{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:20:25Z","timestamp":1793298025870,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.actbio.2025.10.058","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:52:17Z","timestamp":1761810737000},"page":"293-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Inflammation-responsive biodegradable nanocomposite hydrogels for enhanced metalloimmunotherapy in chronic periodontitis"],"prefix":"10.1016","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8241-9992","authenticated-orcid":false,"given":"Xiao","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanrui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangzhuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enshi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2426-6690","authenticated-orcid":false,"given":"Shahin","family":"Homaeigohar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-6677","authenticated-orcid":false,"given":"Kai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.actbio.2025.10.058_bib0001","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.it.2014.05.001","article-title":"Divalent cation signaling in immune cells","volume":"35","author":"Chaigne-Delalande","year":"2014","journal-title":"Trends. Immunol."},{"key":"10.1016\/j.actbio.2025.10.058_bib0002","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/bs.ai.2019.11.007","article-title":"Metalloimmunology: The metal ion-controlled immunity","volume":"145","author":"Wang","year":"2020","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.actbio.2025.10.058_bib0003","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/s41551-024-01221-7","article-title":"Strategies for the development of metalloimmunotherapies","author":"Sun","year":"2024","journal-title":"Nat. Biomed. Eng."},{"issue":"22","key":"10.1016\/j.actbio.2025.10.058_bib0004","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1039\/D3BM01146A","article-title":"Metal ions: the unfading stars of bone regeneration-from bone metabolism regulation to biomaterial applications","volume":"11","author":"Luo","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.actbio.2025.10.058_bib0005","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biomaterials.2016.01.046","article-title":"The two faces of metal ions: From implants rejection to tissue repair\/regeneration","volume":"84","author":"Vasconcelos","year":"2016","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2025.10.058_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/ma15062194","article-title":"Bioactive glasses in periodontal regeneration: existing strategies and future prospects-a literature review","volume":"15","author":"Cannillo","year":"2022","journal-title":"Materials (Basel)"},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0007","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.3390\/ph14020075","article-title":"Silica-based bioactive glasses and their applications in hard tissue regeneration: a review","volume":"14","author":"Al-Harbi","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.actbio.2025.10.058_bib0008","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.actbio.2021.08.023","article-title":"Immunomodulatory bioactive glasses for tissue regeneration","volume":"133","author":"Zheng","year":"2021","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0009","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1053\/j.tcam.2008.02.003","article-title":"Periodontal disease","volume":"23","author":"Niemiec","year":"2008","journal-title":"Top. Companion Anim. Med."},{"issue":"11","key":"10.1016\/j.actbio.2025.10.058_bib0010","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.tibtech.2018.05.013","article-title":"Point-of-care periodontitis testing: biomarkers, current technologies, and perspectives","volume":"36","author":"He","year":"2018","journal-title":"Trends Biotechnol."},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0011","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/0022034510385236","article-title":"Inflammation and uncoupling as mechanisms of periodontal bone loss","volume":"90","author":"Graves","year":"2011","journal-title":"J. Dent. Res."},{"issue":"11","key":"10.1016\/j.actbio.2025.10.058_bib0012","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/cdd.2016.74","article-title":"Decreased MORF leads to prolonged endoplasmic reticulum stress in periodontitis-associated chronic inflammation","volume":"23","author":"Xue","year":"2016","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.actbio.2025.10.058_bib0013","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2017.59","article-title":"Bone biomaterials and interactions with stem cells","volume":"5","author":"Gao","year":"2017","journal-title":"Bone Res."},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0014","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrrheum.2017.205","article-title":"Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis","volume":"14","author":"Bouta","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0015","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/path.5070","article-title":"The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization","volume":"245","author":"Gucciardo","year":"2018","journal-title":"J. Pathol."},{"key":"10.1016\/j.actbio.2025.10.058_bib0016","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s43587-024-00691-3","article-title":"Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage","author":"Du","year":"2024","journal-title":"Nat. Aging"},{"issue":"4","key":"10.1016\/j.actbio.2025.10.058_bib0017","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/0022034516681762","article-title":"Role of hyperplasia of gingival lymphatics in periodontal inflammation","volume":"96","author":"Papadakou","year":"2017","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0018","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jemt.10006","article-title":"Lymphatic networks in the periodontal tissue and dental pulp as revealed by histochemical study","volume":"56","author":"Matsumoto","year":"2002","journal-title":"Microsc. Res. Tech."},{"issue":"7-8","key":"10.1016\/j.actbio.2025.10.058_bib0019","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/00220345780570071001","article-title":"Lymphatic vessels of healthy and inflamed gingiva","volume":"57","author":"Bernick","year":"1978","journal-title":"J. Dent. Res."},{"issue":"12","key":"10.1016\/j.actbio.2025.10.058_bib0020","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1177\/0022034513504589","article-title":"Lymphangiogenesis and lymphatic function in periodontal disease","volume":"92","author":"Berggreen","year":"2013","journal-title":"J. Dent. Res."},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0021","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.yexcr.2013.12.006","article-title":"Lymphatic function and responses in periodontal disease","volume":"325","author":"Berggreen","year":"2014","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.actbio.2025.10.058_bib0022","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.ajpath.2012.05.027","article-title":"Gingival lymphatic drainage protects against porphyromonas gingivalis-induced bone loss in mice","volume":"181","author":"Mkonyi","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.actbio.2025.10.058_bib0023","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/path.5456","article-title":"Effect of VEGFC on lymph flow and inflammation-induced alveolar bone loss","volume":"251","author":"Wang","year":"2020","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0024","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/prd.12008","article-title":"Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts","volume":"62","author":"Heitz-Mayfield","year":"2013","journal-title":"Periodontology 2000"},{"issue":"8 Suppl","key":"10.1016\/j.actbio.2025.10.058_bib0025","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1902\/jop.2008.080213","article-title":"Mapping the pathogenesis of periodontitis: a new look","volume":"79","author":"Kornman","year":"2008","journal-title":"J. Periodontol."},{"issue":"10","key":"10.1016\/j.actbio.2025.10.058_bib0026","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/sj.bjc.6603120","article-title":"Targeting lymphangiogenesis to prevent tumour metastasis","volume":"94","author":"Achen","year":"2006","journal-title":"Br. J. Cancer"},{"issue":"7","key":"10.1016\/j.actbio.2025.10.058_bib0027","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1089\/wound.2017.0768","article-title":"Physiological perspective on therapies of lymphatic vessels","volume":"7","author":"Kilarski","year":"2018","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.actbio.2025.10.058_bib0028","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.actbio.2020.09.044","article-title":"Biological properties of copper-doped biomaterials for orthopedic applications: a review of antibacterial, angiogenic and osteogenic aspects","volume":"117","author":"Jacobs","year":"2020","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.actbio.2025.10.058_bib0029","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1167\/iovs.09-4158","article-title":"Time-lapse imaging of retinal angiogenesis reveals decreased development and progression of neovascular sprouting by anecortave desacetate","volume":"51","author":"Unoki","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2025.10.058_bib0030","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/(SICI)1097-4644(19980601)69:3<326::AID-JCB10>3.0.CO;2-A","article-title":"Copper stimulates proliferation of human endothelial cells under culture","volume":"69","author":"Hu","year":"1998","journal-title":"J. Cell Biochem."},{"issue":"3","key":"10.1016\/j.actbio.2025.10.058_bib0031","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1530-0277.1987.tb01298.x","article-title":"Effect of acute alcohol on attention and the processing of hierarchical patterns","volume":"11","author":"Lamb","year":"1987","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0032","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1440-1681.2008.04969.x","article-title":"Copper and angiogenesis: unravelling a relationship key to cancer progression","volume":"36","author":"Finney","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"11","key":"10.1016\/j.actbio.2025.10.058_bib0033","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1038\/mt.2014.161","article-title":"Neovascularization capacity of mesenchymal stromal cells from critical limb ischemia patients is equivalent to healthy controls","volume":"22","author":"Gremmels","year":"2014","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4889(00)00041-0","article-title":"Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions","volume":"1497","author":"Michiels","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.actbio.2025.10.058_bib0035","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12038-016-9629-6","article-title":"Copper transporters and chaperones: Their function on angiogenesis and cellular signalling","volume":"41","author":"Bharathi Devi","year":"2016","journal-title":"J. Biosci."},{"issue":"6","key":"10.1016\/j.actbio.2025.10.058_bib0036","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/CIRCRESAHA.110.225334","article-title":"Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration","volume":"107","author":"Ashino","year":"2010","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.actbio.2025.10.058_bib0037","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0038","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.addr.2011.02.008","article-title":"New developments and opportunities in oral mucosal drug delivery for local and systemic disease","volume":"64","author":"Hearnden","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202209466","article-title":"Stem cell-niche engineering via multifunctional hydrogel potentiates stem cell therapies for inflammatory bone loss","volume":"33","author":"Li","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"16","key":"10.1016\/j.actbio.2025.10.058_bib0040","article-title":"Hydrogel transformed from nanoparticles for prevention of tissue injury and treatment of inflammatory diseases","volume":"34","author":"Li","year":"2022","journal-title":"Adv. Mater."},{"issue":"32","key":"10.1016\/j.actbio.2025.10.058_bib0041","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202301523","article-title":"Pathogenesis-guided engineering of multi-bioactive hydrogel co-delivering inflammation-resolving nanotherapy and pro-osteogenic protein for bone regeneration","volume":"33","author":"Liu","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2025.10.058_bib0042","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1021\/bm200464x","article-title":"Catechol-functionalized chitosan\/pluronic hydrogels for tissue adhesives and hemostatic materials","volume":"12","author":"Ryu","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2025.10.058_bib0043","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fchem.2019.00497","article-title":"Toward highly dispersed mesoporous bioactive glass nanoparticles with high Cu concentration using Cu\/ascorbic acid complex as precursor","volume":"7","author":"Zheng","year":"2019","journal-title":"Front. Chem."},{"issue":"10","key":"10.1016\/j.actbio.2025.10.058_bib0045","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3390\/pharmaceutics13101550","article-title":"Mg-BGNs\/DCECM composite scaffold for cartilage regeneration: a preliminary in vitro study","volume":"13","author":"Yuan","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.actbio.2025.10.058_bib0046","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.coi.2018.04.003","article-title":"Cytokines regulating lymphangiogenesis","volume":"53","author":"Sainz-Jaspeado","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.actbio.2025.10.058_bib0047","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.660072","article-title":"Cox4i2 triggers an increase in reactive oxygen species, leading to ferroptosis and apoptosis in HHV7 infected schwann cells","volume":"8","author":"Chang","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.actbio.2025.10.058_bib0048","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.597374","article-title":"Ras pathways on Prox1 and lymphangiogenesis: insights for therapeutics","volume":"7","author":"Bui","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0049","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbrc.2010.04.115","article-title":"Positive regulation of the Egr-1\/osteopontin positive feedback loop in rat vascular smooth muscle cells by TGF-beta, ERK, JNK, and p38 MAPK signaling","volume":"396","author":"Yu","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.actbio.2025.10.058_bib0050","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. Dent. Res."},{"issue":"11","key":"10.1016\/j.actbio.2025.10.058_bib0051","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/sctm.19-0418","article-title":"Exosomes derived from P2X7 receptor gene-modified cells rescue inflammation-compromised periodontal ligament stem cells from dysfunction","volume":"9","author":"Xu","year":"2020","journal-title":"Stem Cells Transl. Med."},{"issue":"37","key":"10.1016\/j.actbio.2025.10.058_bib0052","doi-asserted-by":"crossref","first-page":"21084","DOI":"10.1039\/C9CP04392F","article-title":"Theoretical studies on the energy structures and optical properties of copper cysteamine - a novel sensitizer","volume":"21","author":"Alias","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"9","key":"10.1016\/j.actbio.2025.10.058_bib0053","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/pharmaceutics14091838","article-title":"Effectiveness of copper nanoparticles in wound healing process using in vivo and in vitro studies: a systematic review","volume":"14","author":"Sandoval","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.actbio.2025.10.058_bib0054","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.clnesp.2020.09.022","article-title":"Copper as a potential adjunct therapy for critically ill COVID-19 patients","volume":"40","author":"Fooladi","year":"2020","journal-title":"Clin. Nutr. ESPEN."},{"issue":"6","key":"10.1016\/j.actbio.2025.10.058_bib0055","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3390\/nu13061898","article-title":"Relation of serum copper status to survival in COVID-19","volume":"13","author":"Hackler","year":"2021","journal-title":"Nutrient."},{"issue":"6586","key":"10.1016\/j.actbio.2025.10.058_bib0056","first-page":"1254","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science (1979)"},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0057","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1086\/421243","article-title":"Activation of extracellular signal-regulated kinase mediates apoptosis induced by uropathogenic Escherichia coli toxins via nitric oxide synthase: protective role of heme oxygenase-1","volume":"190","author":"Chen","year":"2004","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0058","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: mechanisms of ERK-induced cell death\u2013apoptosis, autophagy and senescence","volume":"277","author":"Cagnol","year":"2010","journal-title":"FEBS. J."},{"issue":"20","key":"10.1016\/j.actbio.2025.10.058_bib0059","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1182\/blood.2019001736","article-title":"Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC","volume":"134","author":"Lim","year":"2019","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0060","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ni1013","article-title":"Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins","volume":"5","author":"Karkkainen","year":"2004","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2025.10.058_bib0061","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12903-023-02898-z","article-title":"Bioactive glass for periodontal regeneration: a systematic review","volume":"23","author":"Motta","year":"2023","journal-title":"BM. Oral Health"},{"key":"10.1016\/j.actbio.2025.10.058_bib0062","article-title":"Li-doped bioglass(R) 45S5 for potential treatment of prevalent oral diseases","volume":"105","author":"Cordero","year":"2021","journal-title":"J. Dent."},{"key":"10.1016\/j.actbio.2025.10.058_bib0063","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actbio.2022.03.046","article-title":"ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis","volume":"146","author":"Liu","year":"2022","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2025.10.058_bib0064","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2022.12.031","article-title":"Lymphatic vessels in bone support regeneration after injury","volume":"186","author":"Biswas","year":"2023","journal-title":"Cell"},{"issue":"0059","key":"10.1016\/j.actbio.2025.10.058_bib65","article-title":"A Janus adhesive hydrogel with integrated attack and defense for bacteriaKilling and antifouling","volume":"5","author":"Ren","year":"2024","journal-title":"BME Front"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125008037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125008037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:25:29Z","timestamp":1775042729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125008037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":64,"alternative-id":["S1742706125008037"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.10.058","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation-responsive biodegradable nanocomposite hydrogels for enhanced metalloimmunotherapy in chronic periodontitis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.10.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}