{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:43:15Z","timestamp":1793227395563,"version":"4.5.0"},"reference-count":249,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401121"],"award-info":[{"award-number":["82401121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170963"],"award-info":[{"award-number":["82170963"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370967"],"award-info":[{"award-number":["82370967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016927","name":"National Museum of Nature and Science","doi-asserted-by":"publisher","award":["82501166"],"award-info":[{"award-number":["82501166"]}],"id":[{"id":"10.13039\/100016927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB024"],"award-info":[{"award-number":["2024AFB024"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506300"],"award-info":[{"award-number":["2023YFC2506300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042025kf0006"],"award-info":[{"award-number":["2042025kf0006"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025373","name":"School of Stomatology, Wuhan University","doi-asserted-by":"publisher","award":["ZW202402"],"award-info":[{"award-number":["ZW202402"]}],"id":[{"id":"10.13039\/501100025373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.actbio.2025.11.060","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:12:22Z","timestamp":1764259942000},"page":"457-480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Engineered extracellular vesicles as multifunctional therapeutics for restoring periodontal homeostasis"],"prefix":"10.1016","volume":"210","author":[{"given":"Junjie","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongshuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-9034","authenticated-orcid":false,"given":"Zhengguo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.11.060_bib0001","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0002","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/prd.12094","article-title":"Epithelial barrier and oral bacterial infection","volume":"69","author":"Groeger","year":"2015","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.actbio.2025.11.060_bib0003","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/0022034516685711","article-title":"MicroRNAs and periodontal homeostasis","volume":"96","author":"Luan","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0004","doi-asserted-by":"crossref","first-page":"19980","DOI":"10.1021\/acsnano.2c11298","article-title":"Analysis and biomedical applications of functional cargo in extracellular vesicles","volume":"16","author":"Qian","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.11.060_bib0005","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/jcpe.13338","article-title":"Systematic review and sequential network meta-analysis on the efficacy of periodontal regenerative therapies","volume":"47","author":"Tsai","year":"2020","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.actbio.2025.11.060_bib0006","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/cells8060537","article-title":"Periodontal bone-ligament-cementum regeneration via scaffolds and stem cells","volume":"8","author":"Liu","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.actbio.2025.11.060_bib0007","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1631\/jzus.B2200702","article-title":"Current status and future prospects of stomatology research","volume":"24","author":"Chen","year":"2023","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.actbio.2025.11.060_bib0008","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.actbio.2025.11.060_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102210","article-title":"Multi-prospects of bacterial extracellular vesicles in immune modulation, inflammation regulation, and periodontitis treatment","volume":"55","author":"Jiang","year":"2024","journal-title":"NANO TODAY"},{"key":"10.1016\/j.actbio.2025.11.060_bib0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00109-025-02513-4","article-title":"Mesenchymal stem cell-derived extracellular vesicles in periodontal bone repair","volume":"103","author":"Chen","year":"2025","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.actbio.2025.11.060_bib0011","article-title":"Engineered extracellular vesicles for cancer therapy","volume":"33","author":"Zhang","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.11.060_bib0012","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13287-023-03275-x","article-title":"Engineering exosomes and biomaterial-assisted exosomes as therapeutic carriers for bone regeneration","volume":"14","author":"Lu","year":"2023","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2025.11.060_bib0013","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.2147\/IJN.S444582","article-title":"Engineered exosome for drug delivery: recent development and clinical applications","volume":"18","author":"Tian","year":"2023","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0014","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.7150\/ijbs.80430","article-title":"Exosomes and their bioengineering strategies in the cutaneous wound healing and related complications: current knowledge and future perspectives","volume":"19","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0016","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.actbio.2025.11.060_bib0017","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.actbio.2025.11.060_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.vesic.2024.100053","article-title":"Extracellular vesicle-based drug delivery systems in cancer","volume":"4","author":"Huang","year":"2024","journal-title":"Extracell Vesicle"},{"key":"10.1016\/j.actbio.2025.11.060_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115284","article-title":"Engineered extracellular vesicles in female reproductive disorders","volume":"166","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actbio.2025.11.060_bib0020","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/ars.2019.7922","article-title":"Liquid biopsies: microvesicles in cardiovascular disease","volume":"33","author":"Badimon","year":"2020","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.actbio.2025.11.060_bib0021","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12951-025-03259-4","article-title":"Extracellular vesicle-mediated bidirectional communication between the liver and other organs: mechanistic exploration and prospects for clinical applications","volume":"23","author":"Mo","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0022","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1038\/ncomms8439","article-title":"A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure","volume":"6","author":"Gk","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.11.060_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12260","article-title":"Understanding the extracellular vesicle surface for clinical molecular biology","volume":"11","author":"Hallal","year":"2022","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.actbio.2025.11.060_bib0024","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2147\/JIR.S504612","article-title":"Extracellular vesicles in periodontitis: pathogenic mechanisms and therapeutic potential","volume":"18","author":"Zhang","year":"2025","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.actbio.2025.11.060_bib0025","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041415","article-title":"Lipids in extracellular vesicles: what can Be learned about membrane structure and function?","volume":"15","author":"Skotland","year":"2023","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0026","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actbio.2025.11.060_bib0027","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12463","article-title":"Inter-laboratory multiplex bead-based surface protein profiling of MSC-derived EV preparations identifies MSC-EV surface marker signatures","volume":"13","author":"Nguyen","year":"2024","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.actbio.2025.11.060_bib0028","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1074\/jbc.M109.045427","article-title":"Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells","volume":"285","author":"Leffler","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.actbio.2025.11.060_bib0029","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20240005","article-title":"Engineering strategies for apoptotic bodies","volume":"3","author":"Hu","year":"2024","journal-title":"Smart Med"},{"key":"10.1016\/j.actbio.2025.11.060_bib0030","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1021\/jacs.4c13516","article-title":"Lipophilicity modulation of fluorescent probes for In situ imaging of cellular microvesicle dynamics","volume":"147","author":"Huang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2025.11.060_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-013-1084-8","article-title":"Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies","volume":"113","author":"Akers","year":"2013","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0032","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41419-018-0632-8","article-title":"Caspase-mediated cleavage of the centrosomal proteins during apoptosis","volume":"9","author":"Seo","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0033","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1021\/acs.molpharmaceut.3c01121","article-title":"Preclinical and clinical studies on the use of extracellular vesicles derived from mesenchymal stem cells in the treatment of chronic wounds","volume":"21","author":"Rezaei","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actbio.2025.11.060_bib0034","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12964-023-01251-9","article-title":"Advances in biological functions and applications of apoptotic vesicles","volume":"21","author":"Zou","year":"2023","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.actbio.2025.11.060_bib0035","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.3390\/ijms24065790","article-title":"The applications and potentials of extracellular vesicles from different cell sources in periodontal regeneration","volume":"24","author":"Huang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0036","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13287-023-03242-6","article-title":"Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration","volume":"14","author":"Chen","year":"2023","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2025.11.060_bib0037","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1089\/scd.2019.0031","article-title":"Periodontal ligament stem cells: regenerative potency in periodontium","volume":"28","author":"Tomokiyo","year":"2019","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.actbio.2025.11.060_bib0038","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/odi.14375","article-title":"Effects of periodontal ligament stem cell-derived exosomes on osteoblastic proliferation, migration, differentiation, apoptosis, and signaling pathways","volume":"30","author":"Lan","year":"2024","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0039","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1111\/odi.14671","article-title":"Effect of human periodontal ligament stem cell-derived exosomes on cementoblast activity","volume":"30","author":"Li","year":"2024","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0040","doi-asserted-by":"crossref","first-page":"8479","DOI":"10.1038\/s41598-023-35172-x","article-title":"Rab27a-mediated extracellular vesicle secretion contributes to osteogenesis in periodontal ligament-bone niche communication","volume":"13","author":"Lu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.11.060_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.154625","article-title":"VDAC1-enriched apoptotic extracellular vesicles emerge as an autophagy activator orchestrating PDLSC-based bone regeneration","volume":"497","author":"Deng","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.11.060_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.687258","article-title":"Exosomes regulate interclonal communication on osteogenic differentiation among heterogeneous osteogenic single-cell clones through PINK1\/Parkin-mediated mitophagy","volume":"9","author":"Fei","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.actbio.2025.11.060_bib0043","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/s41598-024-52073-9","article-title":"Periodontal ligament cells-derived exosomes promote osteoclast differentiation via modulating macrophage polarization","volume":"14","author":"Bai","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.11.060_bib0044","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1089\/scd.2019.0021","article-title":"Extracellular vesicles suppress basal and lipopolysaccharide-induced nf\u03bab activity in Human periodontal ligament stem cells","volume":"28","author":"Cebatariuniene","year":"2019","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.actbio.2025.11.060_bib0045","doi-asserted-by":"crossref","first-page":"20662","DOI":"10.1002\/jcp.28671","article-title":"Exosomal microRNA-155-5p from PDLSCs regulated Th17\/treg balance by targeting sirtuin-1 in chronic periodontitis","volume":"234","author":"Zheng","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0046","doi-asserted-by":"crossref","first-page":"e743","DOI":"10.1002\/iid3.743","article-title":"Exosomal miR-205-5p derived from periodontal ligament stem cells attenuates the inflammation of chronic periodontitis via targeting XBP1","volume":"11","author":"Kang","year":"2023","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0047","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/odi.15181","article-title":"ApoEVs transfer mitochondrial component to modulate macrophages in periodontal regeneration","volume":"31","author":"Liu","year":"2024","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0048","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/stmcls\/sxac087","article-title":"Inflammatory periodontal ligament stem cells drive M1 macrophage polarization via exosomal miR-143-3p-mediated regulation of PI3K\/AKT\/NF-\u03bab signaling","volume":"41","author":"Wang","year":"2023","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2025.11.060_bib0049","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.2147\/IJN.S420967","article-title":"Dental pulp stem cell-derived exosomes regulate anti-inflammatory and osteogenesis in periodontal ligament stem cells and promote the repair of experimental periodontitis in rats","volume":"18","author":"Qiao","year":"2023","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0050","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13026","article-title":"Periodontitis-compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA-378a promote local angiogenesis by targeting Sufu to activate the Hedgehog\/Gli1 signalling","volume":"54","author":"Zhou","year":"2021","journal-title":"Cell Prolif"},{"key":"10.1016\/j.actbio.2025.11.060_bib0051","doi-asserted-by":"crossref","DOI":"10.1111\/jre.13390","article-title":"Extracellular vesicles from dental pulp cells promote osteogenic differentiation in periodontal ligament cells","author":"Li","year":"2025","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0052","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jre.12949","article-title":"Exosomes from dental pulp cells attenuate bone loss in mouse experimental periodontitis","volume":"57","author":"Shimizu","year":"2022","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0053","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13287-020-01614-w","article-title":"The proangiogenic effects of extracellular vesicles secreted by dental pulp stem cells derived from periodontally compromised teeth","volume":"11","author":"Zhou","year":"2020","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2025.11.060_bib0054","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3390\/pharmaceutics14050908","article-title":"Exosomes derived from dental pulp stem cells show different angiogenic and osteogenic properties in relation to the age of the donor","volume":"14","author":"Brunello","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.actbio.2025.11.060_bib0055","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1111\/odi.14153","article-title":"SHED-derived exosomes improve the repair capacity and osteogenesis potential of hPDLCs","volume":"29","author":"Wang","year":"2023","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0056","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202400260","article-title":"Odontogenesis-empowered extracellular vesicles safeguard donor-recipient stem cell interplay to support tooth regeneration","volume":"20","author":"Huang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.actbio.2025.11.060_bib0057","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/s12951-024-02752-6","article-title":"Youthful small extracellular vesicles restore the function and reparative capacity of inflammatory-impaired periodontal ligament stem cells via delivering protein biglycan for bone regeneration","volume":"22","author":"Yang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106030","article-title":"Role of gingival mesenchymal stem cell exosomes in macrophage polarization under inflammatory conditions","volume":"81","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0059","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.863364","article-title":"Exosomes derived from human gingival mesenchymal stem cells attenuate the inflammatory response in periodontal ligament stem cells","volume":"10","author":"Sun","year":"2022","journal-title":"Front Chem"},{"key":"10.1016\/j.actbio.2025.11.060_bib0060","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/jcpe.13798","article-title":"Human gingival mesenchymal stem cell-derived exosomes cross-regulate the wnt\/\u03b2-catenin and NF-\u03bab signalling pathways in the periodontal inflammation microenvironment","volume":"50","author":"Hu","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0061","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1177\/00220345221084975","article-title":"Human bone marrow stromal cell exosomes ameliorate periodontitis","volume":"101","author":"Yue","year":"2022","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0062","doi-asserted-by":"crossref","first-page":"8774","DOI":"10.3390\/ijms22168774","article-title":"First experimental study of the influence of extracellular vesicles derived from multipotent stromal cells on osseointegration of dental implants","volume":"22","author":"Maiborodin","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0063","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1021\/acsnano.3c11050","article-title":"Apoptotic extracellular vesicles induced endothelial cell-mediated autologous stem cell recruitment dominates allogeneic stem cell therapeutic mechanism for bone repair","volume":"18","author":"Yu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.11.060_bib0064","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/00220345211068338","article-title":"BMSC-derived ApoEVs promote craniofacial bone repair via ROS\/JNK signaling","volume":"101","author":"Li","year":"2022","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0065","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/JPER.21-0657","article-title":"Apoptotic extracellular vesicles alleviate pg-LPS induced inflammation of macrophages via AMPK\/SIRT1\/NF-\u03baB pathway and inhibit adjacent osteoclast formation","volume":"93","author":"Ye","year":"2022","journal-title":"J. Periodontol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0066","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbrc.2018.11.109","article-title":"Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia\/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro","volume":"508","author":"Ren","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.actbio.2025.11.060_bib0067","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1186\/s12951-023-02214-5","article-title":"Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K\/Akt\/NRF2 pathway","volume":"21","author":"Fu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0068","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s13287-024-03936-5","article-title":"Extracellular vesicles as therapeutic tools in regenerative dentistry","volume":"15","author":"Xia","year":"2024","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2025.11.060_bib0069","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/sctm.21-0086","article-title":"Notch signaling in the dynamics of perivascular stem cells and their niches","volume":"10","author":"Pagella","year":"2021","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.actbio.2025.11.060_bib0070","article-title":"Advances in the research of immunomodulatory mechanism of mesenchymal stromal\/stem cells on periodontal tissue regeneration","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0071","doi-asserted-by":"crossref","first-page":"e8970","DOI":"10.7717\/peerj.8970","article-title":"Exosomes derived from M0, M1 and M2 macrophages exert distinct influences on the proliferation and differentiation of mesenchymal stem cells","volume":"8","author":"Xia","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.actbio.2025.11.060_bib0072","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1111\/odi.14947","article-title":"Macrophage-derived exosomes rescue the TNF-\u0251-suppressed osteo-\/cementogenic differentiation of hPDLCs","volume":"30","author":"Deng","year":"2024","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102645","article-title":"Exosomes secreted from M2-polarized macrophages inhibit osteoclast differentiation via CYLD","volume":"93","author":"Guo","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.actbio.2025.11.060_bib0074","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1186\/s12903-024-04831-4","article-title":"M2 macrophage-derived exosomes enable osteogenic differentiation and inhibit inflammation in human periodontal ligament stem cells through promotion of CXCL12 expression","volume":"24","author":"Gao","year":"2024","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.actbio.2025.11.060_bib0075","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12951-025-03178-4","article-title":"Macrophage-derived mitochondria-rich extracellular vesicles aggravate bone loss in periodontitis by disrupting the mitochondrial dynamics of BMSCs","volume":"23","author":"Yan","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0076","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4185972","article-title":"Macrophages with different polarization phenotypes influence cementoblast mineralization through exosomes","volume":"2022","author":"Zhao","year":"2022","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.actbio.2025.11.060_bib0077","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1186\/s12951-024-02934-2","article-title":"Apoptotic vesicles from macrophages exacerbate periodontal bone resorption in periodontitis via delivering miR-143-3p targeting Igfbp5","volume":"22","author":"Xiao","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0078","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s13287-022-03004-w","article-title":"Macrophage-derived apoptotic vesicles regulate fate commitment of mesenchymal stem cells via miR155","volume":"13","author":"Zhu","year":"2022","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2025.11.060_bib0079","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1111\/odi.14808","article-title":"Macrophage-derived apoptotic bodies impair the osteogenic ability of osteoblasts in periodontitis","volume":"30","author":"Liu","year":"2024","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0080","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.2147\/IJN.S491222","article-title":"T cell-derived apoptotic extracellular vesicles ameliorate bone loss via CD39 and CD73-mediated ATP hydrolysis","volume":"20","author":"Yang","year":"2025","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0081","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/s41598-017-01809-x","article-title":"Dendritic cell-derived extracellular vesicles mediate mesenchymal stem\/stromal cell recruitment","volume":"7","author":"Silva","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.11.060_bib0082","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2020.1795362","article-title":"Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo","volume":"9","author":"Elashiry","year":"2020","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.actbio.2025.11.060_bib0083","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/nu14020344","article-title":"Modulation of dendritic cells by microbiota extracellular vesicles influences the cytokine profile and exosome cargo","volume":"14","author":"Diaz-Garrido","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.actbio.2025.11.060_bib0084","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/jre.13171","article-title":"Effects of periodontal cells-derived extracellular vesicles on mesenchymal stromal cell function","volume":"58","author":"Han","year":"2023","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0085","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2147\/IJN.S395607","article-title":"Osteoblasts-derived exosomal lncRNA-MALAT1 promotes osteoclastogenesis by targeting the miR-124\/NFATc1 signaling axis in bone marrow-derived macrophages","volume":"18","author":"Zhang","year":"2023","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0086","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612770","article-title":"Osteoblast-derived matrix vesicles exhibit exosomal traits and a unique subset of microRNA: their caveolae-dependent endocytosis results in reduced osteogenic differentiation","volume":"24","author":"Skelton","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0087","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.825596","article-title":"Extracellular vesicles derived from murine cementoblasts possess the potential to increase receptor activator of nuclear factor-\u03baB Ligand-induced osteoclastogenesis","volume":"13","author":"Sato","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0088","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.2147\/IJN.S413692","article-title":"Osteoclast-derived exosomal miR-5134-5p interferes with alveolar bone homeostasis by targeting the JAK2\/STAT3 axis","volume":"18","author":"Pan","year":"2023","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0089","doi-asserted-by":"crossref","first-page":"14234","DOI":"10.1096\/fj.202000970RR","article-title":"miR-124-3p increases in high glucose induced osteocyte-derived exosomes and regulates galectin-3 expression: a possible mechanism in bone remodeling alteration in diabetic periodontitis","volume":"34","author":"Li","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.actbio.2025.11.060_bib0090","first-page":"4020","article-title":"Schwann cell-derived exosomes accelerate periodontal bone regeneration with osteogenesis, angiogenesis, and neurogenesis","volume":"13","author":"Cui","year":"2025","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.actbio.2025.11.060_bib0091","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1177\/0022034516633172","article-title":"Epithelial microvesicles promote an inflammatory phenotype in fibroblasts","volume":"95","author":"Bi","year":"2016","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0092","article-title":"Effect of salivary exosomal miR-25-3p on periodontitis with insulin resistance","volume":"12","author":"Byun","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0093","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12951-021-00986-2","article-title":"Artificial exosomes for translational nanomedicine","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0094","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1779346","article-title":"Preconditioning and engineering strategies for improving the efficacy of mesenchymal stem cell-derived exosomes in cell-free therapy","volume":"2022","author":"Chen","year":"2022","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.actbio.2025.11.060_bib0095","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/CIRCRESAHA.115.307516","article-title":"A large-scale investigation of hypoxia-preconditioned allogeneic mesenchymal stem cells for myocardial repair in nonhuman primates: paracrine activity without remuscularization","volume":"118","author":"Hu","year":"2016","journal-title":"Circ. Res"},{"key":"10.1016\/j.actbio.2025.11.060_bib0096","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.isci.2019.05.029","article-title":"Serum deprivation of mesenchymal stem cells improves exosome activity and alters lipid and protein composition","volume":"16","author":"Haraszti","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.actbio.2025.11.060_bib0097","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jor.21517","article-title":"Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells","volume":"30","author":"Hung","year":"2012","journal-title":"J. Orth. Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0098","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12951-024-02455-y","article-title":"Advances in the application of extracellular vesicles derived from three-dimensional culture of stem cells","volume":"22","author":"Chen","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0099","article-title":"Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles","volume":"16","author":"Song","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0100","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s12951-022-01757-3","article-title":"Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential","volume":"20","author":"Deng","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0101","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-70688-w","article-title":"Metformin enhances the therapeutic effects of extracellular vesicles derived from human periodontal ligament stem cells on periodontitis","volume":"14","author":"Xiang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.11.060_bib0102","doi-asserted-by":"crossref","DOI":"10.1177\/20417314251319474","article-title":"Extracellular vesicles: from large-scale production and engineering to clinical applications","volume":"16","author":"Wang","year":"2025","journal-title":"J Tissue Eng"},{"key":"10.1016\/j.actbio.2025.11.060_bib0103","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1039\/C9NR05865F","article-title":"SPION decorated exosome delivery of TNF-\u03b1 to cancer cell membranes through magnetism","volume":"12","author":"Zhuang","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.actbio.2025.11.060_bib0104","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2022.103628","article-title":"New advances in exosome-based targeted drug delivery systems","volume":"172","author":"Ferreira","year":"2022","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0105","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1039\/C9NR01255A","article-title":"Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the tau protein through the AKT\/GSK-3\u03b2 pathway","volume":"11","author":"Wang","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.actbio.2025.11.060_bib0106","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.7150\/thno.81860","article-title":"Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease","volume":"13","author":"Yin","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.11.060_bib0107","doi-asserted-by":"crossref","first-page":"43374","DOI":"10.1021\/acsomega.3c04479","article-title":"Research advances of engineered exosomes as drug delivery carrier","volume":"8","author":"Huang","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.actbio.2025.11.060_bib0108","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jconrel.2014.07.042","article-title":"Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery","volume":"192","author":"Pascucci","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.11.060_bib0109","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113835","article-title":"Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)","volume":"176","author":"Ke","year":"2021","journal-title":"Adv. Drug Delivery. Rev."},{"key":"10.1016\/j.actbio.2025.11.060_bib0110","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.4049\/jimmunol.1800304","article-title":"Therapeutic potential of mesenchymal cell-derived miRNA-150-5p-expressing exosomes in rheumatoid arthritis mediated by the modulation of MMP14 and VEGF","volume":"201","author":"Chen","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0111","article-title":"Exosomes as drug carriers in anti-cancer therapy","volume":"10","author":"Chen","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.actbio.2025.11.060_bib0112","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.omtm.2019.01.001","article-title":"Improved loading of plasma-derived extracellular vesicles to encapsulate antitumor miRNAs","volume":"13","author":"Pomatto","year":"2019","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.actbio.2025.11.060_bib0113","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12951-023-02081-0","article-title":"Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification","volume":"21","author":"Liu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0114","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejps.2018.05.001","article-title":"Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems","volume":"121","author":"Lu","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0115","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3390\/molecules26061544","article-title":"Factors affecting extracellular vesicles based drug delivery systems","volume":"26","author":"Gaurav","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.actbio.2025.11.060_bib0116","doi-asserted-by":"crossref","first-page":"36938","DOI":"10.1021\/acsami.0c10458","article-title":"Chondrocyte-targeted MicroRNA delivery by engineered exosomes toward a cell-free osteoarthritis therapy","volume":"12","author":"Liang","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.actbio.2025.11.060_bib0117","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.bbagen.2018.02.001","article-title":"Facile metabolic glycan labeling strategy for exosome tracking","volume":"1862","author":"Lee","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.actbio.2025.11.060_bib0118","doi-asserted-by":"crossref","first-page":"8047","DOI":"10.1038\/s41467-023-43914-8","article-title":"Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines","volume":"14","author":"Bhatta","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.11.060_bib0119","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jconrel.2020.07.042","article-title":"Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: strategies and significance","volume":"326","author":"Salunkhe","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.11.060_bib0120","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12951-018-0388-4","article-title":"Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display","volume":"16","author":"Antes","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0121","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121056","article-title":"Designer exosomes enabling tumor targeted efficient chemo\/gene\/photothermal therapy","volume":"276","author":"Wang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.11.060_bib0122","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.7150\/thno.33183","article-title":"Focused ultrasound-augmented targeting delivery of nanosonosensitizers from homogenous exosomes for enhanced sonodynamic cancer therapy","volume":"9","author":"Liu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.11.060_bib0123","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160915","article-title":"Click chemistry-based modified exosomes: towards enhancing precision in cancer theranostics","volume":"512","author":"Mukerjee","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.11.060_bib0124","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.phrs.2016.07.006","article-title":"Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: new nanotools for cancer treatment","volume":"111","author":"Kooijmans","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216107","article-title":"Hybrid extracellular vesicles for drug delivery","volume":"558","author":"Ducrot","year":"2023","journal-title":"Cancer Lett"},{"key":"10.1016\/j.actbio.2025.11.060_bib0126","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jconrel.2022.12.027","article-title":"Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications","volume":"353","author":"Mondal","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.11.060_bib0127","article-title":"Programming assembly of biomimetic exosomes: an emerging theranostic nanomedicine platform","volume":"22","author":"Xu","year":"2023","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.actbio.2025.11.060_bib0128","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54431-4","article-title":"Embryonic stem cell-derived extracellular vesicle-mimetic nanovesicles rescue erectile function by enhancing penile neurovascular regeneration in the streptozotocin-induced diabetic mouse","volume":"9","author":"Kwon","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.11.060_bib0129","doi-asserted-by":"crossref","DOI":"10.1016\/j.vesic.2024.100057","article-title":"Novel administration strategies for tissue-specific delivery of extracellular vesicles","volume":"4","author":"Deng","year":"2024","journal-title":"Extracell Vesicle"},{"key":"10.1016\/j.actbio.2025.11.060_bib0130","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.2147\/IJN.S502591","article-title":"Extracellular vesicles: a review of their therapeutic potentials, sources, biodistribution, and administration routes","volume":"20","author":"Su","year":"2025","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0131","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011092","article-title":"Exosome-laden hydrogels as promising carriers for oral and bone tissue engineering: insight into cell-free drug delivery","volume":"25","author":"Villani","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0132","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.2147\/IJN.S264498","article-title":"Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0133","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.3390\/ijms22126203","article-title":"Advanced hydrogels as exosome delivery systems for osteogenic differentiation of MSCs: application in bone regeneration","volume":"22","author":"Pishavar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0134","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117386","article-title":"Advantages and disadvantages of various hydrogel scaffold types: a research to improve the clinical conversion rate of loaded MSCs-Exos hydrogel scaffolds","volume":"179","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actbio.2025.11.060_bib0135","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404966","article-title":"A smart MMP-9-responsive hydrogel releasing M2 macrophage-derived exosomes for diabetic wound healing","volume":"14","author":"Meng","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0136","first-page":"137","article-title":"Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect","volume":"38","author":"Lu","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0137","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1021\/acsabm.1c00311","article-title":"Exosome-functionalized ceramic bone substitute promotes critical-sized bone defect repair in rats","volume":"4","author":"Teotia","year":"2021","journal-title":"ACS Appl Bio Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0138","doi-asserted-by":"crossref","first-page":"rbae078","DOI":"10.1093\/rb\/rbae078","article-title":"Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies","volume":"11","author":"Li","year":"2024","journal-title":"Regen Biomater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0139","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.158142","article-title":"Exosome-anchored scholzite conversion coating on titanium with long-term stability and immunomodulatory ability to enhance osteogenesis","volume":"503","author":"Dai","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.11.060_bib0140","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12951-023-02042-7","article-title":"Recent advances in metal nanoparticles to treat periodontitis","volume":"21","author":"Nasiri","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0141","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404024","article-title":"Ultrasound-driven innervated bone regeneration in additively manufactured degradable metallic scaffolds","volume":"14","author":"Song","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0142","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119706","article-title":"Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications","volume":"232","author":"Cheng","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.11.060_bib0143","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202100383","article-title":"Recent advances in synthetic and natural biomaterials-based therapy for bone defects","volume":"22","author":"Alvarez Echaz\u00fa","year":"2022","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0144","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111558","article-title":"Association between periodontitis and inflammatory comorbidities: the common role of innate immune cells, underlying mechanisms and therapeutic targets","volume":"128","author":"Wu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0146","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1111\/odi.14239","article-title":"Dental follicle cells-derived small extracellular vesicles inhibit pathogenicity of Porphyromonas gingivalis","volume":"29","author":"Huang","year":"2023","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0147","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114466","article-title":"Gelatin methacryloyl @MP196\/exos hydrogel induced neutrophil apoptosis and macrophage M2 polarization to inhibit periodontal bone loss","volume":"248","author":"Zhuo","year":"2025","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.actbio.2025.11.060_bib0148","doi-asserted-by":"crossref","first-page":"33053","DOI":"10.1021\/acsami.4c05062","article-title":"Synergistic effects of shed-derived exosomes, Cu2+, and an injectable hyaluronic acid hydrogel on antibacterial, anti-inflammatory, and osteogenic activity for periodontal bone regeneration","volume":"16","author":"Yu","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.actbio.2025.11.060_bib0149","doi-asserted-by":"crossref","first-page":"32899","DOI":"10.1021\/acsnano.4c12458","article-title":"Nanobiohybrid extracellular vesicle nanoreactor with improving metabolical activity for biocatalytic therapy","volume":"18","author":"Wan","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.11.060_bib0150","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1021\/acsbiomaterials.3c00493","article-title":"Small extracellular vesicles laden oxygen-releasing thermosensitive hydrogel for enhanced antibacterial therapy against anaerobe-induced periodontitis alveolar bone defect","volume":"10","author":"Ming","year":"2024","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.actbio.2025.11.060_bib0151","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.3390\/ijms24043158","article-title":"Regulation of the host immune microenvironment in periodontitis and periodontal bone remodeling","volume":"24","author":"Han","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0152","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1447536","article-title":"Immunomodulatory properties of na\u00efve and inflammation-informed dental pulp stem cell derived extracellular vesicles","volume":"15","author":"Umar","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0153","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-17692-0","article-title":"Extracellular vesicles derived from GMSCs stimulated with TNF-\u03b1 and IFN-\u03b1 promote M2 macrophage polarization via enhanced CD73 and CD5L expression","volume":"12","author":"Watanabe","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.11.060_bib0154","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.046","article-title":"Exosomes from TNF-\u03b1-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss","volume":"122","author":"Nakao","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0155","article-title":"Extracellular vesicles from compression-loaded cementoblasts promote the tissue repair function of macrophages","volume":"11","author":"Yang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.actbio.2025.11.060_bib0156","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcis.2024.05.209","article-title":"Enhancing bone regeneration and immunomodulation via gelatin methacryloyl hydrogel-encapsulated exosomes from osteogenic pre-differentiated mesenchymal stem cells","volume":"672","author":"Li","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0157","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12951-023-01863-w","article-title":"Genetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis","volume":"21","author":"Luo","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0158","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbrc.2023.05.024","article-title":"Aspirin loaded extracellular vesicles inhibit inflammation of macrophages via switching metabolic phenotype in periodontitis","volume":"667","author":"Shi","year":"2023","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.actbio.2025.11.060_bib0159","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molimm.2025.04.005","article-title":"Methotrexate loaded extracellular vesicles attenuate periodontitis by suppressing ACSL1 and promoting anti-inflammatory macrophage","volume":"182","author":"Liu","year":"2025","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0160","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20210157","article-title":"Recent applications of immunomodulatory biomaterials for disease immunotherapy","volume":"2","author":"Dai","year":"2022","journal-title":"Exploration"},{"key":"10.1016\/j.actbio.2025.11.060_bib0161","first-page":"1113","article-title":"Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism","volume":"5","author":"Shen","year":"2020","journal-title":"Bioact Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0162","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12951-024-02333-7","article-title":"Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity","volume":"22","author":"Ding","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0163","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1021\/acsnano.3c00839","article-title":"Biotin-avidin system-based delivery enhances the therapeutic performance of MSC-derived exosomes","volume":"17","author":"Deng","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.11.060_bib0164","article-title":"Treatment with mesenchymal stem cell-derived nanovesicle-containing gelatin methacryloyl hydrogels alleviates osteoarthritis by modulating chondrogenesis and macrophage polarization","volume":"12","author":"Pang","year":"2023","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0165","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/jre.12958","article-title":"The Th17\/treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis","volume":"57","author":"Deng","year":"2022","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0166","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41419-020-02788-0","article-title":"IFN-\u03b3 promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b","volume":"11","author":"Yang","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0167","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41368-021-00150-4","article-title":"Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell\/treg balance in inflamed periodontium","volume":"13","author":"Zhang","year":"2021","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0168","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300674RR","article-title":"Human bone marrow mesenchymal stem cell-derived extracellular vesicles restore Th17\/treg homeostasis in periodontitis via miR-1246","volume":"37","author":"Xia","year":"2023","journal-title":"FASEB J"},{"key":"10.1016\/j.actbio.2025.11.060_bib0169","article-title":"Engineered delivery of dental stem-cell-derived extracellular vesicles for periodontal tissue regeneration","volume":"11","author":"Zarubova","year":"2022","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0170","doi-asserted-by":"crossref","first-page":"136","DOI":"10.14336\/AD.2022.0623","article-title":"Microbially-induced exosomes from dendritic cells promote paracrine immune senescence: novel mechanism of bone degenerative disease in mice","volume":"14","author":"Elsayed","year":"2023","journal-title":"Aging Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0171","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.669989","article-title":"Porphyromonas gingivalis provokes exosome secretion and paracrine immune senescence in bystander dendritic cells","volume":"11","author":"Elsayed","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.actbio.2025.11.060_bib0172","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411306","article-title":"Engineered Human dendritic cell exosomes as effective delivery system for immune modulation","volume":"24","author":"Elsayed","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0173","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/erm.2013.8","article-title":"Inflammatory mediators in the pathogenesis of periodontitis","volume":"15","author":"Yucel-Lindberg","year":"2013","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.actbio.2025.11.060_bib0174","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/scd.2025.0064","article-title":"Persistent stimulation of human mesenchymal stem\/stromal cells with TNF-\u03b1 and IFN-\u03b3 affects the release of large extracellular vesicles with immunoregulatory phenotype","volume":"34","author":"Castro-Manrreza","year":"2025","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.actbio.2025.11.060_bib0175","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.3390\/nano14171396","article-title":"Effects of scutellaria baicalensis extract-induced exosomes on the periodontal stem cells and immune cells under fine dust","volume":"14","author":"Yun","year":"2024","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.actbio.2025.11.060_bib0176","article-title":"Functions of hemp-induced exosomes against periodontal deterioration caused by fine dust","volume":"25","author":"Kim","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0177","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12951-025-03194-4","article-title":"Lipid metabolism of apoptotic vesicles accelerates cutaneous wound healing by modulating macrophage function","volume":"23","author":"Qin","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0178","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s11658-023-00422-3","article-title":"Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles","volume":"28","author":"Li","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.actbio.2025.11.060_bib0179","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.4049\/jimmunol.174.10.6440","article-title":"Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis","volume":"174","author":"Kim","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0180","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.636222","article-title":"Proteomic characterization, biodistribution, and functional studies of immune-therapeutic exosomes: implications for inflammatory lung diseases","volume":"12","author":"Elashiry","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0181","article-title":"Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis","volume":"4","author":"Liang","year":"2023","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.actbio.2025.11.060_bib0182","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13036-022-00301-z","article-title":"A tailored bioactive 3D porous poly(lactic-acid)-exosome scaffold with osteo-immunomodulatory and osteogenic differentiation properties","volume":"16","author":"Zhang","year":"2022","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.actbio.2025.11.060_bib0183","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3389\/fphys.2017.00910","article-title":"Oxidative stress and antioxidant system in periodontitis","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0184","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2147\/IJN.S350869","article-title":"Lipopolysaccharide-preconditioned dental follicle stem cells derived small extracellular vesicles treating periodontitis via reactive oxygen species\/mitogen-activated protein kinase signaling-mediated antioxidant effect","volume":"17","author":"Huang","year":"2022","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0185","doi-asserted-by":"crossref","first-page":"26733","DOI":"10.1021\/acsnano.4c06921","article-title":"Hydrogel microneedle patches loaded with stem cell mitochondria-enriched microvesicles boost the chronic wound healing","volume":"18","author":"Yao","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.11.060_bib0186","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.2147\/IJN.S470419","article-title":"FoxO1-Overexpressed small extracellular vesicles derived from hPDLSCs promote periodontal tissue regeneration by reducing mitochondrial dysfunction to regulate osteogenesis and inflammation","volume":"19","author":"Niu","year":"2024","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0187","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12964-021-00799-8","article-title":"Regulated cell death: discovery, features and implications for neurodegenerative diseases","volume":"19","author":"Cui","year":"2021","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.actbio.2025.11.060_bib0188","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/odi.12574","article-title":"Programmed cell death in periodontitis: recent advances and future perspectives","volume":"23","author":"Song","year":"2017","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0189","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/s12276-023-01078-x","article-title":"Diversity and complexity of cell death: a historical review","volume":"55","author":"Park","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.actbio.2025.11.060_bib0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2024.105964","article-title":"Small extracellular vesicles derived from lipopolysaccharide-preconditioned dental follicle cells inhibit cell apoptosis and alveolar bone loss in periodontitis","volume":"162","author":"Huang","year":"2024","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0191","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.953277","article-title":"Pyroptosis in periodontitis: from the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects","volume":"12","author":"Xu","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.actbio.2025.11.060_bib0192","first-page":"85","article-title":"Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus","volume":"33","author":"Liu","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0193","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000519569","article-title":"Effect of Human periodontal ligament stem cell-derived extracellular vesicles on macrophage pyroptosis and periodontal inflammatory injury in periodontitis","volume":"211","author":"Han","year":"2022","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.actbio.2025.11.060_bib0194","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3389\/fimmu.2019.01310","article-title":"Cyclic stretch force induces periodontal ligament cells to secrete exosomes that suppress IL-1\u03b2 production through the inhibition of the NF-\u03bab signaling pathway in macrophages","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0195","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13287-025-04216-6","article-title":"Human dental follicle stem cell-derived exosomes reduce root resorption by inhibiting periodontal ligament cell pyroptosis","volume":"16","author":"Li","year":"2025","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2025.11.060_bib0196","doi-asserted-by":"crossref","unstructured":"J. Wang, Y. Zhang, J. Cao, Y. Wang, N. Anwar, Z. Zhang, D. Zhang, Y. Ma, Y. Xiao, L. Xiao, X. Wang, The role of autophagy in bone metabolism and clinical significance, Autophagy 19 2409\u20132427.","DOI":"10.1080\/15548627.2023.2186112"},{"key":"10.1016\/j.actbio.2025.11.060_bib0197","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1111\/odi.14982","article-title":"Transplanted MSCs promote alveolar bone repair via hypoxia-induced extracellular vesicle secretion","volume":"30","author":"Liu","year":"2024","journal-title":"Oral Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0198","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.actbio.2019.01.006","article-title":"Exosome-integrated titanium oxide nanotubes for targeted bone regeneration","volume":"86","author":"Wei","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0199","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41368-024-00328-6","article-title":"A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes","volume":"16","author":"Wang","year":"2024","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0200","article-title":"Ferroptosis and cuproptosis in periodontitis: recent biological insights and therapeutic advances","volume":"16","author":"Zheng","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0201","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/sctm.18-0181","article-title":"Concise review: periodontal tissue regeneration using stem cells: strategies and translational considerations","volume":"8","author":"Xu","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.actbio.2025.11.060_bib0202","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/jfb14040193","article-title":"Research advances on stem cell-derived extracellular vesicles promoting the reconstruction of alveolar bone through RANKL\/RANK\/OPG pathway","volume":"14","author":"Huang","year":"2023","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0203","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1021\/acsbiomaterials.0c00882","article-title":"Small extracellular vesicles from lipopolysaccharide-preconditioned dental follicle cells promote periodontal regeneration in an inflammatory microenvironment","volume":"6","author":"Shi","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.actbio.2025.11.060_bib0204","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12967-022-03412-9","article-title":"Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p\/LMBR1\/BMP2\/4 axis","volume":"20","author":"Yan","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.actbio.2025.11.060_bib0205","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1225449","article-title":"Curcumin-primed periodontal ligament stem cells-derived extracellular vesicles improve osteogenic ability through the wnt\/\u03b2-catenin pathway","volume":"11","author":"Lan","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.actbio.2025.11.060_bib0206","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jds.2024.09.010","article-title":"2,3,5,4\u2032-tetrahydroxystilbene-2-O-\u03b2-d-glucoside-stimulated dental pulp stem cells-derived exosomes for wound healing and bone regeneration","volume":"20","author":"Lin","year":"2025","journal-title":"J Dent Sci"},{"key":"10.1016\/j.actbio.2025.11.060_bib0207","article-title":"Versatile hypoxic extracellular vesicles laden in an injectable and bioactive hydrogel for accelerated bone regeneration","volume":"33","author":"Deng","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.11.060_bib0208","doi-asserted-by":"crossref","first-page":"7564","DOI":"10.3390\/ijms24087564","article-title":"Epigenetic reprogramming via synergistic hypomethylation and hypoxia enhances the therapeutic efficacy of mesenchymal stem cell extracellular vesicles for bone repair","volume":"24","author":"Man","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0209","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.2147\/IJN.S409664","article-title":"Periodontal ligament stem cell exosomes key to regulate Periodontal regeneration by miR-31-5p in mice model","volume":"18","author":"Lu","year":"2023","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0210","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.gendis.2022.06.009","article-title":"Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis","volume":"10","author":"Zhang","year":"2023","journal-title":"Genes Dis"},{"key":"10.1016\/j.actbio.2025.11.060_bib0211","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.141488","article-title":"Mechano-responsive microRNA-functionalized PDLSC exosomes as a novel therapeutic for inflammatory bone loss in periodontitis","volume":"458","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.11.060_bib0212","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.actbio.2021.03.030","article-title":"3D Encapsulation and tethering of functionally engineered extracellular vesicles to hydrogels","volume":"126","author":"Huang","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0213","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12155","article-title":"Cell trafficking and regulation of osteoblastogenesis by extracellular vesicle associated bone morphogenetic protein 2","volume":"10","author":"Yerneni","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.actbio.2025.11.060_bib0214","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/sctm.19-0418","article-title":"Exosomes derived from P2\u00d77 receptor gene-modified cells rescue inflammation-compromised periodontal ligament stem cells from dysfunction","volume":"9","author":"Xu","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.actbio.2025.11.060_bib0215","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s10529-023-03376-w","article-title":"Bone marrow mesenchymal stem cell-derived exosomes loaded with miR-26a through the novel immunomodulatory peptide DP7-C can promote osteogenesis","volume":"45","author":"Lai","year":"2023","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.actbio.2025.11.060_bib0216","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114709","article-title":"Immunomodulatory peptide DP7-C mediates macrophage-derived exosomal miR-21b to promote bone regeneration via the SOCS1\/JAK2\/STAT3 axis","volume":"253","author":"Lai","year":"2025","journal-title":"Colloids Surf. B. Biointerfaces."},{"key":"10.1016\/j.actbio.2025.11.060_bib0217","article-title":"Small RNA cargo armed extracellular vesicles alleviate periodontitis in OVX mice via M2 macrophage polarization","volume":"435","author":"Li","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.11.060_bib0218","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41368-023-00255-y","article-title":"Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function","volume":"15","author":"Li","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0219","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2147\/IJN.S433511","article-title":"Bone-targeting peptide and RNF146 modified apoptotic extracellular vesicles alleviate osteoporosis","volume":"19","author":"Gui","year":"2024","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0220","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.2147\/IJN.S502192","article-title":"Human umbilical cord mesenchymal stem cells-derived exosomes attenuates experimental periodontitis in mice partly by delivering miRNAs","volume":"20","author":"Li","year":"2025","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0221","article-title":"Biomaterials and nanomedicine for bone regeneration: progress and future prospects","volume":"1","author":"Zhou","year":"2021","journal-title":"Exploration"},{"key":"10.1016\/j.actbio.2025.11.060_bib0222","first-page":"206","article-title":"A multifunctional neuromodulation platform utilizing schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation, angiogenesis and osteogenesis","volume":"23","author":"Hao","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0223","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2024.213770","article-title":"3D bioprinted small extracellular vesicles from periodontal cells enhance mesenchymal stromal cell function","volume":"158","author":"Han","year":"2024","journal-title":"Biomater Adv"},{"key":"10.1016\/j.actbio.2025.11.060_bib0224","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2147\/IJN.S346755","article-title":"Periodontal ligament stem cell-derived small extracellular vesicles embedded in Matrigel enhance bone repair through the adenosine receptor signaling pathway","volume":"17","author":"Zhao","year":"2022","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.actbio.2025.11.060_bib0225","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.actbio.2021.12.035","article-title":"Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes","volume":"141","author":"Lei","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0226","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13287-022-02767-6","article-title":"Small extracellular vesicles from dental follicle stem cells provide biochemical cues for periodontal tissue regeneration","volume":"13","author":"Ma","year":"2022","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2025.11.060_bib0227","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.actbio.2019.03.021","article-title":"Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration","volume":"89","author":"Chew","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0228","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13287-022-02721-6","article-title":"Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC\/PKC\/MAPK pathway","volume":"13","author":"Yi","year":"2022","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.actbio.2025.11.060_bib0229","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4815284","article-title":"PLGA containing Human adipose-derived stem cell-derived extracellular vesicles accelerates the repair of alveolar bone defects via transfer of CGRP","volume":"2022","author":"Yang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.actbio.2025.11.060_bib0230","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s13046-020-01709-5","article-title":"The role of microenvironment in tumor angiogenesis","volume":"39","author":"Jiang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.actbio.2025.11.060_bib0231","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138947","article-title":"Gelatin methacryloyl hydrogel encapsulating molybdenum-inspired macrophage-derived exosomes accelerates wound healing via immune regulation and angiogenesis","volume":"291","author":"Deng","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2025.11.060_bib0232","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-79692-6","article-title":"Apoptosis-induced exosomes from human exfoliated deciduous teeth enhance angiogenesis in human umbilical vein endothelial cells","volume":"14","author":"Sunartvanichkul","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2025.11.060_bib0233","doi-asserted-by":"crossref","first-page":"18472","DOI":"10.1021\/acsami.0c22671","article-title":"Umbilical mesenchymal stem cell-derived exosome-encapsulated hydrogels accelerate bone repair by enhancing angiogenesis","volume":"13","author":"Zhang","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.actbio.2025.11.060_bib0234","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1021\/acsbiomaterials.9b00607","article-title":"Exosomes secreted by stem cells from human exfoliated deciduous teeth promote alveolar bone defect repair through the regulation of angiogenesis and osteogenesis","volume":"5","author":"Wu","year":"2019","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.actbio.2025.11.060_bib0235","doi-asserted-by":"crossref","first-page":"8777","DOI":"10.1021\/acsnano.3c11542","article-title":"Osteoinductive dental pulp stem cell-derived extracellular vesicle-loaded multifunctional hydrogel for bone regeneration","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.11.060_bib0236","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.jds.2024.02.025","article-title":"Cementocyte-derived extracellular vesicles regulate osteoclastogenesis and osteoblastogenesis","volume":"19","author":"Li","year":"2024","journal-title":"J Dent Sci"},{"key":"10.1016\/j.actbio.2025.11.060_bib0237","first-page":"473","article-title":"Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: from mechanism to therapy","volume":"32","author":"Huang","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.actbio.2025.11.060_bib0238","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1111\/jcmm.16037","article-title":"microRNA-106b derived from endothelial cell-secreted extracellular vesicles prevents skin wound healing by inhibiting JMJD3 and RIPK3","volume":"25","author":"Qi","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.actbio.2025.11.060_bib0239","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.3390\/ijms23147668","article-title":"Evaluation of platelet-derived extracellular vesicles in gingival fibroblasts and keratinocytes for periodontal applications","volume":"23","author":"Antich-Rossell\u00f3","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115753","article-title":"Clinical efficacy of extracellular vesicle therapy in periodontitis: reduced inflammation and enhanced regeneration","volume":"25","author":"Puletic","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0241","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/ijms26010297","article-title":"Small extracellular vesicles derived from lipopolysaccharide-treated stem cells from the apical papilla modulate macrophage phenotypes and inflammatory interactions in pulpal and periodontal tissues","volume":"26","author":"Tessier","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.11.060_bib0242","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s10753-023-01845-y","article-title":"Small extracellular vesicles from periodontal ligament stem cells primed by lipopolysaccharide regulate macrophage M1 polarization via miR-433-3p targeting TLR2\/TLR4\/NF-\u03bab","volume":"46","author":"Cui","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.actbio.2025.11.060_bib0243","doi-asserted-by":"crossref","first-page":"32421","DOI":"10.1021\/acsnano.4c04730","article-title":"Efficient, high-quality engineering of therapeutic extracellular vesicles on an integrated nanoplatform","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.11.060_bib0244","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibtech.2025.06.020","article-title":"Extracellular vesicle manufacture via FACTORY: fully automated collection technology and optimum machinery for clinical translational applications","author":"Liu","year":"2025","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.actbio.2025.11.060_bib0245","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2016.01.009","article-title":"PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time","volume":"224","author":"Kooijmans","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2025.11.060_bib0246","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2025.11.060_bib0247","first-page":"522","article-title":"Harnessing artificial intelligence for engineering extracellular vesicles","volume":"6","author":"Hui","year":"2025","journal-title":"Journal of Unexplored Medical Data"},{"key":"10.1016\/j.actbio.2025.11.060_bib0248","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114974","article-title":"Towards artificial intelligence-enabled extracellular vesicle precision drug delivery","volume":"199","author":"Greenberg","year":"2023","journal-title":"Adv. Drug Delivery. Rev."},{"key":"10.1016\/j.actbio.2025.11.060_bib0249","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.3390\/vaccines12111282","article-title":"Milk-derived extracellular vesicles: a novel perspective on comparative therapeutics and targeted nanocarrier application","volume":"12","author":"Barathan","year":"2024","journal-title":"Vaccines (Basel)"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125008967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125008967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:17:12Z","timestamp":1781507832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125008967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":249,"alternative-id":["S1742706125008967"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.11.060","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered extracellular vesicles as multifunctional therapeutics for restoring periodontal homeostasis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.11.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}