{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:50:30Z","timestamp":1791600630637,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024HXBH085"],"award-info":[{"award-number":["2024HXBH085"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M762257"],"award-info":[{"award-number":["2024M762257"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32401162"],"award-info":[{"award-number":["32401162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371446"],"award-info":[{"award-number":["32371446"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.actbio.2025.12.035","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:30:09Z","timestamp":1765931409000},"page":"441-456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["ROS-sensitive nanocarriers for synergistic X-PDT\/chemo\/immunotherapy of triple-negative breast cancer and metastasis"],"prefix":"10.1016","volume":"210","author":[{"given":"Chaorong","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingke","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanzhan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0123-4311","authenticated-orcid":false,"given":"Peng","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.12.035_bib0001","doi-asserted-by":"crossref","first-page":"62742","DOI":"10.18632\/oncotarget.18409","article-title":"Improving radiotherapy in cancer treatment: promises and challenges","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.actbio.2025.12.035_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101675","article-title":"Improvement of radiotherapy with an ozone-carried liposome nano- system for synergizing cancer immune checkpoint blockade","volume":"47","author":"Zheng","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.actbio.2025.12.035_bib0003","first-page":"173","article-title":"X-ray-sensitizers: organic pharmaceutical drug intermediates activated directly by X-rays to efficiently populate triplet excitons for cancer treatment","volume":"43","author":"Lin","year":"2024","journal-title":"Engineering-Prc"},{"key":"10.1016\/j.actbio.2025.12.035_bib0004","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.2147\/IJN.S352169","article-title":"Application of radiosensitizers in cancer radiotherapy","volume":"16","author":"Gong","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2025.12.035_bib0005","doi-asserted-by":"crossref","first-page":"19691","DOI":"10.1021\/acsnano.2c07286","article-title":"Recent progress and trends in X-ray-induced photodynamic therapy with low radiation doses","volume":"16","author":"He","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.12.035_bib0006","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1038\/s41467-022-32054-0","article-title":"Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.035_bib0007","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12951-020-00644-z","article-title":"X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system","volume":"18","author":"Gu","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.12.035_bib0008","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.7150\/thno.41578","article-title":"Nanoscintillator-mediated X-ray induced photodynamic therapy for deep-seated tumors: from concept to biomedical applications","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.12.035_bib0009","first-page":"504","article-title":"Study of copper-cysteamine based X-ray induced photodynamic therapy and its effects on cancer cell proliferation and migration in a clinical mimic setting","volume":"7","author":"Chen","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.12.035_bib0010","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.7150\/thno.16141","article-title":"X-ray induced photodynamic therapy: a combination of radiotherapy and photodynamic therapy","volume":"6","author":"Wang","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.12.035_bib0011","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1039\/D0SC01949F","article-title":"Biomimetic nanoscale metal-organic framework harnesses hypoxia for effective cancer radiotherapy and immunotherapy","volume":"11","author":"Ni","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.actbio.2025.12.035_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003338","article-title":"Oxygen-enriched metal-phenolic X-ray nanoprocessor for cancer radio-radiodynamic therapy in combination with checkpoint blockade immunotherapy","volume":"8","author":"Sang","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2025.12.035_bib0013","doi-asserted-by":"crossref","first-page":"12579","DOI":"10.1021\/jacs.0c05039","article-title":"Nanoscale metal-organic framework co-delivers TLR-7 agonists and anti-CD47 antibodies to modulate macrophages and orchestrate cancer immunotherapy","volume":"142","author":"Ni","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2025.12.035_bib0014","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.1039\/c3cs60048c","article-title":"Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance","volume":"42","author":"Ge","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2025.12.035_bib0015","first-page":"e1988","article-title":"Polymer-drug and polymer-protein conjugated nanocarriers: design, drug delivery, imaging, therapy, and clinical applications","volume":"16","author":"Guo","year":"2024","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2025.12.035_bib0016","first-page":"102","article-title":"Enzyme-triggered deep tumor penetration of a dual-drug nanomedicine enables an enhanced cancer combination therapy","volume":"26","author":"Gu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.12.035_bib0017","first-page":"e67","article-title":"Advances and applications of nanoparticles in cancer therapy","volume":"3","author":"Huang","year":"2024","journal-title":"MedComm: Oncol"},{"key":"10.1016\/j.actbio.2025.12.035_bib0018","doi-asserted-by":"crossref","first-page":"0063","DOI":"10.1038\/s41570-017-0063","article-title":"Evolution of macromolecular complexity in drug delivery systems","volume":"1","author":"Kakkar","year":"2017","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.actbio.2025.12.035_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115239","article-title":"Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release, Adv","volume":"207","author":"Liu","year":"2024","journal-title":"Drug Delivery Rev"},{"key":"10.1016\/j.actbio.2025.12.035_bib0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.actbio.2025.12.035_bib0021","doi-asserted-by":"crossref","first-page":"29121","DOI":"10.1021\/acsnano.4c10603","article-title":"A tumor-homing nanoframework for synergistic microwave tumor ablation and provoking strong anticancer immunity against metastasis","volume":"18","author":"Cheng","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.12.035_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120847","article-title":"Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer","volume":"273","author":"Liu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.12.035_bib0023","doi-asserted-by":"crossref","first-page":"13526","DOI":"10.1021\/acsnano.1c04263","article-title":"Nanoprobe-based Magnetic resonance imaging of hypoxia predicts responses to radiotherapy, immunotherapy, and sensitizing treatments in pancreatic tumors","volume":"15","author":"Liu","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.12.035_bib0024","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.7150\/thno.38069","article-title":"Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics","volume":"10","author":"Mi","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2025.12.035_bib0025","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1038\/s41467-018-05118-3","article-title":"Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation","volume":"9","author":"Deng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.035_bib0026","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1021\/acscentsci.9b01121","article-title":"Application of mitochondrially targeted nanoconstructs to neoadjuvant X-ray-induced photodynamic therapy for rectal cancer","volume":"6","author":"Deng","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.actbio.2025.12.035_bib0027","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202107656","article-title":"All-in-one biomimetic nanoplatform based on hollow polydopamine nanoparticles for synergistically enhanced radiotherapy of colon cancer","volume":"18","author":"Gong","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.actbio.2025.12.035_bib0028","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1039\/D2TB00303A","article-title":"Tumor acidity\/redox hierarchical-activable nanoparticles for precise combination of X-ray-induced photodynamic therapy and hypoxia-activated chemotherapy","volume":"10","author":"Zhang","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2025.12.035_bib0029","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3010277","article-title":"TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis","volume":"6","author":"Matsuo","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.actbio.2025.12.035_bib0030","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1021\/acsnano.2c07488","article-title":"Identifying TOPK and hypoxia hallmarks in esophageal tumors for photodynamic\/chemo\/immunotherapy and liver metastasis inhibition with nanocarriers","volume":"17","author":"Shi","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2025.12.035_bib0031","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41419-022-04909-3","article-title":"TOPK\/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC","volume":"13","author":"Sun","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.actbio.2025.12.035_bib0032","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/s41418-020-00655-1","article-title":"Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress","volume":"28","author":"Herbert","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.actbio.2025.12.035_bib0033","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/bjc.2017.197","article-title":"TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy","volume":"117","author":"Pirovano","year":"2017","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.actbio.2025.12.035_bib0034","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biomaterials.2017.08.008","article-title":"Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice","volume":"144","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.12.035_bib0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nmat1081","article-title":"Oxidation-responsive polymeric vesicles","volume":"3","author":"Napoli","year":"2004","journal-title":"Nat. Mater."},{"key":"10.1016\/j.actbio.2025.12.035_bib0036","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1002\/anie.201802351","article-title":"Synchronous chemoradiation nanovesicles by X-ray triggered cascade of drug release","volume":"57","author":"Zhou","year":"2018","journal-title":"Angew. Chem. Int. Edit."},{"key":"10.1016\/j.actbio.2025.12.035_bib0037","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202404395","article-title":"A light-triggered J-aggregation-regulated therapy conversion: from photodynamic\/photothermal therapy to long-lasting chemodynamic therapy for effective tumor ablation","volume":"63","author":"Wei","year":"2024","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2025.12.035_bib0038","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1038\/s41467-022-32160-z","article-title":"Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.035_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202414347","article-title":"A microrobotic system based on engineered bacteria for targeted self-driven photodynamic therapy","volume":"64","author":"Jin","year":"2025","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.actbio.2025.12.035_bib0040","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1038\/s41467-023-42509-7","article-title":"Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.035_bib0041","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41467-023-44665-2","article-title":"In vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy","volume":"15","author":"Hou","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.035_bib0042","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1038\/s41467-023-42399-9","article-title":"NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor","volume":"14","author":"Shi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.035_bib0043","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41419-020-03221-2","article-title":"Detection of immunogenic cell death and its relevance for cancer therapy","volume":"11","author":"Fucikova","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.actbio.2025.12.035_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102380","article-title":"Tumor-targeting and activatable biomimetic nanococktails synergistically regulate immune responses for spatiotemporal immunotherapy of low immunogenic solid tumors","volume":"57","author":"Cui","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.actbio.2025.12.035_bib0045","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1038\/s41467-023-38014-6","article-title":"Temperature sensitive liposome based cancer nanomedicine enables tumour lymph node immune microenvironment remodelling","volume":"14","author":"Fu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.035_bib0046","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1038\/s41467-022-30543-w","article-title":"Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis","volume":"13","author":"Guan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.035_bib0047","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/ot9.0000000000000067","article-title":"Advancements in conventional cancer therapy combined with immunotherapy","volume":"11","author":"Li","year":"2025","journal-title":"Oncol. Transl. Med."},{"key":"10.1016\/j.actbio.2025.12.035_bib0048","doi-asserted-by":"crossref","first-page":"24483","DOI":"10.18632\/oncotarget.8231","article-title":"Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon cancer","volume":"7","author":"Xiao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.actbio.2025.12.035_bib0049","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12943-024-02069-w","article-title":"Cancer, metastasis, and the epigenome","volume":"23","author":"Kiri","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.actbio.2025.12.035_bib0050","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41568-023-00656-5","article-title":"Linking cell mechanical memory and cancer metastasis","volume":"24","author":"Cambria","year":"2024","journal-title":"Nat. Rev. Cancer"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125009420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706125009420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:15:51Z","timestamp":1781507751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706125009420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":50,"alternative-id":["S1742706125009420"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.12.035","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROS-sensitive nanocarriers for synergistic X-PDT\/chemo\/immunotherapy of triple-negative breast cancer and metastasis","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.12.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}