{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:32:42Z","timestamp":1789785162590,"version":"4.0.1"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.actbio.2025.12.024","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:34:51Z","timestamp":1765560891000},"page":"413-440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["In vitro silicone oil emulsification in retinal detachment treatment: Methods, designs, and future strategies"],"prefix":"10.1016","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9452-8194","authenticated-orcid":false,"given":"Natalie","family":"Jaklov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5295-4631","authenticated-orcid":false,"given":"Barbora","family":"Kamenick\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.12.024_bib0001","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s40135-020-00247-9","article-title":"Retinal tamponades: current uses and future technologies","volume":"8","author":"Deobhakta","year":"2020","journal-title":"Curr Ophthalmol Rep"},{"key":"10.1016\/j.actbio.2025.12.024_bib0002","article-title":"Chemical engineering view on the silicone oil utilization in the treatment of retinal detachment","volume":"11","author":"Reh\u00e1\u010dkov\u00e1","year":"2024","journal-title":"Chem Bio Eng Reviews"},{"key":"10.1016\/j.actbio.2025.12.024_bib0003","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/ICU.0b013e32835f8e6b","article-title":"Update on retinal detachment surgery","volume":"24","author":"Schwartz","year":"2013","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0004","doi-asserted-by":"crossref","first-page":"6428","DOI":"10.3390\/jcm11216428","article-title":"Advances in vitreoretinal surgery","volume":"11","author":"Ribeiro","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.actbio.2025.12.024_bib0005","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.survophthal.2010.09.001","article-title":"Vitreous Substitutes: a comprehensive review","volume":"56","author":"Kleinberg","year":"2011","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0006","article-title":"Vitreous substitutes: the present and the future","volume":"1","author":"Donati","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.actbio.2025.12.024_bib0007","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1001\/archopht.1962.00960030594005","article-title":"The use of liquid silicone in retinal detachment surgery","volume":"5","author":"Cibis","year":"1962","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0008","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0161-6420(03)00264-1","article-title":"Comparison of silicone oil versus gas tamponade in the treatment of idiopathic full-thickness macular hole","volume":"110","author":"Lai","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2025.12.024_bib0009","article-title":"Silicone oil: different physical proprieties and clinical applications","volume":"1","author":"Barca","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.actbio.2025.12.024_bib0010","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0161-6420(89)32828-4","article-title":"Silicone oil for the treatment of severe proliferative diabetic retinopathy","volume":"96","author":"Brourman","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2025.12.024_bib0011","doi-asserted-by":"crossref","first-page":"e1600","DOI":"10.1111\/aos.15144","article-title":"Air versus fluorinated gas tamponades in pars plana vitrectomy treatment for primary rhegmatogenous retinal detachment","volume":"100","author":"Govers","year":"2022","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0012","article-title":"Silicone oil: different physical proprieties and clinical applications","volume":"1","author":"Barca","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.actbio.2025.12.024_bib0013","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3390\/jcm13082407","article-title":"Emulsification of silicone oils: altering factors and possible complications\u2014A narrative review","volume":"13","author":"\u0141\u0105tkowska","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.actbio.2025.12.024_bib0014","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3109\/08820538.2014.962181","article-title":"Complications of emulsified silicone oil after retinal detachment repair","volume":"29","author":"Miller","year":"2014","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0015","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1097\/IAE.0b013e3182561f98","article-title":"Time course of silicone oil emulsification","volume":"10","author":"Toklu","year":"2012","journal-title":"Retina"},{"key":"10.1016\/j.actbio.2025.12.024_bib0016","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF02764284","article-title":"Intravitreal silicone oil injection: complications and treatment of 415 consecutive patients","volume":"1","author":"Riedel","year":"1990","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0017","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1167\/iovs.11-8586","article-title":"Emulsification of silicone oil and eye movements","volume":"52","author":"Chan","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0018","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s00417-014-2866-1","article-title":"Quantifying silicone oil emulsification in patients: are we only seeing the tip of the iceberg?","volume":"253","author":"Chan","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0019","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s00417-009-1155-x","article-title":"Silicone oil induced glaucoma: a review","volume":"247","author":"Ichhpujani","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0020","first-page":"25","article-title":"Silicone oil affects fibrosis of Human trabecular meshwork cells by upregulating ferroptosis through a ROS\/NOX4\/Smad3 axis","volume":"66","author":"Wang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0021","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/iovs.66.11.21","article-title":"F4H5 Alleviates increased outflow resistance induced by emulsified silicone oil In vitro","volume":"66","author":"Muuss","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0022","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3390\/bioengineering11111081","article-title":"The role of eye movements in the process of silicone oil emulsification after vitreoretinal surgery","volume":"11","author":"Nepita","year":"2024","journal-title":"Bioengineering"},{"key":"10.1016\/j.actbio.2025.12.024_bib0023","series-title":"Ocular Fluid Dynamics Anatomy, Physiology, Imaging Techniques, and Mathematical Modeling","author":"Guidoboni","year":"2019"},{"key":"10.1016\/j.actbio.2025.12.024_bib0024","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3390\/gels10080501","article-title":"In vitro physicochemical and pharmacokinetic properties of Bevacizumab dissolved in silicone oils compared to hydrogel-substitutes and porcine vitreous bodies","volume":"10","author":"Hammer","year":"2024","journal-title":"Gels"},{"key":"10.1016\/j.actbio.2025.12.024_bib0025","article-title":"The role of endogenous proteins on the emulsification of silicone oils used in vitreoretinal surgery","volume":"1","author":"Nepita","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.actbio.2025.12.024_bib0026","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1167\/iovs.65.13.56","article-title":"Exposure to silicone oil endotamponades induces VEGF antibody aggregation and loss of functionality","volume":"65","author":"Wohlfart","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0027","series-title":"in: Encyclopedia of Life Sciences, Ltd (Ed.)","article-title":"Eye anatomy","author":"Zhu","year":"2012"},{"key":"10.1016\/j.actbio.2025.12.024_bib0028","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/ceo.14205","article-title":"Rhegmatogenous retinal detachment surgery: a review","volume":"51","author":"Warren","year":"2023","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0029","first-page":"0710","article-title":"Retinal detachment","volume":"710","author":"Steel","year":"2010","journal-title":"Clin Evid"},{"key":"10.1016\/j.actbio.2025.12.024_bib0030","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.survophthal.2007.10.007","article-title":"Recent trends in the management of rhegmatogenous retinal detachment","volume":"53","author":"Sodhi","year":"2008","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0031","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3810\/psm.2009.06.1710","article-title":"Rhegmatogenous retinal detachment","volume":"37","author":"Colucciello","year":"2009","journal-title":"Phys Sportsmed"},{"key":"10.1016\/j.actbio.2025.12.024_bib0032","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000079476","article-title":"Posterior vitreous detachment: clinical correlations","volume":"218","author":"Hayreh","year":"2004","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.actbio.2025.12.024_bib0033","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ajo.2009.11.022","article-title":"Posterior vitreous detachment: evolution and complications of its early stages","volume":"149","author":"Johnson","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0034","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.survophthal.2021.12.005","article-title":"Pars plana vitrectomy versus scleral buckle: a comprehensive meta-analysis of 15,947 eyes","volume":"67","author":"Dhoot","year":"2022","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0035","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1088\/0031-9155\/55\/2\/008","article-title":"Mixing processes in the vitreous chamber induced by eye rotations","volume":"55","author":"Stocchino","year":"2010","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0036","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00417-016-3405-z","article-title":"Vision loss under silicone oil tamponade","volume":"254","author":"Tode","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0037","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000470850","article-title":"Polydimethyl siloxane as an internal tamponade for vitreoretinal surgery","volume":"238","author":"Hussain","year":"2017","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.actbio.2025.12.024_bib0038","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3390\/polym2030286","article-title":"The use of polymers in the treatment of retinal detachment: current trends and future perspectives","volume":"2","author":"Baino","year":"2010","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.actbio.2025.12.024_bib0039","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/bjo.2009.170852","article-title":"In vitro emulsification assessment of new silicone oils","volume":"94","author":"Caramoy","year":"2010","journal-title":"British Journal of Ophthalmology"},{"key":"10.1016\/j.actbio.2025.12.024_bib0040","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/aos.14604","article-title":"Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long-term tamponade agents","volume":"99","author":"Chen","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0041","first-page":"1810","article-title":"Refinements in the use of silicone oil as an intraocular tamponade","volume":"38","author":"Wilson","year":"2024","journal-title":"Eye (Basingstoke)"},{"key":"10.1016\/j.actbio.2025.12.024_bib0042","doi-asserted-by":"crossref","first-page":"5432","DOI":"10.1167\/iovs.11-7250","article-title":"Development of emulsification-resistant silicone oils: can we go beyond 2000 mPas silicone oil?","volume":"52","author":"Caramoy","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0043","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s10792-017-0489-3","article-title":"Heavy and standard silicone oil: intraocular inflammation","volume":"38","author":"Russo","year":"2018","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0044","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/IAE.0b013e3181babe0c","article-title":"Increasing the extensional viscosity of silicone oil reduces the tendency for emulsification","volume":"30","author":"Williams","year":"2010","journal-title":"Retina"},{"key":"10.1016\/j.actbio.2025.12.024_bib0045","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.ophtha.2023.12.016","article-title":"Improved outcomes with heavy silicone oil in complex primary retinal detachment","volume":"131","author":"Tzoumas","year":"2024","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2025.12.024_bib0046","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00417-020-04809-2","article-title":"Benchmarking different brands of silicone oils","volume":"259","author":"Dresp","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0047","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/ma15010269","article-title":"What is the cause of toxicity of silicone oil?","volume":"15","author":"Chen","year":"2021","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.actbio.2025.12.024_bib0048","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1167\/iovs.06-0941","article-title":"In vivo retinal tolerance of various heavy silicone oils","volume":"48","author":"Mackiewicz","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.actbio.2025.12.024_bib0049","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3109\/02713683.2012.669511","article-title":"Interaction between perfluorcarbon liquid and heavy silicone oil: risk factor for \u201csticky oil\u201d formation","volume":"37","author":"Romano","year":"2012","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.actbio.2025.12.024_bib0050","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00417-003-0698-5","article-title":"Interactions of perfluorocarbon liquids and silicone oil as characterized by mass spectrometry","volume":"241","author":"Friberg","year":"2003","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0051","first-page":"2694","article-title":"Role of blood components in ocular silicone oil emulsification studies on an In vitro model","volume":"13","author":"Savion","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0052","series-title":"Emulsions and Emulsion Stability","author":"Sj\u00f6blom","year":"2006"},{"key":"10.1016\/j.actbio.2025.12.024_bib0053","doi-asserted-by":"crossref","first-page":"e385","DOI":"10.1111\/aos.13258","article-title":"Towards better characterization and quantification of emulsification of silicone oil in vitro","volume":"95","author":"Chan","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2020.102344","article-title":"Emulsification and emulsion stability: the role of the interfacial properties","volume":"288","author":"Ravera","year":"2021","journal-title":"Adv Colloid Interface Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0055","first-page":"219","volume":"38","author":"Maa","year":"1996","journal-title":"Liquid-liquid emulsification by rotor\/stator homogenization"},{"key":"10.1016\/j.actbio.2025.12.024_bib0056","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1021\/la035517d","article-title":"Stability of various silicone oil\/water emulsion films as a function of surfactant and salt concentration","volume":"20","author":"Neumann","year":"2004","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2025.12.024_bib0057","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0161-6420(88)33080-0","article-title":"Complications associated with the use of silicone oil in 150 eyes after retina-vitreous surgery","volume":"95","author":"Federman","year":"1988","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2025.12.024_bib0058","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cherd.2023.04.017","article-title":"A chemical engineering critique of the \u2018eye-on-a-chip\u2019 device for assessing emulsification of silicone oil tamponades","volume":"193","author":"Mulcahy","year":"2023","journal-title":"Chem Eng Res Des"},{"key":"10.1016\/j.actbio.2025.12.024_bib0059","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/aos.13982","article-title":"Adhesion of silicone oil and emulsification: an in vitro assessment using a microfluidic device and \u2018eye-on-a-chip,\u2019","volume":"97","author":"Lu","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0060","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1136\/bjo.2009.161489","article-title":"F4H5: a novel substance for the removal of silicone oil from intraocular lenses","volume":"94","author":"Stappler","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0061","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ajo.2023.11.018","article-title":"Quantification of straylight induced by silicone oil adherent to intraocular lenses of different materials","volume":"262","author":"Hammer","year":"2024","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0062","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000519520","article-title":"Effect of duration of silicone oil tamponade on retinal structure after rhegmatogenous retinal detachment surgery","volume":"245","author":"Dubroux","year":"2022","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.actbio.2025.12.024_bib0063","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9394(00)00368-8","article-title":"Migration of silicone oil into the brain: a complication of intraocular silicone oil for retinal tamponade","volume":"129","author":"Eller","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0064","first-page":"1557","article-title":"Subretinal and retrolaminar migration of intraocular silicone oil detected on CT","volume":"40","author":"Abdalkader","year":"2019","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0065","doi-asserted-by":"crossref","first-page":"425","DOI":"10.4103\/0301-4738.42425","article-title":"Intraocular tissue migration of silicone oil after silicone oil tamponade: a histopathological study of enucleated silicone oil-filled eyes","volume":"56","author":"Biswas","year":"2008","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0066","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/469163","article-title":"Selective laser trabeculoplasty for glaucoma secondary to emulsified silicone oil after Pars plana vitrectomy: a pilot study","volume":"1","author":"Alkin","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.actbio.2025.12.024_bib0067","series-title":"Shields Textbook of Glaucoma","author":"Allingham","year":"2012"},{"key":"10.1016\/j.actbio.2025.12.024_bib0068","first-page":"1","article-title":"Silicone oil emulsification after vitrectomy for rhegmatogenous retinal detachment","volume":"1","author":"Yu","year":"2020","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0069","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1167\/iovs.15-16728","article-title":"In vitro modeling of emulsification of silicone oil as intraocular tamponade using microengineered eye-on-a-chip","volume":"56","author":"Chan","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0070","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1039\/b908332d","article-title":"Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture","volume":"9","author":"Puleo","year":"2009","journal-title":"Lab Chip"},{"key":"10.1016\/j.actbio.2025.12.024_bib0071","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/IAE.0b013e3182725d49","article-title":"High-density silicone oil densiron-68 as an intraocular tamponade for primary inferior retinal detachments","volume":"33","author":"Levasseur","year":"2013","journal-title":"Retina"},{"key":"10.1016\/j.actbio.2025.12.024_bib0072","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jfda.2016.10.021","article-title":"Techniques and methods to study functional characteristics of emulsion systems","volume":"25","author":"Hu","year":"2017","journal-title":"J Food Drug Anal"},{"key":"10.1016\/j.actbio.2025.12.024_bib0073","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/10408390701289292","article-title":"Critical review of techniques and methodologies for characterization of emulsion stability","volume":"47","author":"Mcclements","year":"2007","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.actbio.2025.12.024_bib0074","first-page":"647","article-title":"Factors contributing to the emulsification of intraocular silicone and fluorosilicone oils","volume":"31","author":"Nakamura","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0075","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1021\/acsomega.1c00017","article-title":"Rapid determination of emulsion stability using turbidity measurement incorporating artificial neural network (ANN): experimental validation using video\/optical microscopy and kinetic modeling","volume":"6","author":"Alade","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.actbio.2025.12.024_bib0076","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/acs.jafc.9b04956","article-title":"Application of flow cytometry As novel technology in studying the effect of droplet size on lipid oxidation in oil-in-water emulsions","volume":"68","author":"Li","year":"2020","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.actbio.2025.12.024_bib0077","doi-asserted-by":"crossref","first-page":"11468","DOI":"10.1021\/acs.langmuir.3c01477","article-title":"Three-dimensional imaging of emulsion separation through liquid-infused membranes using confocal laser scanning microscopy","volume":"39","author":"Song","year":"2023","journal-title":"Langmuir"},{"key":"10.1016\/j.actbio.2025.12.024_bib0078","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235067","article-title":"Comparison of hydrophilic ophthalmic media on silicone oil emulsification","volume":"15","author":"So\u00f3s","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.actbio.2025.12.024_bib0079","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1097\/00006982-199212031-00006","article-title":"A quantitative in vitro model for silicone oil emulsification: role of blood constituents","volume":"3","author":"Bartov","year":"1992","journal-title":"Retina"},{"key":"10.1016\/j.actbio.2025.12.024_bib0080","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1111\/aos.14212","article-title":"Amphiphilic additives in silicone oil tamponade and emulsification: an eye-on-a-chip study","volume":"98","author":"Lu","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0081","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45881","article-title":"Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse","volume":"8","author":"Zhang","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.actbio.2025.12.024_bib0082","article-title":"Characteristics of silicone oil emulsification after vitrectomy for rhegmatogenous retinal detachment: an ultrasound biomicroscopy study","volume":"8","author":"Zhao","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.actbio.2025.12.024_bib0083","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/S0161-6420(94)31084-0","article-title":"Emulsified anterior chamber silicone oil and glaucoma","volume":"101","author":"Valone","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2025.12.024_bib0084","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/sjopt.sjopt_193_23","article-title":"Silicone oil emulsification: a literature review and role of widefield imaging and ultra-widefield imaging with navigated central and peripheral optical coherence tomography technology","volume":"38","author":"Valent\u00edn-Bravo","year":"2024","journal-title":"Saudi J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0085","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF00172269","article-title":"Emulsification of silicone oils with specific physicochemical characteristics","volume":"229","author":"Heidenkummer","year":"1991","journal-title":"Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0086","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cocis.2010.10.001","article-title":"Rheology of simple and multiple emulsions","volume":"16","author":"Pal","year":"2011","journal-title":"Curr Opin Colloid Interface Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0087","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3390\/gels10080501","article-title":"In vitro physicochemical and pharmacokinetic properties of Bevacizumab dissolved in silicone oils compared to hydrogel-substitutes and porcine vitreous bodies","volume":"10","author":"Hammer","year":"2024","journal-title":"Gels"},{"key":"10.1016\/j.actbio.2025.12.024_bib0088","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1111\/aos.14539","article-title":"Assessing bulk emulsification at the silicone oil \u2013 saline solution interface in a 3D model of the eye","volume":"99","author":"Wang","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0089","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1136\/bjo.2004.063768","article-title":"An experimental study on the effect of encircling band procedure on silicone oil emulsification","volume":"89","author":"De Silva","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0090","first-page":"2912","article-title":"Twenty-four-hour pattern of intraocular pressure in the aging population","volume":"40","author":"Liu","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0091","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrn3405","article-title":"The impact of microsaccades on vision: towards a unified theory of saccadic function","volume":"14","author":"Martinez-Conde","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0092","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1755-3768.1989.tb07083.x","article-title":"Estimation of pulsatile ocular blood flow from intraocular pressure","volume":"67","author":"Silver","year":"1989","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0093","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/tvst.10.8.22","article-title":"Computational fluid dynamics of intraocular silicone oil tamponade","volume":"10","author":"Rossi","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0094","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/tvst.11.2.3","article-title":"Physicochemical properties of explanted silicone oil after use as an intraocular tamponade","volume":"11","author":"Hammer","year":"2022","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0095","article-title":"Associations between clinical parameters and optical-physicochemical properties of silicone oil extracted after Pars Plana vitrectomy: an In vitro analysis of 35 eyes","volume":"41","author":"Al-Dwairi","year":"2025","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.actbio.2025.12.024_bib0096","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.3390\/polym11101570","article-title":"Emulsion formation and stabilization by biomolecules: the leading role of cellulose","volume":"11","author":"Costa","year":"2019","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.actbio.2025.12.024_bib0097","first-page":"2030","article-title":"Effects of emulsification, purity, and fluorination of silicone oil on Human retinal pigment epithelial cells","volume":"32","author":"Friberg","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0098","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00417-023-06289-6","article-title":"A minimum specification dataset for liquid ocular endotamponades: recommendations by a European expert panel","volume":"262","author":"Ferrara","year":"2024","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0099","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0161-6420(99)90261-0","article-title":"Chemical stability of silicone oil in the Human eye after prolonged clinical use","volume":"106","author":"Lakits","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.actbio.2025.12.024_bib0100","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3109\/02713689508998529","article-title":"Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy","volume":"14","author":"Elner","year":"1995","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.actbio.2025.12.024_bib0101","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0014-4835(65)80030-6","article-title":"The chemical composition of the Human aqueous Hu-nour in normal and pathological conditions","volume":"4","author":"De Berardinis","year":"1965","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.actbio.2025.12.024_bib0102","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1042\/bj0210066","article-title":"The biochemistry of the aqueous humour","volume":"12","author":"Duke-elder","year":"1927","journal-title":"Biochem J"},{"key":"10.1016\/j.actbio.2025.12.024_bib0103","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12886-017-0515-2","article-title":"Ascorbic acid concentrations in aqueous humor after systemic Vitamin C supplementation in patients with cataract: pilot study","volume":"17","author":"Hah","year":"2017","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0104","doi-asserted-by":"crossref","DOI":"10.1117\/1.1914843","article-title":"Glucose determination in human aqueous humor with Raman spectroscopy","volume":"10","author":"Lambert","year":"2005","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.actbio.2025.12.024_bib0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mad.2018.07.001","article-title":"From bed to bench: how in silico medicine can help ageing research","volume":"177","author":"Viceconti","year":"2019","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.actbio.2025.12.024_bib0106","series-title":"Biomedical Translational Research","first-page":"67","article-title":"Bench-to-bedside research in ophthalmology","author":"Gupta","year":"2022"},{"key":"10.1016\/j.actbio.2025.12.024_bib0107","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2024.100558","article-title":"Straylight of explanted silicone oil samples to predict emulsification","volume":"4","author":"Hammer","year":"2024","journal-title":"Ophthalmology Science"},{"key":"10.1016\/j.actbio.2025.12.024_bib0108","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev-vision-082114-035742","article-title":"Control and functions of fixational eye movements","volume":"1","author":"Rucci","year":"2015","journal-title":"Annu Rev Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0109","first-page":"1","article-title":"Quantitative determination of human aqueous proteins by crossed immunoelectrophoresis","volume":"1","author":"Inada","year":"1984","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0110","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.1167\/iovs.10-5659","article-title":"The relationship between body and ambient temperature and corneal temperature","volume":"51","author":"Kessel","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.actbio.2025.12.024_bib0111","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.3390\/jcm11072053","article-title":"Intraocular temperature distribution in eyes undergoing different types of surgical procedures during vitreous surgery","volume":"11","author":"Shinoda","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.actbio.2025.12.024_bib0112","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.colsurfa.2012.07.001","article-title":"Influence of temperature on production of water-in-oil emulsions by microchannel emulsification","volume":"411","author":"Fujiu","year":"2012","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"key":"10.1016\/j.actbio.2025.12.024_bib0113","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1002\/prot.25354","article-title":"Temperature stability of proteins: analysis of irreversible denaturation using isothermal calorimetry","volume":"85","author":"Sch\u00f6n","year":"2017","journal-title":"Proteins: Struct Funct Bioinf"},{"key":"10.1016\/j.actbio.2025.12.024_bib0114","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1016\/j.cub.2015.11.004","article-title":"Head-eye coordination at a microscopic scale","volume":"25","author":"Poletti","year":"2015","journal-title":"Current Biology"},{"key":"10.1016\/j.actbio.2025.12.024_bib0115","first-page":"1810","article-title":"Refinements in the use of silicone oil as an intraocular tamponade","volume":"38","author":"Wilson","year":"2024","journal-title":"Eye (Basingstoke)"},{"key":"10.1016\/j.actbio.2025.12.024_bib0116","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.compbiomed.2007.10.007","article-title":"Simulation of aqueous humor hydrodynamics in human eye heat transfer","volume":"38","author":"Ooi","year":"2008","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.actbio.2025.12.024_bib0117","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/IAE.0b013e3181babe0c","article-title":"Increasing the extensional viscosity of silicone oil reduces the tendency for emulsification","volume":"30","author":"Williams","year":"2010","journal-title":"Retina"},{"key":"10.1016\/j.actbio.2025.12.024_bib0118","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/0885328215575623","article-title":"Development of emulsification resistant heavier-than-water tamponades using high molecular weight silicone oil polymers","volume":"30","author":"Caramoy","year":"2015","journal-title":"J Biomater Appl"},{"key":"10.1016\/j.actbio.2025.12.024_bib0119","first-page":"29","article-title":"Silicone oil emulsification in retina surgery","volume":"6","author":"Patel","year":"2015","journal-title":"Retina Today"},{"key":"10.1016\/j.actbio.2025.12.024_bib0120","first-page":"577","article-title":"High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells","volume":"15","author":"Pauloin","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.actbio.2025.12.024_bib0121","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/polym13010121","article-title":"Substitutes and colloidal system for vitreous replacement and drug delivery: recent progress and future prospective","volume":"13","author":"Thacker","year":"2020","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.actbio.2025.12.024_bib0122","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3390\/pharmaceutics14071364","article-title":"Intravitreal application: physicochemical properties of drugs dissolved in silicone oils of different density in comparison to the porcine vitreous body","volume":"14","author":"Hammer","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.actbio.2025.12.024_bib0123","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4274\/tjo.galenos.2019.24294","article-title":"Comparative biochemical outcomes, effectiveness and tolerance of densiron 68 and oxane HD for the management of complicated retinal detachment","volume":"49","author":"Keilani","year":"2019","journal-title":"Turk J Ophthalmol"},{"key":"10.1016\/j.actbio.2025.12.024_bib0124","first-page":"25","article-title":"Cross-linking in hydrogels-a review","volume":"2014","author":"Maitra","year":"2014","journal-title":"American Journal of Polymer Science"},{"key":"10.1016\/j.actbio.2025.12.024_bib0125","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/02713683.2020.1805473","article-title":"A new retinal detachment treatment model for evaluation of vitreous tamponades","volume":"46","author":"Barth","year":"2021","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.actbio.2025.12.024_bib0126","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2025.101389","article-title":"Replacing the vitreous body with hydrogels: rationale and strategies","volume":"108","author":"Schulz","year":"2025","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.actbio.2025.12.024_bib0127","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1021\/acs.biomac.5b01091","article-title":"Recent progress in using biomaterials as vitreous substitutes","volume":"16","author":"Su","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.actbio.2025.12.024_bib0128","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00006982-200208000-00008","article-title":"Correlation between quantity of silicone oil emulsified in the anterior chamber and high pressure in vitrectomized eyes","volume":"22","author":"Avitabile","year":"2002","journal-title":"Retina"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125009316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125009316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:20:07Z","timestamp":1781508007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125009316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":128,"alternative-id":["S1742706125009316"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.12.024","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro silicone oil emulsification in retinal detachment treatment: Methods, designs, and future strategies","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}