{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:27:39Z","timestamp":1790792859269,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070724"],"award-info":[{"award-number":["82070724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370768"],"award-info":[{"award-number":["82370768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.actbio.2025.04.058","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:42:52Z","timestamp":1746099772000},"page":"464-475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Trimethylamine N-oxide\u2013derived zwitterion coating for polyurethane ureteral stents prevents encrustation formation"],"prefix":"10.1016","volume":"200","author":[{"given":"Kaiguo","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2965-2614","authenticated-orcid":false,"given":"Guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanfu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-4165","authenticated-orcid":false,"given":"Yezi","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-3689","authenticated-orcid":false,"given":"Zongyao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.04.058_bib0001","doi-asserted-by":"crossref","first-page":"rbac083","DOI":"10.1093\/rb\/rbac083","article-title":"In vivo study on heparin\/poly-l-lysine-copper coating for surface functionalization of ureteral stent","volume":"9","author":"Awonusi","year":"2022","journal-title":"Regen. Biomater"},{"issue":"1-2","key":"10.1016\/j.actbio.2025.04.058_bib0002","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijpharm.2018.04.023","article-title":"Evaluation of a ureteral catheter coating by means of a BioEncrustation in vitro model","volume":"546","author":"Frant","year":"2018","journal-title":"Int. J. Pharm"},{"issue":"1","key":"10.1016\/j.actbio.2025.04.058_bib0003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/08927014.2018.1562549","article-title":"Ureteral stent-associated infection and sepsis: pathogenesis and prevention: a review","volume":"35","author":"Scotland","year":"2019","journal-title":"Biofouling"},{"issue":"2","key":"10.1016\/j.actbio.2025.04.058_bib0004","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1089\/end.2011.0385","article-title":"Ureteral stent encrustation, incrustation, and coloring: morbidity related to indwelling times","volume":"26","author":"Kawahara","year":"2012","journal-title":"J. Endourol"},{"issue":"1","key":"10.1016\/j.actbio.2025.04.058_bib0005","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/JU.0000000000001343","article-title":"Ureteral stent encrustation: epidemiology, pathophysiology, management and current technology","volume":"205","author":"Tomer","year":"2021","journal-title":"J. Urol"},{"key":"10.1016\/j.actbio.2025.04.058_bib0006","first-page":"42","article-title":"Surface treatment strategies to combat implant-related infection from the beginning","volume":"17","author":"Wang","year":"2019","journal-title":"J. Orthop. Transl."},{"issue":"2","key":"10.1016\/j.actbio.2025.04.058_bib0007","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.asjsur.2023.10.136","article-title":"Experience in treating encrusted ureteral stents","volume":"47","author":"Jiang","year":"2024","journal-title":"Asian J. Surg"},{"issue":"4","key":"10.1016\/j.actbio.2025.04.058_bib0008","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ajur.2018.07.002","article-title":"Ureteral stents in urolithiasis","volume":"5","author":"Beysens","year":"2018","journal-title":"Asian J. Urol"},{"issue":"3","key":"10.1016\/j.actbio.2025.04.058_bib0009","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000490621","article-title":"Observations of bacterial biofilm on ureteral stent and studies on the distribution of pathogenic bacteria and drug resistance","volume":"101","author":"Zhang","year":"2018","journal-title":"Urol. Int"},{"issue":"1","key":"10.1016\/j.actbio.2025.04.058_bib0010","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40168-019-0674-x","article-title":"Encrustations on ureteral stents from patients without urinary tract infection reveal distinct urotypes and a low bacterial load","volume":"7","author":"Buhmann","year":"2019","journal-title":"Microbiome"},{"issue":"2","key":"10.1016\/j.actbio.2025.04.058_bib0011","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.urology.2005.03.054","article-title":"Can ureteral stent encrustation analysis predict urinary stone composition?","volume":"66","author":"Roupr\u00eat","year":"2005","journal-title":"Urology"},{"issue":"11","key":"10.1016\/j.actbio.2025.04.058_bib0012","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1021\/acs.langmuir.2c00263","article-title":"Bioinspired phosphorylcholine coating for surface functionalization of interventional biomedical implants with bacterial resistance and anti-encrustation properties","volume":"38","author":"Qian","year":"2022","journal-title":"Langmuir"},{"issue":"14","key":"10.1016\/j.actbio.2025.04.058_bib0013","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1039\/D1TB02318G","article-title":"Bio-inspired antibacterial coatings on urinary stents for encrustation prevention","volume":"10","author":"Yao","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"5","key":"10.1016\/j.actbio.2025.04.058_bib0014","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s10856-011-4285-8","article-title":"Physicochemical characterisation and biological evaluation of polyvinylpyrrolidone-iodine engineered polyurethane (Tecoflex(\u00ae))","volume":"22","author":"Khandwekar","year":"2011","journal-title":"J. Mater. Sci. Mater. Med"},{"key":"10.1016\/j.actbio.2025.04.058_bib0015","doi-asserted-by":"crossref","first-page":"rbac047","DOI":"10.1093\/rb\/rbac047","article-title":"In vitro and in vivo studies on bacteria and encrustation resistance of heparin\/poly-L-lysine-Cu nanoparticles coating mediated by PDA for ureteral stent application","volume":"9","author":"Awonusi","year":"2022","journal-title":"Regen. Biomater"},{"issue":"32","key":"10.1016\/j.actbio.2025.04.058_bib0016","doi-asserted-by":"crossref","first-page":"36473","DOI":"10.1021\/acsami.2c09448","article-title":"Mussel-inspired clickable antibacterial peptide coating on ureteral stents for encrustation prevention","volume":"14","author":"Yao","year":"2022","journal-title":"ACS. Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2025.04.058_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111066","article-title":"Polyvinylpyrrolidone (PVP) hydrogel coating for cylindrical polyurethane scaffolds","volume":"192","author":"Ku\u017ami\u0144ska","year":"2020","journal-title":"Colloids. Surf. B Biointerfaces"},{"key":"10.1016\/j.actbio.2025.04.058_bib0018","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.actbio.2015.03.037","article-title":"Designing of dynamic polyethyleneimine (PEI) brushes on polyurethane (PU) ureteral stents to prevent infections","volume":"21","author":"Gultekinoglu","year":"2015","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2025.04.058_bib0019","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.actbio.2021.03.022","article-title":"The impact of antifouling layers in fabricating bioactive surfaces","volume":"126","author":"Chen","year":"2021","journal-title":"Acta Biomater"},{"issue":"10","key":"10.1016\/j.actbio.2025.04.058_bib0020","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.3390\/molecules27103074","article-title":"Molecular dynamics study on properties of hydration layers above polymer antifouling membranes","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.actbio.2025.04.058_bib0021","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/adma.201404059","article-title":"Molecular understanding and design of zwitterionic materials","volume":"27","author":"Shao","year":"2015","journal-title":"Adv. Mater"},{"issue":"1","key":"10.1016\/j.actbio.2025.04.058_bib0022","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1039\/C4CP02709D","article-title":"Water-mediated interactions between trimethylamine-N-oxide and urea","volume":"17","author":"Hunger","year":"2015","journal-title":"Phys. Chem. Chem. Phys"},{"issue":"6","key":"10.1016\/j.actbio.2025.04.058_bib0023","doi-asserted-by":"crossref","first-page":"eaaw9562","DOI":"10.1126\/sciadv.aaw9562","article-title":"Trimethylamine N-oxide-derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials","volume":"5","author":"Li","year":"2019","journal-title":"Sci. Adv"},{"issue":"9","key":"10.1016\/j.actbio.2025.04.058_bib0024","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/adma.200901407","article-title":"Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications","volume":"22","author":"Jiang","year":"2010","journal-title":"Adv. Mater"},{"issue":"39","key":"10.1016\/j.actbio.2025.04.058_bib0025","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1039\/C9TB01337G","article-title":"Layer-by-layer zwitterionic modification of diverse substrates with durable anti-corrosion and anti-fouling properties","volume":"7","author":"Li","year":"2019","journal-title":"J. Mater. Chem. B"},{"issue":"14","key":"10.1016\/j.actbio.2025.04.058_bib0026","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.3390\/ijms22147705","article-title":"Functional properties of polyurethane ureteral stents with PLGA and papaverine hydrochloride coating","volume":"22","author":"Antonowicz","year":"2021","journal-title":"Int. J. Mol. Sci"},{"key":"10.1016\/j.actbio.2025.04.058_bib0027","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.actbio.2019.03.042","article-title":"An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12 weeks","volume":"90","author":"Belfield","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2025.04.058_bib0028","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.msec.2016.11.125","article-title":"Polyethyleneimine brushes effectively inhibit encrustation on polyurethane ureteral stents both in dynamic bioreactor and in vivo","volume":"71","author":"Gultekinoglu","year":"2017","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl"},{"issue":"13","key":"10.1016\/j.actbio.2025.04.058_bib0029","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0142-9612(99)00026-5","article-title":"Effect of the urine conditioning film on ureteral stent encrustation and characterization of its protein composition","volume":"20","author":"Santin","year":"1999","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.actbio.2025.04.058_bib0030","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.3390\/ijms24044081","article-title":"Human serum albumin: from molecular aspects to biotechnological applications","volume":"24","author":"di Masi","year":"2023","journal-title":"Int. J. Mol. Sci"},{"issue":"5","key":"10.1016\/j.actbio.2025.04.058_bib0031","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/17434440.2023.2198702","article-title":"Surface modification of ureteral stents: development history, classification, function, and future developments","volume":"20","author":"Xia","year":"2023","journal-title":"Expert. Rev. Med. Devices"},{"issue":"6","key":"10.1016\/j.actbio.2025.04.058_bib0032","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0924-8579(02)00097-3","article-title":"Heparin coating reduces encrustation of ureteral stents: a preliminary report","volume":"19","author":"Riedl","year":"2002","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"5","key":"10.1016\/j.actbio.2025.04.058_bib0033","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/089277903322145431","article-title":"Oxalate-degrading enzymes from Oxalobacter formigenes: a novel device coating to reduce urinary tract biomaterial-related encrustation","volume":"17","author":"Watterson","year":"2003","journal-title":"J. Endourol"},{"issue":"1-3","key":"10.1016\/j.actbio.2025.04.058_bib0034","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.molstruc.2007.04.040","article-title":"Bound states of water in poly(vinyl alcohol) hydrogel prepared by repeated freezing and melting method","volume":"875","author":"Nakaoki","year":"2008","journal-title":"J. Mol. Struct"},{"issue":"6","key":"10.1016\/j.actbio.2025.04.058_bib0035","doi-asserted-by":"crossref","first-page":"eaaw5484","DOI":"10.1126\/sciadv.aaw5484","article-title":"Architecting highly hydratable polymer networks to tune the water state for solar water purification","volume":"5","author":"Zhou","year":"2019","journal-title":"Sci. Adv"},{"issue":"2","key":"10.1016\/j.actbio.2025.04.058_bib0036","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/acssensors.0c02241","article-title":"Practical guide to single-protein AFM nanomechanical spectroscopy mapping: insights and pitfalls As unraveled by all-atom MD simulations on immunoglobulin G","volume":"6","author":"Vilhena","year":"2021","journal-title":"ACS. Sens"},{"issue":"48","key":"10.1016\/j.actbio.2025.04.058_bib0037","doi-asserted-by":"crossref","first-page":"30492","DOI":"10.1039\/C8CP06126B","article-title":"Molecular features of hydration layers probed by atomic force microscopy","volume":"20","author":"Zhang","year":"2018","journal-title":"Phys. Chem. Chem. Phys.: PCCP"},{"issue":"2","key":"10.1016\/j.actbio.2025.04.058_bib0038","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.urology.2005.03.054","article-title":"Can ureteral stent encrustation analysis predict urinary stone composition?","volume":"66","author":"Roupr\u00eat","year":"2005","journal-title":"Urology"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125003125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125003125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:51:55Z","timestamp":1774860715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125003125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":38,"alternative-id":["S1742706125003125"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.04.058","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trimethylamine N-oxide\u2013derived zwitterion coating for polyurethane ureteral stents prevents encrustation formation","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.04.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}