{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:27:30Z","timestamp":1790407650405,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-QCXMX0017"],"award-info":[{"award-number":["CSTB2024NSCQ-QCXMX0017"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SWU-KF25025"],"award-info":[{"award-number":["SWU-KF25025"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SWUS23154"],"award-info":[{"award-number":["SWUS23154"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFD1201600"],"award-info":[{"award-number":["2022YFD1201600"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.actbio.2025.07.030","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T19:51:39Z","timestamp":1752609099000},"page":"216-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Genetically engineered sericin hydrogels for the delivery of human adiponectin in treating ulcerative colitis in mice"],"prefix":"10.1016","volume":"202","author":[{"given":"Hongji","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexu","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyou","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-8284","authenticated-orcid":false,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.actbio.2025.07.030_bib0001","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2016.10.020","article-title":"Understanding and preventing the global increase of inflammatory bowel disease","volume":"152","author":"Kaplan","year":"2017","journal-title":"Gastroenterology"},{"issue":"10114","key":"10.1016\/j.actbio.2025.07.030_bib0002","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"issue":"10401","key":"10.1016\/j.actbio.2025.07.030_bib0003","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.actbio.2025.07.030_bib0004","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S2468-1253(20)30212-0","article-title":"The overlap between irritable bowel syndrome and organic gastrointestinal diseases","volume":"6","author":"Aziz","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"9853","key":"10.1016\/j.actbio.2025.07.030_bib0005","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.actbio.2025.07.030_bib0006","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMc1707500","article-title":"Tofacitinib as induction and maintenance therapy for ulcerative colitis reply","volume":"377","author":"Sandborn","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actbio.2025.07.030_bib0007","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.addr.2018.06.021","article-title":"Bioresponsive drug delivery systems in intestinal inflammation: state-of-the-art and future perspectives","volume":"146","author":"Kotla","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7","key":"10.1016\/j.actbio.2025.07.030_bib0008","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome","volume":"116","author":"Kadowaki","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.actbio.2025.07.030_bib0009","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s42255-019-0041-z","article-title":"Metabolic messengers: adiponectin","volume":"1","author":"Straub","year":"2019","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.actbio.2025.07.030_bib0010","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr. Rev."},{"issue":"10","key":"10.1016\/j.actbio.2025.07.030_bib0011","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1007\/s10620-011-1692-0","article-title":"Adiponectin and plant-derived mammalian Adiponectin homolog exert a protective effect in murine colitis","volume":"56","author":"Arsenescu","year":"2011","journal-title":"Dig. Dis. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2025.07.030_bib0012","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1053\/j.gastro.2006.06.015","article-title":"Effect of adiponectin on murine colitis induced by dextran sulfate sodium","volume":"131","author":"Nishihara","year":"2006","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.actbio.2025.07.030_bib0013","doi-asserted-by":"crossref","first-page":"G591","DOI":"10.1152\/ajpgi.00269.2014","article-title":"Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1","volume":"308","author":"Sideri","year":"2015","journal-title":"Am. J. Physiol.-Gastroint. Liver Physiol."},{"issue":"6","key":"10.1016\/j.actbio.2025.07.030_bib0014","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1007\/s10620-021-07015-0","article-title":"Adiponectin alleviates intestinal fibrosis by enhancing AMP-activated protein kinase phosphorylation","volume":"67","author":"Xie","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.actbio.2025.07.030_bib0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jconrel.2014.10.026","article-title":"Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse","volume":"197","author":"Maisel","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.030_bib0016","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.biomaterials.2019.119750","article-title":"Investigational new drug enabling angiotensin oral-delivery studies to attenuate pulmonary hypertension","volume":"233","author":"Daniell","year":"2020","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.actbio.2025.07.030_bib0017","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/ijms19092533","article-title":"Transgenic silkworm-based silk gland bioreactor for large scale production of bioactive Human platelet-derived growth factor (PDGF-BB) in silk cocoons","volume":"19","author":"Chen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.07.030_bib0018","series-title":"Annual Review of Biomedical Engineering","first-page":"79","article-title":"Transgenic and diet-enhanced silk production for reinforced biomaterials: a metamaterial perspective","volume":"22","author":"Leem","year":"2020"},{"issue":"6","key":"10.1016\/j.actbio.2025.07.030_bib0019","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/adma.201906360","article-title":"Fabrication and mechanical properties of engineered protein-based adhesives and fibers","volume":"32","author":"Sun","year":"2020","journal-title":"Adv. Mater."},{"issue":"38","key":"10.1016\/j.actbio.2025.07.030_bib0020","doi-asserted-by":"crossref","first-page":"45175","DOI":"10.1021\/acsami.1c08409","article-title":"Fabrication of a silk sericin hydrogel system delivering Human lactoferrin using genetically engineered silk with improved bioavailability to alleviate chemotherapy-induced immunosuppression","volume":"13","author":"Xu","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"issue":"1","key":"10.1016\/j.actbio.2025.07.030_bib0021","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1271\/bbb.62.145","article-title":"Silk protein, sericin, inhibits lipid peroxidation and tyrosinase activity","volume":"62","author":"Kato","year":"1998","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"12","key":"10.1016\/j.actbio.2025.07.030_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2023.103872","article-title":"Antioxidant and anti-aging role of silk sericin in D-galactose induced mice model","volume":"30","author":"Mumtaz","year":"2023","journal-title":"Saudi J Biol Sci"},{"issue":"12","key":"10.1016\/j.actbio.2025.07.030_bib0023","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/polym12122985","article-title":"Antibacterial mechanism of silkworm seroins","volume":"12","author":"Zhu","year":"2020","journal-title":"Polymers (Basel)"},{"issue":"10","key":"10.1016\/j.actbio.2025.07.030_bib0024","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1271\/bbb.65.2181","article-title":"Supplemental silk protein, sericin, suppresses colon tumorigenesis in 1,2-dimethylhydrazine-treated mice by reducing oxidative stress and cell proliferation","volume":"65","author":"Zhaorigetu","year":"2001","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"1\u20132","key":"10.1016\/j.actbio.2025.07.030_bib0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11010-008-9702-z","article-title":"Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes","volume":"311","author":"Dash","year":"2008","journal-title":"Mol. Cell. Biochem."},{"issue":"5\u20136","key":"10.1016\/j.actbio.2025.07.030_bib0026","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1163\/156856209X426853","article-title":"Sulfated sericin is a novel anticoagulant influencing the blood coagulation cascade","volume":"20","author":"Sano","year":"2009","journal-title":"J. Biomater. Sci.-Polym. Ed."},{"key":"10.1016\/j.actbio.2025.07.030_bib0027","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ijbiomac.2015.07.018","article-title":"Silk sericin loaded alginate nanoparticles: preparation and anti-inflammatory efficacy","volume":"80","author":"Khampieng","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.actbio.2025.07.030_bib0028","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jbiosc.2008.12.012","article-title":"Monitoring of inflammatory mediators induced by silk sericin","volume":"107","author":"Aramwit","year":"2009","journal-title":"J. Biosci. Bioeng."},{"issue":"7","key":"10.1016\/j.actbio.2025.07.030_bib0029","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00403-013-1371-4","article-title":"Silk sericin ameliorates wound healing and its clinical efficacy in burn wounds","volume":"305","author":"Aramwit","year":"2013","journal-title":"Arch. Dermatol. Res."},{"issue":"6085","key":"10.1016\/j.actbio.2025.07.030_bib0030","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.1214804","article-title":"Designing cell-compatible hydrogels for biomedical applications","volume":"336","author":"Seliktar","year":"2012","journal-title":"Science"},{"issue":"15","key":"10.1016\/j.actbio.2025.07.030_bib0031","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.4155\/fmc.11.134","article-title":"Hydrogels for biomedical applications","volume":"3","author":"Cabral","year":"2011","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.actbio.2025.07.030_bib0032","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.msec.2019.04.043","article-title":"Silk sericin-enhanced microstructured bacterial cellulose as tissue engineering scaffold towards prospective gut repair","volume":"102","author":"Lamboni","year":"2019","journal-title":"Mater. Sci. Eng. C-Mater. Biol. Appl."},{"key":"10.1016\/j.actbio.2025.07.030_bib0033","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.carbpol.2018.08.030","article-title":"Flexible agar-sericin hydrogel film dressing for chronic wounds","volume":"200","author":"Tyeb","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.actbio.2025.07.030_bib0034","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nbt771","article-title":"Transgenic silkworms produce recombinant human type III procollagen in cocoons","volume":"21","author":"Tomita","year":"2003","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"10.1016\/j.actbio.2025.07.030_bib0035","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00438-019-01534-2","article-title":"Optimization of a 2A self-cleaving peptide-based multigene expression system for efficient expression of upstream and downstream genes in silkworm","volume":"294","author":"Wang","year":"2019","journal-title":"Mol. Genet. Genomics"},{"issue":"3","key":"10.1016\/j.actbio.2025.07.030_bib0036","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jbiotec.2006.10.019","article-title":"Generation of a transgenic silkworm that secretes recombinant proteins in the sericin layer of cocoon: production of recombinant human serum albumin","volume":"128","author":"Ogawa","year":"2007","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.actbio.2025.07.030_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125527","article-title":"Large-scale and cost-effective production of recombinant human serum albumin (rHSA) in transgenic Bombyx mori cocoons","volume":"245","author":"Tan","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.actbio.2025.07.030_bib0038","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.actbio.2018.12.036","article-title":"Genetically engineered bi-functional silk material with improved cell proliferation and anti-inflammatory activity for medical application","volume":"86","author":"Wang","year":"2019","journal-title":"Acta Biomater"},{"issue":"11","key":"10.1016\/j.actbio.2025.07.030_bib0039","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1039\/C9BM01285K","article-title":"Genetic fabrication of functional silk mats with improved cell proliferation activity for medical applications","volume":"7","author":"Wang","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.actbio.2025.07.030_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122986","article-title":"Fabrication of a transforming growth factor \u03b21 functionalized silk sericin hydrogel through genetical engineering to repair alveolar bone defects in rabbit","volume":"316","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.030_bib0041","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13036-019-0186-z","article-title":"A silkworm based silk gland bioreactor for high-efficiency production of recombinant human lactoferrin with antibacterial and anti-inflammatory activities","volume":"13","author":"Xu","year":"2019","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.actbio.2025.07.030_bib0042","article-title":"An efficient biosynthetic system for developing functional silk fibroin-based biomaterials","author":"Wang","year":"2024","journal-title":"Adv Mater"},{"issue":"7","key":"10.1016\/j.actbio.2025.07.030_bib0043","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1016\/j.actbio.2008.12.013","article-title":"Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound heating","volume":"5","author":"Schneider","year":"2009","journal-title":"Acta Biomater"},{"issue":"9","key":"10.1016\/j.actbio.2025.07.030_bib0044","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.tibtech.2018.04.004","article-title":"Overview of silk fibroin use in wound dressings","volume":"36","author":"Farokhi","year":"2018","journal-title":"Trends Biotechnol"},{"issue":"38","key":"10.1016\/j.actbio.2025.07.030_bib0045","doi-asserted-by":"crossref","first-page":"45175","DOI":"10.1021\/acsami.1c08409","article-title":"Fabrication of a silk sericin hydrogel system delivering Human lactoferrin using genetically engineered silk with improved bioavailability to alleviate chemotherapy-induced immunosuppression","volume":"13","author":"Xu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2025.07.030_bib0046","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.actbio.2022.03.012","article-title":"Genetically engineered pH-responsive silk sericin nanospheres with efficient therapeutic effect on ulcerative colitis","volume":"144","author":"Xu","year":"2022","journal-title":"Acta Biomater"},{"issue":"1","key":"10.1016\/j.actbio.2025.07.030_bib0047","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/71978","article-title":"Germline transformation of the silkworm bombyx moriL-using a piggyBactransposon-derived vector","volume":"18","author":"Tamura","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.actbio.2025.07.030_bib0048","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jconrel.2015.10.035","article-title":"Modulation of vincristine and doxorubicin binding and release from silk films","volume":"220","author":"Coburn","year":"2015","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.actbio.2025.07.030_bib0049","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"issue":"6","key":"10.1016\/j.actbio.2025.07.030_bib0050","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1136\/gutjnl-2016-313535","article-title":"CD177<SUP>+<\/SUP>neutrophils as functionally activated neutrophils negatively regulate IBD","volume":"67","author":"Zhou","year":"2018","journal-title":"Gut"},{"issue":"Pt 19","key":"10.1016\/j.actbio.2025.07.030_bib0051","first-page":"3138","article-title":"Identification and classification of silks using infrared spectroscopy","volume":"218","author":"Boulet-Audet","year":"2015","journal-title":"J Exp Biol"},{"issue":"5","key":"10.1016\/j.actbio.2025.07.030_bib0052","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1021\/bm200062a","article-title":"Regulation of silk material structure by temperature-controlled water vapor annealing","volume":"12","author":"Hu","year":"2011","journal-title":"Biomacromolecules"},{"issue":"20","key":"10.1016\/j.actbio.2025.07.030_bib0053","first-page":"10566","article-title":"Changes in serum inflammatory factors, adiponectin, intestinal flora and immunity in patients with non-small cell lung cancer","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2025.07.030_bib0054","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/hep.23427","article-title":"The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells","volume":"51","author":"Mandal","year":"2010","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.actbio.2025.07.030_bib0055","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.4049\/jimmunol.1002060","article-title":"Adiponectin and heme oxygenase-1 suppress TLR4\/MyD88-independent signaling in rat kupffer cells and in mice after chronic ethanol exposure","volume":"185","author":"Mandal","year":"2010","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.actbio.2025.07.030_bib0056","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1074\/jbc.M109.088708","article-title":"Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype","volume":"285","author":"Ohashi","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.actbio.2025.07.030_bib0057","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/jcp.25201","article-title":"Epigenetic modulation in periodontitis: interaction of adiponectin and JMJD3-IRF4 axis in macrophages","volume":"231","author":"Xuan","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.actbio.2025.07.030_bib0058","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41598-017-08121-8","article-title":"Classification of M1\/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis","volume":"7","author":"Bertani","year":"2017","journal-title":"Sci Rep"},{"issue":"14","key":"10.1016\/j.actbio.2025.07.030_bib0059","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1126\/sciadv.abf6654","article-title":"Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration","volume":"7","author":"Zhu","year":"2021","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.actbio.2025.07.030_bib0060","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0021-9150(02)00305-2","article-title":"The adipocyte lipid binding protein (ALBP\/aP2) gene facilitates foam cell formation in human THP-1 macrophages","volume":"165","author":"Fu","year":"2002","journal-title":"Atherosclerosis"},{"issue":"9","key":"10.1016\/j.actbio.2025.07.030_bib0061","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1371\/journal.pone.0185406","article-title":"Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2025.07.030_bib0062","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.biomaterials.2014.10.059","article-title":"Layer-by-layer assembled milk protein coated magnetic nanoparticle enabled oral drug delivery with high stability in stomach and enzyme-responsive release in small intestine","volume":"39","author":"Huang","year":"2015","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.actbio.2025.07.030_bib0063","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/advs.202004014","article-title":"Drug delivery (Nano)platforms for oral and dental applications: tissue regeneration, infection control, and cancer management","volume":"8","author":"Makvandi","year":"2021","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2025.07.030_bib0064","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/apha.12719","article-title":"Lactobacillus reuteritreatment and DSS colitis: new insight into the mechanism of protection","volume":"217","author":"Petrella","year":"2016","journal-title":"Acta Physiol"},{"key":"10.1016\/j.actbio.2025.07.030_bib0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biomaterials.2019.05.012","article-title":"Multi-bioresponsive silk fibroin-based nanoparticles with on-demand cytoplasmic drug release capacity for CD44-targeted alleviation of ulcerative colitis","volume":"212","author":"Gou","year":"2019","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2025.07.030_bib0066","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010259","article-title":"Multi-omics integration to reveal the mechanism of sericin inhibiting LPS-induced inflammation","volume":"24","author":"Sun","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.actbio.2025.07.030_bib0067","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.2147\/IJN.S399487","article-title":"Sericin\/nano-hydroxyapatite hydrogels based on graphene oxide for effective bone regeneration via immunomodulation and osteoinduction","volume":"18","author":"Fu","year":"2023","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.actbio.2025.07.030_bib0068","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jconrel.2022.05.025","article-title":"Oral antimicrobial peptide-EGCG nanomedicines for synergistic treatment of ulcerative colitis","volume":"347","author":"Liu","year":"2022","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.actbio.2025.07.030_bib0069","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.actbio.2025.07.030_bib0070","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.devcel.2009.12.008","article-title":"The tight junction protein, occludin, regulates the directional migration of epithelial cells","volume":"18","author":"Du","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.actbio.2025.07.030_bib0071","first-page":"1","article-title":"The gut microbiota is associated with immune cell dynamics in humans","author":"Schluter","year":"2020","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.actbio.2025.07.030_bib0072","doi-asserted-by":"crossref","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut microbiota and IBD: causation or correlation?","volume":"14","author":"Ni","year":"2017","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10.1016\/j.actbio.2025.07.030_bib0073","article-title":"Gut microbiota in human metabolic health and disease","author":"Fan","year":"2020","journal-title":"Nature Reviews Microbiology"},{"issue":"4","key":"10.1016\/j.actbio.2025.07.030_bib0074","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/microorganisms8040573","article-title":"The controversial role of Human gut lachnospiraceae","volume":"8","author":"Vacca","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.actbio.2025.07.030_bib0075","article-title":"Sustainable Silk Fibroin Ionic touch screens for flexible biodegradable electronics with integrated AI and IoT functionality","author":"Ye","year":"2024","journal-title":"Adv Mater"},{"issue":"1","key":"10.1016\/j.actbio.2025.07.030_bib0076","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12934-020-01441-x","article-title":"Correction to: gut microbial characteristics ofadult patients with allergy rhinitis","volume":"19","author":"Zhu","year":"2020","journal-title":"Microb. Cell Fact."},{"issue":"4","key":"10.1016\/j.actbio.2025.07.030_bib0077","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.136","article-title":"Intraspecific difference of latilactobacillus sakei in inflammatory bowel diseases: insights into potential mechanisms through comparative genomics and metabolomics analyses","volume":"2","author":"Liu","year":"2023","journal-title":"iMeta"}],"updated-by":[{"DOI":"10.1016\/j.actbio.2025.09.029","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000}},{"DOI":"10.1016\/j.actbio.2025.09.029","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000}}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125005288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125005288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:19:03Z","timestamp":1778944743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125005288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":77,"alternative-id":["S1742706125005288"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.07.030","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetically engineered sericin hydrogels for the delivery of human adiponectin in treating ulcerative colitis in mice","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.07.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}