{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:34:53Z","timestamp":1792197293149,"version":"4.4.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY031461"],"award-info":[{"award-number":["R01EY031461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY029227"],"award-info":[{"award-number":["R01EY029227"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.actbio.2025.06.007","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T02:36:36Z","timestamp":1749090996000},"page":"297-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Co-delivery of neurotrophic factors and a zinc chelator substantially increases retinal ganglion cell survival and axon protection in the optic nerve crush model"],"prefix":"10.1016","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2716-7452","authenticated-orcid":false,"given":"Huynh Quang Dieu","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-3980","authenticated-orcid":false,"given":"Mi-hyun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-5049","authenticated-orcid":false,"given":"Jozsef","family":"Vigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-0315","authenticated-orcid":false,"given":"Joseph","family":"Brzezinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2429-0188","authenticated-orcid":false,"given":"Lucas","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daewon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.06.007_bib0001","series-title":"Clinical Neuro-Ophthalmology","author":"Miller","year":"2007"},{"issue":"10","key":"10.1016\/j.actbio.2025.06.007_bib0002","first-page":"2967","article-title":"The combined effect of brain-derived neurotrophic factor and a free radical scavenger in experimental glaucoma","volume":"41","author":"Ko","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0003","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exer.2009.02.015","article-title":"Effects of different neurotrophic factors on the survival of retinal ganglion cells after a complete intraorbital nerve crush injury: a quantitative in vivo study","volume":"89","author":"Parrilla-Reverter","year":"2009","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0004","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/bjophthalmol-2014-305969","article-title":"Ciliary neurotrophic factor (CNTF)-mediated ganglion cell survival in a rodent model of non-arteritic anterior ischaemic optic neuropathy (NAION)","volume":"99","author":"Mathews","year":"2015","journal-title":"Br. J. Ophthalmol."},{"issue":"9","key":"10.1016\/j.actbio.2025.06.007_bib0005","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1021\/acsbiomaterials.8b00803","article-title":"Injectable neurotrophic factor delivery system supporting retinal ganglion cell survival and regeneration following optic nerve crush","volume":"4","author":"Laughter","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"12","key":"10.1016\/j.actbio.2025.06.007_bib0006","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2165\/00003088-200140120-00003","article-title":"Delivery of neurotrophic factors to the central nervous system - pharmacokinetic considerations","volume":"40","author":"Thorne","year":"2001","journal-title":"Clin. Pharmacokinet."},{"issue":"12","key":"10.1016\/j.actbio.2025.06.007_bib0007","doi-asserted-by":"crossref","first-page":"7544","DOI":"10.1167\/iovs.13-13045","article-title":"Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury","volume":"54","author":"Mead","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0008","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainres.2004.09.038","article-title":"Intravitreal transplants of Schwann cells and fibroblasts promote the survival of axotomized retinal ganglion cells in rats","volume":"1029","author":"Li","year":"2004","journal-title":"Brain Res."},{"issue":"10","key":"10.1016\/j.actbio.2025.06.007_bib0009","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0042-6989(98)00005-4","article-title":"Functional recovery of vision in regenerated optic nerve fibers","volume":"38","author":"Fukuda","year":"1998","journal-title":"Vis. Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.06.007_bib0010","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/jnr.21545","article-title":"Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve grafting","volume":"86","author":"Lorber","year":"2008","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0011","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.brainres.2003.10.029","article-title":"Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice","volume":"996","author":"Tezel","year":"2004","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0012","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/exnr.1999.7113","article-title":"Nitric oxide synthase inhibition delays axonal degeneration and promotes the survival of axotomized retinal ganglion cells","volume":"158","author":"Koeberle","year":"1999","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0013","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1167\/iovs.04-0832","article-title":"Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix","volume":"46","author":"Guo","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0014","doi-asserted-by":"crossref","first-page":"E209","DOI":"10.1073\/pnas.1616811114","article-title":"Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.actbio.2025.06.007_bib0015","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/jbm.a.35345","article-title":"A heparin-mimicking reverse thermal gel for controlled delivery of positively charged proteins","volume":"103","author":"Pena","year":"2015","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0016","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"issue":"10","key":"10.1016\/j.actbio.2025.06.007_bib0017","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1167\/iovs.13-12683","article-title":"BDNF treatment and extended recovery from optic nerve trauma in the cat","volume":"54","author":"Weber","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.actbio.2025.06.007_bib0018","first-page":"966","article-title":"BDNF enhances retinal ganglion cell survival in cats with optic nerve damage","volume":"42","author":"Chen","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.actbio.2025.06.007_bib0019","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.preteyeres.2012.06.005","article-title":"Promoting optic nerve regeneration","volume":"31","author":"Fischer","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"issue":"5","key":"10.1016\/j.actbio.2025.06.007_bib0020","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.exer.2006.05.019","article-title":"CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion","volume":"83","author":"MacLaren","year":"2006","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0021","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0006-8993(00)02305-2","article-title":"Upregulation of ciliary neurotrophic factor in reactive Muller cells in the rat retina following optic nerve transection","volume":"868","author":"Chun","year":"2000","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.actbio.2025.06.007_bib0022","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/nbdi.2000.0285","article-title":"Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo","volume":"7","author":"Weise","year":"2000","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0023","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ica.2011.02.022","article-title":"Intramolecular ether oxygen coordination in the zinc complexes with dipicolylamine (DPA)-derived ligands","volume":"370","author":"Mikata","year":"2011","journal-title":"Inorg. Chim. Acta"},{"issue":"36","key":"10.1016\/j.actbio.2025.06.007_bib0024","doi-asserted-by":"crossref","first-page":"10650","DOI":"10.1021\/ja026442n","article-title":"A novel, cell-permeable, fluorescent probe for ratiometric imaging of zinc ion","volume":"124","author":"Maruyama","year":"2002","journal-title":"J. Am. Chem. Soc."},{"issue":"42","key":"10.1016\/j.actbio.2025.06.007_bib0025","doi-asserted-by":"crossref","first-page":"8073","DOI":"10.1016\/j.tet.2011.08.049","article-title":"Zinc selective chemosensor based on pyridyl-amide fluorescence","volume":"67","author":"Lee","year":"2011","journal-title":"Tetrahedron"},{"key":"10.1016\/j.actbio.2025.06.007_bib0026","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ica.2012.09.009","article-title":"Zinc selective chemosensors based on the flexible dipicolylamine and quinoline","volume":"394","author":"Lee","year":"2013","journal-title":"Inorg. Chim. Acta"},{"issue":"9","key":"10.1016\/j.actbio.2025.06.007_bib0027","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.tetlet.2012.12.054","article-title":"A quinoline based fluorescent probe that can distinguish zinc (II) from cadmium (II) in water","volume":"54","author":"Cai","year":"2013","journal-title":"Tetrahedron Lett."},{"issue":"4","key":"10.1016\/j.actbio.2025.06.007_bib0028","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/002215540104900412","article-title":"Identification and purification of functional human beta-cells by a new specific zinc-fluorescent probe","volume":"49","author":"Lukowiak","year":"2001","journal-title":"J. Histochem. Cytochem."},{"issue":"47","key":"10.1016\/j.actbio.2025.06.007_bib0029","doi-asserted-by":"crossref","first-page":"13658","DOI":"10.1021\/bi701355j","article-title":"Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors","volume":"46","author":"Talmard","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.actbio.2025.06.007_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envexpbot.2017.10.008","article-title":"Zinc and lead accumulation characteristics and in vivo distribution of Zn2+ in the hyperaccumulator Noccaea caerulescens elucidated with fluorescent probes and laser confocal microscopy","volume":"147","author":"Dinh","year":"2018","journal-title":"Environ. Exp. Bot."},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0031","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1039\/C3MT00283G","article-title":"Selectivity and specificity of small molecule fluorescent dyes\/probes used for the detection of Zn2+ and Ca2+ in cells","volume":"6","author":"Figueroa","year":"2014","journal-title":"Metallomics"},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0032","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1039\/C5MT00167F","article-title":"Newport Green, a fluorescent sensor of weakly bound cellular Zn2+: competition with proteome for Zn2+","volume":"8","author":"Karim","year":"2016","journal-title":"Metallomics"},{"issue":"8","key":"10.1016\/j.actbio.2025.06.007_bib0033","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1097\/00001756-199906030-00018","article-title":"Glutamate triggers preferential Zn2+ flux through Ca2+ permeable AMPA channels and consequent ROS production","volume":"10","author":"Sensi","year":"1999","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0034","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0165-0270(02)00144-9","article-title":"Fluorescent zinc indicators for neurobiology","volume":"118","author":"Thompson","year":"2002","journal-title":"J. Neurosci. Methods"},{"issue":"32","key":"10.1016\/j.actbio.2025.06.007_bib0035","doi-asserted-by":"crossref","first-page":"20540","DOI":"10.1021\/acsami.6b04679","article-title":"A self-assembling injectable biomimetic microenvironment encourages retinal ganglion cell axon extension in vitro","volume":"8","author":"Laughter","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2025.06.007_bib0036","doi-asserted-by":"crossref","first-page":"14008","DOI":"10.1523\/JNEUROSCI.3605-10.2010","article-title":"Structural remodeling of fibrous astrocytes after axonal injury","volume":"30","author":"Sun","year":"2010","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0037","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3174\/ajnr.A5437","article-title":"Gadolinium DTPA enhancement characteristics of the rat sciatic nerve after crush injury at 4.7T","volume":"39","author":"Hill","year":"2018","journal-title":"Am. J. Neuroradiol."},{"issue":"3","key":"10.1016\/j.actbio.2025.06.007_bib0038","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1167\/iovs.04-0766","article-title":"The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro","volume":"46","author":"Lagreze","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084387","article-title":"Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-kappa B activation","volume":"9","author":"Morishita","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1044-7431(02)00037-4","article-title":"Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons","volume":"22","author":"Cui","year":"2003","journal-title":"Mol. Cell Neurosci."},{"issue":"3","key":"10.1016\/j.actbio.2025.06.007_bib0041","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1167\/iovs.16-19873","article-title":"Regenerative responses and axon pathfinding of retinal ganglion cells in chronically injured mice","volume":"58","author":"Yungher","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"23","key":"10.1016\/j.actbio.2025.06.007_bib0042","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1073\/pnas.1119449109","article-title":"Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors","volume":"109","author":"de Lima","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S..A."},{"issue":"12","key":"10.1016\/j.actbio.2025.06.007_bib0043","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000","article-title":"Lens injury stimulates axon regeneration in the mature rat optic nerve","volume":"20","author":"Leon","year":"2000","journal-title":"J. Neurosci."},{"issue":"46","key":"10.1016\/j.actbio.2025.06.007_bib0044","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1523\/JNEUROSCI.4340-10.2010","article-title":"Long-distance axon regeneration in the Mature Optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion","volume":"30","author":"Kurimoto","year":"2010","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.actbio.2025.06.007_bib0045","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1021\/bm101041f","article-title":"Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells","volume":"11","author":"Sangaj","year":"2010","journal-title":"Biomacromolecules"},{"issue":"10","key":"10.1016\/j.actbio.2025.06.007_bib0046","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0166-2236(98)01266-1","article-title":"Emerging themes in structural biology of neurotrophic factors","volume":"21","author":"Ibanez","year":"1998","journal-title":"Trends Neurosci."},{"issue":"44","key":"10.1016\/j.actbio.2025.06.007_bib0047","doi-asserted-by":"crossref","first-page":"30341","DOI":"10.1074\/jbc.M803239200","article-title":"Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the Ciliary neurotrophic factor receptor \u03b1 chain","volume":"283","author":"Rousseau","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2025.06.007_bib0048","first-page":"9","article-title":"Brain-derived neurotrophic factor: three ligands, many actions","volume":"126","author":"Hempstead","year":"2015","journal-title":"Trans. Am. Clin. Clim. Assoc."},{"issue":"11","key":"10.1016\/j.actbio.2025.06.007_bib0049","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.tet.2019.02.004","article-title":"Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-\u03b2-lactamase inhibitors","volume":"75","author":"Prandina","year":"2019","journal-title":"Tetrahedron"},{"issue":"3","key":"10.1016\/j.actbio.2025.06.007_bib0050","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0022-3565(25)26443-6","article-title":"Tissue distribution studies of Ionic and chelated Zn65 in mice","volume":"138","author":"Stand","year":"1962","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12640-009-9067-4","article-title":"The role of zinc in the modulation of neuronal proliferation and apoptosis","volume":"17","author":"Adamo","year":"2010","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.actbio.2025.06.007_bib0052","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2008.08.040","article-title":"Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms","volume":"1237","author":"Corniola","year":"2008","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.06.007_bib0053","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12640-009-9072-7","article-title":"Zinc deficiency reduces neurogenesis accompanied by neuronal apoptosis through caspase-dependent and -independent signaling pathways","volume":"16","author":"Gao","year":"2009","journal-title":"Neurotox. Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0054","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0165-3806(84)90057-9","article-title":"Alterations in the postnatal-development of the cerebellar cortex due to zinc-deficiency .2. IMPAIRED maturation of Purkinje-Cells","volume":"16","author":"Dvergsten","year":"1984","journal-title":"Dev. Brain Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0165-3806(84)90058-0","article-title":"Alterations in the postnatal-development of the cerebellar cortex due to zinc-deficiency .3. IMPAIRED dendritic differentiation of basket and stellate cells","volume":"16","author":"Dvergsten","year":"1984","journal-title":"Dev. Brain Res."},{"issue":"11","key":"10.1016\/j.actbio.2025.06.007_bib0056","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/syn.20683","article-title":"Zinc: the brain's dark horse","volume":"63","author":"Bitanihirwe","year":"2009","journal-title":"Synapse"},{"issue":"6","key":"10.1016\/j.actbio.2025.06.007_bib0057","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrn1671","article-title":"The neurobiology of zinc in health and disease","volume":"6","author":"Frederickson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"issue":"11\u201312","key":"10.1016\/j.actbio.2025.06.007_bib0058","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1089\/ars.2005.7.1773","article-title":"Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H2O2","volume":"7","author":"Zago","year":"2005","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.actbio.2025.06.007_bib0059","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.neuro.21.1.347","article-title":"Zinc and brain injury","volume":"21","author":"Choi","year":"1998","journal-title":"Annu Rev. Neurosci."},{"issue":"17","key":"10.1016\/j.actbio.2025.06.007_bib0060","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1016\/j.visres.2006.02.014","article-title":"Inhibition of cyclooxygenase-2 expression by zinc-chelator in retinal ischemia","volume":"46","author":"Choi","year":"2006","journal-title":"Vis. Res."},{"issue":"5","key":"10.1016\/j.actbio.2025.06.007_bib0061","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1167\/iovs.03-1315","article-title":"Protection by pyruvate of rat retinal cells against zinc toxicity in vitro, and pressure-induced ischemia in vivo","volume":"45","author":"Yoo","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5264","key":"10.1016\/j.actbio.2025.06.007_bib0062","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.272.5264.1013","article-title":"The role of zinc in selective neuronal death after transient global cerebral ischemia","volume":"272","author":"Koh","year":"1996","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.actbio.2025.06.007_bib0063","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.nbd.2004.04.017","article-title":"Zinc release contributes to hypoglycemia-induced neuronal death","volume":"16","author":"Suh","year":"2004","journal-title":"Neurobiol. Dis."},{"issue":"10","key":"10.1016\/j.actbio.2025.06.007_bib0064","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/jcbfm.2008.61","article-title":"Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death","volume":"28","author":"Suh","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0065","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.15-17841","article-title":"Apoptotic retinal ganglion cell death after optic nerve transection or crush in mice: delayed RGC loss with BDNF or a caspase 3 inhibitor","volume":"57","author":"S\u00e1nchez-Migall\u00f3n","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0066","first-page":"460","article-title":"Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells","volume":"42","author":"Hyun","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.actbio.2025.06.007_bib0067","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1159\/000479539","article-title":"Zinc depletion by TPEN induces apoptosis in Human acute promyelocytic NB4 cells","volume":"42","author":"Zhu","year":"2017","journal-title":"Cell Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0068","first-page":"101","article-title":"Chelation of intracellular zinc triggers apoptosis in mature thymocytes","volume":"69","author":"McCabe","year":"1993","journal-title":"Lab. Investig."},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0069","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/ana.410350206","article-title":"Ciliary neurotrophic factor - pharmacokinetics and acute-phase response in rat","volume":"35","author":"Dittrich","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.actbio.2025.06.007_bib0070","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/601084","article-title":"Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases","author":"Cai","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"12","key":"10.1016\/j.actbio.2025.06.007_bib0071","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2165\/00003088-200140120-00003","article-title":"2nd, Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations","volume":"40","author":"Thorne","year":"2001","journal-title":"Clin. Pharmacokinet."},{"issue":"2","key":"10.1016\/j.actbio.2025.06.007_bib0072","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0169-328X(95)00250-V","article-title":"Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF","volume":"36","author":"Poduslo","year":"1996","journal-title":"Mol. Brain Res."},{"issue":"8","key":"10.1016\/j.actbio.2025.06.007_bib0073","article-title":"Advances and opportunities in nanoparticle drug delivery for Central nervous system disorders: a review of current advances","volume":"15","author":"Ekhator","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.actbio.2025.06.007_bib0074","article-title":"TPEN loaded poly (lactide-co-glycolide) nanoparticles promote neuroprotection and optic nerve regeneration","volume":"32","author":"Wu","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"8","key":"10.1016\/j.actbio.2025.06.007_bib0075","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nprot.2009.93","article-title":"Multiple neuroanatomical tract-tracing using fluorescent Alexa Fluor conjugates of cholera toxin subunit B in rats","volume":"4","author":"Conte","year":"2009","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.actbio.2025.06.007_bib0076","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030416","article-title":"Zinc homeostasis: an emerging therapeutic target for neuroinflammation related diseases","volume":"13","author":"Liu","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0077","doi-asserted-by":"crossref","DOI":"10.3390\/biom13010028","article-title":"The important role of zinc in neurological diseases","volume":"13","author":"Li","year":"2022","journal-title":"Biomolecules"},{"issue":"23","key":"10.1016\/j.actbio.2025.06.007_bib0078","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.3390\/ijms21238941","article-title":"Zinc in the brain: friend or foe?","volume":"21","author":"Choi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2025.06.007_bib0079","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/STROKEAHA.113.004296","article-title":"Chelating intracellularly accumulated zinc decreased ischemic brain injury through reducing neuronal apoptotic death","volume":"45","author":"Zhao","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.actbio.2025.06.007_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105387","article-title":"Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer\u2019s disease","volume":"116","author":"Zhang","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.actbio.2025.06.007_bib0081","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/molecules27010056","article-title":"Zinc-chelating compounds as inhibitors of human and bacterial zinc metalloproteases","volume":"27","author":"Rahman","year":"2022","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.actbio.2025.06.007_bib0082","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s40520-020-01646-5","article-title":"Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis","volume":"33","author":"Braschi","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"issue":"9","key":"10.1016\/j.actbio.2025.06.007_bib0083","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1021\/acs.bioconjchem.2c00305","article-title":"Porous silicon nanoparticles targeted to the extracellular matrix for therapeutic protein delivery in traumatic brain injury","volume":"33","author":"Waggoner","year":"2022","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.actbio.2025.06.007_bib0084","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.00119","article-title":"Strategies to promote long-distance optic nerve regeneration","author":"Yang","year":"2020","journal-title":"Front. Cell Neurosci."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125004143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125004143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:30:50Z","timestamp":1776843050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125004143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":84,"alternative-id":["S1742706125004143"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.06.007","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-delivery of neurotrophic factors and a zinc chelator substantially increases retinal ganglion cell survival and axon protection in the optic nerve crush model","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}