{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:00:48Z","timestamp":1793412048855,"version":"4.5.0"},"reference-count":168,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MC050"],"award-info":[{"award-number":["ZR2023MC050"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqnz20231237"],"award-info":[{"award-number":["tsqnz20231237"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.actbio.2025.07.057","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T22:40:22Z","timestamp":1753569622000},"page":"59-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Current status and future perspectives of research on intra-articular drug delivery systems for osteoarthritis therapy"],"prefix":"10.1016","volume":"203","author":[{"given":"Mengru","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1262-4182","authenticated-orcid":false,"given":"Wanjun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.07.057_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122483","article-title":"Apoptotic body-inspired nanotherapeutics efficiently attenuate osteoarthritis by targeting BRD4-regulated synovial macrophage polarization","volume":"306","author":"Xu","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0002","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14698","article-title":"Deep-targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma","volume":"30","author":"Xiao","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.actbio.2025.07.057_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119492","article-title":"Glycosaminoglycan-based injectable hydrogels with multi-functions in the alleviation of osteoarthritis","volume":"290","author":"Yu","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2025.07.057_bib0004","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41413-022-00226-9","article-title":"Current understanding of osteoarthritis pathogenesis and relevant new approaches","volume":"10","author":"Tong","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.actbio.2025.07.057_bib0005","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1021\/acsnano.3c11848","article-title":"Nanomedicines promote cartilage regeneration in osteoarthritis by synergistically enhancing chondrogenesis of mesenchymal stem cells and regulating inflammatory environment","volume":"18","author":"Cui","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.07.057_bib0006","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.jcis.2023.09.019","article-title":"Functional nano drug delivery system with dual lubrication and immune escape for treating osteoarthritis","volume":"652","author":"Yang","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.actbio.2025.07.057_bib0007","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/eji.201870125","article-title":"World Arthritis Day 2018 - perspectives on rheumatic musculoskeletal diseases","volume":"48","author":"Radstake","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0008","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41413-024-00375-z","article-title":"Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis","volume":"12","author":"Han","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.actbio.2025.07.057_bib0009","first-page":"2372","article-title":"Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy","volume":"6","author":"Xue","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0010","doi-asserted-by":"crossref","first-page":"21773","DOI":"10.1021\/acsami.1c19853","article-title":"Self-assembled nanospheres with enhanced interfacial lubrication for the treatment of osteoarthritis","volume":"14","author":"Zheng","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2025.07.057_bib0011","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nrrheum.2012.199","article-title":"Osteoarthritis of the spine: the facet joints","volume":"9","author":"Gellhorn","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0012","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.actbio.2020.04.001","article-title":"Tracking osteoarthritis progress through cationic nanoprobe-enhanced photoacoustic imaging of cartilage","volume":"109","author":"Xiao","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0013","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jconrel.2020.11.007","article-title":"The emerging landscape of nanotheranostic-based diagnosis and therapy for osteoarthritis","volume":"328","author":"Xiao","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0014","first-page":"3596","article-title":"Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis","volume":"6","author":"Han","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.tips.2021.12.004","article-title":"Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs","volume":"43","author":"Gao","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.actbio.2025.07.057_bib0016","first-page":"14","article-title":"Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis","volume":"7","author":"Seo","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0017","first-page":"149","article-title":"Nanoparticle-cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy","volume":"13","author":"Li","year":"2021","journal-title":"Nanomicro Lett."},{"key":"10.1016\/j.actbio.2025.07.057_bib0018","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202470310","article-title":"Self-reinforced MOF-based nanogel alleviates osteoarthritis by long-acting drug release","volume":"36","author":"Sun","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0019","article-title":"\u03b5-Poly-l-lysine as an efficient cartilage penetrating and residing drug carrier with high intraarticular injection safety for treating osteoarthritis","volume":"430","author":"Hu","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.07.057_bib0020","article-title":"Intra-articular injection of nanomaterials for the treatment of osteoarthritis: from lubrication function restoration to cell and gene therapy","volume":"34","author":"Yang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.145180","article-title":"Erythrocyte membrane-camouflaged and double-factor sequential delivery nanocarriers postpone the progression of osteoarthritis","volume":"473","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.07.057_bib0022","doi-asserted-by":"crossref","first-page":"39064","DOI":"10.1021\/acsami.3c05861","article-title":"Apoptotic neutrophil membrane-camouflaged liposomes for dually targeting synovial macrophages and fibroblasts to attenuate osteoarthritis","volume":"15","author":"Deng","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2025.07.057_bib0023","doi-asserted-by":"crossref","first-page":"11753","DOI":"10.1021\/acsnano.3c13150","article-title":"Biomimetic nanovesicles as a dual gene delivery system for the synergistic gene therapy of Alzheimer\u2019s disease","volume":"18","author":"Jiang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.07.057_bib0024","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.2106\/JBJS.20.00132","article-title":"Patient preferences for surgical treatment of knee osteoarthritis: a discrete-choice experiment evaluating total and unicompartmental knee arthroplasty","volume":"102","author":"Hutyra","year":"2020","journal-title":"J. Bone Jt. Surg. Am."},{"key":"10.1016\/j.actbio.2025.07.057_bib0025","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(11)60752-6","article-title":"Knee replacement","volume":"379","author":"Carr","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2025.07.057_bib0026","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2106\/JBJS.N.00925","article-title":"The cost-effectiveness of surgical treatment of medial unicompartmental knee osteoarthritis in younger patients: a computer model-based evaluation","volume":"97","author":"Konopka","year":"2015","journal-title":"J. Bone Jt. Surg. Am."},{"key":"10.1016\/j.actbio.2025.07.057_bib0027","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s11427-014-4673-7","article-title":"Treatment of osteoarthritis with mesenchymal stem cells","volume":"57","author":"Wang","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.actbio.2025.07.057_bib0028","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nrrheum.2009.88","article-title":"Surgical options for patients with osteoarthritis of the knee","volume":"5","author":"L\u00fctzner","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0029","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206929","article-title":"Stimulus-responsive drug delivery nanoplatforms for osteoarthritis therapy","volume":"19","author":"Jiang","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.actbio.2025.07.057_bib0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/J.ENG.2017.01.003","article-title":"Regenerative engineering for knee osteoarthritis treatment: biomaterials and cell-based technologies","volume":"3","author":"Escobar Ivirico","year":"2017","journal-title":"Engineering"},{"key":"10.1016\/j.actbio.2025.07.057_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.127674","article-title":"Attenuating osteoarthritis by a high efficient anti-bone resorption injectable pH-responsive bisphosphonate-conjugated nano-apatite system","volume":"420","author":"Geng","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.07.057_bib0032","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2015.40","article-title":"Current research on pharmacologic and regenerative therapies for osteoarthritis","volume":"4","author":"Zhang","year":"2016","journal-title":"Bone Res."},{"key":"10.1016\/j.actbio.2025.07.057_bib0033","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41584-023-01067-4","article-title":"Engineering approaches for RNA-based and cell-based osteoarthritis therapies","volume":"20","author":"DeJulius","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101684","article-title":"Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis","volume":"80","author":"Yu","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.actbio.2025.07.057_bib0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.actbio.2021.01.003","article-title":"Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis","volume":"123","author":"Rahimi","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0036","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-021-00147-z","article-title":"Subchondral bone microenvironment in osteoarthritis and pain","volume":"9","author":"Hu","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.actbio.2025.07.057_bib0037","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1080\/10717544.2021.1971798","article-title":"Targeted treatment for osteoarthritis: drugs and delivery system","volume":"28","author":"Mao","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.actbio.2025.07.057_bib0038","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jama.284.10.1247","article-title":"Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib long-term arthritis safety study","volume":"284","author":"Silverstein","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.actbio.2025.07.057_bib0039","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41584-018-0123-4","article-title":"Intra-articular treatment options for knee osteoarthritis","volume":"15","author":"Jones","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0040","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jconrel.2022.06.015","article-title":"Assessment of joint pharmacokinetics and consequences for the intraarticular delivery of biologics","volume":"348","author":"Siefen","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2020.102273","article-title":"Polymer colloids as drug delivery systems for the treatment of arthritis","volume":"285","author":"Saeedi","year":"2020","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.actbio.2025.07.057_bib0042","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s12951-021-01162-2","article-title":"A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases","volume":"19","author":"Qiu","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0043","doi-asserted-by":"crossref","first-page":"19665","DOI":"10.1021\/acsnano.2c06393","article-title":"Injectable drug delivery systems for osteoarthritis and rheumatoid arthritis","volume":"16","author":"Bruno","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.07.057_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.103482","article-title":"Intra-articular nanodrug delivery strategies for treating osteoarthritis","volume":"28","author":"Zhou","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.actbio.2025.07.057_bib0045","doi-asserted-by":"crossref","first-page":"e1844","DOI":"10.1002\/wnan.1844","article-title":"New insights in osteoarthritis diagnosis and treatment: nano-strategies for an improved disease management","volume":"15","author":"Paesa","year":"2023","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0046","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202107678","article-title":"Charge-guided micro\/nano-hydrogel microsphere for penetrating cartilage matrix","volume":"31","author":"Lin","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0047","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202211980","article-title":"Hydrophobicity-adaptive polymers trigger fission of tumor-cell-derived microparticles for enhanced anticancer drug delivery","volume":"35","author":"Liu","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0048","doi-asserted-by":"crossref","first-page":"eadf0988","DOI":"10.1126\/sciadv.adf0988","article-title":"Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis","volume":"9","author":"Chen","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2025.07.057_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119183","article-title":"Targeted delivery of methotrexate by modified yeast \u03b2-glucan nanoparticles for rheumatoid arthritis therapy","volume":"284","author":"Chen","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actbio.2025.07.057_bib0050","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1039\/D3MH00218G","article-title":"A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment","volume":"10","author":"Zhang","year":"2023","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.actbio.2025.07.057_bib0051","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1021\/acsmacrolett.3c00668","article-title":"Self-report amphiphilic polymer-based drug delivery system with ROS-triggered drug release for osteoarthritis therapy","volume":"13","author":"Tang","year":"2024","journal-title":"ACS Macro. Lett."},{"key":"10.1016\/j.actbio.2025.07.057_bib0052","doi-asserted-by":"crossref","first-page":"10625","DOI":"10.1021\/acsnano.4c00909","article-title":"Nanoparticle-mediated multiple modulation of bone microenvironment to tackle osteoarthritis","volume":"18","author":"Zhan","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.07.057_bib0053","article-title":"A smart MMP13-responsive injectable hydrogel with inflammatory diagnostic logic and multiphase therapeutic ability to orchestrate cartilage regeneration","volume":"33","author":"Zhao","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0054","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12951-020-00666-7","article-title":"MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis","volume":"18","author":"Lan","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119520","article-title":"Cartilage-targeting and dual MMP-13\/pH responsive theranostic nanoprobes for osteoarthritis imaging and precision therapy","volume":"225","author":"Chen","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0056","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001570","article-title":"Biofunctionalized liposomes to monitor rheumatoid arthritis regression stimulated by interleukin-23 neutralization","volume":"10","author":"Lima","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0057","doi-asserted-by":"crossref","first-page":"33937","DOI":"10.1021\/acsnano.4c07992","article-title":"Hybrid nanoparticle engineered with transforming growth factor -\u03b21-overexpressed extracellular vesicle and cartilage-targeted anti-inflammatory liposome for osteoarthritis","volume":"18","author":"Kim","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.07.057_bib0058","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/s41467-023-38597-0","article-title":"An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.07.057_bib0059","article-title":"A metabolic driven bio-responsive hydrogel loading psoralen for therapy of rheumatoid arthritis","volume":"19","author":"Wang","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.actbio.2025.07.057_bib0060","article-title":"In situ remodeling of efferocytosis via lesion-localized microspheres to reverse cartilage senescence","volume":"11","author":"Xiong","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2025.07.057_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121545","article-title":"Nanofat functionalized injectable super-lubricating microfluidic microspheres for treatment of osteoarthritis","volume":"285","author":"Han","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0062","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jconrel.2021.11.019","article-title":"M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization","volume":"341","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0063","article-title":"Microneedle-delivered PDA@Exo for multifaceted osteoarthritis treatment via PI3K-Akt-mTOR pathway","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2025.07.057_bib0064","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jconrel.2022.11.018","article-title":"Applications and prospects of intra-articular drug delivery system in arthritis therapeutics","volume":"352","author":"Song","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0065","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0066","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.actbio.2019.03.010","article-title":"Intra-articular targeting of nanomaterials for the treatment of osteoarthritis","volume":"93","author":"Brown","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0067","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s12951-023-02118-4","article-title":"Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy","volume":"21","author":"Ma","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0068","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.joca.2015.06.020","article-title":"Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS\/Akt\/FOXO3 signaling","volume":"23","author":"Shen","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.07.057_bib0069","doi-asserted-by":"crossref","first-page":"14458","DOI":"10.1002\/anie.202100873","article-title":"Structural transformative antioxidants for dual-responsive anti-inflammatory delivery and photoacoustic inflammation imaging","volume":"60","author":"Zhao","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2025.07.057_bib0070","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.joca.2007.09.001","article-title":"Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury","volume":"16","author":"Regan","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.actbio.2025.07.057_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121437","article-title":"Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy","volume":"283","author":"Gui","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0072","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201700500","article-title":"Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidants for treating neuropathic pain","volume":"6","author":"Kartha","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0073","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/adhm.201400299","article-title":"Biocompatible reactive oxygen species (ROS)-responsive nanoparticles as superior drug delivery vehicles","volume":"4","author":"Zhang","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0074","article-title":"Reactive-oxygen-species-responsive drug delivery systems: promises and challenges","volume":"4","author":"Saravanakumar","year":"2017","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2025.07.057_bib0075","article-title":"Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment","volume":"14","author":"Zhang","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.actbio.2025.07.057_bib0076","first-page":"545","article-title":"Reactive oxygen species (ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession","volume":"33","author":"Xue","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0077","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/art.40696","article-title":"Attenuated joint tissue damage associated with improved synovial lymphatic function following treatment with bortezomib in a mouse model of experimental posttraumatic osteoarthritis","volume":"71","author":"Wang","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0078","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jconrel.2020.04.027","article-title":"Photo-triggered self-destructive ROS-responsive nanoparticles of high paclitaxel\/chlorin e6 co-loading capacity for synergetic chemo-photodynamic therapy","volume":"323","author":"Yang","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0079","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41536-022-00254-3","article-title":"ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis","volume":"7","author":"Wu","year":"2022","journal-title":"NPJ Regen. Med."},{"key":"10.1016\/j.actbio.2025.07.057_bib0080","article-title":"ROS-sensitive nanoparticles co-delivering dexamethasone and CDMP-1 for the treatment of osteoarthritis through chondrogenic differentiation induction and inflammation inhibition","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0081","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12951-022-01629-w","article-title":"Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis","volume":"20","author":"Jiang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0082","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.1039\/D2TB00968D","article-title":"Connecting the dynamics and reactivity of arylboronic acids to emergent and stimuli-responsive material properties","volume":"10","author":"Han","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2025.07.057_bib0083","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100883","article-title":"ROS-responsive boronate-stabilized polyphenol-poloxamer 188 assembled dexamethasone nanodrug for macrophage repolarization in osteoarthritis treatment","volume":"10","author":"Li","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0084","doi-asserted-by":"crossref","first-page":"11419","DOI":"10.1002\/anie.201503640","article-title":"A photoactivatable AIE polymer for light-controlled gene delivery: concurrent endo\/lysosomal escape and DNA unpacking","volume":"54","author":"Yuan","year":"2015","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2025.07.057_bib0085","doi-asserted-by":"crossref","first-page":"863","DOI":"10.7150\/thno.11852","article-title":"Cell or cell membrane-based drug delivery systems","volume":"5","author":"Tan","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.07.057_bib0086","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.213232","article-title":"Advances in cell membrane-coated nanoparticles and their applications for bone therapy","volume":"144","author":"Chen","year":"2023","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.actbio.2025.07.057_bib0087","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201706759","article-title":"Cell membrane coating nanotechnology","volume":"30","author":"Fang","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0088","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s12951-022-01746-6","article-title":"Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment","volume":"20","author":"Wu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0089","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12951-024-02351-5","article-title":"Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity","volume":"22","author":"Xue","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.addr.2017.04.001","article-title":"Nanoparticles for drug delivery to the anterior segment of the eye","volume":"122","author":"Janagam","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2025.07.057_bib0091","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jconrel.2023.09.011","article-title":"Gout therapeutics and drug delivery","volume":"362","author":"Peng","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0092","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jconrel.2020.08.041","article-title":"Drug delivery in intervertebral disc degeneration and osteoarthritis: selecting the optimal platform for the delivery of disease-modifying agents","volume":"328","author":"Colella","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113851","article-title":"Liposome composition in drug delivery design, synthesis, characterization, and clinical application","volume":"176","author":"Large","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2025.07.057_bib0094","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.addr.2021.01.019","article-title":"Overcoming barriers by local drug delivery with liposomes","volume":"174","author":"Antimisiaris","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.actbio.2025.07.057_bib0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/MMBR.00064-15","article-title":"The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases","volume":"80","author":"Petta","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.actbio.2025.07.057_bib0096","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2017.10.010","article-title":"Therapeutic mechanisms of glucocorticoids","volume":"29","author":"Vandewalle","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.actbio.2025.07.057_bib0097","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.jcis.2023.07.087","article-title":"Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction","volume":"650","author":"Bordon","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.actbio.2025.07.057_bib0098","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","article-title":"Mitophagy in degenerative joint diseases","volume":"17","author":"Sun","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.actbio.2025.07.057_bib0099","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12815","article-title":"Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis","volume":"73","author":"Zhang","year":"2022","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2025.07.057_bib0100","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s12951-023-02211-8","article-title":"Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis","volume":"21","author":"Liu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0101","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/CM9.0000000000001057","article-title":"Mitochondrial transfer from bone-marrow-derived mesenchymal stromal cells to chondrocytes protects against cartilage degenerative mitochondrial dysfunction in rats chondrocytes","volume":"134","author":"Wang","year":"2021","journal-title":"Chin. Med. J. (Engl)."},{"key":"10.1016\/j.actbio.2025.07.057_bib0102","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nrd.2018.174","article-title":"Mitochondria as a therapeutic target for common pathologies","volume":"17","author":"Murphy","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.actbio.2025.07.057_bib0103","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jconrel.2023.01.059","article-title":"Mechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer\/delivery","volume":"354","author":"Malekpour","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0104","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00018-022-04207-3","article-title":"Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact","volume":"79","author":"Velarde","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.actbio.2025.07.057_bib0105","doi-asserted-by":"crossref","first-page":"306","DOI":"10.34133\/research.0306","article-title":"Mitochondrial-oriented injectable hydrogel microspheres maintain homeostasis of chondrocyte metabolism to promote subcellular therapy in osteoarthritis","volume":"7","author":"Chen","year":"2024","journal-title":"Research"},{"key":"10.1016\/j.actbio.2025.07.057_bib0106","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122350","article-title":"Fusogenic liposomes encapsulating mitochondria as a promising delivery system for osteoarthritis therapy","volume":"302","author":"Kim","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0107","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103260","article-title":"Exosomes as biomarkers and therapeutic delivery for autoimmune diseases: opportunities and challenges","volume":"22","author":"Fang","year":"2023","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.actbio.2025.07.057_bib0108","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gpb.2015.02.001","article-title":"Exosome and exosomal microRNA: trafficking, sorting, and function","volume":"13","author":"Zhang","year":"2015","journal-title":"Genom. Proteom. Bioinform."},{"key":"10.1016\/j.actbio.2025.07.057_bib0109","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.apsb.2016.02.001","article-title":"Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges","volume":"6","author":"Ha","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.actbio.2025.07.057_bib0110","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.07.057_bib0111","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jconrel.2015.07.030","article-title":"Using exosomes, naturally-equipped nanocarriers, for drug delivery","volume":"219","author":"Batrakova","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0112","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s11095-014-1593-y","article-title":"Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio rerio","volume":"32","author":"Yang","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.actbio.2025.07.057_bib0113","article-title":"Exosome-liposome hybrid nanoparticles deliver CRISPR\/Cas9 system in MSCs","volume":"5","author":"Lin","year":"2018","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2025.07.057_bib0114","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12951-021-00969-3","article-title":"Directional homing of glycosylation-modified bone marrow mesenchymal stem cells for bone defect repair","volume":"19","author":"Chen","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0115","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13045-021-01208-w","article-title":"Mesenchymal stem\/stromal cells in cancer therapy","volume":"14","author":"Lan","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0116","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.actbio.2014.01.002","article-title":"Mesenchymal stem cell-collagen microspheres for articular cartilage repair: cell density and differentiation status","volume":"10","author":"Li","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0117","article-title":"Treatment with mesenchymal stem cell-derived nanovesicle-containing gelatin methacryloyl hydrogels alleviates osteoarthritis by modulating chondrogenesis and macrophage polarization","volume":"12","author":"Pang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0118","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101838","article-title":"Microenvironment-responsive nanocarriers for targeted bone disease therapy","volume":"50","author":"Li","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.actbio.2025.07.057_bib0119","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12951-023-02086-9","article-title":"Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in osteoarthritis","volume":"21","author":"Zhao","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0120","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1002\/art.34626","article-title":"Anti-inflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis","volume":"64","author":"ter Huurne","year":"2012","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0121","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202207637","article-title":"Regulation of synovial macrophages polarization by mimicking efferocytosis for therapy of osteoarthritis","volume":"32","author":"Yang","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0122","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12951-024-02336-4","article-title":"M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis","volume":"22","author":"Qian","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0123","article-title":"Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases","volume":"18","author":"Wang","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.actbio.2025.07.057_bib0124","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41413-020-0100-9","article-title":"Exosomes: roles and therapeutic potential in osteoarthritis","volume":"8","author":"Ni","year":"2020","journal-title":"Bone Res."},{"key":"10.1016\/j.actbio.2025.07.057_bib0125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.7150\/thno.62708","article-title":"Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics","volume":"12","author":"Yin","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.07.057_bib0126","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101479","article-title":"Injectable natural polymer hydrogels for treatment of knee osteoarthritis","volume":"11","author":"Lin","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0127","first-page":"4","article-title":"Adhesive hydrogels in osteoarthritis: from design to application","volume":"10","author":"Duan","year":"2023","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.actbio.2025.07.057_bib0128","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.actbio.2022.12.056","article-title":"Injectable spontaneous hydrogen-releasing hydrogel for long-lasting alleviation of osteoarthritis","volume":"158","author":"Zhang","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0129","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2019.05.034","article-title":"Hydrogel-based ocular drug delivery systems: emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations","volume":"306","author":"Cooper","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.triboint.2014.12.013","article-title":"Evaluation of a superior lubrication mechanism with biphasic hydrogels for artificial cartilage","volume":"89","author":"Murakami","year":"2015","journal-title":"Tribol. Int."},{"key":"10.1016\/j.actbio.2025.07.057_bib0131","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jconrel.2021.08.056","article-title":"Spatiotemporally controlled calcitonin delivery: long-term and targeted therapy of skeletal diseases","volume":"338","author":"Yu","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0132","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.110702","article-title":"Injectable hydrogel-based drug delivery system for cartilage regeneration","volume":"110","author":"Garc\u00eda-Fern\u00e1ndez","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.actbio.2025.07.057_bib0133","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1016\/j.biomaterials.2012.04.050","article-title":"A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering","volume":"33","author":"Billiet","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0134","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201904344","article-title":"Functional nanomaterials on 2D surfaces and in 3D nanocomposite hydrogels for biomedical applications","volume":"29","author":"Tutar","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0135","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001341","article-title":"Recent advances in injectable hydrogels for controlled and local drug delivery","volume":"10","author":"Rizzo","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0136","doi-asserted-by":"crossref","first-page":"7771","DOI":"10.1038\/s41467-023-43334-8","article-title":"Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.07.057_bib0137","first-page":"18","article-title":"In situ deposition of drug and gene nanoparticles on a patterned supramolecular hydrogel to construct a directionally osteochondral plug","volume":"16","author":"Kang","year":"2023","journal-title":"Nanomicro Lett."},{"key":"10.1016\/j.actbio.2025.07.057_bib0138","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120539","article-title":"Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration","volume":"269","author":"Xu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0139","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1126\/science.1215157","article-title":"A stem cell-based approach to cartilage repair","volume":"336","author":"Johnson","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.actbio.2025.07.057_bib0140","article-title":"Triple cross-linked dynamic responsive hydrogel loaded with selenium nanoparticles for modulating the inflammatory microenvironment via PI3K\/Akt\/NF-\u03baB and MAPK signaling pathways","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2025.07.057_bib0141","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202109189","article-title":"Mucus penetrating and cell-binding polyzwitterionic micelles as potent oral nanomedicine for cancer drug delivery","volume":"34","author":"Fan","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0142","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1039\/D3MH00042G","article-title":"Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair","volume":"10","author":"Wu","year":"2023","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.actbio.2025.07.057_bib0143","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128658","article-title":"Targeted drug delivery systems for matrix metalloproteinase-responsive nanoparticles in tumor cells: a review","volume":"257","author":"Guo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0144","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.ijbiomac.2020.10.079","article-title":"An injectable, self-healing and MMP-inhibiting hyaluronic acid gel via iron coordination","volume":"165","author":"Gao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0145","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1021\/jm900261f","article-title":"N-O-Isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis","volume":"52","author":"Nuti","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.actbio.2025.07.057_bib0146","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140823","article-title":"Development of a dual-responsive injectable GelMA\/F127DA hydrogel for enhanced cartilage regeneration in osteoarthritis: harnessing MMP-triggered and mechanical stress-induced release of therapeutic agents","volume":"304","author":"Sun","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0147","article-title":"Hypoxia and matrix metalloproteinase 13-responsive hydrogel microspheres alleviate osteoarthritis progression in vivo","volume":"20","author":"Zhou","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.actbio.2025.07.057_bib0148","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300962","article-title":"An MMP-2 responsive nanotheranostic probe enabled synergistic therapy of rheumatoid arthritis and MR\/CT assessment of therapeutic response in situ","volume":"12","author":"Chen","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0149","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1038\/s41467-021-22454-z","article-title":"Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis","volume":"12","author":"Deng","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.07.057_bib0150","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1038\/s41467-018-04346-x","article-title":"Author correction: towards an arthritis flare-responsive drug delivery system","volume":"9","author":"Joshi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.07.057_bib0151","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2017.08.006","article-title":"Injectable hydrogels for sustained release of therapeutic agents","volume":"267","author":"Thambi","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0152","article-title":"Microspheres for targeted drug delivery - a review on recent applications","volume":"75","author":"Yawalkar","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0153","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ijbiomac.2022.08.123","article-title":"Enzyme-responsive nano-drug delivery system for combined antitumor therapy","volume":"220","author":"Guo","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0154","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2012.10.015","article-title":"Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres-a review","volume":"165","author":"Versypt","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.07.057_bib0155","article-title":"Stem cells expansion vector via bioadhesive porous microspheres for accelerating articular cartilage regeneration","volume":"13","author":"Bai","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0156","doi-asserted-by":"crossref","first-page":"9984","DOI":"10.1016\/j.biomaterials.2014.08.042","article-title":"Intra-articular delivery of kartogenin-conjugated chitosan nano\/microparticles for cartilage regeneration","volume":"35","author":"Kang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0157","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0142-9612(00)00183-6","article-title":"Influence of the degree of acetylation on some biological properties of chitosan films","volume":"22","author":"Chatelet","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.07.057_bib0158","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.msec.2019.04.012","article-title":"Magnetic and self-healing chitosan-alginate hydrogel encapsulated gelatin microspheres via covalent cross-linking for drug delivery","volume":"101","author":"Chen","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.actbio.2025.07.057_bib0159","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41584-018-0033-5","article-title":"Molecular transport in articular cartilage - what have we learned from the past 50 years?","volume":"14","author":"DiDomenico","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2025.07.057_bib0160","article-title":"Regulating chondro-bone metabolism for treatment of osteoarthritis via high-permeability micro\/nano hydrogel microspheres","volume":"11","author":"Zuo","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2025.07.057_bib0161","first-page":"242","article-title":"Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments","volume":"32","author":"Xiao","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0162","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202170227","article-title":"Injectable microfluidic hydrogel microspheres for cell and drug delivery","volume":"31","author":"Zhao","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0163","article-title":"Visualizable and lubricating hydrogel microspheres via NanoPOSS for cartilage regeneration","volume":"10","author":"Yao","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2025.07.057_bib0164","first-page":"153","article-title":"Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration","volume":"12","author":"Shen","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0165","article-title":"Living and injectable porous hydrogel microsphere with paracrine activity for cartilage regeneration","volume":"19","author":"Li","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.actbio.2025.07.057_bib0166","article-title":"Research progress on injectable microspheres as new strategies for the treatment of osteoarthritis through promotion of cartilage repair","volume":"34","author":"Lin","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.07.057_bib0167","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2147\/DDDT.S357386","article-title":"Knee osteoarthritis therapy: recent advances in intra-articular drug delivery systems","volume":"16","author":"Ma","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.actbio.2025.07.057_bib0168","article-title":"Recent advances in clinical translation of intra-articular osteoarthritis drug delivery systems","volume":"4","author":"DeJulius","year":"2021","journal-title":"Adv. Ther. (Weinh.)"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125005562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125005562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:22:24Z","timestamp":1772781744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125005562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":168,"alternative-id":["S1742706125005562"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.07.057","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current status and future perspectives of research on intra-articular drug delivery systems for osteoarthritis therapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.07.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}