructive surgery: risks and benefits","volume":"18","author":"Baessler","year":"2006","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0005","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00192-022-05388-y","article-title":"Long-term mesh exposure after minimally invasive total hysterectomy and sacrocolpopexy","volume":"34","author":"Matthews","year":"2023","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.actbio.2025.04.003_bib0006","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.actbio.2011.11.031","article-title":"Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials","volume":"8","author":"Brown","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.04.003_bib0007","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajog.2016.04.008","article-title":"Host response to synthetic mesh in women with mesh complications","volume":"215","author":"Nolfi","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2015.08.002","article-title":"Characterization of the host inflammatory response following implantation of prolapse mesh in rhesus macaque","volume":"213","author":"Brown","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0009","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4240\/wjgs.v7.i10.226","article-title":"Mesh implants: an overview of crucial mesh parameters","volume":"7","author":"Zhu","year":"2015","journal-title":"World J. Gastrointest. Surg."},{"key":"10.1016\/j.actbio.2025.04.003_bib0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.niox.2005.06.005","article-title":"Nitrative DNA damage in inflammation and its possible role in carcinogenesis","volume":"14","author":"Sawa","year":"2006","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.actbio.2025.04.003_bib0011","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/34923","article-title":"Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils","volume":"391","author":"Eiserich","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2025.04.003_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.655048","article-title":"From cell death to regeneration: rebuilding after injury","volume":"9","author":"Guerin","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09205063.2017.1279045","article-title":"Oxidation and degradation of polypropylene transvaginal mesh","volume":"28","author":"Talley","year":"2017","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.actbio.2025.04.003_bib0014","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jbm.b.33502","article-title":"Degradation of polypropylene in vivo: a microscopic analysis of meshes explanted from patients","volume":"105","author":"Iakovlev","year":"2017","journal-title":"J. Biomed. Mater. Res. Part B Appl Biomater."},{"key":"10.1016\/j.actbio.2025.04.003_bib0015","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00192-016-3131-4","article-title":"The myth: in vivo degradation of polypropylene-based meshes","volume":"28","author":"Thames","year":"2017","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.actbio.2025.04.003_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106722","article-title":"Evidence of time dependent degradation of polypropylene surgical mesh explanted from the abdomen and vagina of sheep","volume":"160","author":"Farr","year":"2024","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2025.04.003_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168946","article-title":"The potential toxicity of microplastics on human health","volume":"912","author":"Zhao","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.actbio.2025.04.003_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2024.213800","article-title":"Uncovering the relationship between macrophages and polypropylene surgical mesh","volume":"159","author":"Farr","year":"2024","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.actbio.2025.04.003_bib0019","first-page":"141","article-title":"Deformation of transvaginal mesh in response to multiaxial loading","author":"Barone","year":"2019","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2025.04.003_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2016.03.023","article-title":"Textile properties of synthetic prolapse mesh in response to uniaxial loading","volume":"215","author":"Barone","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0021","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.actbio.2022.05.051","article-title":"Mesh deformation: a mechanism underlying polypropylene prolapse mesh complications in vivo","volume":"148","author":"Knight","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.04.003_bib0022","first-page":"140","article-title":"Preventing mesh pore collapse by designing mesh pores with auxetic geometries: a comprehensive evaluation via computational modeling","author":"Knight","year":"2018","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2025.04.003_bib0023","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00192-011-1616-8","article-title":"Uniaxial biomechanical properties of seven different vaginally implanted meshes for pelvic organ prolapse","volume":"23","author":"Shepherd","year":"2012","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.actbio.2025.04.003_bib0024","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ajog.2014.08.008","article-title":"Impact of prolapse meshes on the metabolism of vaginal extracellular matrix in rhesus macaque","volume":"212","author":"Liang","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0025","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/1471-0528.12077","article-title":"Deterioration in biomechanical properties of the vagina following implantation of a high-stiffness prolapse mesh","volume":"120","author":"Feola","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.actbio.2025.04.003_bib0026","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/1471-0528.13514","article-title":"The impact of prolapse mesh on vaginal smooth muscle structure and function","volume":"123","author":"Jallah","year":"2016","journal-title":"BJOG"},{"key":"10.1016\/j.actbio.2025.04.003_bib0027","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/1471-0528.12085","article-title":"Vaginal degeneration following implantation of synthetic mesh with increased stiffness","volume":"120","author":"Liang","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.actbio.2025.04.003_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1279250","article-title":"Approaches and methods to measure oxidative stress in clinical samples: research applications in the cancer field","author":"Katerji","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.actbio.2025.04.003_bib0029","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.04.003_bib0030","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00192-012-1901-1","article-title":"Characterizing the ex vivo textile and structural properties of synthetic prolapse mesh products","volume":"24","author":"Feola","year":"2013","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.actbio.2025.04.003_bib0031","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.622524","article-title":"Foreign body reaction to implanted biomaterials and its impact in nerve neuroprosthetics","volume":"9","author":"Carnicer-Lombarte","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0033","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0142-9612(02)00429-5","article-title":"Histological analysis of silicone breast implant capsules and correlation with capsular contracture","volume":"24","author":"Siggelkow","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.04.003_bib0034","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1590\/0001-3765201620150874","article-title":"Capsular contracture in silicone breast implants: insights from rat models","volume":"88","author":"Vieira","year":"2016","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.actbio.2025.04.003_bib0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.22336\/rjo.2018.3","article-title":"Ocular implants-methods of ocular reconstruction following radical surgical interventions","volume":"62","author":"Catalu","year":"2018","journal-title":"Rom. J. Ophthalmol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0036","article-title":"Friend or foe? Inflammation and the foreign body response to orthopedic biomaterials","author":"Gibon","year":"2023","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2025.04.003_bib0037","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000070045","article-title":"Mesh implants in hernia repair. Inflammatory cell response in a rat model","volume":"35","author":"Rosch","year":"2003","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.actbio.2025.04.003_bib0038","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123862","article-title":"Polypropylene mesh implantation for hernia repair causes myeloid cell\u2013driven persistent inflammation","author":"Heymann","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.actbio.2025.04.003_bib0039","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/19420889.2022.2101193","article-title":"Macrophages and vimentin in tissues adjacent to megaprostheses and mesh in reconstructive surgeries","volume":"15","author":"Asanuma","year":"2022","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.actbio.2019.07.031","article-title":"Mesh induced fibrosis: the protective role of T regulatory cells","volume":"96","author":"Artsen","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.04.003_bib0041","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ajog.2018.11.121","article-title":"Characterization of the T-cell response to polypropylene mesh in women with complications","volume":"220","author":"Tennyson","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0042","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10029-021-02396-7","article-title":"Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen","volume":"26","author":"Dievernich","year":"2022","journal-title":"Hernia"},{"key":"10.1016\/j.actbio.2025.04.003_bib0043","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.actbio.2020.07.051","article-title":"T regulatory cells and TGF-\u03b21: predictors of the host response in mesh complications","volume":"115","author":"Artsen","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.04.003_bib0044","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1253\/circj.CJ-16-0924","article-title":"Macrophage apoptosis and efferocytosis in the pathogenesis of atherosclerosis","volume":"80","author":"Linton","year":"2016","journal-title":"Circ. J."},{"key":"10.1016\/j.actbio.2025.04.003_bib0045","first-page":"247","article-title":"Heavy-weight versus low-weight polypropylene meshes for open sublay mesh repair of incisional hernia","volume":"10","author":"Schmidbauer","year":"2005","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.actbio.2025.04.003_bib0046","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/jsre.2002.6358","article-title":"Impact of polymer pore size on the interface scar formation in a rat model","volume":"103","author":"Klinge","year":"2002","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.actbio.2025.04.003_bib0047","first-page":"11","article-title":"Choice of polymer, but not mesh structure variation, reduces the risk of bacterial infection with Staphylococcus aureus in vivo","author":"Schmitz","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.actbio.2025.04.003_bib0048","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10029-016-1481-y","article-title":"Hydrogel coated mesh decreases tissue reaction resulting from polypropylene mesh implant: implication in hernia repair","volume":"20","author":"Poppas","year":"2016","journal-title":"Hernia"},{"key":"10.1016\/j.actbio.2025.04.003_bib0049","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fimmu.2013.00026","article-title":"Manifestations of immune tolerance in the human female reproductive tract","volume":"4","author":"Clark","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0050","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.coi.2012.05.006","article-title":"Unique features of antiviral immune system of the vaginal mucosa","volume":"24","author":"Kumamoto","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0051","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1031941","article-title":"Vaginal neutrophil infiltration is contingent on ovarian cycle phase and independent of pathogen infection","volume":"13","author":"Latorre","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2025.04.003_bib0052","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/jbm.a.37762","article-title":"The cellular and molecular properties of capsule surrounding silicone implants in humans vary uniquely according to the tissue type adjacent to the implant","volume":"112","author":"Nepon","year":"2024","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.actbio.2025.04.003_bib0053","doi-asserted-by":"crossref","DOI":"10.1115\/1.4062490","article-title":"Deformation and durability of soft three-dimensional-printed polycarbonate urethane porous membranes for potential use in pelvic organ prolapse","volume":"145","author":"Bachtiar","year":"2023","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2025.04.003_bib0054","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2016.10.019","article-title":"Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration","volume":"112","author":"Hachim","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.04.003_bib0055","doi-asserted-by":"crossref","DOI":"10.1002\/app.56408","article-title":"Optimizing melt electrowriting prototypes for printing non-medical and medical grade polycaprolactone meshes in prolapse repair","volume":"142","author":"Vaz","year":"2025","journal-title":"J. Appl. Polym. Sci."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125002454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125002454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:57:44Z","timestamp":1762556264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125002454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":55,"alternative-id":["S1742706125002454"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.04.003","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polypropylene surgical mesh induces lipid oxidation in a nonhuman primate model","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}