{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:55:29Z","timestamp":1793030129296,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2418600"],"award-info":[{"award-number":["2024YFC2418600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016334","name":"Jiangsu Provincial Medical Center","doi-asserted-by":"publisher","award":["CXZX202227"],"award-info":[{"award-number":["CXZX202227"]}],"id":[{"id":"10.13039\/501100016334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370931"],"award-info":[{"award-number":["82370931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.actbio.2025.12.031","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T16:56:59Z","timestamp":1765904219000},"page":"562-578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Targeting injury-triggered grancalcin from senescent macrophages enhances aged bone healing"],"prefix":"10.1016","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0746-9721","authenticated-orcid":false,"given":"Yangjiele","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwei","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zesheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziji","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-0381","authenticated-orcid":false,"given":"Hongbing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.12.031_bib0001","first-page":"129","article-title":"Biomaterial scaffolds in maxillofacial bone tissue engineering: a review of recent advances","volume":"33","author":"Huang","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.12.031_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1152301","article-title":"Uncovering the unique characteristics of the mandible to improve clinical approaches to mandibular regeneration","volume":"14","author":"Soares","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.actbio.2025.12.031_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116995","article-title":"Jaw osteoporosis: challenges to oral health and emerging perspectives of treatment","volume":"177","author":"Liu","year":"2024","journal-title":"Biomed. PharmacOther"},{"issue":"8","key":"10.1016\/j.actbio.2025.12.031_bib0004","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1007\/s00784-023-05087-y","article-title":"Influence of age and gender on alveolar bone healing post tooth extraction in 129 sv mice: a microtomographic, histological, and biochemical characterization","volume":"27","author":"Biguetti","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.actbio.2025.12.031_bib0005","article-title":"Interaction between immuno-stem dual lineages in jaw bone formation and injury repair","volume":"12","author":"Liu","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.actbio.2025.12.031_bib0006","doi-asserted-by":"crossref","first-page":"rbaf024","DOI":"10.1093\/rb\/rbaf024","article-title":"Biomaterials-based approaches to mandibular tissue engineering: where we were, where we are, where we are going","volume":"12","author":"Kennedy","year":"2025","journal-title":"Regen. Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0007","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41413-025-00417-0","article-title":"Cell communication and relevant signaling pathways in osteogenesis-angiogenesis coupling","volume":"13","author":"Li","year":"2025","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0008","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41413-024-00346-4","article-title":"Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system","volume":"12","author":"Mi","year":"2024","journal-title":"Bone Res."},{"issue":"13","key":"10.1016\/j.actbio.2025.12.031_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137411","article-title":"Cellular senescence and inflammaging in the bone: pathways, genetics, anti-aging strategies and interventions","volume":"25","author":"Lawrence","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00223-023-01100-4","article-title":"\"Bone-SASP\" in skeletal aging","volume":"113","author":"Fang","year":"2023","journal-title":"Calcif. Tissue Int."},{"issue":"3","key":"10.1016\/j.actbio.2025.12.031_bib0011","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154888","article-title":"Cellular senescence and the skeleton: pathophysiology and therapeutic implications","volume":"132","author":"Khosla","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0012","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40001-023-01604-7","article-title":"Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature","volume":"29","author":"Zhao","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"4","key":"10.1016\/j.actbio.2025.12.031_bib0013","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jormas.2019.09.002","article-title":"Epidemiology of maxillofacial trauma in the elderly: a European multicenter study","volume":"121","author":"Brucoli","year":"2020","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"issue":"7","key":"10.1016\/j.actbio.2025.12.031_bib0014","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.adaj.2024.03.005","article-title":"Implant and implant restoration trends among adults 50 years and older in the United States, National Health and Nutrition Examination Survey 1999-2020","volume":"155","author":"Weatherspoon","year":"2024","journal-title":"J. Am. Dent. Assoc."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41405-024-00262-z","article-title":"Healthy ageing and oral health: priority, policy and public health","volume":"10","author":"Patel","year":"2024","journal-title":"BDJ. Open."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0016","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s41232-023-00279-1","article-title":"Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy","volume":"43","author":"Kushioka","year":"2023","journal-title":"Inflamm. Regen."},{"issue":"3","key":"10.1016\/j.actbio.2025.12.031_bib0017","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.it.2025.02.003","article-title":"Novel insights and recent progress in osteoimmunology","volume":"46","author":"Adamopoulos","year":"2025","journal-title":"Trends. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0018","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41413-024-00347-3","article-title":"Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma","volume":"12","author":"Hachemi","year":"2024","journal-title":"Bone Res."},{"issue":"6","key":"10.1016\/j.actbio.2025.12.031_bib0019","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s11914-023-00820-8","article-title":"Influences of aged bone marrow macrophages on skeletal health and senescence","volume":"21","author":"Pappert","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.actbio.2025.12.031_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.bj.2023.02.001","article-title":"Cellular senescence and the host immune system in aging and age-related disorders","volume":"46","author":"Giannoula","year":"2023","journal-title":"Biomed. J."},{"issue":"6","key":"10.1016\/j.actbio.2025.12.031_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70350","article-title":"Antisenescence therapies for age-related bone loss: target factors, medicines, biomedical materials","volume":"15","author":"Zhu","year":"2025","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0023","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41413-023-00309-1","article-title":"Age-related secretion of grancalcin by macrophages induces skeletal stem\/progenitor cell senescence during fracture healing","volume":"12","author":"Zou","year":"2024","journal-title":"Bone Res."},{"issue":"10","key":"10.1016\/j.actbio.2025.12.031_bib0024","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.cmet.2021.08.009","article-title":"Senescent immune cells release grancalcin to promote skeletal aging","volume":"33","author":"Li","year":"2021","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.actbio.2025.12.031_bib0025","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/s43587-024-00694-0","article-title":"Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence","volume":"4","author":"Hou","year":"2024","journal-title":"Nat. Aging"},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0026","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.031_bib0027","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bone.2016.02.020","article-title":"Inflammation, fracture and bone repair","volume":"86","author":"Loi","year":"2016","journal-title":"Bone"},{"issue":"20","key":"10.1016\/j.actbio.2025.12.031_bib0028","doi-asserted-by":"crossref","first-page":"eadl6343","DOI":"10.1126\/sciadv.adl6343","article-title":"Early infiltrating NKT lymphocytes attenuate bone regeneration through secretion of CXCL2","volume":"10","author":"Lin","year":"2024","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.actbio.2025.12.031_bib0029","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13112","article-title":"Age-related changes to macrophages are detrimental to fracture healing in mice","volume":"19","author":"Clark","year":"2020","journal-title":"Aging Cell"},{"issue":"6","key":"10.1016\/j.actbio.2025.12.031_bib0030","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/edt.12778","article-title":"Mandibular fractures in aged patients - challenges in diagnosis","volume":"38","author":"Kannari","year":"2022","journal-title":"Dent. Traumatol."},{"issue":"2","key":"10.1016\/j.actbio.2025.12.031_bib0031","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10006-024-01213-6","article-title":"Surgical treatment of clinically infected mandibular fractures","volume":"28","author":"Oksa","year":"2024","journal-title":"Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0032","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-37652-6","article-title":"Prevalence of surgical site infections after open reduction and internal fixation for mandibular fractures: a systematic review and meta-analysis","volume":"13","author":"Kostares","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0033","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.actbio.2025.12.031_bib0034","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/bjd\/ljae205","article-title":"Fibroblasts with high matrix metalloproteinase 2 expression regulate CD8+ T-cell residency and inflammation via CD100 in psoriasis","volume":"191","author":"Dong","year":"2024","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0035","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/s41467-021-22131-1","article-title":"Osteoclasts protect bone blood vessels against senescence through the angiogenin\/plexin-B2 axis","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.actbio.2025.12.031_bib0036","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","article-title":"The Human transcription factors","volume":"172","author":"Lambert","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2025.12.031_bib0037","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev-cellbio-022823-013847","article-title":"Transcription factor dynamics: one molecule at a time","volume":"39","author":"Wagh","year":"2023","journal-title":"Annu Rev. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.actbio.2025.12.031_bib0038","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s43587-024-00607-1","article-title":"Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1","volume":"4","author":"Wu","year":"2024","journal-title":"Nat. Aging"},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0039","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s42003-022-03888-7","article-title":"PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development","volume":"5","author":"Zhao","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.actbio.2025.12.031_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1204160","article-title":"PU.1 is required to restrain myelopoiesis during chronic inflammatory stress","volume":"11","author":"Chavez","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0041","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/1673-5374.375343","article-title":"Spi1 regulates the microglial\/macrophage inflammatory response via the PI3K\/AKT\/mTOR signaling pathway after intracerebral hemorrhage","volume":"19","author":"Zhang","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0042","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1038\/s41467-024-48484-x","article-title":"Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of A\u03b2 amyloidosis","volume":"15","author":"Kim","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0043","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94324-z","article-title":"Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease","volume":"11","author":"Jones","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0044","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41413-025-00421-4","article-title":"SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis","volume":"13","author":"Zu","year":"2025","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0045","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12672-022-00592-0","article-title":"SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma","volume":"13","author":"Feng","year":"2022","journal-title":"Discov. Oncol."},{"issue":"7","key":"10.1016\/j.actbio.2025.12.031_bib0046","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13858","article-title":"AP-1 is a regulatory transcription factor of inflammaging in the murine kidney and liver","volume":"22","author":"Yu","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.actbio.2025.12.031_bib0047","doi-asserted-by":"crossref","DOI":"10.1093\/jimmun\/vkaf109","article-title":"The ETS-family transcription factor PU.1 is a critical regulator of the inhibitory fc\u03b3 receptor IIB expression in humans","author":"Carter","year":"2025","journal-title":"J. Immunol."},{"issue":"18","key":"10.1016\/j.actbio.2025.12.031_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251810004","article-title":"ETS transcription factors in immune cells and immune-related diseases","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.actbio.2025.12.031_bib0049","article-title":"Cellular senescence in acute and chronic wound repair","volume":"14","author":"Wilkinson","year":"2022","journal-title":"Cold. Spring. Harb. Perspect. Biol."},{"key":"10.1016\/j.actbio.2025.12.031_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1400462","article-title":"New insights into the role of cellular senescence and chronic wounds","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"16","key":"10.1016\/j.actbio.2025.12.031_bib0051","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1101\/gad.390506","article-title":"c-Jun\/AP-1 controls liver regeneration by repressing p53\/p21 and p38 MAPK activity","volume":"20","author":"Stepniak","year":"2006","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0052","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/emboj\/18.1.188","article-title":"c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms","volume":"18","author":"Wisdom","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.actbio.2025.12.031_bib0053","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1453710","article-title":"c-Jun N-terminal kinase signaling in aging","volume":"16","author":"Li","year":"2024","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.actbio.2025.12.031_bib0054","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13792","article-title":"Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging","volume":"22","author":"Karakaslar","year":"2023","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.actbio.2025.12.031_bib0055","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41392-021-00830-x","article-title":"Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity","volume":"6","author":"Cao","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.actbio.2025.12.031_bib0056","doi-asserted-by":"crossref","DOI":"10.3390\/ph15020171","article-title":"Gelatin methacrylate hydrogel for tissue engineering applications-A review on material modifications","volume":"15","author":"Bupphathong","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.actbio.2025.12.031_bib0057","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"issue":"22","key":"10.1016\/j.actbio.2025.12.031_bib0058","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25225305","article-title":"Applications of gelatin methacryloyl (GelMA) hydrogels in microfluidic technique-assisted tissue engineering","volume":"25","author":"Liu","year":"2020","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.actbio.2025.12.031_bib0059","doi-asserted-by":"crossref","first-page":"460","DOI":"10.7150\/thno.103725","article-title":"Advancements in GelMA bioactive hydrogels: strategies for infection control and bone tissue regeneration","volume":"15","author":"Huang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.12.031_bib0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actbio.2025.02.046","article-title":"A calcitonin gene-related peptide co-crosslinked hydrogel promotes diabetic wound healing by regulating M2 macrophage polarization and angiogenesis","volume":"196","author":"Li","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2025.12.031_bib0061","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.actbio.2025.05.044","article-title":"A hydrogel crosslinked with mixed-valence copper nanoclusters for diabetic wound healing","volume":"200","author":"Qiu","year":"2025","journal-title":"Acta Biomater."},{"issue":"20","key":"10.1016\/j.actbio.2025.12.031_bib0062","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011154","article-title":"Computational strategies for assessing adverse outcome pathways: hepatic steatosis as a case study","volume":"25","author":"Ortega-Vallbona","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2025.12.031_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103354","article-title":"Phytic acid-loaded polyvinyl alcohol hydrogel promotes wound healing of injured corneal epithelium through inhibiting ferroptosis","volume":"76","author":"Gong","year":"2024","journal-title":"Redox. Biol."},{"issue":"5","key":"10.1016\/j.actbio.2025.12.031_bib0064","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tibtech.2016.01.002","article-title":"Gelatin-methacryloyl hydrogels: towards biofabrication-based tissue repair","volume":"34","author":"Klotz","year":"2016","journal-title":"Trends Biotechnol."},{"issue":"14","key":"10.1016\/j.actbio.2025.12.031_bib0065","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202305856","article-title":"Targeting grancalcin accelerates wound healing by improving angiogenesis in diabetes","volume":"11","author":"Xiang","year":"2024","journal-title":"Adv. Sci."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125009389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125009389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T02:53:12Z","timestamp":1771987992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125009389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":65,"alternative-id":["S1742706125009389"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.12.031","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting injury-triggered grancalcin from senescent macrophages enhances aged bone healing","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.12.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}