{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:34:05Z","timestamp":1792683245586,"version":"4.5.0"},"reference-count":264,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"am","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1RF1NS125578-01"],"award-info":[{"award-number":["1RF1NS125578-01"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["UL1TR002736"],"award-info":[{"award-number":["UL1TR002736"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019337","name":"Miami Clinical and Translational Science Institute, University of Miami","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.actbio.2025.05.026","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T11:18:38Z","timestamp":1746875918000},"page":"703-723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Effects of iron accumulation and its chelation on oxidative stress in intracortical implants"],"prefix":"10.1016","volume":"200","author":[{"given":"Melissa E.","family":"Franklin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8189-2158","authenticated-orcid":false,"given":"Jordan L.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9793-7261","authenticated-orcid":false,"given":"Grant M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6743-1054","authenticated-orcid":false,"given":"Anabel","family":"Alvarez-Ciara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3025-5168","authenticated-orcid":false,"given":"Serene","family":"Mattis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2648-0977","authenticated-orcid":false,"given":"Nicolas","family":"Gallardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Corrales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0470-2005","authenticated-orcid":false,"given":"Xinyan Tracy","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8030-6947","authenticated-orcid":false,"given":"Jeffrey R.","family":"Capadona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-9052","authenticated-orcid":false,"given":"Wolfgang J.","family":"Streit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Hubert","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4068-9511","authenticated-orcid":false,"given":"Robert W.","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-4942","authenticated-orcid":false,"given":"W. Dalton","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-8834","authenticated-orcid":false,"given":"Juan Pablo","family":"de Rivero Vaccari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-9400","authenticated-orcid":false,"given":"Abhishek","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0001","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/STROKEAHA.110.602755","article-title":"The role of iron in brain injury after intraventricular hemorrhage","volume":"42","author":"Chen","year":"2011","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0002","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/STROKEAHA.116.015609","article-title":"Neuronal death after hemorrhagic stroke In vitro and In vivo shares features of ferroptosis and necroptosis","volume":"48","author":"Zille","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.actbio.2025.05.026_bib0003","first-page":"13","article-title":"Deciphering the iron side of stroke: neurodegeneration at the crossroads between iron dyshomeostasis, excitotoxicity, and ferroptosis","author":"DeGregorio-Rocasolano","year":"2019","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0004","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/STROKEAHA.123.044930","article-title":"Causal association of iron status with functional outcome after ischemic stroke","volume":"55","author":"He","year":"2024","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0005","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/jnc.15807","article-title":"Ferroptosis, and ischemic stroke","volume":"165","author":"Guo","year":"2023","journal-title":"J. Neurochem."},{"key":"10.1016\/j.actbio.2025.05.026_bib0006","first-page":"12","article-title":"The involvement of iron in traumatic brain injury and neurodegenerative disease","author":"Daglas","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.949573","article-title":"Spatial-temporal changes of iron deposition and iron metabolism after traumatic brain injury in mice","volume":"15","author":"Cheng","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0008","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s13311-020-00954-y","article-title":"Iron and ferroptosis as therapeutic targets in Alzheimer\u2019s disease","volume":"18","author":"Gleason","year":"2021","journal-title":"Neurotherapeutics."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0009","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40478-021-01126-5","article-title":"Iron loading is a prominent feature of activated microglia in Alzheimer\u2019s Disease patients","volume":"9","author":"Kenkhuis","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.actbio.2025.05.026_bib0010","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3389\/fnins.2018.00632","article-title":"Iron and Alzheimer\u2019s disease: from pathogenesis to therapeutic implications","volume":"12","author":"Liu","year":"2018","journal-title":"Front. Neurosci."},{"issue":"S1","key":"10.1016\/j.actbio.2025.05.026_bib0011","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer\u2019s Disease and Parkinson\u2019s Disease: targets for therapeutics","volume":"139","author":"Belaidi","year":"2016","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41531-023-00496-y","article-title":"Exploring the genetic and genomic connection underlying neurodegeneration with Brain iron accumulation and the risk for Parkinson\u2019s disease","volume":"9","author":"Alvarez Jerez","year":"2023","journal-title":"NPJ. Parkinsons. Dis."},{"key":"10.1016\/j.actbio.2025.05.026_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101896","article-title":"Parkinson\u2019s Disease: alterations in iron and redox biology as a key to unlock therapeutic strategies","volume":"41","author":"Ma","year":"2021","journal-title":"Redox. Biol."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/cells12050763","article-title":"The neuroprotective activities of the novel multi-target iron-chelators in models of Alzheimer\u2019s disease, amyotrophic lateral sclerosis and aging","volume":"12","author":"Kupershmidt","year":"2023","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.actbio.2025.05.026_bib0015","doi-asserted-by":"crossref","DOI":"10.21037\/qims-20-187","article-title":"Serial assessment of iron in the motor cortex in limb-onset amyotrophic lateral sclerosis using quantitative susceptibility mapping","volume":"10","author":"Bhattarai","year":"2020","journal-title":"Quant. ImAging Med. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0016","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-019-1430-7","article-title":"Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro","volume":"16","author":"Yauger","year":"2019","journal-title":"J. Neuroinflammation."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0017","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1023\/A:1020727218493","article-title":"Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures","volume":"16","author":"Ega\u00f1a","year":"2003","journal-title":"Biometals"},{"issue":"8","key":"10.1016\/j.actbio.2025.05.026_bib0018","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2174\/092986707780363014","article-title":"Oxidative stress and early neurological deterioration in ischemic stroke","volume":"14","author":"Carbonell","year":"2007","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0019","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/jnc.14906","article-title":"Iron potentiates microglial interleukin-1\u03b2 secretion induced by amyloid-\u03b2","volume":"154","author":"Nnah","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.actbio.2025.05.026_bib0020","doi-asserted-by":"crossref","unstructured":"; B\u00f3rquez, D. A.; N\u00fa\u00f1ez, M. T. Inflaming the brain with iron. Antioxidants 2021, 10 (1), 61. https:\/\/doi.org\/10.3390\/antiox10010061.","DOI":"10.3390\/antiox10010061"},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0021","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/antiox12040918","article-title":"The interplay between intracellular iron homeostasis and neuroinflammation in neurodegenerative diseases","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.actbio.2025.05.026_bib0022","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2008.12.030","article-title":"Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons","volume":"1257","author":"Yu","year":"2009","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0023","doi-asserted-by":"crossref","DOI":"10.1136\/svn-2018-000205","article-title":"Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage","volume":"4","author":"Wan","year":"2019","journal-title":"Stroke Vasc. Neurol."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0024","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3390\/cells8020198","article-title":"Iron exposure and the cellular mechanisms linked to neuron degeneration in adult mice","volume":"8","author":"Li","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.actbio.2025.05.026_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101984","article-title":"Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury","volume":"43","author":"Feng","year":"2021","journal-title":"Redox. Biol."},{"key":"10.1016\/j.actbio.2025.05.026_bib0026","doi-asserted-by":"crossref","unstructured":"Zhang, L.M.; Liang, X.; Xiong, G.; Xing, X.L.; Zhang, Q.; Zhang, B.; Liu, M. Analysis and identification of oxidative stress-ferroptosis related biomarkers in ischemic stroke. Sci. Rep. 2024, 14 (1), 3803. https:\/\/doi.org\/10.1038\/s41598-024-54555-2.","DOI":"10.1038\/s41598-024-54555-2"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)03179-7","article-title":"Iron intake increases infarct volume after permanent middle cerebral artery occlusion in rats","volume":"952","author":"Castellanos","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.actbio.2025.05.026_bib0028","series-title":"Management of Severe Traumatic Brain Injury: Evidence, Tricks, and Pitfalls; Sundstr\u00f8m","first-page":"35","article-title":"Pathophysiology of severe traumatic brain injury","author":"Marklund","year":"2020"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0029","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12974-021-02192-1","article-title":"Endothelial glycocalyx in traumatic brain injury associated coagulopathy: potential mechanisms and impact","volume":"18","author":"Zou","year":"2021","journal-title":"J. Neuroinflammation."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0030","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1039\/C3SC53461H","article-title":"An iron\u2013Dopamine index predicts risk of parkinsonian neurodegeneration in the Substantia Nigra Pars Compacta","volume":"5","author":"Hare","year":"2014","journal-title":"Chem. Sci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0031","doi-asserted-by":"crossref","unstructured":"Teferi, N.; Challa, M.; Woodiwiss, T.; Allen, B.; Petronek, M. Mitochondrial dysfunction, iron accumulation, and ferroptosis in Parkinson\u2019s Disease. 2023. 10.1530\/REM-23-0004.","DOI":"10.1530\/REM-23-0004"},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0032","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11064-004-2442-x","article-title":"Histological Co-localization of iron in a\u03b2 plaques of PS\/APP transgenic mice","volume":"30","author":"Falangola","year":"2005","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0033","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1074\/jbc.M110.158980","article-title":"Iron promotes the toxicity of amyloid \u03b2 peptide by impeding its ordered aggregation *","volume":"286","author":"Liu","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0034","doi-asserted-by":"crossref","first-page":"994","DOI":"10.3390\/ijms20040994","article-title":"Targeting the iron-response elements of the mRNAs for the Alzheimer\u2019s amyloid precursor protein and ferritin to treat acute lead and manganese neurotoxicity","volume":"20","author":"Rogers","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40035-020-00189-z","article-title":"Current understanding of metal ions in the pathogenesis of Alzheimer\u2019s disease","volume":"9","author":"Wang","year":"2020","journal-title":"Transl. Neurodegener."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0036","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuint.2012.12.005","article-title":"Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain","volume":"62","author":"Guo","year":"2013","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0037","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1046\/j.1471-4159.2002.t01-1-01061.x","article-title":"Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to Iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer\u2019s disease","volume":"82","author":"Yamamoto","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.actbio.2025.05.026_bib0038","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fnmol.2018.00276","article-title":"Untangling tau and iron: exploring the interaction between iron and tau in neurodegeneration","volume":"11","author":"Rao","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0039","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/8\/2\/025027","article-title":"Neural control of cursor trajectory and click by a Human with tetraplegia 1000 days after implant of an intracortical microelectrode array","volume":"8","author":"Simeral","year":"2011","journal-title":"J. Neural Eng."},{"issue":"51","key":"10.1016\/j.actbio.2025.05.026_bib0040","doi-asserted-by":"crossref","first-page":"17849","DOI":"10.1073\/pnas.0403504101","article-title":"Control of a two-dimensional movement signal by a noninvasive brain-computer interface in humans","volume":"101","author":"Wolpaw","year":"2004","journal-title":"Proc. National Acad. Sci."},{"issue":"7099","key":"10.1016\/j.actbio.2025.05.026_bib0041","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nature04970","article-title":"Neuronal ensemble control of prosthetic devices by a Human with tetraplegia","volume":"442","author":"Hochberg","year":"2006","journal-title":"Nature"},{"issue":"7398","key":"10.1016\/j.actbio.2025.05.026_bib0042","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature11076","article-title":"Reach and grasp by people with tetraplegia using a neurally controlled robotic arm","volume":"485","author":"Hochberg","year":"2012","journal-title":"Nature"},{"issue":"9866","key":"10.1016\/j.actbio.2025.05.026_bib0043","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0140-6736(12)61816-9","article-title":"High-performance neuroprosthetic control by an individual with tetraplegia","volume":"381","author":"Collinger","year":"2013","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0044","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neuron.2006.09.019","article-title":"Brain-controlled interfaces: movement restoration with neural prosthetics","volume":"52","author":"Schwartz","year":"2006","journal-title":"Neuron"},{"issue":"7398","key":"10.1016\/j.actbio.2025.05.026_bib0045","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature10987","article-title":"Restoration of grasp following paralysis through brain-controlled stimulation of muscles","volume":"485","author":"Ethier","year":"2012","journal-title":"Nature"},{"issue":"7222","key":"10.1016\/j.actbio.2025.05.026_bib0046","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nature07418","article-title":"Direct control of paralysed muscles by cortical neurons","volume":"456","author":"Moritz","year":"2008","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0047","doi-asserted-by":"crossref","first-page":"e5924","DOI":"10.1371\/journal.pone.0005924","article-title":"Toward the restoration of hand use to a paralyzed monkey: brain-controlled functional electrical stimulation of forearm muscles","volume":"4","author":"Pohlmeyer","year":"2009","journal-title":"PLoS. One"},{"issue":"6095","key":"10.1016\/j.actbio.2025.05.026_bib0048","first-page":"735","article-title":"Closed-loop control of epilepsy by transcranial electrical stimulation","volume":"337","author":"Ber\u00e9nyi","year":"2012","journal-title":"Science (1979)"},{"key":"10.1016\/j.actbio.2025.05.026_bib0049","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2014.00296","article-title":"Restoration of motor function following spinal cord injury via optimal control of intraspinal microstimulation: toward a next generation closed-loop neural prosthesis","volume":"8","author":"Grahn","year":"2014","journal-title":"Front. Neurosci."},{"issue":"31\u201332","key":"10.1016\/j.actbio.2025.05.026_bib0050","first-page":"519","article-title":"Deep brain stimulation in neurological and psychiatric disorders","volume":"112","author":"Coenen","year":"2015","journal-title":"Dtsch. Arztebl. Int."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0051","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3171\/2019.4.JNS181761","article-title":"Current and future directions of deep brain stimulation for neurological and psychiatric disorders","volume":"131","author":"Lee","year":"2019","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.actbio.2025.05.026_bib0052","first-page":"1051","article-title":"Current perspectives on deep brain stimulation for severe neurological and psychiatric disorders","volume":"11","author":"Kocabicak","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0053","first-page":"266","article-title":"Treatment of neurological and psychiatric disorders with deep brain stimulation; raising hopes and future challenges","volume":"4","author":"Sharifi","year":"2013","journal-title":"Basic Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0054","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3233\/NRE-2008-23111","article-title":"Deep Brain stimulation: treating neurological and psychiatric disorders by modulating brain activity","volume":"23","author":"Siddiqui","year":"2008","journal-title":"NeuroRehabilitation."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0055","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1109\/10.141202","article-title":"Factors influencing the biocompatibility of insertable silicon microshafts in cerebral cortex","volume":"39","author":"Edell","year":"1992","journal-title":"IEEE Trans. Biomed. Eng."},{"issue":"9","key":"10.1016\/j.actbio.2025.05.026_bib0056","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/mi9090430","article-title":"Chronically implanted intracranial electrodes: tissue reaction and electrical changes","volume":"9","author":"Campbell","year":"2018","journal-title":"Micromachines. (Basel)"},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0057","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/7\/4\/046011","article-title":"Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in Vivo two-photon mapping","volume":"7","author":"Kozai","year":"2010","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.actbio.2025.05.026_bib0058","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biomaterials.2018.04.043","article-title":"In vivo imaging of neuronal calcium during electrode implantation: spatial and temporal mapping of damage and recovery","volume":"174","author":"Eles","year":"2018","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0059","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2005.04.020","article-title":"Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays","volume":"195","author":"Biran","year":"2005","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0060","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/6\/5\/056003","article-title":"Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration","volume":"6","author":"McConnell","year":"2009","journal-title":"J. Neural Eng."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0061","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/abf2e6","article-title":"Spatiotemporal patterns of gene expression around implanted silicon electrode arrays","volume":"18","author":"Thompson","year":"2021","journal-title":"J. Neural Eng."},{"issue":"11","key":"10.1016\/j.actbio.2025.05.026_bib0062","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41551-017-0154-1","article-title":"Glial responses to implanted electrodes in the brain","volume":"1","author":"Salatino","year":"2017","journal-title":"Nat. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0063","doi-asserted-by":"crossref","first-page":"376a","DOI":"10.1016\/j.bpj.2012.11.2092","article-title":"Is the extent of blood-brain-barrier breach predictive of intracortical electrode performance?","volume":"104","author":"Bellamkonda","year":"2013","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0064","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1021\/cn500256e","article-title":"Brain tissue responses to neural implants impact signal sensitivity and intervention strategies","volume":"6","author":"Kozai","year":"2015","journal-title":"ACS. Chem. Neurosci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0065","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.biomaterials.2015.02.081","article-title":"BBB leakage, astrogliosis, and tissue loss correlate with Silicon microelectrode array recording performance","volume":"53","author":"Nolta","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.05.026_bib0066","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.02.036","article-title":"Blood brain barrier (BBB)-disruption in intracortical silicon microelectrode implants","volume":"164","author":"Bennett","year":"2018","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"10.1016\/j.actbio.2025.05.026_bib0067","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0006-8993(03)03023-3","article-title":"Brain responses to micro-machined silicon devices","volume":"983","author":"Szarowski","year":"2003","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0068","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/exnr.1998.6983","article-title":"Cerebral astrocyte response to micromachined silicon implants","volume":"156","author":"Turner","year":"1999","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0069","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/9\/4\/046020","article-title":"Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses","volume":"9","author":"Potter","year":"2012","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.actbio.2025.05.026_bib0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fbioe.2018.00009","article-title":"Implantation of neural probes in the brain elicits oxidative stress","volume":"6","author":"Ereifej","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2025.05.026_bib0071","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biomaterials.2018.09.040","article-title":"Neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption in acute Utah electrode array implants and the effect of deferoxamine as an iron chelator on acute foreign body response","volume":"188","author":"Bennett","year":"2019","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0072","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/abbi.2001.2642","article-title":"The neutrophil NADPH oxidase","volume":"397","author":"Babior","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0073","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.biocel.2007.10.003","article-title":"The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals","volume":"40","author":"Segal","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"14","key":"10.1016\/j.actbio.2025.05.026_bib0074","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.1074\/jbc.274.14.9573","article-title":"Mechanism of superoxide generation by neuronal nitric-oxide synthase *","volume":"274","author":"Pou","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"Pt 2","key":"10.1016\/j.actbio.2025.05.026_bib0075","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2980249","article-title":"Nitric oxide synthases in mammals","volume":"298","author":"Knowles","year":"1994","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0076","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1038\/s41598-019-44147-w","article-title":"Synergistic role of oxidative stress and blood-brain barrier permeability as injury mechanisms in the acute pathophysiology of blast-induced neurotrauma","volume":"9","author":"Kuriakose","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0077","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0078","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jnr.10633","article-title":"Hemin induces an iron-dependent, oxidative injury to Human neuron-like cells","volume":"73","author":"Goldstein","year":"2003","journal-title":"J. Neurosci. Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0079","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pneurobio.2010.08.001","article-title":"Preclinical and clinical research on inflammation after intracerebral hemorrhage","volume":"92","author":"Wang","year":"2010","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0080","first-page":"164","article-title":"Review on iron and its importance for Human health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0081","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110173","article-title":"Essential metals in health and disease","volume":"367","author":"Jomova","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0082","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000362888","article-title":"Physiology of iron metabolism","volume":"41","author":"Waldvogel-Abramowski","year":"2014","journal-title":"Transfus. Med. HemOther"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0083","first-page":"5","article-title":"Normal iron metabolism and the pathophysiology of iron overload disorders","volume":"27","author":"Siah","year":"2006","journal-title":"Clin. Biochem. Rev."},{"issue":"10","key":"10.1016\/j.actbio.2025.05.026_bib0084","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.actbio.2025.05.026_bib0085","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0378-4274(95)03532-X","article-title":"Toxicity of iron and hydrogen peroxide: the Fenton reaction","volume":"82\u201383","author":"Winterbourn","year":"1995","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0086","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0300-483X(00)00231-6","article-title":"The Haber-Weiss reaction and mechanisms of toxicity","volume":"149","author":"Kehrer","year":"2000","journal-title":"Toxicology."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0087","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.toxlet.2011.05.001","article-title":"Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure","volume":"205","author":"Wang","year":"2011","journal-title":"Toxicol. Lett."},{"issue":"8","key":"10.1016\/j.actbio.2025.05.026_bib0088","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.bbamcr.2006.04.012","article-title":"Ferritin levels in microglia depend upon activation: modulation by reactive oxygen species","volume":"1763","author":"Mehlhase","year":"2006","journal-title":"Biochimica et Biophysica Acta (BBA) - Mol. Cell Res."},{"issue":"20","key":"10.1016\/j.actbio.2025.05.026_bib0089","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1074\/jbc.RA118.001949","article-title":"Inflammation-induced iron transport and metabolism by brain microglia","volume":"293","author":"McCarthy","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2025.05.026_bib0090","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbi.2017.10.017","article-title":"Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP\/PS1 mice","volume":"68","author":"Holland","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0091","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","article-title":"TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord","volume":"83","author":"Kroner","year":"2014","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0092","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.eplepsyres.2013.09.010","article-title":"Inflammation and iron metabolism in adult patients with epilepsy: does a link exist?","volume":"107","author":"Tombini","year":"2013","journal-title":"Epilepsy Res."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0093","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.bbadis.2013.01.021","article-title":"Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen\/nitrogen species production in ventral mesencephalic neurons","volume":"1832","author":"Wang","year":"2013","journal-title":"Biochimica et Biophysica Acta (BBA) - Mol. Basis Disease"},{"issue":"13","key":"10.1016\/j.actbio.2025.05.026_bib0094","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.3390\/ijms23137267","article-title":"Neuroinflammation and neurodegeneration","volume":"23","author":"Ward","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101494","article-title":"Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine\/glutamate antiporter in Alzheimer\u2019s disease: evidence of ferroptosis","volume":"32","author":"Ashraf","year":"2020","journal-title":"Redox. Biol."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0096","doi-asserted-by":"crossref","first-page":"C1117","DOI":"10.1152\/ajpcell.00444.2004","article-title":"Iron alters glutamate secretion by regulating cytosolic aconitase activity","volume":"288","author":"McGahan","year":"2005","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.actbio.2025.05.026_bib0097","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1113081","article-title":"The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: glutamate accumulation","volume":"16","author":"Fan","year":"2023","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0098","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cmi.2014.89","article-title":"An overview from structure to innate immunity-associated pathologies","volume":"12","author":"Panday","year":"2015","journal-title":"Cell Mol. Immunol."},{"issue":"26","key":"10.1016\/j.actbio.2025.05.026_bib0099","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.1073\/pnas.1702293114","article-title":"Crystal structures and atomic model of NADPH oxidase","volume":"114","author":"Magnani","year":"2017","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0100","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1089\/ars.2011.3923","article-title":"Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases","volume":"15","author":"Lehner","year":"2011","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.actbio.2025.05.026_bib0101","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fneur.2013.00032","article-title":"Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke","volume":"4","author":"Lakhan","year":"2013","journal-title":"Front. Neurol."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0102","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1471-4159.2006.04393.x","article-title":"Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction","volume":"101","author":"Haorah","year":"2007","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0103","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12868-019-0507-7","article-title":"Iron concentrations in neurons and glial cells with estimates on ferritin concentrations","volume":"20","author":"Reinert","year":"2019","journal-title":"BMC. Neurosci."},{"issue":"9","key":"10.1016\/j.actbio.2025.05.026_bib0104","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1182\/blood-2005-02-0460","article-title":"Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells","volume":"106","author":"Glickstein","year":"2005","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0105","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/cyto.b.21633","article-title":"Labile iron pool as a parameter to monitor iron overload and oxidative stress status in \u03b2-thalassemic erythrocytes","volume":"94","author":"Chutvanichkul","year":"2018","journal-title":"Cytometry Part B: Clin. Cytometry"},{"issue":"9","key":"10.1016\/j.actbio.2025.05.026_bib0106","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, Lipids and Proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0107","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0108","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s12031-007-0060-1","article-title":"Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders","volume":"33","author":"Hamilton","year":"2007","journal-title":"J. Mol. Neurosci."},{"issue":"8","key":"10.1016\/j.actbio.2025.05.026_bib0109","article-title":"Lipid processing in the brain: a key regulator of systemic metabolism","author":"Bruce","year":"2017","journal-title":"Front. Endocrinol"},{"key":"10.1016\/j.actbio.2025.05.026_bib0110","unstructured":"Clarke, D.D.; Sokoloff, L. Regulation of cerebral metabolic rate. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition; Lippincott-Raven, 1999."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0111","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3945\/ajcn.2010.29885","article-title":"Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure1234","volume":"92","author":"Wang","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"issue":"36","key":"10.1016\/j.actbio.2025.05.026_bib0112","doi-asserted-by":"crossref","first-page":"13010","DOI":"10.1073\/pnas.1323099111","article-title":"Metabolic costs and evolutionary implications of Human brain development","volume":"111","author":"Kuzawa","year":"2014","journal-title":"Proc. National Acad. Sci."},{"issue":"19","key":"10.1016\/j.actbio.2025.05.026_bib0113","doi-asserted-by":"crossref","first-page":"7152","DOI":"10.3390\/ijms21197152","article-title":"Neuroprotective effect of antioxidants in the brain","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0114","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative stress and the Central nervous system","volume":"360","author":"Salim","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.actbio.2025.05.026_bib0115","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 Reasons why the brain is susceptible to oxidative stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox. Biol."},{"issue":"15","key":"10.1016\/j.actbio.2025.05.026_bib0116","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.3390\/ijms21155551","article-title":"Pyridoxine deficiency exacerbates neuronal damage after ischemia by increasing oxidative stress and reduces proliferating cells and neuroblasts in the Gerbil hippocampus","volume":"21","author":"Jung","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0117","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.freeradbiomed.2022.02.004","article-title":"Oxidative stress and regeneration","volume":"181","author":"Jaganjac","year":"2022","journal-title":"Free Radical Biol. Med."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0118","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/j.actbio.2014.01.018","article-title":"Curcumin-releasing mechanically adaptive intracortical implants improve the proximal neuronal density and blood\u2013Brain barrier stability","volume":"10","author":"Potter","year":"2014","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0119","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1021\/acsabm.2c00969","article-title":"Development of a slow-degrading polymerized curcumin coating for intracortical microelectrodes","volume":"6","author":"Ziemba","year":"2023","journal-title":"ACS. Appl. Bio Mater."},{"key":"10.1016\/j.actbio.2025.05.026_bib0120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.biomaterials.2018.07.026","article-title":"Melatonin improves quality and longevity of chronic neural recording","volume":"180","author":"Golabchi","year":"2018","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.actbio.2025.05.026_bib0121","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.3390\/mi14101902","article-title":"Antioxidant dimethyl fumarate temporarily but not chronically improves intracortical microelectrode performance","volume":"14","author":"Hoeferlin","year":"2023","journal-title":"Micromachines. (Basel)"},{"issue":"29","key":"10.1016\/j.actbio.2025.05.026_bib0122","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1016\/j.biomaterials.2013.05.035","article-title":"The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes","volume":"34","author":"Potter","year":"2013","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.actbio.2025.05.026_bib0123","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3390\/mi12121446","article-title":"Investigation of the feasibility of ventricular delivery of resveratrol to the microelectrode tissue interface","volume":"12","author":"Kim","year":"2021","journal-title":"Micromachines. (Basel)"},{"key":"10.1016\/j.actbio.2025.05.026_bib0124","first-page":"7","article-title":"Electrode impedance analysis of chronic tungsten microwire neural implants: understanding abiotic vs. biotic contributions","author":"Sankar","year":"2014","journal-title":"Front. Neuroeng."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0125","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/9\/2\/026028","article-title":"Quantifying long-term microelectrode array functionality using chronic in vivo impedance testing","volume":"9","author":"Prasad","year":"2012","journal-title":"J. Neural Eng."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0126","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/9\/5\/056015","article-title":"Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants","volume":"9","author":"Prasad","year":"2012","journal-title":"J. Neural Eng."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0127","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/aa9f32","article-title":"Potential for thermal damage to the blood-brain barrier during craniotomy: implications for intracortical recording microelectrodes","volume":"15","author":"Shoffstall","year":"2018","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.actbio.2025.05.026_bib0128","doi-asserted-by":"crossref","unstructured":"Abbasi, A.; Rangwani, R.; Bowen, D.W.; Fealy, A.W.; Danielsen, N.P.; Gulati, T. Cortico-cerebellar coordination facilitates neuroprosthetic control. Sci. Adv. 10 (15), eadm8246. https:\/\/doi.org\/10.1126\/sciadv.adm8246.","DOI":"10.1126\/sciadv.adm8246"},{"issue":"9","key":"10.1016\/j.actbio.2025.05.026_bib0129","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1182\/blood-2006-02-002394","article-title":"Oral chelators Deferasirox and Deferiprone for transfusional iron overload in Thalassemia major: new data, new questions","volume":"107","author":"Neufeld","year":"2006","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.actbio.2025.05.026_bib0130","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/chemosensors10110468","article-title":"Deferoxamine-based materials and sensors for Fe(III) detection","volume":"10","author":"Alberti","year":"2022","journal-title":"Chemosensors"},{"issue":"20","key":"10.1016\/j.actbio.2025.05.026_bib0131","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1182\/blood-2009-05-224188","article-title":"Specific iron chelators determine the route of ferritin degradation","volume":"114","author":"De Domenico","year":"2009","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0132","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s12975-020-00844-7","article-title":"Deferoxamine treatment prevents post-stroke vasoregression and neurovascular unit remodeling leading to improved functional outcomes in type 2 male diabetic rats: role of endothelial ferroptosis","volume":"12","author":"Abdul","year":"2021","journal-title":"Transl. Stroke Res."},{"issue":"7","key":"10.1016\/j.actbio.2025.05.026_bib0133","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/j.1460-9568.2006.04699.x","article-title":"Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat","volume":"23","author":"Freret","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0134","doi-asserted-by":"crossref","first-page":"e895","DOI":"10.1016\/j.wneu.2019.05.024","article-title":"Deferoxamine alleviates iron overload and brain injury in a rat model of brainstem hemorrhage","volume":"128","author":"Guo","year":"2019","journal-title":"World Neurosurg."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0135","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s12975-013-0270-5","article-title":"Deferoxamine reduces neuronal death and hematoma lysis after intracerebral hemorrhage in aged rats","volume":"4","author":"Hatakeyama","year":"2013","journal-title":"Transl. Stroke Res."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0136","first-page":"S90","article-title":"Deferoxamine mesylate: a new hope for intracerebral hemorrhage: from bench to clinical trials","volume":"40","author":"Selim","year":"2009","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0137","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12028-013-9861-y","article-title":"High dose deferoxamine in intracerebral hemorrhage (Hi-Def) trial: rationale, design, and methods","volume":"19","author":"Yeatts","year":"2013","journal-title":"Neurocrit. Care"},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0138","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4103\/1673-5374.245480","article-title":"Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis","volume":"14","author":"Yao","year":"2019","journal-title":"Neural Regen. Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0139","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bcmd.2014.04.004","article-title":"Deferiprone versus deferoxamine in sickle cell disease: results from a 5-year long-term Italian multi-center randomized clinical trial","volume":"53","author":"Calvaruso","year":"2014","journal-title":"Blood Cells, Mol., Diseases"},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0140","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1182\/blood-2003-10-3373","article-title":"Safety and efficacy of subcutaneous bolus injection of deferoxamine in adult patients with iron overload: an update","volume":"103","author":"Franchini","year":"2004","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0141","first-page":"48","article-title":"Iron chelation by deferoxamine in sickle cell patients with severe transfusion-induced hemosiderosis: a randomized, double-blind study of the dose-response relationship","volume":"122","author":"Silliman","year":"1993","journal-title":"J. Lab. Clin. Med."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0142","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1034\/j.1600-0609.2001.067001030.x","article-title":"Comparison between deferoxamine and deferiprone (L1) in iron-loaded thalassemia patients","volume":"67","author":"Taher","year":"2001","journal-title":"Eur. J. Haematol."},{"issue":"12","key":"10.1016\/j.actbio.2025.05.026_bib0143","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082662","article-title":"Comparative efficacy and safety of deferoxamine, Deferiprone and Deferasirox on severe thalassemia: a meta-analysis of 16 randomized controlled trials","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS. One"},{"key":"10.1016\/j.actbio.2025.05.026_bib0144","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.actbio.2019.11.017","article-title":"Differential expression of genes involved in the acute innate immune response to intracortical microelectrodes","volume":"102","author":"Bedell","year":"2020","journal-title":"Acta Biomater."},{"issue":"15","key":"10.1016\/j.actbio.2025.05.026_bib0145","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.3390\/cells11152348","article-title":"Neuroinflammatory gene expression analysis reveals pathways of interest as potential targets to improve the recording performance of intracortical microelectrodes","volume":"11","author":"Song","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.actbio.2025.05.026_bib0146","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122102","article-title":"Activation of inflammasomes and their effects on neuroinflammation at the microelectrode-tissue interface in intracortical implants","volume":"297","author":"Franklin","year":"2023","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.actbio.2025.05.026_bib0147","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109902","article-title":"Validation of housekeeping genes in the brains of rats submitted to chronic intermittent hypoxia, a sleep apnea model","volume":"9","author":"Julian","year":"2014","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0148","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71895-x","article-title":"Validation of reference genes for expression analysis in a Murine trauma model combining traumatic brain injury and femoral fracture","volume":"10","author":"Otto","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0149","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.actbio.2025.05.026_bib0150","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6750-5-31","article-title":"Standardisation of data from real-time quantitative PCR methods - evaluation of outliers and comparison of calibration curves","volume":"5","author":"Burns","year":"2005","journal-title":"BMC. Biotechnol."},{"issue":"11","key":"10.1016\/j.actbio.2025.05.026_bib0151","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1021\/acs.analchem.9b01466","article-title":"Framework for DNA quantification and outlier detection using multidimensional standard curves","volume":"91","author":"Moniri","year":"2019","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0152","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression \u2013 a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC. Bioinformatics."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0153","first-page":"71","article-title":"An improvement of the 2\u02c6 (\u2013Delta Delta CT) method for quantitative real-time polymerase chain reaction data analysis","volume":"3","author":"Rao","year":"2013","journal-title":"Biostat. Bioinforma Biomath."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0154","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1679\/aohc.68.171","article-title":"The presence of ferric and ferrous iron in the nonheme iron store of resident macrophages in different tissues and organs: histochemical demonstrations by the perfusion-Perls and -Turnbull methods in the rat","volume":"68","author":"Meguro","year":"2005","journal-title":"Arch. Histol. Cytol."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1679\/aohc.70.1","article-title":"Nonheme-iron histochemistry for light and electron microscopy: a historical, theoretical and technical review","volume":"70","author":"Meguro","year":"2007","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.actbio.2025.05.026_bib0156","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1038\/s41598-018-21744-9","article-title":"Sub-cellular in-situ characterization of ferritin(Iron) in a rodent model of spinal cord injury","volume":"8","author":"Blissett","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.actbio.2025.05.026_bib0157","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1369\/0022155413501325","article-title":"Comparison of histological techniques to visualize iron in paraffin-embedded brain tissue of patients with Alzheimer\u2019s disease","volume":"61","author":"Duijn","year":"2013","journal-title":"J. Histochem. Cytochem."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0158","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF00274100","article-title":"A sensitive post-DAB enhancement technique for demonstration of iron in the Central nervous system","volume":"99","author":"Moos","year":"1993","journal-title":"Histochemistry"},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0159","article-title":"Abiotic-biotic characterization of Pt\/Ir microelectrode arrays in chronic implants","volume":"7","author":"Prasad","year":"2014","journal-title":"Front. Neuroeng."},{"key":"10.1016\/j.actbio.2025.05.026_bib0160","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.brainres.2009.05.052","article-title":"Toward a comparison of microelectrodes for acute and chronic recordings","volume":"1282","author":"Ward","year":"2009","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0161","doi-asserted-by":"crossref","DOI":"10.1038\/srep42964","article-title":"Image processing in digital pathology: an opportunity to solve inter-batch variability of immunohistochemical staining","volume":"7","author":"Van Eycke","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.actbio.2025.05.026_bib0162","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/cyto.a.22345","article-title":"Image thresholding techniques for localization of sub-resolution fluorescent biomarkers","volume":"83","author":"Ghaye","year":"2013","journal-title":"Cytometry Part A"},{"key":"10.1016\/j.actbio.2025.05.026_bib0163","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2105-10-94","article-title":"Statistical and visual differentiation of subcellular imaging","volume":"10","author":"Hamilton","year":"2009","journal-title":"BMC. Bioinf."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0164","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/mi13030480","article-title":"Characterization of active electrode yield for intracortical arrays: awake versus anesthesia","volume":"13","author":"Sturgill","year":"2022","journal-title":"Micromachines. (Basel)"},{"issue":"8","key":"10.1016\/j.actbio.2025.05.026_bib0165","doi-asserted-by":"crossref","first-page":"972","DOI":"10.3390\/mi12080972","article-title":"Intracortical microelectrode array unit yield under chronic conditions: a comparative evaluation","volume":"12","author":"Usoro","year":"2021","journal-title":"Micromachines. (Basel)"},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0166","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pneurobio.2007.07.009","article-title":"Brain iron metabolism: neurobiology and neurochemistry","volume":"83","author":"Ke","year":"2007","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0167","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/jnc.14860","article-title":"Microglia and the aging brain: are senescent microglia the key to neurodegeneration?","volume":"151","author":"Angelova","year":"2019","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0168","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12974-023-02932-5","article-title":"Erythrocyte\u2013brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo","volume":"20","author":"Zhang","year":"2023","journal-title":"J. Neuroinflammation."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0169","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s12975-021-00980-8","article-title":"The fate of erythrocytes after cerebral hemorrhage","volume":"13","author":"Xia","year":"2022","journal-title":"Transl. Stroke Res."},{"issue":"9","key":"10.1016\/j.actbio.2025.05.026_bib0170","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.3390\/ijms23094490","article-title":"Iron homeostasis in the CNS: an overview of the pathological consequences of iron metabolism disruption","volume":"23","author":"Porras","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0171","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4155\/fmc.09.140","article-title":"Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders","volume":"2","author":"Mills","year":"2010","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.actbio.2025.05.026_bib0172","first-page":"10","article-title":"Iron-tracking strategies: chaperones capture iron in the cytosolic labile Iron pool","author":"Philpott","year":"2023","journal-title":"Front. Mol. Biosci."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0173","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/s41380-023-02399-z","article-title":"Iron imbalance in neurodegeneration","volume":"29","author":"Levi","year":"2024","journal-title":"Mol. Psychiatry"},{"issue":"31","key":"10.1016\/j.actbio.2025.05.026_bib0174","doi-asserted-by":"crossref","first-page":"12735","DOI":"10.1074\/jbc.R117.786632","article-title":"Iron transport proteins: gateways of cellular and systemic Iron homeostasis","volume":"292","author":"Knutson","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0175","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00401-008-0421-z","article-title":"The pathology of superficial siderosis of the central nervous system","volume":"116","author":"Koeppen","year":"2008","journal-title":"Acta Neuropathol."},{"issue":"12","key":"10.1016\/j.actbio.2025.05.026_bib0176","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1161\/01.STR.0000103140.52838.45","article-title":"Iron and Iron-handling proteins in the brain after intracerebral hemorrhage","volume":"34","author":"Wu","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.actbio.2025.05.026_bib0177","series-title":"Methods in Mouse Atherosclerosis; Andr\u00e9s","first-page":"339","article-title":"Detection of intraplaque hemorrhage in mouse atherosclerotic lesions","author":"Sluimer","year":"2015"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0178","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10571-021-01175-3","article-title":"The critical role of erythrolysis and microglia\/macrophages in clot resolution after intracerebral hemorrhage: a review of the mechanisms and potential therapeutic targets","volume":"43","author":"Zheng","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"issue":"95","key":"10.1016\/j.actbio.2025.05.026_bib0179","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2014.0165","article-title":"Ferrous iron formation following the Co-aggregation of ferric iron and the Alzheimer\u2019s disease peptide \u03b2-amyloid (1\u201342)","volume":"11","author":"Everett","year":"2014","journal-title":"J. Royal Society Interface"},{"key":"10.1016\/j.actbio.2025.05.026_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117080","article-title":"The influence of iron oxidation state on quantitative MRI parameters in post mortem Human brain","volume":"220","author":"Birkl","year":"2020","journal-title":"Neuroimage"},{"issue":"16","key":"10.1016\/j.actbio.2025.05.026_bib0181","doi-asserted-by":"crossref","first-page":"eade7622","DOI":"10.1126\/sciadv.ade7622","article-title":"Simultaneous Fe2+\/Fe3+ imaging shows Fe3+ over Fe2+ enrichment in Alzheimer\u2019s disease mouse brain","volume":"9","author":"Wu","year":"2023","journal-title":"Sci. Adv."},{"issue":"14","key":"10.1016\/j.actbio.2025.05.026_bib0182","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.3390\/cells11142152","article-title":"Iron-induced oxidative stress in Human diseases","volume":"11","author":"Kawabata","year":"2022","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.actbio.2025.05.026_bib0183","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118535","article-title":"Iron homeostasis and oxidative stress: an intimate relationship","volume":"1866","author":"Galaris","year":"2019","journal-title":"Biochimica et Biophysica Acta (BBA) - Mol. Cell Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0184","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/cns.13069","article-title":"Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice","volume":"25","author":"Xie","year":"2019","journal-title":"CNS. Neurosci. Ther."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0185","doi-asserted-by":"crossref","DOI":"10.1177\/1759091416670978","article-title":"Enhanced histochemical detection of iron in paraffin sections of mouse Central nervous system tissue: application in the APP\/PS1 mouse model of Alzheimer\u2019s disease","volume":"8","author":"Sands","year":"2016","journal-title":"ASN. Neuro"},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0186","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10072-012-1090-1","article-title":"Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury","volume":"34","author":"Zhang","year":"2013","journal-title":"Neurol. Sci."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0187","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1161\/STROKEAHA.108.539536","article-title":"Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets","volume":"40","author":"Gu","year":"2009","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0188","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/acs.molpharmaceut.0c00474","article-title":"Challenges and opportunities of deferoxamine delivery for treatment of Alzheimer\u2019s disease, Parkinson\u2019s disease, and intracerebral hemorrhage","volume":"18","author":"Farr","year":"2021","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2025.05.026_bib0189","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148383","article-title":"Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury","volume":"1812","author":"Jia","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.actbio.2025.05.026_bib0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110878","article-title":"Deferoxamine reduces endothelial ferroptosis and protects cerebrovascular function after experimental traumatic brain injury","volume":"207","author":"Liang","year":"2024","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.actbio.2025.05.026_bib0191","doi-asserted-by":"crossref","unstructured":"Nakamura, T.; Keep, R.F.; Hua, Y.; Schallert, T.; Hoff, J.T.; Xi, G. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. 2003. https:\/\/doi.org\/10.3171\/foc.2003.15.4.10.","DOI":"10.3171\/foc.2003.15.4.10"},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0192","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/STROKEAHA.109.569830","article-title":"Deferoxamine treatment for intracerebral hemorrhage in aged rats","volume":"41","author":"Okauchi","year":"2010","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0193","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1021\/acsnano.7b08172","article-title":"Targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in parkinsonian mice","volume":"12","author":"You","year":"2018","journal-title":"ACS. Nano"},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0194","first-page":"239","article-title":"A review on iron chelators in treatment of iron overload syndromes","volume":"10","author":"Mobarra","year":"2016","journal-title":"Int. J. Hematol. Oncol. Stem Cell Res."},{"issue":"7","key":"10.1016\/j.actbio.2025.05.026_bib0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133050","article-title":"A speciation study on the perturbing effects of iron chelators on the homeostasis of essential metal ions","volume":"10","author":"Crisponi","year":"2015","journal-title":"PLoS. One"},{"issue":"7","key":"10.1016\/j.actbio.2025.05.026_bib0196","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/jcp.47.7.657","article-title":"Zinc concentration in patients with iron overload receiving oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one or desferrioxamine","volume":"47","author":"al-Refaie","year":"1994","journal-title":"J. Clin. Pathol."},{"issue":"13","key":"10.1016\/j.actbio.2025.05.026_bib0197","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1182\/blood.V98.13.3831","article-title":"Cellular zinc content is a major determinant of iron chelator-induced apoptosis of thymocytes","volume":"98","author":"Maclean","year":"2001","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.actbio.2025.05.026_bib0198","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3390\/antiox10111715","article-title":"Oxidative stress and energy metabolism in the brain: midlife as a turning point","volume":"10","author":"Lushchak","year":"2021","journal-title":"Antioxidants"},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0199","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/jnc.14654","article-title":"The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A","volume":"148","author":"Stepanova","year":"2019","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0200","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"Lambeth","year":"2004","journal-title":"Nature Rev. Immunol."},{"issue":"17","key":"10.1016\/j.actbio.2025.05.026_bib0201","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1089\/ars.2013.5703","article-title":"New insights on NOX enzymes in the central nervous system","volume":"20","author":"Nayernia","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"issue":"14","key":"10.1016\/j.actbio.2025.05.026_bib0202","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1007\/s00018-012-1015-4","article-title":"Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors","volume":"69","author":"Surace","year":"2012","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0203","doi-asserted-by":"crossref","unstructured":"Ma, M.; Wang, J.; Zhang, Q.; Wang, R.; Dhandapani, K.; Vadlamudi, R.; Brann, D. NADPH oxidase in brain injury and neurodegenerative disorders. Mol. Neurodegener. 12AD, 12. https:\/\/doi.org\/10.1186\/s13024-017-0150-7.","DOI":"10.1186\/s13024-017-0150-7"},{"issue":"12","key":"10.1016\/j.actbio.2025.05.026_bib0204","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.3390\/ijms19123824","article-title":"The role of NADPH oxidases and oxidative stress in neurodegenerative disorders","volume":"19","author":"Tarafdar","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0205","article-title":"Oxidative stress-mediated blood-brain barrier (BBB) disruption in neurological diseases","volume":"2020","author":"Song","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.actbio.2025.05.026_bib0206","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.freeradbiomed.2023.03.001","article-title":"Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration","volume":"200","author":"Tu","year":"2023","journal-title":"Free Radical Biol. Med."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0207","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1074\/jbc.C200613200","article-title":"Two novel proteins activate superoxide generation by the NADPH oxidase NOX1*","volume":"278","author":"B\u00e1nfi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2025.05.026_bib0208","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u03bab in oxidative stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0209","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuroscience.2004.12.038","article-title":"Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia","volume":"132","author":"Vallet","year":"2005","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0210","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.actbio.2025.05.026_bib0211","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1742-2094-10-155","article-title":"Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury","volume":"10","author":"Cooney","year":"2013","journal-title":"J. Neuroinflammation."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0212","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1742-2094-7-41","article-title":"Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury","volume":"7","author":"Dohi","year":"2010","journal-title":"J. Neuroinflammation."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0213","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1038\/s41467-022-33711-0","article-title":"Structure of the core human NADPH oxidase NOX2","volume":"13","author":"Noreng","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.05.026_bib0214","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mcn.2016.10.001","article-title":"NADPH oxidase isoform expression is temporally regulated and may contribute to microglial\/macrophage polarization after spinal cord injury","volume":"77","author":"Bermudez","year":"2016","journal-title":"Molecular Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0215","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/jcbfm.2010.166","article-title":"Nadph oxidase mediates striatal neuronal injury after transient global cerebral ischemia","volume":"31","author":"Yoshioka","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"5","key":"10.1016\/j.actbio.2025.05.026_bib0216","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/ars.2014.5862","article-title":"NOX2 As a target for drug development: indications, possible complications, and progress","volume":"23","author":"Diebold","year":"2015","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.actbio.2025.05.026_bib0217","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1038\/s41598-017-09202-4","article-title":"The NADPH oxidase NOX2 mediates loss of parvalbumin interneurons in traumatic brain injury: human autoptic immunohistochemical evidence","volume":"7","author":"Schiavone","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.05.026_bib0218","first-page":"6","article-title":"The role of iron regulation in immunometabolism and immune-related disease","author":"Cronin","year":"2019","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0219","first-page":"9","article-title":"Therapeutic targeting of microglia mediated oxidative stress after neurotrauma","author":"Smith","year":"2022","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0220","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1080\/10715762.2017.1311015","article-title":"Involvement of Nox2 and Nox4 NADPH oxidases in early brain injury after subarachnoid hemorrhage","volume":"51","author":"Zhang","year":"2017","journal-title":"Free Radic. Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0221","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/12\/4\/046002","article-title":"Implications of chronic daily anti-oxidant administration on the inflammatory response to intracortical microelectrodes","volume":"12","author":"Potter-Baker","year":"2015","journal-title":"J. Neural Eng."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0222","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/10590500902885684","article-title":"8-Hydroxy-2\u2032 -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis","volume":"27","author":"VALAVANIDIS","year":"2009","journal-title":"J. Environ. Sci. Health, Part C"},{"key":"10.1016\/j.actbio.2025.05.026_bib0223","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107187","article-title":"The role of DNA and RNA guanosine oxidation in cardiovascular diseases","volume":"204","author":"Li","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"20","key":"10.1016\/j.actbio.2025.05.026_bib0224","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015240","article-title":"Chemical insights into oxidative and nitrative modifications of DNA","volume":"24","author":"Andr\u00e9s","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0225","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1097\/01.TA.0000130759.62286.0E","article-title":"Oxidative DNA lesions in a rodent model of traumatic brain injury","volume":"56","author":"Mendez","year":"2004","journal-title":"J. Trauma Acute Care Surg."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0226","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24759","article-title":"Ginkgolide a attenuated apoptosis via inhibition of oxidative stress in mice with traumatic brain injury","volume":"10","author":"Zhu","year":"2024","journal-title":"Heliyon."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0227","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/STROKEAHA.107.486654","article-title":"Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage","volume":"39","author":"Nakamura","year":"2008","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0228","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pneurobio.2006.11.009","article-title":"Advances in the treatment of Parkinson\u2019s disease","volume":"81","author":"Singh","year":"2007","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0229","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/labinvest.3780028","article-title":"Age and organ dependent spontaneous generation of nuclear 8-hydroxydeoxyguanosine in male Fischer 344 rats","volume":"80","author":"Nakae","year":"2000","journal-title":"Lab. Invest."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0230","first-page":"3371","article-title":"Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: implications for central presbycusis","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.actbio.2025.05.026_bib0231","doi-asserted-by":"crossref","unstructured":"Farooqui, A. A. Chapter 4 - contribution of nucleic acids in the pathogenesis of Alzheimer\u2019s disease. In Neurochemical Aspects of Alzheimer\u2019s Disease; Farooqui, A. A., Ed.; Academic Press, 2017; pp 129\u2013162. https:\/\/doi.org\/10.1016\/B978-0-12-809937-7.00004-5.","DOI":"10.1016\/B978-0-12-809937-7.00004-5"},{"issue":"9","key":"10.1016\/j.actbio.2025.05.026_bib0232","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.neurobiolaging.2006.06.008","article-title":"Alzheimer\u2019 s disease, oxidative stress and gammahydroxybutyrate","volume":"28","author":"Mamelak","year":"2007","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0233","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejphar.2006.06.026","article-title":"Oxidative stress in Alzheimer\u2019s disease brain: new insights from redox proteomics","volume":"545","author":"Butterfield","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.actbio.2025.05.026_bib0234","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnana.2020.00030","article-title":"Differential susceptibility and vulnerability of brain cells in C57BL\/6 mouse to mitochondrial dysfunction induced by short-term cuprizone exposure","volume":"14","author":"Luo","year":"2020","journal-title":"Front. Neuroanat."},{"issue":"11\u201312","key":"10.1016\/j.actbio.2025.05.026_bib0235","first-page":"859","article-title":"Plasma and urinary HPLC-ED determination of the ratio of 8-OHdG\/2-dG in Parkinson\u2019s disease","volume":"57","author":"Bolner","year":"2011","journal-title":"Clin. Lab."},{"key":"10.1016\/j.actbio.2025.05.026_bib0236","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1874205X01206010051","article-title":"The relation of urinary 8-OHdG, a marker of oxidative stress to DNA, and clinical outcomes for ischemic stroke","volume":"6","author":"Nakajima","year":"2012","journal-title":"Open. Neurol. J."},{"issue":"5\u20136","key":"10.1016\/j.actbio.2025.05.026_bib0237","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000237221","article-title":"Zerr, I. 8-OHdG in cerebrospinal fluid as a marker of oxidative stress in various neurodegenerative diseases","volume":"6","author":"Gmitterov\u00e1","year":"2009","journal-title":"Neurodegener. Dis."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0238","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0891-5849(00)00185-4","article-title":"Fluorescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant fab and confocal scanning laser microscopy","volume":"28","author":"Soultanakis","year":"2000","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.actbio.2025.05.026_bib0239","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.freeradbiomed.2023.02.015","article-title":"Nox4-and Tf\/TfR-mediated peroxidation and iron overload exacerbate neuronal ferroptosis after intracerebral hemorrhage: involvement of EAAT3 dysfunction","volume":"199","author":"Xie","year":"2023","journal-title":"Free Radical Biol. Med."},{"issue":"7","key":"10.1016\/j.actbio.2025.05.026_bib0240","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.mad.2008.02.001","article-title":"Brain capacity for repair of oxidatively damaged DNA and preservation of neuronal function","volume":"129","author":"Englander","year":"2008","journal-title":"Mech. Ageing Dev."},{"issue":"3\u20136","key":"10.1016\/j.actbio.2025.05.026_bib0241","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/10715768909087933","article-title":"Endogenous oxidative DNA damage, aging, and cancer","volume":"7","author":"Ames","year":"1989","journal-title":"Free Radic. Res. Commun."},{"issue":"12","key":"10.1016\/j.actbio.2025.05.026_bib0242","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1073\/pnas.0307446101","article-title":"Nitric oxide, oxidants, and protein tyrosine nitration","volume":"101","author":"Radi","year":"2004","journal-title":"Proc. National Acad. Sci."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0243","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/ar300234c","article-title":"Protein tyrosine nitration: biochemical mechanisms and structural basis of its functional effects","volume":"46","author":"Radi","year":"2013","journal-title":"Acc. Chem. Res."},{"issue":"23","key":"10.1016\/j.actbio.2025.05.026_bib0244","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1523\/JNEUROSCI.1038-06.2006","article-title":"Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells","volume":"26","author":"Blanchard-Fillion","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.actbio.2025.05.026_bib0245","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.brainres.2007.02.084","article-title":"Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer\u2019s disease","volume":"1148","author":"Butterfield","year":"2007","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0246","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(02)03280-8","article-title":"Aberrant expression of NOS isoforms in Alzheimer\u2019s disease is structurally related to nitrotyrosine formation","volume":"953","author":"L\u00fcth","year":"2002","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0247","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-5728(97)00013-1","article-title":"Extensive peroxynitrite activity during progressive stages of Central nervous system inflammation","volume":"77","author":"van der Veen","year":"1997","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0248","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-0173(99)00014-4","article-title":"Neurodegenerative disorders: the role of peroxynitrite","volume":"30","author":"Torreilles","year":"1999","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"6","key":"10.1016\/j.actbio.2025.05.026_bib0249","first-page":"1427","article-title":"Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats","volume":"43","author":"Wada","year":"1998","journal-title":"Neurosurgery."},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0250","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12079-021-00663-x","article-title":"The modulation of neuroinflammation by inducible nitric oxide synthase","volume":"16","author":"Justo","year":"2022","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.actbio.2025.05.026_bib0251","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101581","article-title":"Chemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-\u03bab: implications for the health effects of air pollution and oxidative stress","volume":"37","author":"Ziegler","year":"2020","journal-title":"Redox. Biol."},{"issue":"16","key":"10.1016\/j.actbio.2025.05.026_bib0252","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1002\/jnr.22510","article-title":"Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury","volume":"88","author":"Readnower","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"10","key":"10.1016\/j.actbio.2025.05.026_bib0253","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1038\/jcbfm.2008.66","article-title":"L-arginine decreases fluid-percussion injury-induced neuronal nitrotyrosine immunoreactivity in rats","volume":"28","author":"Avila","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"12","key":"10.1016\/j.actbio.2025.05.026_bib0254","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/prca.201600004","article-title":"Neuroproteomic study of nitrated proteins in moderate traumatic brain injured rats treated with gamma glutamyl cysteine ethyl ester administration post injury: insight into the role of glutathione elevation in nitrosative stress","volume":"10","author":"Henderson","year":"2016","journal-title":"Proteomics. Clin. Appl."},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2005.08.015","article-title":"Response of brain tissue to chronically implanted neural electrodes","volume":"148","author":"Polikov","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.actbio.2025.05.026_bib0256","first-page":"13","article-title":"Revealing spatial and temporal patterns of cell death, glial proliferation, and blood-brain barrier dysfunction around implanted intracortical neural interfaces","author":"Wellman","year":"2019","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.actbio.2025.05.026_bib0257","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1088\/1741-2560\/3\/3\/002","article-title":"Effects of insertion conditions on tissue strain and vascular damage during neuroprosthetic device insertion","volume":"3","author":"Bjornsson","year":"2006","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.actbio.2025.05.026_bib0258","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119831","article-title":"Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation","volume":"238","author":"Welle","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2025.05.026_bib0259","article-title":"Longitudinal multimodal assessment of neurodegeneration and vascular remodeling correlated with signal degradation in chronic cortical silicon microelectrodes","volume":"7","author":"Solarana","year":"2020","journal-title":"NPh"},{"key":"10.1016\/j.actbio.2025.05.026_bib0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121060","article-title":"Long-term in vivo two-photon imaging of the neuroinflammatory response to intracortical implants and micro-vessel disruptions in awake mice","volume":"276","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2025.05.026_bib0261","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/aps.2017.113","article-title":"Iron dysregulates APP processing accompanying with sAPP\u03b1 cellular retention and \u03b2-secretase inhibition in rat cortical neurons","volume":"39","author":"Chen","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.actbio.2025.05.026_bib0262","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1109\/TBME.2009.2018457","article-title":"In vivo electrical impedance spectroscopy of tissue reaction to microelectrode arrays","volume":"56","author":"Mercanzini","year":"2009","journal-title":"IEEE Trans. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.actbio.2025.05.026_bib0263","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1088\/1741-2560\/4\/4\/007","article-title":"Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants","volume":"4","author":"Williams","year":"2007","journal-title":"J. Neural Eng."},{"issue":"8","key":"10.1016\/j.actbio.2025.05.026_bib0264","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.4103\/1673-5374.274344","article-title":"Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons","volume":"15","author":"Zhang","year":"2020","journal-title":"Neural Regen. Res."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125003496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125003496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:59:56Z","timestamp":1778824796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125003496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":264,"alternative-id":["S1742706125003496"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.05.026","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of iron accumulation and its chelation on oxidative stress in intracortical implants","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}