{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:30:51Z","timestamp":1791574251881,"version":"4.3.4"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD018516"],"award-info":[{"award-number":["S10OD018516"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32OD011000"],"award-info":[{"award-number":["T32OD011000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD025049"],"award-info":[{"award-number":["S10OD025049"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10RR025502"],"award-info":[{"award-number":["S10RR025502"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007231","name":"Cornell University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","award":["C029155"],"award-info":[{"award-number":["C029155"]}],"id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE \\u2013 2139899"],"award-info":[{"award-number":["DGE \\u2013 2139899"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.actbio.2025.05.031","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T13:15:39Z","timestamp":1746796539000},"page":"313-325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Multiscale characterization of ultrasmall fluorescent core-shell silica nanoparticles in cartilage and synovial joints reveals rapid cartilage penetration and sustained joint residence"],"prefix":"10.1016","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0338-5644","authenticated-orcid":false,"given":"Aiyana G.","family":"Fortin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Naguib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-5444","authenticated-orcid":false,"given":"Erica J.","family":"Secor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi L.","family":"Reesink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-3755","authenticated-orcid":false,"given":"Ulrich B.","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence J.","family":"Bonassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.05.031_bib0001","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2025.05.031_bib0002","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.3390\/jcm11143958","article-title":"Relative efficacy and safety of anti-inflammatory biologic agents for osteoarthritis: a conventional and network meta-analysis","volume":"11","author":"Li","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.actbio.2025.05.031_bib0003","article-title":"Comparison of the effectiveness of intra-articular infiltration of hyaluronic acid and corticosteroids in the management of knee osteoarthritis: a prospective comparative study","volume":"15","author":"Khan","year":"2023","journal-title":"Cureus."},{"key":"10.1016\/j.actbio.2025.05.031_bib0004","article-title":"Corticosteroid injection of the knee within one month prior to meniscus repair increases the risk of repair failure requiring meniscectomy","author":"Zhang","year":"2023","journal-title":"Phys Sport."},{"key":"10.1016\/j.actbio.2025.05.031_bib0005","first-page":"S101","article-title":"Viscosupplementation: techniques, indications, results","volume":"101","author":"Legr\u00e9-Boyer","year":"2015","journal-title":"Orthop. Traumatol.: Surg. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/JSM.0000000000000274","article-title":"AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes","volume":"26","author":"Trojian","year":"2016","journal-title":"Clin. J. Sport Med."},{"key":"10.1016\/j.actbio.2025.05.031_bib0007","doi-asserted-by":"crossref","unstructured":"E.J. Strauss, J.A. Hart, M.D. Miller, R.D. Altman, J.E. Rosen, Hyaluronic acid viscosupplementation and osteoarthritis, https:\/\/doi.org\/10.1177\/0363546508326984 37 (2009) 1636\u20131644. https:\/\/doi.org\/10.1177\/0363546508326984.","DOI":"10.1177\/0363546508326984"},{"key":"10.1016\/j.actbio.2025.05.031_bib0008","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/art.24096","article-title":"Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study","volume":"61","author":"Chevalier","year":"2009","journal-title":"Arthritis Care Res (Hob.)"},{"key":"10.1016\/j.actbio.2025.05.031_bib0009","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/0300060517723182","article-title":"Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: an open-label randomized controlled trial","volume":"46","author":"Wang","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0010","doi-asserted-by":"crossref","first-page":"R206","DOI":"10.1186\/ar4044","article-title":"Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee","volume":"14","author":"Maksymowych","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.actbio.2025.05.031_bib0011","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.joca.2011.12.009","article-title":"Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254)","volume":"20","author":"Kraus","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.05.031_bib0012","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1600-065X.1995.tb00070.x","article-title":"Monoclonal anti-tnf\u03b1 antibody as a probe of pathogenesis and therapy of rheumatoid disease","volume":"144","author":"Maini","year":"1995","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.actbio.2025.05.031_bib0013","first-page":"13","article-title":"Pharmacologic therapy for osteoarthritis\u2014The era of disease modification","author":"Hunter","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0014","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis, an inflammatory disease potential implication for the selection of new therapeutic targets","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2025.05.031_bib0015","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1517\/14728214.2011.576670","article-title":"Emerging drugs for osteoarthritis","volume":"16","author":"Matthews","year":"2011","journal-title":"Expert. Opin. Emerg. Drugs"},{"key":"10.1016\/j.actbio.2025.05.031_bib0016","doi-asserted-by":"crossref","DOI":"10.1115\/1.4041768","article-title":"The effect of charge and mechanical loading on antibody diffusion through the articular surface of cartilage","volume":"141","author":"DiDomenico","year":"2019","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2025.05.031_bib0017","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41584-018-0033-5","article-title":"Molecular transport in articular cartilage - what have we learned from the past 50 years?","volume":"14","author":"Didomenico","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0018","doi-asserted-by":"crossref","DOI":"10.1115\/1.4037202","article-title":"The effect of antibody size and mechanical loading on solute diffusion through the articular surface of cartilage","volume":"139","author":"Didomenico","year":"2017","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2025.05.031_bib0019","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/jor.22630","article-title":"Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints","volume":"32","author":"Bajpayee","year":"2014","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrrheum.2016.210","article-title":"Cartilage-targeting drug delivery: can electrostatic interactions help?","volume":"13","author":"Bajpayee","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0021","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/BOR.0000000000000761","article-title":"Recent advances in targeted drug delivery for treatment of osteoarthritis","volume":"33","author":"Mehta","year":"2021","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0022","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.actbio.2018.12.004","article-title":"Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues","volume":"93","author":"Vedadghavami","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0023","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.joca.2021.05.060","article-title":"Sliding contact accelerates solute transport into the cartilage surface compared to axial loading","volume":"29","author":"Culliton","year":"2021","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.05.031_bib0024","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jconrel.2019.12.020","article-title":"Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs","volume":"318","author":"He","year":"2020","journal-title":"J. Control Release"},{"key":"10.1016\/j.actbio.2025.05.031_bib0025","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.actbio.2022.08.010","article-title":"Charge-based drug delivery to cartilage: hydrophobic and not electrostatic interactions are the dominant cause of competitive binding of cationic carriers in synovial fluid","volume":"151","author":"Vedadghavami","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0026","doi-asserted-by":"crossref","DOI":"10.1177\/23259671231155950","article-title":"A review of recent innovations in cartilage regeneration strategies for the treatment of primary osteoarthritis of the knee intra-articular injections","author":"Householder","year":"2023","journal-title":"Orthop. J. Sports Med."},{"key":"10.1016\/j.actbio.2025.05.031_bib0027","doi-asserted-by":"crossref","unstructured":"M. Cao, M.T.Y. Ong, P.S.H. Yung YZ, R.S. Tuan Z X, Y. Jiang Y Z, Role of synovial lymphatic function in osteoarthritis, (2022). https:\/\/doi.org\/10.1016\/j.joca.2022.04.003.","DOI":"10.1016\/j.joca.2022.04.003"},{"key":"10.1016\/j.actbio.2025.05.031_bib0028","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tvjl.2010.09.019","article-title":"Intra-articular drug delivery: the challenge to extend drug residence time within the joint","volume":"190","author":"Edwards","year":"2011","journal-title":"Vet. J."},{"key":"10.1016\/j.actbio.2025.05.031_bib0029","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrrheum.2013.159","article-title":"Progress in intra-articular therapy","volume":"10","author":"Evans","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0030","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.actbio.2019.04.025","article-title":"Endothelin-1 inhibits size dependent lymphatic clearance of PEG-based conjugates after intra-articular injection into the rat knee","volume":"93","author":"Doan","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0031","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/jor.22841","article-title":"A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage","volume":"33","author":"Bajpayee","year":"2015","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0032","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1113\/expphysiol.1991.sp003474","article-title":"Fraser, turnover of hyaluronan in synovial joints: elimination of labelled hyaluronan from the knee joint of the rabbit","volume":"76","author":"Brown","year":"1991","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0033","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2165\/00003088-200241080-00004","article-title":"Elimination of stabilised hyaluronan from the knee joint in healthy men","volume":"41","author":"Lindqvist","year":"2002","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.actbio.2025.05.031_bib0034","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.joca.2018.07.006","article-title":"How can 50 years of solute transport data in articular cartilage inform the design of arthritis therapeutics?","volume":"26","author":"DiDomenico","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.05.031_bib0035","series-title":"The Mathematics of Diffusion","author":"Crank","year":"1975"},{"key":"10.1016\/j.actbio.2025.05.031_bib0036","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2018.05.029","article-title":"Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints","volume":"283","author":"Mwangi","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.05.031_bib0037","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/jor.25245","article-title":"Assessment of osteoarthritis functional outcomes and intra-articular injection volume in the rat anterior cruciate ligament transection model","volume":"40","author":"Wang","year":"2022","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0038","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.actbio.2019.03.010","article-title":"Intra-articular targeting of nanomaterials for the treatment of osteoarthritis","volume":"93","author":"Brown","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0039","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.1021\/acsbiomaterials.0c00960","article-title":"Articular cartilage- and synoviocyte-binding poly(ethylene glycol) nanocomposite microgels as intra-Articular drug delivery vehicles for the treatment of osteoarthritis","volume":"6","author":"Mancipe Castro","year":"2020","journal-title":"ACS. Biomater. Sci. Eng."},{"key":"10.1016\/j.actbio.2025.05.031_bib0040","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat8800","article-title":"Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis","volume":"10","author":"Geiger","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2025.05.031_bib0041","doi-asserted-by":"crossref","first-page":"9984","DOI":"10.1016\/j.biomaterials.2014.08.042","article-title":"Intra-articular delivery of kartogenin-conjugated chitosan nano\/microparticles for cartilage regeneration","volume":"35","author":"Kang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.05.031_bib0042","doi-asserted-by":"crossref","first-page":"7665","DOI":"10.1016\/j.biomaterials.2012.06.101","article-title":"Self-assembling nanoparticles for intra-articular delivery of anti-inflammatory proteins","volume":"33","author":"Whitmire","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.05.031_bib0043","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2015.12.015","article-title":"Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice","volume":"498","author":"Pradal","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2025.05.031_bib0044","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijpharm.2015.02.059","article-title":"Synthesis and characterization of silk fibroin microparticles for intra-articular drug delivery","volume":"485","author":"Mwangi","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2025.05.031_bib0045","first-page":"5263","article-title":"Cationic PLGA\/eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint","volume":"10","author":"Kim","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2025.05.031_bib0046","doi-asserted-by":"crossref","DOI":"10.1021\/nn504537b","article-title":"Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes","volume":"8","author":"Sacchetti","year":"2014","journal-title":"ACS. Nano"},{"key":"10.1016\/j.actbio.2025.05.031_bib0047","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5312\/wjo.v5.i3.351","article-title":"Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis","volume":"5","author":"Ayhan","year":"2014","journal-title":"World J. Orthop."},{"key":"10.1016\/j.actbio.2025.05.031_bib0048","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1002\/jps.21346","article-title":"Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders","volume":"97","author":"Larsen","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.actbio.2025.05.031_bib0049","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009524","article-title":"Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe","volume":"6","author":"Phillips","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2025.05.031_bib0050","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.1936","article-title":"Use of Ultrasmall core-shell fluorescent silica nanoparticles for image-guided sentinel lymph node biopsy in head and neck melanoma: a nonrandomized clinical trial","volume":"4","author":"Zanoni","year":"2021","journal-title":"JAMa Netw. Open."},{"key":"10.1016\/j.actbio.2025.05.031_bib0051","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1021\/acs.chemmater.1c04447","article-title":"Molecular engineering of surface functional groups enabling clinical translation of nanoparticle-drug conjugates","volume":"34","author":"Wu","year":"2022","journal-title":"Chem. Mater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0052","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1039\/c2ib20174g","article-title":"Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions","volume":"5","author":"Bradbury","year":"2013","journal-title":"Integr. Biol. (Camb)"},{"key":"10.1016\/j.actbio.2025.05.031_bib0053","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202305937","article-title":"Overcoming barriers associated with oral delivery of differently sized fluorescent core-shell silica nanoparticles","volume":"36","author":"Erstling","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0054","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1021\/cm7026866","article-title":"Silica nanoparticle architecture determines radiative properties of encapsulated fluorophores","volume":"20","author":"Larson","year":"2008","journal-title":"Chem. Mater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0055","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/marc.200900389","article-title":"Large stokes-shift fluorescent silica nanoparticles with enhanced emission over free dye for single excitation multiplexing","volume":"30","author":"Herz","year":"2009","journal-title":"Macromol. Rapid. Commun."},{"key":"10.1016\/j.actbio.2025.05.031_bib0056","doi-asserted-by":"crossref","first-page":"9813","DOI":"10.1021\/acs.jpcc.9b00297","article-title":"Dye encapsulation in fluorescent core-shell silica nanoparticles as probed by fluorescence correlation spectroscopy","volume":"123","author":"Kohle","year":"2019","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.actbio.2025.05.031_bib0057","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1021\/acs.chemmater.6b00030","article-title":"Elucidating the mechanism of silica nanoparticle PEGylation processes using fluorescence correlation spectroscopies","volume":"28","author":"Ma","year":"2016","journal-title":"Chem. Mater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0058","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1021\/acs.chemmater.5b01222","article-title":"Control of ultrasmall sub-10 nm ligand-functionalized fluorescent core-shell silica nanoparticle growth in water","volume":"27","author":"Ma","year":"2015","journal-title":"Chem. Mater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0059","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1021\/acs.chemmater.7b03033","article-title":"Cancer-targeting ultrasmall silica nanoparticles for clinical translation: physicochemical structure and biological property correlations","volume":"29","author":"Chen","year":"2017","journal-title":"Chem. Mater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0060","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1021\/acs.chemmater.7b02009","article-title":"Modular and orthogonal post-PEGylation surface modifications by insertion enabling penta-functional ultrasmall organic-silica hybrid nanoparticles","volume":"29","author":"Ma","year":"2017","journal-title":"Chem. Mater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0061","article-title":"Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.05.031_bib0062","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/wnan.1380","article-title":"Intraoperative mapping of sentinel lymph node metastases using a clinically translated ultrasmall silica nanoparticle","volume":"8","author":"Bradbury","year":"2016","journal-title":"Wiley. Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0063","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jbiomech.2018.10.019","article-title":"Measurement of local diffusion and composition in degraded articular cartilage reveals the unique role of surface structure in controlling macromolecular transport","volume":"82","author":"DiDomenico","year":"2019","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2025.05.031_bib0064","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1002\/jor.24936","article-title":"Cartilage articulation exacerbates chondrocyte damage and death after impact injury","volume":"39","author":"Ayala","year":"2021","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0065","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/jor.24567","article-title":"Mitoprotective therapy prevents rapid, strain-dependent mitochondrial dysfunction after articular cartilage injury","volume":"38","author":"Bartell","year":"2020","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0066","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00011-020-01317-1","article-title":"Thirty days after anterior cruciate ligament transection is sufficient to induce signs of knee osteoarthritis in rats: pain, functional impairment, and synovial inflammation","volume":"69","author":"Barbosa","year":"2020","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0067","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/jcpt.13669","article-title":"Pharmacokinetics, safety and efficacy of intra-articular non-steroidal anti-inflammatory drug injections for the treatment of osteoarthritis: a narrative review","volume":"47","author":"Selig","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.actbio.2025.05.031_bib0068","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jor.24191","article-title":"Two compartment pharmacokinetic model describes the intra-articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig","volume":"37","author":"Hurtig","year":"2019","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122026","article-title":"Rat synovial tissue and blood rapamycin pharmacokinetics after intra-articular injection of free solution or nanoparticles vs free rapamycin intravenous shot","volume":"624","author":"Pape","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actbio.2025.05.031_bib0070","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.05.031_bib0071","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.05.031_bib0072","unstructured":"Ulrich B. Wiesner, Kai Ma, Carlie Mendoza, Ultrasmall nanoparticles and methods of making and using same, US2018\/0133346A1, 2018."},{"key":"10.1016\/j.actbio.2025.05.031_bib0073","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2217\/nnm-2017-0335","article-title":"Chondrocyte affinity peptide modified PAMAM conjugate as a nanoplatform for targeting and retention in cartilage","volume":"13","author":"Hu","year":"2018","journal-title":"Nanomed. (L.)"},{"key":"10.1016\/j.actbio.2025.05.031_bib0074","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1290871","article-title":"Cell uptake and intracellular trafficking of bioreducible poly(amidoamine) nanoparticles for efficient mRNA translation in chondrocytes","volume":"11","author":"Pontes","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0075","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmat2116","article-title":"Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage","volume":"7","author":"Rothenfluh","year":"2008","journal-title":"Nat. Mater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0076","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1021\/acs.molpharmaceut.1c00066","article-title":"Cellular uptake of three different nanoparticles in an inflammatory arthritis scenario versus normal conditions","volume":"18","author":"Lima","year":"2021","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2025.05.031_bib0077","doi-asserted-by":"crossref","first-page":"9751","DOI":"10.1126\/scitranslmed.adh9751","article-title":"Chondrocyte membrane-coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis","volume":"16","author":"Deng","year":"2024","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.actbio.2025.05.031_bib0078","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bone.2005.08.007","article-title":"Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis","volume":"38","author":"Hayami","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2025.05.031_bib0079","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.joca.2007.10.001","article-title":"Solute transport in the deep and calcified zones of articular cartilage","volume":"16","author":"Arkill","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.05.031_bib0080","first-page":"1","article-title":"Characterization of intra-cartilage transport properties of cationic peptide carriers","volume":"2020","author":"Vedadghavami","year":"2020","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.actbio.2025.05.031_bib0081","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1021\/acsbiomaterials.0c01081","article-title":"Osteoarthritis: new strategies for transport and drug delivery across length scales","volume":"6","author":"Ngo","year":"2020","journal-title":"ACS. Biomater. Sci. Eng."},{"key":"10.1016\/j.actbio.2025.05.031_bib0082","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119467","article-title":"Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress","volume":"224","author":"Kumar","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.05.031_bib0083","article-title":"Co-polymer carrier with dual advantages of cartilage-penetrating and targeting improves delivery and efficacy of MicroRNA treatment of osteoarthritis","volume":"12","author":"Zhao","year":"2023","journal-title":"Adv Heal. Mater"},{"key":"10.1016\/j.actbio.2025.05.031_bib0084","article-title":"Cyclic mechanical loading enhances transport of antibodies into articular cartilage","volume":"139","author":"Di Domenico","year":"2017","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2025.05.031_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.133018","article-title":"\u03b5-poly-l-lysine as an efficient cartilage penetrating and residing drug carrier with high intraarticular injection safety for treating osteoarthritis","volume":"430","author":"Lin","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.05.031_bib0086","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/acs.molpharmaceut.7b00484","article-title":"Nanoparticle properties for delivery to cartilage: the implications of disease State, synovial fluid, and off-target uptake","volume":"16","author":"Brown","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2025.05.031_bib0087","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1365-2362.1993.tb00731.x","article-title":"Lymphatic clearance of synovial fluid in conscious pigs: the aminoterminal propeptide of type III procollagen","volume":"23","author":"JENSEN","year":"1993","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.actbio.2025.05.031_bib0088","first-page":"107","article-title":"The elimination of alpha 2-macroglobulin complexes from the arthritic joint. An experimental study in dogs","volume":"16","author":"Ekerot","year":"1982","journal-title":"Scand. J. Plast. Reconstr. Surg."},{"key":"10.1016\/j.actbio.2025.05.031_bib0089","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.actbio.2019.10.003","article-title":"Effects of cartilage-targeting moieties on nanoparticle biodistribution in healthy and osteoarthritic joints","volume":"101","author":"Brown","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.05.031_bib0090","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1208\/s12248-011-9315-4","article-title":"Disposition of human recombinant lubricin in naive rats and in a rat model of post-traumatic arthritis after intra-articular or intravenous administration","volume":"14","author":"Vugmeyster","year":"2012","journal-title":"AAPS J."},{"key":"10.1016\/j.actbio.2025.05.031_bib0091","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/art.1780230121","article-title":"Methotrexate pharnacokinetics after intraarticular injection in patients with rheumatoid arthritis","volume":"23","author":"Wigginton","year":"1980","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2025.05.031_bib0092","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1248\/bpb.20.732","article-title":"Metabolic fate of ulinastatin (2); pharmacokinetics in rabbits following intra-articular administration","volume":"20","author":"Ohzawa","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.actbio.2025.05.031_bib0093","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/art.1780150407","article-title":"Significance of xenon-133 clearance rate from canine and human joints","volume":"15","author":"Phelps","year":"1972","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2025.05.031_bib0094","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/ard.27.2.163","article-title":"Radioactive xenon (133Xe) disappearance rates from the synovial cavity of the human knee joint in normal and arthritic subjects","volume":"27","author":"St Onge","year":"1968","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.actbio.2025.05.031_bib0095","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/art.1780100406","article-title":"Disposition and metabolism of intra-articularly injected 4-C14-cortisol in rheumatoid arthritis","volume":"10","author":"Winter","year":"1967","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.actbio.2025.05.031_bib0096","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3109\/17435390.2010.513836","article-title":"Cellular recognition and trafficking of amorphous silica nanoparticles by macrophage scavenger receptor a","volume":"5","author":"Orr","year":"2011","journal-title":"Nanotoxicology."},{"key":"10.1016\/j.actbio.2025.05.031_bib0097","first-page":"12","article-title":"Induced models of osteoarthritis in animal models: a systematic review","author":"Longo","year":"2023","journal-title":"Biol. (Basel)"},{"key":"10.1016\/j.actbio.2025.05.031_bib0098","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/art.38278","article-title":"Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice","volume":"66","author":"Shi","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0099","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1023\/A:1014260513728","article-title":"Size-dependency of DL-lactide\/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium","volume":"19","author":"Horisawa","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0307-742X(21)00336-2","volume":"7","author":"Jayson","year":"1981","journal-title":"Clin. Rheum. Dis."},{"key":"10.1016\/j.actbio.2025.05.031_bib0101","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-014-0448-1","article-title":"Mechanisms of post-traumatic osteoarthritis after ACL injury","volume":"16","author":"Dare","year":"2014","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.actbio.2025.05.031_bib0102","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.joca.2015.08.015","article-title":"Inflammation in joint injury and post-traumatic osteoarthritis","volume":"23","author":"Lieberthal","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.05.031_bib0103","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrrheum.2013.72","article-title":"Post-traumatic osteoarthritis: from mouse models to clinical trials","volume":"9","author":"Little","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.05.031_bib0104","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/s41551-021-00780-3","article-title":"Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage","volume":"5","author":"Bedingfield","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.actbio.2025.05.031_bib0105","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.biomaterials.2013.09.091","article-title":"Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis","volume":"35","author":"Bajpayee","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.05.031_bib0106","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1177\/0363546511417172","article-title":"Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in vitro matrix production","volume":"39","author":"Bonasia","year":"2011","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.actbio.2025.05.031_bib0107","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s10439-020-02717-4","article-title":"Size-dependent effective diffusivity in healthy Human and porcine joint synovium","volume":"49","author":"Guang","year":"2021","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2025.05.031_bib0108","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1158\/1078-0432.CCR-20-0851","article-title":"Molecular engineering of ultrasmall silica nanoparticle-drug conjugates as lung cancer therapeutics","volume":"26","author":"Madajewski","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.actbio.2025.05.031_bib0109","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1021\/nl803405h","article-title":"Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine","volume":"9","author":"Burns","year":"2009","journal-title":"Nano Lett."},{"key":"10.1016\/j.actbio.2025.05.031_bib0110","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/adhm.201400051","article-title":"Nano-engineered particles for enhanced intra-articular retention and delivery of proteins","volume":"3","author":"Singh","year":"2014","journal-title":"Adv Heal. Mater"},{"key":"10.1016\/j.actbio.2025.05.031_bib0111","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12010073","article-title":"Induction of WNT16 via peptide-mRNA nanoparticle-based delivery maintains cartilage homeostasis","volume":"12","author":"Yan","year":"2020","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.actbio.2025.05.031_bib0112","first-page":"46","article-title":"Designing drug delivery systems for articular joints","author":"Geiger","year":"2018","journal-title":"Chem. Eng. Prog."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125003563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125003563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:52:12Z","timestamp":1774860732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125003563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":112,"alternative-id":["S1742706125003563"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.05.031","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiscale characterization of ultrasmall fluorescent core-shell silica nanoparticles in cartilage and synovial joints reveals rapid cartilage penetration and sustained joint residence","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}