{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:38:21Z","timestamp":1792813101576,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L234022"],"award-info":[{"award-number":["L234022"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L244001"],"award-info":[{"award-number":["L244001"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2405800"],"award-info":[{"award-number":["2022YFC2405800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.actbio.2025.08.056","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T15:10:57Z","timestamp":1756480257000},"page":"270-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["An endoscopy deliverable hydrogel dry powder for sealing and repairing gastric perforation"],"prefix":"10.1016","volume":"205","author":[{"given":"Panxianzhi","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengbinpei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-6737","authenticated-orcid":false,"given":"Tun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingdong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.actbio.2025.08.056_bib0001","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1021\/acsnano.3c02083","article-title":"Hybrid dry powders for rapid sealing of gastric perforations under an endoscope","volume":"17","author":"Guo","year":"2023","journal-title":"ACS. Nano"},{"issue":"15","key":"10.1016\/j.actbio.2025.08.056_bib0002","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.7150\/thno.87639","article-title":"Photocurable injectable Janus hydrogel with minimally invasive delivery for all-in-one treatment of gastric perforations and postoperative adhesions","volume":"13","author":"Wu","year":"2023","journal-title":"Theranostics."},{"issue":"3","key":"10.1016\/j.actbio.2025.08.056_bib0003","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.actbio.2025.08.056_bib0004","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s40843-021-1849-3","article-title":"Dual-network hydrogel based on ionic nano-reservoir for gastric perforation sealing","volume":"65","author":"Yuan","year":"2021","journal-title":"Sci. China Mater."},{"issue":"4","key":"10.1016\/j.actbio.2025.08.056_bib0005","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.gie.2012.04.476","article-title":"A comprehensive approach to the management of acute endoscopic perforations (with videos)","volume":"76","author":"Baron","year":"2012","journal-title":"Gastrointest. Endosc."},{"issue":"4","key":"10.1016\/j.actbio.2025.08.056_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.gie.2015.03.1977","article-title":"Endoscopic closure of acute perforations of the GI tract: a systematic review of the literature","volume":"82","author":"Verlaan","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.actbio.2025.08.056_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.102105","article-title":"A Janus hydrogel sealant with instant wet adhesion and anti-swelling behavior for gastric perforation repair","volume":"54","author":"Liang","year":"2024","journal-title":"Nano Today"},{"issue":"1","key":"10.1016\/j.actbio.2025.08.056_bib0008","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cnc.2017.10.014","article-title":"Gastrointestinal traumatic injuries Gastrointestinal perforation","volume":"30","author":"Revell","year":"2018","journal-title":"Crit. Care Nurs. Clin. North Am."},{"issue":"1","key":"10.1016\/j.actbio.2025.08.056_bib0009","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1021\/acsnano.2c05247","article-title":"Endoscopy deliverable and mushroom-cap-inspired hyperboloid-shaped drug-laden bioadhesive hydrogel for stomach perforation repair","volume":"17","author":"Liu","year":"2022","journal-title":"ACS. Nano"},{"issue":"1","key":"10.1016\/j.actbio.2025.08.056_bib0010","doi-asserted-by":"crossref","DOI":"10.1186\/s13017-019-0283-9","article-title":"Perforated and bleeding peptic ulcer: WSES guidelines","volume":"15","author":"Tarasconi","year":"2020","journal-title":"World Journal of Emergency Surgery"},{"issue":"18","key":"10.1016\/j.actbio.2025.08.056_bib0011","doi-asserted-by":"crossref","first-page":"11336","DOI":"10.1021\/acs.chemrev.0c00798","article-title":"Polymeric tissue adhesives","volume":"121","author":"Nam","year":"2021","journal-title":"Chem. Rev."},{"issue":"630","key":"10.1016\/j.actbio.2025.08.056_bib0012","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abh2857","article-title":"An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects","volume":"14","author":"Wu","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"21","key":"10.1016\/j.actbio.2025.08.056_bib0013","article-title":"Analyzing mushroom structural patterns of a highly compressible and expandable hemostatic foam for gastric perforation repair","volume":"11","author":"Shu","year":"2024","journal-title":"Advanced Science"},{"issue":"1","key":"10.1016\/j.actbio.2025.08.056_bib0014","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09351-2","article-title":"Plant-inspired adhesive and tough hydrogel based on Ag-lignin nanoparticles-triggered dynamic redox catechol chemistry","volume":"10","author":"Gan","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.actbio.2025.08.056_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10004-7","article-title":"A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds","volume":"10","author":"Hong","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.actbio.2025.08.056_bib0016","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax8258","article-title":"Bioinspired structural color patch with anisotropic surface adhesion","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.actbio.2025.08.056_bib0017","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27529-5","article-title":"Hydrogel tapes for fault-tolerant strong wet adhesion","volume":"12","author":"Xue","year":"2021","journal-title":"Nat. Commun."},{"issue":"8016","key":"10.1016\/j.actbio.2025.08.056_bib0018","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41586-024-07426-9","article-title":"Adhesive anti-fibrotic interfaces on diverse organs","volume":"630","author":"Wu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2025.08.056_bib0019","first-page":"703","article-title":"Robust hydrogel adhesives for emergency rescue and gastric perforation repair","volume":"19","author":"Yu","year":"2023","journal-title":"Bioact. Mater."},{"issue":"23","key":"10.1016\/j.actbio.2025.08.056_bib0020","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1039\/D3TB00239J","article-title":"A chitosan-optimized polyethyleneimine\/polyacrylic acid multifunctional hydrogel for reducing the risk of ulcerative arterial bleeding","volume":"11","author":"Ni","year":"2023","journal-title":"Journal of Materials Chemistry B"},{"issue":"32","key":"10.1016\/j.actbio.2025.08.056_bib0021","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201801884","article-title":"Tough hydrogels with fast, strong, and reversible underwater adhesion based on a multiscale design","volume":"30","author":"Rao","year":"2018","journal-title":"Advanced Materials"},{"issue":"7","key":"10.1016\/j.actbio.2025.08.056_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201907064","article-title":"Self-hydrophobization in a dynamic hydrogel for creating nonspecific repeatable underwater adhesion","volume":"30","author":"Han","year":"2019","journal-title":"Adv. Funct. Mater."},{"issue":"7781","key":"10.1016\/j.actbio.2025.08.056_bib0023","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41586-019-1710-5","article-title":"Dry double-sided tape for adhesion of wet tissues and devices","volume":"575","author":"Yuk","year":"2019","journal-title":"Nature"},{"issue":"6349","key":"10.1016\/j.actbio.2025.08.056_bib0024","first-page":"378","article-title":"Tough adhesives for diverse wet surfaces","volume":"357","author":"Li","year":"2017","journal-title":"Science (1979)"},{"issue":"29","key":"10.1016\/j.actbio.2025.08.056_bib0025","article-title":"Hydrogel bioadhesives with extreme acid-tolerance for gastric perforation repairing","volume":"32","author":"Chen","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"6","key":"10.1016\/j.actbio.2025.08.056_bib0026","doi-asserted-by":"crossref","first-page":"9913","DOI":"10.1021\/acsnano.1c01199","article-title":"Injectable self-healing hydrogel via biological environment-adaptive supramolecular assembly for gastric perforation healing","volume":"15","author":"Wang","year":"2021","journal-title":"ACS. Nano"},{"key":"10.1016\/j.actbio.2025.08.056_bib0027","first-page":"52","article-title":"An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation","volume":"14","author":"Chen","year":"2022","journal-title":"Bioact. Mater."},{"issue":"23","key":"10.1016\/j.actbio.2025.08.056_bib0028","article-title":"An integrally formed Janus hydrogel for robust wet-tissue adhesive and anti-postoperative adhesion","volume":"35","author":"Wang","year":"2023","journal-title":"Advanced Materials"},{"issue":"17","key":"10.1016\/j.actbio.2025.08.056_bib0029","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202106115","article-title":"Polyglutamic acid-based elastic and tough adhesive patch promotes tissue regeneration through In situ macrophage modulation","volume":"9","author":"Zhu","year":"2022","journal-title":"Advanced Science"},{"issue":"410","key":"10.1016\/j.actbio.2025.08.056_bib0030","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai7466","article-title":"Engineering a highly elastic human protein-based sealant for surgical applications","volume":"9","author":"Annabi","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2025.08.056_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.154519","article-title":"Bioadhesive chitosan hydrogel with ROS scavenging promotes angiogenesis and mucosal repair for the treatment of gastric ulcer","volume":"497","author":"Ni","year":"2024","journal-title":"Chemical Engineering Journal"},{"key":"10.1016\/j.actbio.2025.08.056_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.137244","article-title":"Self-healable and redox active hydrogel obtained via incorporation of ferric ion for supercapacitor applications","volume":"446","author":"Lin","year":"2022","journal-title":"Chemical Engineering Journal"},{"key":"10.1016\/j.actbio.2025.08.056_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121466","article-title":"An injectable carboxymethyl chitosan hydrogel scaffold formed via coordination bond for antibacterial and osteogenesis in osteomyelitis","volume":"324","author":"Zhou","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"15","key":"10.1016\/j.actbio.2025.08.056_bib0034","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1021\/acs.macromol.6b00584","article-title":"Dual physically cross-linked hydrogels with high stretchability, toughness, and good self-recoverability","volume":"49","author":"Hu","year":"2016","journal-title":"Macromolecules."},{"issue":"14","key":"10.1016\/j.actbio.2025.08.056_bib0035","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1021\/ma100963m","article-title":"Ionically cross-linked triblock copolymer hydrogels with high strength","volume":"43","author":"Henderson","year":"2010","journal-title":"Macromolecules."},{"issue":"24","key":"10.1016\/j.actbio.2025.08.056_bib0036","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1021\/acs.macromol.6b02150","article-title":"Metal-coordination complexes mediated physical hydrogels with high toughness, stick\u2013Slip tearing behavior, and good processability","volume":"49","author":"Zheng","year":"2016","journal-title":"Macromolecules."},{"issue":"11","key":"10.1016\/j.actbio.2025.08.056_bib0037","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1007\/s11426-022-1345-3","article-title":"Engineering multifunctional bioadhesive powders through dynamic metal-ligand coordination","volume":"65","author":"Guo","year":"2022","journal-title":"Sci. China Chem."},{"issue":"44","key":"10.1016\/j.actbio.2025.08.056_bib0038","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1039\/D2SM01122K","article-title":"Modelling viscoelastic relaxation mechanisms in thermorheologically complex Fe(iii)\u2013poly(acrylic acid) hydrogels","volume":"18","author":"Lenoch","year":"2022","journal-title":"Soft. Matter."},{"key":"10.1016\/j.actbio.2025.08.056_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121589","article-title":"Nanohybrid dual-network chitosan-based hydrogels: synthesis, characterization, quicken infected wound healing by angiogenesis and immune-microenvironment regulation","volume":"325","author":"Liu","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"33","key":"10.1016\/j.actbio.2025.08.056_bib0040","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202311344","article-title":"Magnesium ions promote the induction of immunosuppressive bone microenvironment and bone repair through HIF-1\u03b1-TGF-\u03b2 axis in dendritic cells","volume":"20","author":"Dai","year":"2024","journal-title":"Small."},{"key":"10.1016\/j.actbio.2025.08.056_bib0041","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad103","article-title":"Exogeneous metal ions as therapeutic agents in cardiovascular disease and their delivery strategies","volume":"11","author":"Hong","year":"2024","journal-title":"Regen. Biomater."},{"issue":"22","key":"10.1016\/j.actbio.2025.08.056_bib0042","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1021\/acsnano.3c04556","article-title":"Exudate absorbing and antimicrobial hydrogel integrated with multifunctional curcumin-loaded magnesium polyphenol network for facilitating burn wound healing","volume":"17","author":"Gong","year":"2023","journal-title":"ACS. Nano"},{"issue":"8","key":"10.1016\/j.actbio.2025.08.056_bib0043","first-page":"2315","article-title":"Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration","volume":"6","author":"Lin","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.08.056_bib0044","first-page":"231","article-title":"Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg2+ for diabetic wounds","author":"Zhu","year":"2022","journal-title":"Composites Part B: Engineering"},{"issue":"11","key":"10.1016\/j.actbio.2025.08.056_bib0045","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1021\/acs.biomac.1c00842","article-title":"A three-in-one strategy: injectable biomimetic porous hydrogels for accelerating bone regeneration via shape-adaptable scaffolds, controllable magnesium ion release, and enhanced osteogenic differentiation","volume":"22","author":"Zhou","year":"2021","journal-title":"Biomacromolecules."},{"issue":"2","key":"10.1016\/j.actbio.2025.08.056_bib0046","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1039\/C9MH01255A","article-title":"Wound dressing change facilitated by spraying zinc ions","volume":"7","author":"Xie","year":"2020","journal-title":"Mater. Horiz."},{"issue":"43","key":"10.1016\/j.actbio.2025.08.056_bib0047","doi-asserted-by":"crossref","first-page":"21369","DOI":"10.1073\/pnas.1906349116","article-title":"Expanding the stoichiometric window for metal cross-linked gel assembly using competition","volume":"116","author":"Cazzell","year":"2019","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.actbio.2025.08.056_bib0048","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.colsurfb.2018.07.032","article-title":"Reduced inflammatory response by incorporating magnesium into porous TiO2 coating on titanium substrate","volume":"171","author":"Li","year":"2018","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"key":"10.1016\/j.actbio.2025.08.056_bib0049","article-title":"Biocompatible, adhesive and stable GelMAc\/PVAMA\/MPDA@cur hydrogels regulate immune response to improve endoscopic submucosal dissection-induced gastric ulcer healing in vivo","volume":"28","author":"Zhang","year":"2022","journal-title":"Appl. Mater. Today"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125006488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125006488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:24:56Z","timestamp":1780039496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125006488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":49,"alternative-id":["S1742706125006488"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.08.056","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An endoscopy deliverable hydrogel dry powder for sealing and repairing gastric perforation","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.08.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}